PT1330659E - Método e dispositivo para dissolver material sólido hiperpolarizado para análise por rmn - Google Patents
Método e dispositivo para dissolver material sólido hiperpolarizado para análise por rmn Download PDFInfo
- Publication number
- PT1330659E PT1330659E PT01992900T PT01992900T PT1330659E PT 1330659 E PT1330659 E PT 1330659E PT 01992900 T PT01992900 T PT 01992900T PT 01992900 T PT01992900 T PT 01992900T PT 1330659 E PT1330659 E PT 1330659E
- Authority
- PT
- Portugal
- Prior art keywords
- sample
- polarized
- dissolved
- cryostat
- dissolution
- Prior art date
Links
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- YAINYZJQSQEGND-LBPDFUHNSA-N [1-(hydroxymethyl)cyclopropyl](113C)methanol Chemical compound O[13CH2]C1(CC1)CO YAINYZJQSQEGND-LBPDFUHNSA-N 0.000 description 1
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- JUPQTSLXMOCDHR-UHFFFAOYSA-N benzene-1,4-diol;bis(4-fluorophenyl)methanone Chemical compound OC1=CC=C(O)C=C1.C1=CC(F)=CC=C1C(=O)C1=CC=C(F)C=C1 JUPQTSLXMOCDHR-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/30—Sample handling arrangements, e.g. sample cells, spinning mechanisms
- G01R33/307—Sample handling arrangements, e.g. sample cells, spinning mechanisms specially adapted for moving the sample relative to the MR system, e.g. spinning mechanisms, flow cells or means for positioning the sample inside a spectrometer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- High Energy & Nuclear Physics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
- Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Soft Magnetic Materials (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Spectrometry And Color Measurement (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Complex Calculations (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Polarising Elements (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0004034A SE0004034D0 (sv) | 2000-11-03 | 2000-11-03 | Methods and devices for polarized material |
| US25697401P | 2001-01-05 | 2001-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1330659E true PT1330659E (pt) | 2006-12-29 |
Family
ID=26655292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT01992900T PT1330659E (pt) | 2000-11-03 | 2001-11-02 | Método e dispositivo para dissolver material sólido hiperpolarizado para análise por rmn |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7372274B2 (enExample) |
| EP (3) | EP1330659B1 (enExample) |
| JP (2) | JP4061192B2 (enExample) |
| KR (2) | KR100656313B1 (enExample) |
| CN (1) | CN100392422C (enExample) |
| AT (1) | ATE336727T1 (enExample) |
| AU (3) | AU2002216004B2 (enExample) |
| BR (1) | BR0115126B1 (enExample) |
| CA (1) | CA2427732C (enExample) |
| DE (1) | DE60122361T2 (enExample) |
| DK (1) | DK1330659T3 (enExample) |
| ES (1) | ES2269507T3 (enExample) |
| HU (2) | HU227603B1 (enExample) |
| IL (3) | IL155476A0 (enExample) |
| PT (1) | PT1330659E (enExample) |
| RU (2) | RU2281526C2 (enExample) |
| WO (1) | WO2002037132A1 (enExample) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4061192B2 (ja) * | 2000-11-03 | 2008-03-12 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 分極ｎｍｒ試料用のデバイス及び方法 |
| NO20031736D0 (no) * | 2003-04-15 | 2003-04-15 | Amersham Health As | Forbindelser |
| NO20035626D0 (no) * | 2003-12-17 | 2003-12-17 | Amersham Health As | Metode |
| US20050254998A1 (en) * | 2004-03-01 | 2005-11-17 | Ebara Corporation | Reactive detection chip and spotter suitable for manufacturing the chip |
| GB0411072D0 (en) * | 2004-05-18 | 2004-06-23 | Oxford Instr Superconductivity | Apparatus and method for performing in-vitro dnp-nmr measurements |
| DE102004029632B4 (de) * | 2004-06-18 | 2011-06-09 | Bruker Biospin Gmbh | Verfahren und Vorrichtung zum Zuführen einer flüssigen Probe in ein NMR-Spektrometer |
| KR20070063504A (ko) | 2004-07-30 | 2007-06-19 | 지이 헬스케어 에이에스 | 조성물의 제조 방법, 조성물 및 그의 용도 |
| GB0424725D0 (en) * | 2004-11-09 | 2004-12-08 | Oxford Instr Superconductivity | Cryostat assembly |
| GB0507174D0 (en) | 2005-04-08 | 2005-05-18 | Oxford Instr Molecular Biotool | Method of operating a dynamic nuclear polarization system |
| GB0514303D0 (en) | 2005-07-12 | 2005-08-17 | Oxford Instr Molecular Biotool | Magnet assembly |
| JP2007021008A (ja) * | 2005-07-20 | 2007-02-01 | Hitachi Ltd | Ｄｎｐ過分極手段を備えた磁気共鳴イメージング装置 |
| ES2654520T3 (es) * | 2005-10-11 | 2018-02-14 | Huntington Medical Research Institutes | Agentes de formación de imágenes y métodos de uso de los mismos |
| CA2628539C (en) | 2005-12-01 | 2014-04-29 | Ge Healthcare As | Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion |
| EP1968426B1 (en) * | 2005-12-19 | 2013-09-25 | Techmin Pty Ltd | Induction coil sensing |
| US8703102B2 (en) | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| KR101321862B1 (ko) | 2006-02-21 | 2013-10-28 | 밀리켈빈 테크놀로지스 엘엘씨 | 과분극화 방법, 시스템 및 조성물 |
| US9207298B2 (en) | 2011-03-23 | 2015-12-08 | Millikelvin Technologies Llc | Techniques, systems and machine readable programs for magnetic resonance |
| US7573268B2 (en) * | 2006-02-22 | 2009-08-11 | Los Alamos National Security, Llc | Direct imaging of neural currents using ultra-low field magnetic resonance techniques |
| JP5269791B2 (ja) | 2006-08-30 | 2013-08-21 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物 |
| US7631507B2 (en) * | 2006-11-02 | 2009-12-15 | General Electric Company | Methods and devices for polarized samples for use in MRI |
| EP2117607A4 (en) | 2007-01-11 | 2012-08-08 | Huntington Medical Res Inst | PICTURES AND METHOD FOR THEIR USE |
| US20080229928A1 (en) * | 2007-03-20 | 2008-09-25 | Urbahn John A | Sorption pump with integrated thermal switch |
| US8731640B2 (en) | 2007-03-28 | 2014-05-20 | General Electric Company | Fluid path system for dissolution and transport of a hyperpolarized material |
| US20080240998A1 (en) * | 2007-03-28 | 2008-10-02 | Urbahn John A | Fluid path system for dissolution and transport of a hyperpolarized material |
| US20080242974A1 (en) | 2007-04-02 | 2008-10-02 | Urbahn John A | Method and apparatus to hyperpolarize materials for enhanced mr techniques |
| US7519492B2 (en) * | 2007-05-02 | 2009-04-14 | General Electric Company | Apparatus and method for fully automated closed system quality control of a substance |
| WO2009027645A2 (en) * | 2007-08-24 | 2009-03-05 | The Universtiy Of Nottingham | Improvements in the preparation of a sample (e.g. involving dynamic nuclear polarisation) for analysis (e.g. by nmr or mri) |
| EP2028505A3 (en) | 2007-08-24 | 2010-03-17 | Oxford Instruments Molecular Biotools Ltd. | Coolant assembly of a DNP apparatus |
| DK2183610T3 (en) * | 2007-08-28 | 2016-06-27 | Ge Healthcare Ltd | Nozzle for Dynamic Core Spin Polarization (DNP) Polarizer |
| DE102007044016B4 (de) * | 2007-09-14 | 2010-12-16 | Bruker Biospin Gmbh | Probenwechseleinrichtung mit auf mäanderförmiger Bahn geführten Probenaufnahmen, insbesondere für ein NMR-Spektrometer, und Kernspinresonanz-Spektrometer |
| WO2009046457A2 (en) * | 2007-10-05 | 2009-04-09 | Huntington Medical Research Institutes | Imaging of genetic material with magnetic resonance |
| EP2902041A1 (en) | 2007-12-19 | 2015-08-05 | GE Healthcare Limited | Composition and method for generating a metabolic profile using 13C-MR detection |
| WO2009089007A2 (en) * | 2008-01-08 | 2009-07-16 | The University Of Georgia Research Foundation, Inc. | Upper stack for a nuclear magnetic resonance spectrometer apparatus and associated method of operating a nuclear magnetic resonance spectrometer apparatus |
| JP4871311B2 (ja) * | 2008-02-26 | 2012-02-08 | 株式会社日立製作所 | 核磁気共鳴装置、磁気共鳴イメージング装置および磁気共鳴分析装置 |
| US8763410B2 (en) * | 2008-04-21 | 2014-07-01 | General Electric Company | Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media |
| WO2009133169A1 (en) | 2008-05-02 | 2009-11-05 | General Electric Company | Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate |
| DE102008033886B4 (de) * | 2008-07-18 | 2012-03-08 | Bruker Biospin Ag | Apparatur zur Durchführung von DNP-NMR Messungen mit Kompensationsanordnung |
| WO2010020776A2 (en) * | 2008-08-19 | 2010-02-25 | Oxford Instruments Molecular Biotools Limited | Dynamic nuclear polarisation system |
| US7633290B1 (en) * | 2008-09-09 | 2009-12-15 | General Electric Company | Apparatus and method for a fully automated preparation of a hyperpolarizing imaging agent |
| WO2010061191A1 (en) * | 2008-11-27 | 2010-06-03 | Oxford Instruments Molecular Biotools Limited | Apparatus for dynamic nuclear polarisation |
| DE102008063703B3 (de) * | 2008-12-19 | 2010-06-17 | Bruker Biospin Ag | Automatische Transportvorrichtung für NMR-Messproben, Kryomagnetsystem mit automatischer Transportvorrichtung, Transportbehälter für automatische Transportvorrichtung und Verfahren zum Befördern einer NMR-Messprobe |
| BRPI1013677A2 (pt) | 2009-04-02 | 2016-04-26 | Ge Healthcare Ltd | método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem. |
| US20100251732A1 (en) * | 2009-04-06 | 2010-10-07 | General Electric Company | Apparatus and method for introduction of a material into a cryogenic system |
| JP2012529960A (ja) * | 2009-06-19 | 2012-11-29 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 軌道角運動量を持つ光子を使用した過分極装置と組み合わせたｍｒｉ温度測定 |
| US20120086453A1 (en) * | 2009-06-19 | 2012-04-12 | Koninklijke Philips Electronics N.V. | Mri with hyperpolarisation device using photons with orbital angular momentum |
| KR20120101339A (ko) * | 2009-08-31 | 2012-09-13 | 밀리켈빈 테크놀로지스 엘엘씨 | 과분극 물질 및 그 혼합물의 제조용 시스템 및 제조방법 |
| EP2476009A1 (en) | 2009-09-10 | 2012-07-18 | GE Healthcare UK Limited | 13c-mr detection using hyperpolarised 13c-fructose |
| US8427161B2 (en) * | 2009-12-18 | 2013-04-23 | General Electric Company | Method and apparatus for generating hyperpolarized materials |
| EP2348327B1 (en) * | 2010-01-18 | 2013-11-27 | Bruker BioSpin AG | Method for NMR measurements using dissolution dynamic nuclear polarization (DNP) with elimination of free radicals |
| RU2565337C2 (ru) * | 2010-02-16 | 2015-10-20 | Конинклейке Филипс Электроникс Н.В. | Оптическая гиперполяризация на основе света, обладающего оптическим угловым моментом |
| EP2555803B1 (en) | 2010-04-08 | 2018-09-12 | Bracco Imaging S.p.A | Process for preparing hyperpolarized substrates and method for mri |
| JP5879333B2 (ja) | 2010-05-03 | 2016-03-08 | ジーイー・ヘルスケア・リミテッド | Ｌｄｈ活性を決定するための過分極乳酸塩造影剤 |
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