PT1583524E - Compostos bis ( tio-hidrazida amida ) para o tratamento do cancro resistente a múltiplos fármacos - Google Patents

Compostos bis ( tio-hidrazida amida ) para o tratamento do cancro resistente a múltiplos fármacos Download PDF

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Publication number
PT1583524E
PT1583524E PT04702560T PT04702560T PT1583524E PT 1583524 E PT1583524 E PT 1583524E PT 04702560 T PT04702560 T PT 04702560T PT 04702560 T PT04702560 T PT 04702560T PT 1583524 E PT1583524 E PT 1583524E
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PT
Portugal
Prior art keywords
group
represent
methyl
substituted
unsubstituted
Prior art date
Application number
PT04702560T
Other languages
English (en)
Portuguese (pt)
Inventor
Lijun Sun
Keizo Koya
Yaming Wu
Timoty Korbut
Dan Zhou
Zhenjian Du
Shoujun Chen
Noriaki Tatsuta
Guiqing Liang
Mitsunori Ono
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Synta Pharmaceuticals Corp
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Publication date
Application filed by Synta Pharmaceuticals Corp filed Critical Synta Pharmaceuticals Corp
Publication of PT1583524E publication Critical patent/PT1583524E/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
PT04702560T 2003-01-15 2004-01-15 Compostos bis ( tio-hidrazida amida ) para o tratamento do cancro resistente a múltiplos fármacos PT1583524E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44040603P 2003-01-15 2003-01-15

Publications (1)

Publication Number Publication Date
PT1583524E true PT1583524E (pt) 2006-12-29

Family

ID=32771813

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04702560T PT1583524E (pt) 2003-01-15 2004-01-15 Compostos bis ( tio-hidrazida amida ) para o tratamento do cancro resistente a múltiplos fármacos

Country Status (14)

Country Link
US (1) US7763658B2 (pt-PT)
EP (1) EP1583524B1 (pt-PT)
JP (1) JP4852409B2 (pt-PT)
AT (1) ATE336991T1 (pt-PT)
AU (1) AU2004206865B2 (pt-PT)
CA (1) CA2512797C (pt-PT)
CY (1) CY1106246T1 (pt-PT)
DE (1) DE602004002087T2 (pt-PT)
DK (1) DK1583524T3 (pt-PT)
ES (1) ES2271839T3 (pt-PT)
HK (1) HK1084024A1 (pt-PT)
PT (1) PT1583524E (pt-PT)
TW (1) TWI330079B (pt-PT)
WO (1) WO2004064826A1 (pt-PT)

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US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
US20100028339A1 (en) 2004-03-29 2010-02-04 Cheng Jin Q Compositions including triciribine and trastuzumab and methods of use thereof
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TW200829543A (en) 2006-09-15 2008-07-16 Synta Pharmaceuticals Corp Purification of bis(thiohydrazide amides)
US8618170B2 (en) * 2007-11-09 2013-12-31 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
WO2009073148A2 (en) * 2007-11-28 2009-06-11 Synta Pharmaceuticals Corp. Polymorphs of n-malonyl-bis(n'-methyl-n'-thiobenzoylhydrazide)
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Also Published As

Publication number Publication date
ATE336991T1 (de) 2006-09-15
CA2512797C (en) 2012-02-21
ES2271839T3 (es) 2007-04-16
DE602004002087T2 (de) 2007-03-08
HK1084024A1 (en) 2006-07-21
WO2004064826A1 (en) 2004-08-05
DE602004002087D1 (de) 2006-10-05
AU2004206865A1 (en) 2004-08-05
EP1583524A1 (en) 2005-10-12
US7763658B2 (en) 2010-07-27
TWI330079B (en) 2010-09-11
JP2006515626A (ja) 2006-06-01
AU2004206865B2 (en) 2006-07-13
EP1583524B1 (en) 2006-08-23
CY1106246T1 (el) 2011-06-08
TW200418449A (en) 2004-10-01
DK1583524T3 (da) 2006-12-27
CA2512797A1 (en) 2004-08-05
US20040225016A1 (en) 2004-11-11
JP4852409B2 (ja) 2012-01-11

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