PT1458388E - Formulação farmacêutica líquida compreendendo nicotina para a administração na cavidade oral - Google Patents

Formulação farmacêutica líquida compreendendo nicotina para a administração na cavidade oral Download PDF

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Publication number
PT1458388E
PT1458388E PT02793665T PT02793665T PT1458388E PT 1458388 E PT1458388 E PT 1458388E PT 02793665 T PT02793665 T PT 02793665T PT 02793665 T PT02793665 T PT 02793665T PT 1458388 E PT1458388 E PT 1458388E
Authority
PT
Portugal
Prior art keywords
administration
nicotine
oral cavity
liquid pharmaceutical
pharmaceutical formulation
Prior art date
Application number
PT02793665T
Other languages
English (en)
Inventor
Katarina Lindell
Bengt Bosson
Gunnar Bergengren
Anette Schlueter
Original Assignee
Mcneil Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20286485&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT1458388(E) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Mcneil Ab filed Critical Mcneil Ab
Publication of PT1458388E publication Critical patent/PT1458388E/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/465—Nicotine; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
PT02793665T 2001-12-27 2002-12-18 Formulação farmacêutica líquida compreendendo nicotina para a administração na cavidade oral PT1458388E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0104388A SE0104388D0 (sv) 2001-12-27 2001-12-27 New formulation and use and manufacture thereof

Publications (1)

Publication Number Publication Date
PT1458388E true PT1458388E (pt) 2009-05-15

Family

ID=20286485

Family Applications (2)

Application Number Title Priority Date Filing Date
PT90025693T PT2186507E (pt) 2001-12-27 2002-12-18 Formulação farmacêutica líquida compreendendo nicotina para a administração na cavidade oral
PT02793665T PT1458388E (pt) 2001-12-27 2002-12-18 Formulação farmacêutica líquida compreendendo nicotina para a administração na cavidade oral

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PT90025693T PT2186507E (pt) 2001-12-27 2002-12-18 Formulação farmacêutica líquida compreendendo nicotina para a administração na cavidade oral

Country Status (21)

Country Link
EP (2) EP2186507B1 (pt)
JP (1) JP5264036B2 (pt)
KR (1) KR20040075035A (pt)
CN (1) CN1607950B (pt)
AT (1) ATE427109T1 (pt)
AU (1) AU2002359152B2 (pt)
BR (1) BR0215393A (pt)
CA (1) CA2471906C (pt)
CY (1) CY1109146T1 (pt)
DE (1) DE60231835D1 (pt)
DK (2) DK1458388T3 (pt)
ES (2) ES2537334T3 (pt)
IL (1) IL162662A0 (pt)
MX (1) MXPA04006395A (pt)
NZ (1) NZ533714A (pt)
PT (2) PT2186507E (pt)
RU (1) RU2279871C2 (pt)
SE (1) SE0104388D0 (pt)
SI (1) SI1458388T1 (pt)
WO (1) WO2003055486A1 (pt)
ZA (1) ZA200404964B (pt)

Families Citing this family (106)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7767698B2 (en) 2002-06-03 2010-08-03 Mcneil Ab Formulation and use thereof
DK1803444T3 (en) 2002-12-20 2019-02-25 Niconovum Ab PROCEDURE FOR PREPARING A NICOTIC PARTICULATE MATERIAL WITH A CRYSTALLINE CELLULOSE (ESPECIALLY MCC)
US9358296B2 (en) 2003-02-24 2016-06-07 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US9498454B2 (en) 2003-02-24 2016-11-22 Pharmaceutical Productions Inc. Transmucosal drug delivery system
US9254294B2 (en) 2003-02-24 2016-02-09 Pharmaceutical Productions Inc. Transmucosal hormone delivery system
EP2316418A3 (en) 2003-02-24 2011-09-21 Pharmaceutical Productions Inc. Transmucosal drug delivery system
CN100381083C (zh) 2003-04-29 2008-04-16 韩力 一种非可燃性电子喷雾香烟
CN2719043Y (zh) 2004-04-14 2005-08-24 韩力 雾化电子烟
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
EP1802258A4 (en) 2004-09-13 2015-09-23 Chrono Therapeutics Inc BIOSYNCHRONE TRANSDERMAL MEDICINES
WO2006100075A2 (en) * 2005-03-22 2006-09-28 Niconovum Ab Use of an artificial sweetener to enhance absorption of nicotine
JP5000932B2 (ja) * 2005-06-21 2012-08-15 日東電工株式会社 ニコチン含有経皮吸収製剤
US9675109B2 (en) 2005-07-19 2017-06-13 J. T. International Sa Method and system for vaporization of a substance
US10244793B2 (en) 2005-07-19 2019-04-02 Juul Labs, Inc. Devices for vaporization of a substance
WO2007104573A2 (en) 2006-03-16 2007-09-20 Niconovum Ab Improved snuff composition
NZ572366A (en) * 2006-05-08 2012-02-24 Herrera Arturo Solis THE USE OF NICOTINE, ANALOGUES THEREOF, PRECURSORS THEREOF OR DERIVATIVES THEREOF IN THE TREATMENT OF VARIOUS PATHOLOGICAL PROCESSES CAPABLE OF IMPROVEMENT WITH a-MSH ADMINISTERED IN PROPHYLACTIC OR THERAPEUTIC FORM
US20070269386A1 (en) * 2006-05-16 2007-11-22 Per Steen New product and use and manufacture thereof
CN201067079Y (zh) 2006-05-16 2008-06-04 韩力 仿真气溶胶吸入器
FR2906140B1 (fr) * 2006-09-22 2008-12-05 Philippe Perovitch Forme galenique pour l'administration par voie trans-muqueuse de principes actifs
JP2010504931A (ja) 2006-09-27 2010-02-18 ニコノヴァム エービー 指向性の使用
ES2521494T3 (es) 2007-04-02 2014-11-12 Parkinson's Institute Métodos y composiciones para la reducción de los efectos secundarios de tratamientos terapéuticos
US20080286340A1 (en) * 2007-05-16 2008-11-20 Sven-Borje Andersson Buffered nicotine containing products
US20090041800A1 (en) 2007-08-06 2009-02-12 Synosia Therapeutics, Inc. Methods for Treating Dependence
US8991402B2 (en) 2007-12-18 2015-03-31 Pax Labs, Inc. Aerosol devices and methods for inhaling a substance and uses thereof
CN201379072Y (zh) 2009-02-11 2010-01-13 韩力 一种改进的雾化电子烟
JP5702389B2 (ja) 2009-09-16 2015-04-15 フィリップ・モーリス・プロダクツ・ソシエテ・アノニム 医薬品を送達するための改良型装置及び方法
WO2011065754A2 (ko) * 2009-11-24 2011-06-03 주식회사 에바코 기화 흡입용 장치, 이에 적용되는 기화 흡입용 조성물 및 그 기화 흡입용 조성물의 기화시키는 방법
KR100955080B1 (ko) * 2009-11-24 2010-04-28 주식회사 에바코 기화 흡입용 조성물 및 장치
US20110268809A1 (en) 2010-04-28 2011-11-03 Paul Andrew Brinkley Nicotine-Containing Pharmaceutical Compositions
US20110274628A1 (en) 2010-05-07 2011-11-10 Borschke August J Nicotine-containing pharmaceutical compositions
GB201012090D0 (en) 2010-07-19 2010-09-01 British American Tobacco Co Cellulosic material
US9399110B2 (en) 2011-03-09 2016-07-26 Chong Corporation Medicant delivery system
US9913950B2 (en) 2011-03-09 2018-03-13 Chong Corporation Medicant delivery system
US8903228B2 (en) 2011-03-09 2014-12-02 Chong Corporation Vapor delivery devices and methods
CA2841785A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
WO2013025921A1 (en) 2011-08-16 2013-02-21 Ploom, Inc. Low temperature electronic vaporization device and methods
US20130078307A1 (en) 2011-09-22 2013-03-28 Niconovum Usa, Inc. Nicotine-containing pharmaceutical composition
US9907748B2 (en) 2011-10-21 2018-03-06 Niconovum Usa, Inc. Excipients for nicotine-containing therapeutic compositions
US9668969B1 (en) 2012-02-22 2017-06-06 Arturo Solis Herrera Methods of using QIAPINE
US20130255702A1 (en) 2012-03-28 2013-10-03 R.J. Reynolds Tobacco Company Smoking article incorporating a conductive substrate
US10517530B2 (en) 2012-08-28 2019-12-31 Juul Labs, Inc. Methods and devices for delivering and monitoring of tobacco, nicotine, or other substances
CN102960852B (zh) * 2012-11-14 2015-04-22 湖北中烟工业有限责任公司 淡雅香型电子烟雾化烟液及其制备方法
US10034988B2 (en) 2012-11-28 2018-07-31 Fontem Holdings I B.V. Methods and devices for compound delivery
US10279934B2 (en) 2013-03-15 2019-05-07 Juul Labs, Inc. Fillable vaporizer cartridge and method of filling
KR20230013165A (ko) 2013-05-06 2023-01-26 쥴 랩스, 인크. 에어로졸 장치를 위한 니코틴 염 제제 및 그 방법
CN111642812A (zh) 2013-06-14 2020-09-11 尤尔实验室有限公司 电子汽化设备中的具有单独的可汽化材料的多个加热元件
JP5730355B2 (ja) * 2013-07-24 2015-06-10 学校法人近畿大学 Ｃｙｐ２ａ１３阻害剤
WO2015042412A1 (en) 2013-09-20 2015-03-26 E-Nicotine Technology. Inc. Devices and methods for modifying delivery devices
US10357054B2 (en) 2013-10-16 2019-07-23 R.J. Reynolds Tobacco Company Smokeless tobacco pastille
AU2014357622B2 (en) 2013-12-05 2019-10-24 Juul Labs, Inc. Nicotine liquid formulations for aerosol devices and methods thereof
US10159282B2 (en) 2013-12-23 2018-12-25 Juul Labs, Inc. Cartridge for use with a vaporizer device
USD842536S1 (en) 2016-07-28 2019-03-05 Juul Labs, Inc. Vaporizer cartridge
US10076139B2 (en) 2013-12-23 2018-09-18 Juul Labs, Inc. Vaporizer apparatus
US9549573B2 (en) 2013-12-23 2017-01-24 Pax Labs, Inc. Vaporization device systems and methods
KR102256889B1 (ko) 2013-12-23 2021-05-31 쥴 랩스, 인크. 기화 디바이스 시스템 및 방법
USD825102S1 (en) 2016-07-28 2018-08-07 Juul Labs, Inc. Vaporizer device with cartridge
US10058129B2 (en) 2013-12-23 2018-08-28 Juul Labs, Inc. Vaporization device systems and methods
US20160366947A1 (en) 2013-12-23 2016-12-22 James Monsees Vaporizer apparatus
CN103798952B (zh) * 2014-01-21 2016-04-27 江苏中烟工业有限责任公司 通窍提神型烟草鼻腔喷剂组合物及其制备方法
CN103750539B (zh) * 2014-01-21 2016-03-23 江苏中烟工业有限责任公司 一种消炎抗菌型烟草鼻腔喷剂组合物及其制备方法
US11478021B2 (en) 2014-05-16 2022-10-25 Juul Labs, Inc. Systems and methods for aerosolizing a vaporizable material
CN105433428A (zh) * 2014-09-01 2016-03-30 上海羿康生物科技有限公司 含咖啡因雾化液及含咖啡因雾化液的生产方法
KR101506708B1 (ko) 2014-09-03 2015-03-30 주식회사 다림바이오텍 금연 보조용 설하분무제와 트로키를 제조하는 방법 및 이에 의하여 제조된 설하분무제와 트로키
GB2535427A (en) 2014-11-07 2016-08-24 Nicoventures Holdings Ltd Solution
KR102627987B1 (ko) 2014-12-05 2024-01-22 쥴 랩스, 인크. 교정된 투여량 제어
AU2016211330A1 (en) 2015-01-28 2017-08-03 Chrono Therapeutics Inc. Drug delivery methods and systems
US10679516B2 (en) 2015-03-12 2020-06-09 Morningside Venture Investments Limited Craving input and support system
GB201516729D0 (en) * 2015-09-22 2015-11-04 The Technology Partnership Plc Liquid nicotine formulation
US10532046B2 (en) 2015-12-03 2020-01-14 Niconovum Usa, Inc. Multi-phase delivery compositions and products incorporating such compositions
US20170165252A1 (en) 2015-12-10 2017-06-15 Niconovum Usa Inc. Protein-enriched therapeutic composition
CN105361238A (zh) * 2015-12-16 2016-03-02 浙江中烟工业有限责任公司 一种含pH调节剂的电子烟烟液及提高电子烟烟液抽吸感的方法
EP3419443A4 (en) 2016-02-11 2019-11-20 Juul Labs, Inc. SAFE MOUNTING OF CARTRIDGES FOR EVAPORATOR DEVICES
DE202017007467U1 (de) 2016-02-11 2021-12-08 Juul Labs, Inc. Befüllbare Verdampferkartusche
US10405582B2 (en) 2016-03-10 2019-09-10 Pax Labs, Inc. Vaporization device with lip sensing
USD849996S1 (en) 2016-06-16 2019-05-28 Pax Labs, Inc. Vaporizer cartridge
USD848057S1 (en) 2016-06-23 2019-05-07 Pax Labs, Inc. Lid for a vaporizer
USD836541S1 (en) 2016-06-23 2018-12-25 Pax Labs, Inc. Charging device
USD851830S1 (en) 2016-06-23 2019-06-18 Pax Labs, Inc. Combined vaporizer tamp and pick tool
KR200486087Y1 (ko) 2016-09-02 2018-04-03 삼성중공업 주식회사 방연 댐퍼 유닛의 풀링 와이어 관통관
US11660403B2 (en) 2016-09-22 2023-05-30 Juul Labs, Inc. Leak-resistant vaporizer device
CN106727449A (zh) * 2016-12-20 2017-05-31 大连丹特生物技术有限公司 一种木糖醇烟碱喷剂及其制备方法
WO2018129304A1 (en) 2017-01-06 2018-07-12 Chrono Therapeutics Inc. Transdermal drug delivery devices and methods
US20180228203A1 (en) * 2017-02-16 2018-08-16 Altria Client Services Llc Pre-vapor formulation for formation of organic acids during operation of an e-vaping device
USD887632S1 (en) 2017-09-14 2020-06-16 Pax Labs, Inc. Vaporizer cartridge
CN111447921B (zh) 2017-12-08 2023-10-13 费尔廷制药公司 烟碱片剂
EP3720499A1 (en) * 2017-12-08 2020-10-14 Fertin Pharma A/S Nicotine mouth spray
EP3720497A1 (en) * 2017-12-08 2020-10-14 Fertin Pharma A/S High nicotine concentration
US20210345656A1 (en) * 2017-12-08 2021-11-11 Fertin Pharma A/S High nicotine absorption
US11957786B2 (en) * 2018-02-12 2024-04-16 TPRX Tech, LLC Liquid vape base and extraction process
CN108185539B (zh) * 2018-03-21 2021-03-05 福建中烟工业有限责任公司 一种感官质量得到改善的电子烟及其制作方法
EP3801732A4 (en) 2018-05-29 2022-04-27 Morningside Venture Investments Limited DRUG DELIVERY METHODS AND SYSTEMS
WO2019239356A1 (en) 2018-06-15 2019-12-19 R. J. Reynolds Tobacco Company Purification of nicotine
GB201817862D0 (en) * 2018-11-01 2018-12-19 Nicoventures Trading Ltd Aerosolisable formulation
GB201817865D0 (en) * 2018-11-01 2018-12-19 Nicoventures Trading Ltd Aerosolisable formulation
CN110236958B (zh) * 2019-06-28 2020-12-29 武汉大学 一种用于促进牙齿缺损缺失组织修复的材料及其制备方法
CN110946319A (zh) * 2019-11-20 2020-04-03 许达勇 一种烟碱推进剂及其制备方法
US11911559B2 (en) 2019-12-15 2024-02-27 Shaheen Innovations Holding Limited Ultrasonic mist inhaler
US11589610B2 (en) 2019-12-15 2023-02-28 Shaheen Innovations Holding Limited Nicotine delivery device having a mist generator device and a driver device
US11666713B2 (en) 2019-12-15 2023-06-06 Shaheen Innovations Holding Limited Mist inhaler devices
KR20230042763A (ko) 2019-12-15 2023-03-29 샤힌 이노베이션즈 홀딩 리미티드 미스트 흡입장치
KR20220141282A (ko) 2019-12-15 2022-10-19 샤힌 이노베이션즈 홀딩 리미티드 초음파 미스트 흡입장치
US11730191B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
WO2021123871A1 (en) 2019-12-15 2021-06-24 Shaheen Innovations Holding Limited Ultrasonic mist inhaler
US11730193B2 (en) 2019-12-15 2023-08-22 Shaheen Innovations Holding Limited Hookah device
BR102020002169A2 (pt) * 2020-01-31 2021-08-10 Bruno Ghizoni Da Silva Comércio De Produtos E Serviços Inovadores-Me Bebida estimulante
US20230188901A1 (en) 2021-12-15 2023-06-15 Shaheen Innovations Holding Limited Apparatus for transmitting ultrasonic waves

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3241437A1 (de) * 1982-11-10 1984-05-10 Ferdinand Prof. Dr.med. 6901 Wilhelmsfeld Schmidt Mittel zum zwecke der raucherentwoehnung und/oder fuer nebenwirkungsfreien nikotingenuss bei suchtrauchern
GB8301659D0 (en) * 1983-01-21 1983-02-23 Leo Ab Smoking substitutes
US4721618A (en) 1983-06-27 1988-01-26 Queen's University At Kingston Method for controlling bleeding
US4536392A (en) 1983-06-27 1985-08-20 Queen's University At Kingston Method for controlling hemophilia in mammals
DE3645036A1 (de) * 1986-11-18 1989-01-05 Forschungsgesellschaft Rauchen Nikotinhaltiges mittel
GB9111224D0 (en) * 1991-05-24 1991-07-17 Charwell Consumer Prod Smoking substitute preparation
GB9200047D0 (en) * 1992-01-03 1992-02-26 Univ Alberta Nicotine-containing nasal spray
US6024097A (en) * 1992-02-20 2000-02-15 J Mom Trust Product for assisting a smoker in giving up the habit
US5362496A (en) * 1993-08-04 1994-11-08 Pharmetrix Corporation Method and therapeutic system for smoking cessation
US5955098A (en) * 1996-04-12 1999-09-21 Flemington Pharmaceutical Corp. Buccal non polar spray or capsule
US6211194B1 (en) * 1998-04-30 2001-04-03 Duke University Solution containing nicotine
FR2792200B3 (fr) * 1999-04-16 2001-06-08 Unicliffe Ltd Substitut du tabac sous forme d'un comprime ou d'une pastille a sucer

Also Published As

Publication number Publication date
AU2002359152B2 (en) 2006-11-09
EP2186507B1 (en) 2015-04-01
IL162662A0 (en) 2005-11-20
EP1458388B1 (en) 2009-04-01
EP2186507A3 (en) 2011-08-10
NZ533714A (en) 2005-04-29
CN1607950B (zh) 2010-04-14
SE0104388D0 (sv) 2001-12-27
SI1458388T1 (sl) 2009-08-31
KR20040075035A (ko) 2004-08-26
WO2003055486A1 (en) 2003-07-10
DE60231835D1 (de) 2009-05-14
ATE427109T1 (de) 2009-04-15
CN1607950A (zh) 2005-04-20
CA2471906C (en) 2012-10-16
EP1458388A1 (en) 2004-09-22
DK1458388T3 (da) 2009-07-13
BR0215393A (pt) 2004-12-07
CA2471906A1 (en) 2003-07-10
ES2323228T3 (es) 2009-07-09
ZA200404964B (en) 2005-11-30
CY1109146T1 (el) 2014-07-02
JP2005518392A (ja) 2005-06-23
RU2004119434A (ru) 2005-04-20
AU2002359152A1 (en) 2003-07-15
DK2186507T3 (en) 2015-06-15
EP2186507A2 (en) 2010-05-19
PT2186507E (pt) 2015-06-24
RU2279871C2 (ru) 2006-07-20
MXPA04006395A (es) 2004-10-04
JP5264036B2 (ja) 2013-08-14
ES2537334T3 (es) 2015-06-05

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