PT1513834E - Tiofenos substituidos, processo para a sua preparacao, sua utilizacao como medicamento ou meio de diagnostico bem como medicamento que os contem - Google Patents

Tiofenos substituidos, processo para a sua preparacao, sua utilizacao como medicamento ou meio de diagnostico bem como medicamento que os contem

Info

Publication number
PT1513834E
PT1513834E PT03740148T PT03740148T PT1513834E PT 1513834 E PT1513834 E PT 1513834E PT 03740148 T PT03740148 T PT 03740148T PT 03740148 T PT03740148 T PT 03740148T PT 1513834 E PT1513834 E PT 1513834E
Authority
PT
Portugal
Prior art keywords
thiofens
medicine
substituted
preparation
product containing
Prior art date
Application number
PT03740148T
Other languages
English (en)
Portuguese (pt)
Inventor
Hans-Jochen Lang
Uwe Heinelt
Hofmeister Armin
Klaus Wirth
Gekle Michael
Bleich Markus
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PT1513834E publication Critical patent/PT1513834E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Psychiatry (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
PT03740148T 2002-06-04 2003-05-26 Tiofenos substituidos, processo para a sua preparacao, sua utilizacao como medicamento ou meio de diagnostico bem como medicamento que os contem PT1513834E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10224892A DE10224892A1 (de) 2002-06-04 2002-06-04 Substituierte Thiophene, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Publications (1)

Publication Number Publication Date
PT1513834E true PT1513834E (pt) 2006-06-30

Family

ID=29557542

Family Applications (1)

Application Number Title Priority Date Filing Date
PT03740148T PT1513834E (pt) 2002-06-04 2003-05-26 Tiofenos substituidos, processo para a sua preparacao, sua utilizacao como medicamento ou meio de diagnostico bem como medicamento que os contem

Country Status (32)

Country Link
EP (1) EP1513834B1 (https=)
JP (1) JP4511924B2 (https=)
KR (1) KR101087966B1 (https=)
CN (1) CN1324024C (https=)
AR (1) AR040239A1 (https=)
AT (1) ATE320425T1 (https=)
AU (1) AU2003273553B2 (https=)
BR (1) BR0311548A (https=)
CA (1) CA2488242C (https=)
CR (1) CR7577A (https=)
DE (2) DE10224892A1 (https=)
DK (1) DK1513834T3 (https=)
EC (1) ECSP045471A (https=)
ES (1) ES2258722T3 (https=)
HR (1) HRP20041153A2 (https=)
IL (1) IL165519A (https=)
MA (1) MA27204A1 (https=)
ME (1) MEP27608A (https=)
MX (1) MXPA04011986A (https=)
MY (1) MY129832A (https=)
NO (1) NO329351B1 (https=)
OA (1) OA12827A (https=)
PE (1) PE20040534A1 (https=)
PL (1) PL372589A1 (https=)
PT (1) PT1513834E (https=)
RS (1) RS51141B (https=)
RU (1) RU2315766C2 (https=)
TN (1) TNSN04240A1 (https=)
TW (1) TWI283675B (https=)
UA (1) UA77551C2 (https=)
WO (1) WO2003101984A1 (https=)
ZA (1) ZA200409095B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040242560A1 (en) 2003-05-22 2004-12-02 Aventis Pharma Deutschland Gmbh Process for synthesizing heterocyclic compounds
DE10323701A1 (de) 2003-05-22 2004-12-23 Aventis Pharma Deutschland Gmbh Verfahren zur Synthese heterocyclischer Verbindungen
EP1640361B9 (en) 2003-06-30 2015-11-04 Sumitomo Chemical Company, Limited Asymmetric urea compounds and process for producing asymmetric compounds by asymmetric conjugate addition reaction using the same as catalyst
US20100056515A1 (en) * 2006-10-25 2010-03-04 Kazuyoshi Aso Benzimidazole compounds
JP5745406B2 (ja) 2008-09-02 2015-07-08 サノフイ 置換アミノインダン及びそのアナログ、及びその医薬使用
RU2373929C1 (ru) * 2008-11-11 2009-11-27 Государственное образовательное учреждение высшего профессионального образования "БАШКИРСКИЙ ГОСУДАРСТВЕННЫЙ МЕДИЦИНСКИЙ УНИВЕРСИТЕТ Федерального Агентства по здравоохранению и социальному развитию" (ГОУ ВПО БГМУ РОСЗДРАВА) Корректор системы гемостаза, проявляющий ингибирующее действие на адгезивно-агрегационную функцию тромбоцитов для профилактики патологического тромбообразования
CN102712601A (zh) * 2009-11-12 2012-10-03 赛尔维他股份公司 化合物、其制备方法、药物组合物、化合物的用途、用于调节或调控丝氨酸/苏氨酸激酶的方法以及丝氨酸/苏氨酸激酶调节剂
RU2518740C1 (ru) * 2013-03-22 2014-06-10 Федеральное государственное автономное образовательное учреждение высшего профессионального образования "ЮЖНЫЙ ФЕДЕРАЛЬНЫЙ УНИВЕРСИТЕТ" СРЕДСТВО, ИНГИБИРУЮЩЕЕ Na+/H+-ОБМЕН, И ДИГИДРОХЛОРИД 2-(3,4-МЕТИЛЕНДИОКСИФЕНИЛ)-9-МОРФОЛИНОЭТИЛИМИДАЗО[1,2-a]БЕНЗИМИДАЗОЛА
RU2703456C2 (ru) 2014-07-25 2019-10-17 Тайсо Фармасьютикал Ко., Лтд. Фенилтетрагидроизохинолиновое соединение, замещенное гетероарилом
KR102840252B1 (ko) * 2023-04-27 2025-07-30 한국화학연구원 시아노벤즈이미다졸 유도체, 약제학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물
CN120112529B (zh) * 2023-09-28 2026-01-06 四川大学华西医院 一种含吡啶的化合物及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754935A (fr) * 1969-08-13 1971-02-17 Hoechst Ag 2-(thienyl-3'-amino)-1,3-diazacycloalcenes et leur preparation
BR6915362D0 (pt) * 1969-08-16 1973-01-04 Hoechst Ag Processo para a preparacao de 2(tienil-3-amino)1,3-diazacicloalquenos
DE2830279A1 (de) * 1978-07-10 1980-01-31 Boehringer Sohn Ingelheim 2-eckige klammer auf n-(2'-chlor-4'- methyl-thienyl-3')-n-(cyclopropylmethyl)- amino eckige klammer zu-imidazolin-(2), dessen saeureadditionssalze, dieses enthaltende arzneimittel und verfahren zu seiner herstellung
US5395847A (en) * 1993-12-02 1995-03-07 Smithkline Beecham Corporation Imidazolyl-alkenoic acids
WO2000006169A1 (en) * 1998-07-29 2000-02-10 Merck & Co., Inc. Integrin receptor antagonists
DE19921883A1 (de) * 1999-05-12 2000-11-16 Bayer Ag Substituierte Thienocycloalk(en)ylamino-1,3,5-triazine
DE19960204A1 (de) * 1999-12-14 2001-06-28 Aventis Pharma Gmbh Substituierte Norlbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
WO2003082272A1 (en) * 2002-03-29 2003-10-09 Chiron Corporation Substituted benzazoles and use thereof as raf kinase inhibitors

Also Published As

Publication number Publication date
RU2315766C2 (ru) 2008-01-27
AR040239A1 (es) 2005-03-23
AU2003273553A1 (en) 2003-12-19
PL372589A1 (en) 2005-07-25
ATE320425T1 (de) 2006-04-15
PE20040534A1 (es) 2004-10-25
DK1513834T3 (da) 2006-07-17
MEP27608A (en) 2010-06-10
TNSN04240A1 (en) 2007-03-12
TWI283675B (en) 2007-07-11
DE10224892A1 (de) 2003-12-18
CN1324024C (zh) 2007-07-04
AU2003273553B2 (en) 2008-12-04
ES2258722T3 (es) 2006-09-01
KR20050005532A (ko) 2005-01-13
NO20045504L (no) 2005-01-25
JP4511924B2 (ja) 2010-07-28
UA77551C2 (en) 2006-12-15
NO329351B1 (no) 2010-10-04
IL165519A (en) 2010-05-31
EP1513834A1 (de) 2005-03-16
EP1513834B1 (de) 2006-03-15
MY129832A (en) 2007-05-31
ECSP045471A (es) 2005-01-28
DE50302673D1 (de) 2006-05-11
RU2004138812A (ru) 2005-07-20
TW200406409A (en) 2004-05-01
ZA200409095B (en) 2005-05-10
JP2005533038A (ja) 2005-11-04
CR7577A (es) 2005-06-16
HRP20041153A2 (en) 2005-06-30
BR0311548A (pt) 2005-04-12
IL165519A0 (en) 2006-01-15
MA27204A1 (fr) 2005-01-03
CN1659163A (zh) 2005-08-24
RS51141B (sr) 2010-10-31
MXPA04011986A (es) 2005-03-07
KR101087966B1 (ko) 2011-12-01
CA2488242C (en) 2011-08-02
WO2003101984A1 (de) 2003-12-11
HK1076460A1 (en) 2006-01-20
CA2488242A1 (en) 2003-12-11
OA12827A (en) 2006-07-11
RS103804A (sr) 2006-12-15

Similar Documents

Publication Publication Date Title
PT1194403E (pt) Benzenocarbonamidas substituidas com indanilo, processo para a sua preparacao, sua utilizacao como medicamento bem como preparacoes farmaceuticas que as contem
BR9911914B1 (pt) n-arilamidas do ácido sulfonilaminocarboxìlico substituìdas por enxofre, processo para sua preparação, bem como preparações farmacêuticas que compreendem as mesmas.
BR9605417A (pt) Sulfonimidamidas substituídas processos para a sua preparação seu emprego como medicamento ou diagnóstico bem como o medicamento contendo as mesmas
PT1339675E (pt) Compostos bisarilo orto, meta-substituidos, processo para a sua preparacao, sua utilizacao como medicamentos e composicoes farmaceuticas que os contem
PT1222163E (pt) 1,1-bifenil-2-carboxamidas substituidas na posicao 2 processo para a sua preparacao, sua utilizacao como medicamento, bem como preparacoes farmaceuticas contendo estas
PT1294682E (pt) Derivados de acilfenilureia processo para a sua preparacao e sua aplicacao como medicamentos
PT807629E (pt) Cromanos substituidos por sulfonamidas processo para a sua preparacao a sua utilizacao como medicamentos ou agentes de diagnostico bem como medicamentos que os contem
PT1218341E (pt) Derivados de sulfonilcarboxamidas, processo para a sua preparacao e sua utilizacao como medicamentos
PT1513834E (pt) Tiofenos substituidos, processo para a sua preparacao, sua utilizacao como medicamento ou meio de diagnostico bem como medicamento que os contem
ECSP056071A (es) Nueva difenilazetidinona con características fisiológicas mejoradas, correspondiente método de producción, medicamentos que contienen dicho compuesto y su uso
BR9105921A (pt) Substancia,vacina contra aids,tecnica de diagnostico para o deteccao de uma substancia,estojo,processo para o ensaio de uma atividade anti-aids de uma substancia e processo para a fabricacao de uma vacina
ATE343563T1 (de) Pentafluorsulfanyl-benzoylguanidine, verfahren zu ihrer hertellung, ihre verwendung als medikament oder diagnostikum sowie sie enthaltendes medikament
BRPI0416005A (pt) tiazolidinonas, na preparação e utilização como medicamento
BR9603911A (pt) Benzoilguanidinas substituídas processo para a sua preparação seu emprego como medicamento ou diagnóstico bem como o medicamento contendo as mesmas
PT1097140E (pt) Derivados de imidazole substituidos com bifenilsulfonilo processo para a sua preparacao sua aplicacao como medicamento ou meio de diagnostico asim como medicamento neles incluido
PT913396E (pt) Derivados de benzopiranos substituidos com sulfonamida processo para a sua preparacao sua utilizacao como medicamento bem como preparacoes farmaceuticas que as contem
PT915087E (pt) Compostos anelados de cinco aneis, susbtituidos por sulfonamida, sua utilizacao como medicamentos, bem como preparacoes farmaceuticas contendo os mesmos
PT905131E (pt) Cromanos substituidos por sulfonamida processo para a sua preparacao sua utilizacao como medicamento bem como preparacoes farmaceuticas que os contem
PT1411057E (pt) Derivados de [3,4-a:3,4-c]carbazole processo para a sua preparacao e as composicoes farmaceuticas que os contem
PT811610E (pt) Benzoilguanidinas orto-substituidas processo para a sua preparacao sua utilizacao como medicamento ou agente de diagnostico assim como os medicamentos que as contem
PT1157020E (pt) 1,2,3,4,5,6-hexa-hidro-2,6-metano-3-benzazocin-10-ois substituidos processo para a sua preparacao e sua utilizacao como medicamentos
PT1165528E (pt) Novos derivados de morfolina, processo para a sua preparacao e composicoes farmaceuticas que os contem
PT1277746E (pt) Novos derivados de n-benzilpiperazina, processo para a sua preparacao e as composicoes farmaceuticas que os contem
BR9703617A (pt) Benzoilguanidinas orto-substituídas processo para a sua preparação seu emprego como medicamento ou diagnóstico bem como medicamento contendo as mesmas
BR9700990A (pt) Guanididas de ácidos tiofenilalquenilcarboxílicos substituídas processo para a sua preparação sua aplicação como medicamento ou diagnóstico bem como medicamento que as contém