AU2004206865B2 - Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer - Google Patents

Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer Download PDF

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Publication number
AU2004206865B2
AU2004206865B2 AU2004206865A AU2004206865A AU2004206865B2 AU 2004206865 B2 AU2004206865 B2 AU 2004206865B2 AU 2004206865 A AU2004206865 A AU 2004206865A AU 2004206865 A AU2004206865 A AU 2004206865A AU 2004206865 B2 AU2004206865 B2 AU 2004206865B2
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AU
Australia
Prior art keywords
methyl
substituted
group
unsubstituted
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2004206865A
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English (en)
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AU2004206865A1 (en
Inventor
Shoujun Chen
Zhenjian Du
Timothy Korbut
Keizo Koya
Guiqing Liang
Mitsunori Ono
Lijun Sun
Noriaki Tatsuta
Yaming Wu
Dan Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synta Phamaceuticals Corp
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Synta Phamaceuticals Corp
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Filing date
Publication date
Application filed by Synta Phamaceuticals Corp filed Critical Synta Phamaceuticals Corp
Publication of AU2004206865A1 publication Critical patent/AU2004206865A1/en
Application granted granted Critical
Publication of AU2004206865B2 publication Critical patent/AU2004206865B2/en
Priority to AU2006228035A priority Critical patent/AU2006228035B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2004206865A 2003-01-15 2004-01-15 Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer Ceased AU2004206865B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2006228035A AU2006228035B2 (en) 2003-01-15 2006-10-11 Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44040603P 2003-01-15 2003-01-15
US60/440,406 2003-01-15
PCT/US2004/001089 WO2004064826A1 (en) 2003-01-15 2004-01-15 Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2006228035A Division AU2006228035B2 (en) 2003-01-15 2006-10-11 Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer

Publications (2)

Publication Number Publication Date
AU2004206865A1 AU2004206865A1 (en) 2004-08-05
AU2004206865B2 true AU2004206865B2 (en) 2006-07-13

Family

ID=32771813

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2004206865A Ceased AU2004206865B2 (en) 2003-01-15 2004-01-15 Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer

Country Status (14)

Country Link
US (1) US7763658B2 (pt-PT)
EP (1) EP1583524B1 (pt-PT)
JP (1) JP4852409B2 (pt-PT)
AT (1) ATE336991T1 (pt-PT)
AU (1) AU2004206865B2 (pt-PT)
CA (1) CA2512797C (pt-PT)
CY (1) CY1106246T1 (pt-PT)
DE (1) DE602004002087T2 (pt-PT)
DK (1) DK1583524T3 (pt-PT)
ES (1) ES2271839T3 (pt-PT)
HK (1) HK1084024A1 (pt-PT)
PT (1) PT1583524E (pt-PT)
TW (1) TWI330079B (pt-PT)
WO (1) WO2004064826A1 (pt-PT)

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US20100009929A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
AU2005228410A1 (en) 2004-03-29 2005-10-13 University Of South Florida Effective treatment of tumors and cancer with triciribine and related compounds
US20110008327A1 (en) 2004-03-29 2011-01-13 Cheng Jin Q Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof
US20100009928A1 (en) 2004-03-29 2010-01-14 Cheng Jin Q Compositions including triciribine and taxanes and methods of use thereof
KR101313027B1 (ko) 2004-06-23 2013-10-02 신타 파마슈티칼스 코프. 암 치료용 비스(티오-히드라지드 아미드) 염
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JP2008540658A (ja) 2005-05-16 2008-11-20 シンタ ファーマシューティカルズ コーポレーション ビス（チオ−ヒドラジドアミド）塩の合成
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AU2007294969A1 (en) * 2006-09-11 2008-03-20 Synta Pharmaceuticals Corp. Bis (thiohydrazide amides) formulation
US9498528B2 (en) * 2006-09-13 2016-11-22 Genzyme Corporation Treatment of multiple sclerosis (MS)
US7645904B2 (en) * 2006-09-15 2010-01-12 Synta Pharmaceuticals Corp. Purification of bis(thiohydrazide amides)
WO2009064374A2 (en) * 2007-11-09 2009-05-22 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
US8637704B2 (en) 2007-11-28 2014-01-28 Synta Pharmaceuticals Corp. Polymorphs of N-malonyl-bis(N′-methyl-N′-thiobenzoylhydrazide)
WO2009105257A1 (en) * 2008-02-21 2009-08-27 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
US8633323B2 (en) * 2008-03-31 2014-01-21 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
WO2010048284A1 (en) 2008-10-22 2010-04-29 Synta Pharmaceuticals Corp. Transition metal complexes of bis[thiohydrazide amide] compounds
AU2009308511B2 (en) * 2008-10-22 2013-03-07 Synta Pharmaceutical Corp. Transition metal complexes of a bis[thiohydrazide amide] compound
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US8822532B2 (en) 2009-12-04 2014-09-02 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
US8815945B2 (en) 2010-04-20 2014-08-26 Masazumi Nagai Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers
US20140329892A1 (en) * 2011-11-10 2014-11-06 Synta Pharmaceuticals Corp. Administration of a bis(thiohydrazide amide) compound for treating cancers
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Also Published As

Publication number Publication date
JP4852409B2 (ja) 2012-01-11
EP1583524A1 (en) 2005-10-12
CA2512797C (en) 2012-02-21
TWI330079B (en) 2010-09-11
CY1106246T1 (el) 2011-06-08
CA2512797A1 (en) 2004-08-05
TW200418449A (en) 2004-10-01
WO2004064826A1 (en) 2004-08-05
US20040225016A1 (en) 2004-11-11
EP1583524B1 (en) 2006-08-23
DK1583524T3 (da) 2006-12-27
JP2006515626A (ja) 2006-06-01
PT1583524E (pt) 2006-12-29
AU2004206865A1 (en) 2004-08-05
US7763658B2 (en) 2010-07-27
DE602004002087D1 (de) 2006-10-05
ES2271839T3 (es) 2007-04-16
HK1084024A1 (en) 2006-07-21
ATE336991T1 (de) 2006-09-15
DE602004002087T2 (de) 2007-03-08

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