PT1341528E - Comprimido de desintegração rápida compreendendo um ingrediente activo lábil a ácido - Google Patents
Comprimido de desintegração rápida compreendendo um ingrediente activo lábil a ácido Download PDFInfo
- Publication number
- PT1341528E PT1341528E PT01999360T PT01999360T PT1341528E PT 1341528 E PT1341528 E PT 1341528E PT 01999360 T PT01999360 T PT 01999360T PT 01999360 T PT01999360 T PT 01999360T PT 1341528 E PT1341528 E PT 1341528E
- Authority
- PT
- Portugal
- Prior art keywords
- active ingredient
- tablet
- acid
- acid labile
- mixture
- Prior art date
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- 239000004480 active ingredient Substances 0.000 title claims abstract description 104
- 239000000203 mixture Substances 0.000 claims abstract description 69
- 239000012188 paraffin wax Substances 0.000 claims abstract description 47
- 239000007787 solid Substances 0.000 claims abstract description 46
- -1 fatty acid ester Chemical class 0.000 claims abstract description 25
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 22
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 18
- 239000000194 fatty acid Substances 0.000 claims abstract description 18
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- 239000011159 matrix material Substances 0.000 claims abstract description 16
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- 239000000126 substance Substances 0.000 claims abstract description 14
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229940124531 pharmaceutical excipient Drugs 0.000 claims abstract description 5
- 239000002253 acid Substances 0.000 claims description 45
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 36
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- 235000019359 magnesium stearate Nutrition 0.000 claims description 18
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- IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 claims description 16
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- YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 claims description 5
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- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims description 2
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- 235000013539 calcium stearate Nutrition 0.000 claims description 2
- 239000002775 capsule Substances 0.000 claims description 2
- MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims description 2
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- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims description 2
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- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 2
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- 239000003826 tablet Substances 0.000 description 75
- 238000004519 manufacturing process Methods 0.000 description 24
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- PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 22
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- DUXYWXYOBMKGIN-UHFFFAOYSA-N trimyristin Chemical compound CCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCC DUXYWXYOBMKGIN-UHFFFAOYSA-N 0.000 description 12
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
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- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00126807 | 2000-12-07 |
Publications (1)
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| PT1341528E true PT1341528E (pt) | 2012-03-20 |
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| PT01999360T PT1341528E (pt) | 2000-12-07 | 2001-12-06 | Comprimido de desintegração rápida compreendendo um ingrediente activo lábil a ácido |
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| EP (1) | EP1341528B1 (enExample) |
| JP (1) | JP2004514737A (enExample) |
| KR (1) | KR20030072555A (enExample) |
| CN (1) | CN100335040C (enExample) |
| AT (1) | ATE541564T1 (enExample) |
| AU (1) | AU2002221939A1 (enExample) |
| BR (1) | BR0115986A (enExample) |
| CA (1) | CA2430829C (enExample) |
| CY (1) | CY1112615T1 (enExample) |
| DK (1) | DK1341528T3 (enExample) |
| ES (1) | ES2380654T3 (enExample) |
| PT (1) | PT1341528E (enExample) |
| SI (1) | SI1341528T1 (enExample) |
| WO (1) | WO2002045694A1 (enExample) |
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| US7988999B2 (en) * | 2000-12-07 | 2011-08-02 | Nycomed Gmbh | Pharmaceutical preparation in the form of a paste comprising an acid-labile active ingredient |
| JP5009482B2 (ja) * | 2000-12-07 | 2012-08-22 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 酸に不安定な活性成分を含有する懸濁液の形の製薬製剤 |
| UA80393C2 (uk) * | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| IL159584A0 (en) * | 2001-07-16 | 2004-06-01 | Astrazeneca Ab | Pharmaceutical formulation comprising a proton pump inhibitor and antacids |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| ES2335498T3 (es) | 2003-03-10 | 2010-03-29 | Nycomed Gmbh | Nuevo proceso para la preparacion de reflumilast. |
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-
2001
- 2001-12-06 DK DK01999360.9T patent/DK1341528T3/da active
- 2001-12-06 BR BR0115986-0A patent/BR0115986A/pt not_active Application Discontinuation
- 2001-12-06 PT PT01999360T patent/PT1341528E/pt unknown
- 2001-12-06 US US10/433,397 patent/US7147869B2/en not_active Expired - Fee Related
- 2001-12-06 AU AU2002221939A patent/AU2002221939A1/en not_active Abandoned
- 2001-12-06 KR KR10-2003-7007557A patent/KR20030072555A/ko not_active Ceased
- 2001-12-06 EP EP01999360A patent/EP1341528B1/en not_active Expired - Lifetime
- 2001-12-06 SI SI200131011T patent/SI1341528T1/sl unknown
- 2001-12-06 JP JP2002547480A patent/JP2004514737A/ja active Pending
- 2001-12-06 ES ES01999360T patent/ES2380654T3/es not_active Expired - Lifetime
- 2001-12-06 WO PCT/EP2001/014340 patent/WO2002045694A1/en not_active Ceased
- 2001-12-06 CN CNB018202594A patent/CN100335040C/zh not_active Expired - Fee Related
- 2001-12-06 AT AT01999360T patent/ATE541564T1/de active
- 2001-12-06 CA CA2430829A patent/CA2430829C/en not_active Expired - Fee Related
-
2012
- 2012-04-09 CY CY20121100345T patent/CY1112615T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE541564T1 (de) | 2012-02-15 |
| CN100335040C (zh) | 2007-09-05 |
| JP2004514737A (ja) | 2004-05-20 |
| EP1341528A1 (en) | 2003-09-10 |
| ES2380654T3 (es) | 2012-05-17 |
| CN1479613A (zh) | 2004-03-03 |
| SI1341528T1 (sl) | 2012-05-31 |
| US7147869B2 (en) | 2006-12-12 |
| AU2002221939A1 (en) | 2002-06-18 |
| EP1341528B1 (en) | 2012-01-18 |
| CA2430829C (en) | 2010-06-22 |
| WO2002045694A1 (en) | 2002-06-13 |
| US20040110661A1 (en) | 2004-06-10 |
| CY1112615T1 (el) | 2016-02-10 |
| CA2430829A1 (en) | 2002-06-13 |
| BR0115986A (pt) | 2003-12-23 |
| HK1062264A1 (zh) | 2004-10-29 |
| DK1341528T3 (da) | 2012-03-26 |
| KR20030072555A (ko) | 2003-09-15 |
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