CN100418533C - 环加氧酶-2抑制剂和阿片剂的药物组合体 - Google Patents

环加氧酶-2抑制剂和阿片剂的药物组合体 Download PDF

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Publication number
CN100418533C
CN100418533C CNB038085321A CN03808532A CN100418533C CN 100418533 C CN100418533 C CN 100418533C CN B038085321 A CNB038085321 A CN B038085321A CN 03808532 A CN03808532 A CN 03808532A CN 100418533 C CN100418533 C CN 100418533C
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pain
meloxicam
codeine
acetaminophen
combination
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Expired - Fee Related
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CNB038085321A
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Chinese (zh)
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CN1646133A (zh
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迈克尔·克里斯蒂安·诺里斯
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Adcock Ingram Ltd
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Adcock Ingram Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Reproductive Health (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CNB038085321A 2002-02-19 2003-02-14 环加氧酶-2抑制剂和阿片剂的药物组合体 Expired - Fee Related CN100418533C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA200201395 2002-02-19
ZA2002/1395 2002-02-19

Publications (2)

Publication Number Publication Date
CN1646133A CN1646133A (zh) 2005-07-27
CN100418533C true CN100418533C (zh) 2008-09-17

Family

ID=27758232

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CNB038085321A Expired - Fee Related CN100418533C (zh) 2002-02-19 2003-02-14 环加氧酶-2抑制剂和阿片剂的药物组合体

Country Status (20)

Country Link
US (1) US20050090517A1 (https=)
EP (2) EP2050453B1 (https=)
JP (1) JP2005519936A (https=)
CN (1) CN100418533C (https=)
AP (1) AP1862A (https=)
AT (2) ATE524186T1 (https=)
AU (1) AU2003208485B2 (https=)
CA (1) CA2476939C (https=)
CY (1) CY1108839T1 (https=)
DE (1) DE60325020D1 (https=)
DK (1) DK1478366T3 (https=)
EG (1) EG24845A (https=)
ES (2) ES2376500T3 (https=)
IL (2) IL163637A0 (https=)
NZ (1) NZ535500A (https=)
OA (1) OA12778A (https=)
PT (2) PT1478366E (https=)
SI (1) SI1478366T1 (https=)
WO (1) WO2003070251A1 (https=)
ZA (1) ZA200407485B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005094832A1 (en) * 2004-04-01 2005-10-13 Boehringer Ingelheim International Gmbh Compositions comprising meloxicam
JP2008501655A (ja) * 2004-06-04 2008-01-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング メロキシカム含有組成物
ITMI20060983A1 (it) * 2006-05-18 2007-11-19 Formevet S P A Composizioni farmaceutiche veterinarie per il trattamento del dolore e dell'inifiamazione
WO2007138466A2 (en) * 2006-06-01 2007-12-06 Wockhardt Ltd Pharmaceutical compositions comprising meloxicam and tramadol combination
US20080031950A1 (en) * 2007-04-27 2008-02-07 Nectid Inc. Novel anelgesic combination
US20080026054A1 (en) * 2007-04-27 2008-01-31 Nectid Inc. Novel anelgesic combination
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
EP2311446A1 (en) 2009-10-16 2011-04-20 Laboratorios Del. Dr. Esteve, S.A. Compositions comprising Tramadol and Celecoxib in the treatment of pain
IT1398321B1 (it) * 2010-02-26 2013-02-22 Formevet Spa Ora Formevet Srl Associazione tra un analgesico ad azione centrale e un antinfiammatorio inibitore selettivo della cicloossigenasi 2 per il trattamento dell'infiammazione e del dolore in campo veterinario
EP2392319A1 (en) * 2010-06-04 2011-12-07 Laboratorios Del. Dr. Esteve, S.A. Pharmaceutical compositions of co-crystals of tramadol and coxibs
WO2015004505A1 (es) * 2013-07-11 2015-01-15 More Pharma Corporation, S. De R.L. De C.V. Combinación sinergística de paracetamol/celecoxib para el tratamiento de dolor inflamatorio
MX2018013070A (es) 2017-12-29 2019-10-15 Gruenenthal Gmbh Combinación farmacéutica que comprende clorhidrato de tramadol de liberación extendida y etoricoxib de liberación inmediata, y su uso para el tratamiento del dolor.
WO2020061475A2 (en) * 2018-09-21 2020-03-26 The Johns Hopkins University Compositions and methods for treating metabolic disorders
CN115300515A (zh) * 2022-08-11 2022-11-08 南京红地生物科技有限公司 一种含有美洛昔康和盐酸曲马多的长效注射液

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA845785B (en) * 1983-06-10 1985-03-27 Adcock Ingram Lab Ltd Pharmaceutical unit
ZA893422B (en) * 1988-02-24 1991-01-30 Adcock Ingram Lab Ltd Pharmaceutical composition
WO1997020551A1 (en) * 1995-12-05 1997-06-12 Adcock Ingram Limited Pharmaceutical composition comprising a skeletal muscle relaxant, a non-steroidal antiinflammatory agent and an analgesic
WO1999021585A1 (en) * 1997-10-27 1999-05-06 Laboratoires Upsa Pharmaceutical combination of a cyclooxigenase-2 inhibitor and acetaminophen or an opiate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS49982B (sr) * 1997-09-17 2008-09-29 Euro-Celtique S.A., Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2
EP1041987B1 (en) * 1997-12-22 2006-04-19 Euro-Celtique S.A. Pharmaceutical oral dosage form comprising a combination of an opioid agonist and naltrexone
US6375957B1 (en) * 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
WO2001091736A2 (en) * 2000-05-31 2001-12-06 Warner-Lambert Company Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic
IL153303A0 (en) * 2000-06-13 2003-07-06 Wyeth Corp Analgesic and anti-inflammatory compositions conaining cox-2 inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA845785B (en) * 1983-06-10 1985-03-27 Adcock Ingram Lab Ltd Pharmaceutical unit
ZA893422B (en) * 1988-02-24 1991-01-30 Adcock Ingram Lab Ltd Pharmaceutical composition
WO1997020551A1 (en) * 1995-12-05 1997-06-12 Adcock Ingram Limited Pharmaceutical composition comprising a skeletal muscle relaxant, a non-steroidal antiinflammatory agent and an analgesic
WO1999021585A1 (en) * 1997-10-27 1999-05-06 Laboratoires Upsa Pharmaceutical combination of a cyclooxigenase-2 inhibitor and acetaminophen or an opiate

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Postoperative analgesia is not different after local vs systemicadministration of meloxicam in patients undergoing inguinalhernia repair.. Romsing-Janne {a}, Mysager-Steffen, Vilmann-Peter,Sonne-Jesper, Larsen-Niels-Erik, Ostergaard-Doris.Canadian-Journal-of-Anesthesia.,Vol.48 No.10. 2001
Postoperative analgesia is not different after local vs systemicadministration of meloxicam in patients undergoing inguinalhernia repair.. Romsing-Janne {a}, Mysager-Steffen, Vilmann-Peter,Sonne-Jesper, Larsen-Niels-Erik, Ostergaard-Doris.Canadian-Journal-of-Anesthesia.,Vol.48 No.10. 2001 *

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Publication number Publication date
AU2003208485B2 (en) 2009-05-28
DK1478366T3 (da) 2009-03-30
EP2050453B1 (en) 2011-09-14
ES2318113T3 (es) 2009-05-01
WO2003070251A1 (en) 2003-08-28
EP1478366A1 (en) 2004-11-24
CN1646133A (zh) 2005-07-27
CA2476939C (en) 2012-08-28
SI1478366T1 (sl) 2009-06-30
EG24845A (en) 2010-10-21
ZA200407485B (en) 2005-12-28
ATE524186T1 (de) 2011-09-15
ES2376500T3 (es) 2012-03-14
AP1862A (en) 2008-07-07
ATE415971T1 (de) 2008-12-15
IL163637A (en) 2010-11-30
OA12778A (en) 2006-07-06
EP2050453A1 (en) 2009-04-22
DE60325020D1 (de) 2009-01-15
US20050090517A1 (en) 2005-04-28
CY1108839T1 (el) 2014-07-02
CA2476939A1 (en) 2003-08-28
PT1478366E (pt) 2009-03-10
JP2005519936A (ja) 2005-07-07
IL163637A0 (en) 2005-12-18
AU2003208485A1 (en) 2003-09-09
PT2050453E (pt) 2012-01-03
EP1478366B1 (en) 2008-12-03
AP2004003134A0 (en) 2004-09-30
NZ535500A (en) 2006-09-29

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