PT1478366E - Combinações farmacêuticas de meloxicam, fosfato de codeína e paracetamol - Google Patents
Combinações farmacêuticas de meloxicam, fosfato de codeína e paracetamol Download PDFInfo
- Publication number
- PT1478366E PT1478366E PT03706774T PT03706774T PT1478366E PT 1478366 E PT1478366 E PT 1478366E PT 03706774 T PT03706774 T PT 03706774T PT 03706774 T PT03706774 T PT 03706774T PT 1478366 E PT1478366 E PT 1478366E
- Authority
- PT
- Portugal
- Prior art keywords
- meloxicam
- paracetamol
- combination
- codeine
- daily dose
- Prior art date
Links
- ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 title claims description 57
- 229960001929 meloxicam Drugs 0.000 title claims description 57
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 title claims description 54
- 229960005489 paracetamol Drugs 0.000 title claims description 52
- DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 title claims description 11
- 229960004415 codeine phosphate Drugs 0.000 title claims description 11
- 208000002193 Pain Diseases 0.000 claims description 25
- 230000036407 pain Effects 0.000 claims description 25
- 208000004454 Hyperalgesia Diseases 0.000 claims description 18
- 208000035154 Hyperesthesia Diseases 0.000 claims description 18
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- 208000005171 Dysmenorrhea Diseases 0.000 claims description 4
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- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 92
- 229960004126 codeine Drugs 0.000 description 46
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 46
- 230000003070 anti-hyperalgesia Effects 0.000 description 30
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 2
- 230000003040 nociceptive effect Effects 0.000 description 2
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- 239000000825 pharmaceutical preparation Substances 0.000 description 2
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 2
- 229940113147 shellac Drugs 0.000 description 2
- 229960004380 tramadol Drugs 0.000 description 2
- TVYLLZQTGLZFBW-GOEBONIOSA-N tramadol Natural products COC1=CC=CC([C@@]2(O)[C@@H](CCCC2)CN(C)C)=C1 TVYLLZQTGLZFBW-GOEBONIOSA-N 0.000 description 2
- 101100275473 Caenorhabditis elegans ctc-3 gene Proteins 0.000 description 1
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- 102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 description 1
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- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
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- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
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- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Emergency Medicine (AREA)
- Immunology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ZA200201395 | 2002-02-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1478366E true PT1478366E (pt) | 2009-03-10 |
Family
ID=27758232
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT03706774T PT1478366E (pt) | 2002-02-19 | 2003-02-14 | Combinações farmacêuticas de meloxicam, fosfato de codeína e paracetamol |
| PT08170195T PT2050453E (pt) | 2002-02-19 | 2003-02-14 | Combinações farmacêuticas de meloxicam, tramadol e paracetamol |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT08170195T PT2050453E (pt) | 2002-02-19 | 2003-02-14 | Combinações farmacêuticas de meloxicam, tramadol e paracetamol |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20050090517A1 (https=) |
| EP (2) | EP1478366B1 (https=) |
| JP (1) | JP2005519936A (https=) |
| CN (1) | CN100418533C (https=) |
| AP (1) | AP1862A (https=) |
| AT (2) | ATE524186T1 (https=) |
| AU (1) | AU2003208485B2 (https=) |
| CA (1) | CA2476939C (https=) |
| CY (1) | CY1108839T1 (https=) |
| DE (1) | DE60325020D1 (https=) |
| DK (1) | DK1478366T3 (https=) |
| EG (1) | EG24845A (https=) |
| ES (2) | ES2318113T3 (https=) |
| IL (2) | IL163637A0 (https=) |
| NZ (1) | NZ535500A (https=) |
| OA (1) | OA12778A (https=) |
| PT (2) | PT1478366E (https=) |
| SI (1) | SI1478366T1 (https=) |
| WO (1) | WO2003070251A1 (https=) |
| ZA (1) | ZA200407485B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007530620A (ja) * | 2004-04-01 | 2007-11-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | メロキシカムを含む組成物 |
| WO2005117895A2 (en) * | 2004-06-04 | 2005-12-15 | Boehringer Ingelheim International Gmbh | Compositions comprising meloxicam |
| ITMI20060983A1 (it) * | 2006-05-18 | 2007-11-19 | Formevet S P A | Composizioni farmaceutiche veterinarie per il trattamento del dolore e dell'inifiamazione |
| WO2007138466A2 (en) * | 2006-06-01 | 2007-12-06 | Wockhardt Ltd | Pharmaceutical compositions comprising meloxicam and tramadol combination |
| US20080031950A1 (en) * | 2007-04-27 | 2008-02-07 | Nectid Inc. | Novel anelgesic combination |
| US20080026054A1 (en) * | 2007-04-27 | 2008-01-31 | Nectid Inc. | Novel anelgesic combination |
| EP2177215A1 (en) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
| EP2311446A1 (en) * | 2009-10-16 | 2011-04-20 | Laboratorios Del. Dr. Esteve, S.A. | Compositions comprising Tramadol and Celecoxib in the treatment of pain |
| IT1398321B1 (it) * | 2010-02-26 | 2013-02-22 | Formevet Spa Ora Formevet Srl | Associazione tra un analgesico ad azione centrale e un antinfiammatorio inibitore selettivo della cicloossigenasi 2 per il trattamento dell'infiammazione e del dolore in campo veterinario |
| EP2392319A1 (en) * | 2010-06-04 | 2011-12-07 | Laboratorios Del. Dr. Esteve, S.A. | Pharmaceutical compositions of co-crystals of tramadol and coxibs |
| WO2015004505A1 (es) * | 2013-07-11 | 2015-01-15 | More Pharma Corporation, S. De R.L. De C.V. | Combinación sinergística de paracetamol/celecoxib para el tratamiento de dolor inflamatorio |
| WO2019130049A1 (en) | 2017-12-29 | 2019-07-04 | Grünenthal GmbH | Pharmaceutical combination comprising extended-release tramadol hydrochloride and immediate-release etoricoxib, and its use for the treatment of pain |
| US20210346328A1 (en) * | 2018-09-21 | 2021-11-11 | The Johns Hopkins University | Compositions and methods for treating metabolic disorders |
| CN115300515A (zh) * | 2022-08-11 | 2022-11-08 | 南京红地生物科技有限公司 | 一种含有美洛昔康和盐酸曲马多的长效注射液 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA845785B (en) * | 1983-06-10 | 1985-03-27 | Adcock Ingram Lab Ltd | Pharmaceutical unit |
| ZA893422B (en) * | 1988-02-24 | 1991-01-30 | Adcock Ingram Lab Ltd | Pharmaceutical composition |
| WO1997020551A1 (en) * | 1995-12-05 | 1997-06-12 | Adcock Ingram Limited | Pharmaceutical composition comprising a skeletal muscle relaxant, a non-steroidal antiinflammatory agent and an analgesic |
| RS49982B (sr) * | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
| FR2770131A1 (fr) * | 1997-10-27 | 1999-04-30 | Union Pharma Scient Appl | Nouvelle association pharmaceutique a activite analgesique |
| JP2001526228A (ja) * | 1997-12-22 | 2001-12-18 | ユーロ−セルティーク，エス．エイ． | オピオイド作動薬／拮抗薬の併用 |
| US6375957B1 (en) * | 1997-12-22 | 2002-04-23 | Euro-Celtique, S.A. | Opioid agonist/opioid antagonist/acetaminophen combinations |
| JP2003535061A (ja) * | 2000-05-31 | 2003-11-25 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | エンドセリン受容体拮抗剤および疼痛軽減特性を有する抗癲癇化合物または鎮痛剤の複合物 |
| MXPA02012344A (es) * | 2000-06-13 | 2004-02-26 | Wyeth Corp | Composiciones y anti-inflamatorias que contienen inhibidores cox-2. |
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2003
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- 2003-02-14 EP EP03706774A patent/EP1478366B1/en not_active Expired - Lifetime
- 2003-02-14 WO PCT/IB2003/000500 patent/WO2003070251A1/en not_active Ceased
- 2003-02-14 JP JP2003569207A patent/JP2005519936A/ja active Pending
- 2003-02-14 CN CNB038085321A patent/CN100418533C/zh not_active Expired - Fee Related
- 2003-02-14 AT AT08170195T patent/ATE524186T1/de not_active IP Right Cessation
- 2003-02-14 US US10/505,291 patent/US20050090517A1/en not_active Abandoned
- 2003-02-14 AU AU2003208485A patent/AU2003208485B2/en not_active Ceased
- 2003-02-14 IL IL16363703A patent/IL163637A0/xx unknown
- 2003-02-14 ES ES03706774T patent/ES2318113T3/es not_active Expired - Lifetime
- 2003-02-14 CA CA2476939A patent/CA2476939C/en not_active Expired - Lifetime
- 2003-02-14 DK DK03706774T patent/DK1478366T3/da active
- 2003-02-14 PT PT03706774T patent/PT1478366E/pt unknown
- 2003-02-14 SI SI200331530T patent/SI1478366T1/sl unknown
- 2003-02-14 AP APAP/P/2004/003134A patent/AP1862A/en active
- 2003-02-14 OA OA1200400220A patent/OA12778A/en unknown
- 2003-02-14 ES ES08170195T patent/ES2376500T3/es not_active Expired - Lifetime
- 2003-02-14 EP EP08170195A patent/EP2050453B1/en not_active Expired - Lifetime
- 2003-02-14 DE DE60325020T patent/DE60325020D1/de not_active Expired - Lifetime
- 2003-02-14 AT AT03706774T patent/ATE415971T1/de active
- 2003-02-14 PT PT08170195T patent/PT2050453E/pt unknown
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2004
- 2004-08-19 IL IL163637A patent/IL163637A/en active IP Right Grant
- 2004-08-19 EG EGNA2004000074 patent/EG24845A/xx active
- 2004-09-17 ZA ZA2004/07485A patent/ZA200407485B/en unknown
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2009
- 2009-02-27 CY CY20091100239T patent/CY1108839T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL163637A0 (en) | 2005-12-18 |
| CN100418533C (zh) | 2008-09-17 |
| CA2476939A1 (en) | 2003-08-28 |
| ES2376500T3 (es) | 2012-03-14 |
| PT2050453E (pt) | 2012-01-03 |
| SI1478366T1 (sl) | 2009-06-30 |
| US20050090517A1 (en) | 2005-04-28 |
| WO2003070251A1 (en) | 2003-08-28 |
| CA2476939C (en) | 2012-08-28 |
| DK1478366T3 (da) | 2009-03-30 |
| IL163637A (en) | 2010-11-30 |
| ATE524186T1 (de) | 2011-09-15 |
| EG24845A (en) | 2010-10-21 |
| AU2003208485A1 (en) | 2003-09-09 |
| NZ535500A (en) | 2006-09-29 |
| EP2050453B1 (en) | 2011-09-14 |
| AP1862A (en) | 2008-07-07 |
| EP2050453A1 (en) | 2009-04-22 |
| ES2318113T3 (es) | 2009-05-01 |
| EP1478366B1 (en) | 2008-12-03 |
| JP2005519936A (ja) | 2005-07-07 |
| AU2003208485B2 (en) | 2009-05-28 |
| OA12778A (en) | 2006-07-06 |
| CY1108839T1 (el) | 2014-07-02 |
| ZA200407485B (en) | 2005-12-28 |
| AP2004003134A0 (en) | 2004-09-30 |
| EP1478366A1 (en) | 2004-11-24 |
| DE60325020D1 (de) | 2009-01-15 |
| CN1646133A (zh) | 2005-07-27 |
| ATE415971T1 (de) | 2008-12-15 |
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