PT1305056E - Enxerto osseo sintetico poroso e processo para a sua fabricacao - Google Patents

Enxerto osseo sintetico poroso e processo para a sua fabricacao

Info

Publication number
PT1305056E
PT1305056E PT01953223T PT01953223T PT1305056E PT 1305056 E PT1305056 E PT 1305056E PT 01953223 T PT01953223 T PT 01953223T PT 01953223 T PT01953223 T PT 01953223T PT 1305056 E PT1305056 E PT 1305056E
Authority
PT
Portugal
Prior art keywords
synthetic
pore
forming agent
poroso
manufacture
Prior art date
Application number
PT01953223T
Other languages
English (en)
Inventor
Lo Wei Jen
Original Assignee
Orthogem Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0019003.3A external-priority patent/GB0019003D0/en
Application filed by Orthogem Ltd filed Critical Orthogem Ltd
Publication of PT1305056E publication Critical patent/PT1305056E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/01—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics
    • C04B35/447—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products based on oxide ceramics based on phosphates, e.g. hydroxyapatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor
    • A61F2/4644—Preparation of bone graft, bone plugs or bone dowels, e.g. grinding or milling bone material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/62605—Treating the starting powders individually or as mixtures
    • C04B35/6261—Milling
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • C04B35/634—Polymers
    • C04B35/63404—Polymers obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • C04B35/63424—Polyacrylates; Polymethacrylates
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
    • C04B35/636—Polysaccharides or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B38/00—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof
    • C04B38/02—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by adding chemical blowing agents
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B38/00—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof
    • C04B38/06—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by burning-out added substances by burning natural expanding materials or by sublimating or melting out added substances
    • C04B38/0615—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by burning-out added substances by burning natural expanding materials or by sublimating or melting out added substances the burned-out substance being a monolitic element having approximately the same dimensions as the final article, e.g. a porous polyurethane sheet or a prepreg obtained by bonding together resin particles
    • C04B38/062—Porous mortars, concrete, artificial stone or ceramic ware; Preparation thereof by burning-out added substances by burning natural expanding materials or by sublimating or melting out added substances the burned-out substance being a monolitic element having approximately the same dimensions as the final article, e.g. a porous polyurethane sheet or a prepreg obtained by bonding together resin particles the burned-out substance being formed in situ, e.g. by polymerisation of a prepolymer composition containing ceramic powder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2835—Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
    • A61F2002/3006—Properties of materials and coating materials
    • A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2/30942—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques
    • A61F2002/30957—Designing or manufacturing processes for designing or making customized prostheses, e.g. using templates, CT or NMR scans, finite-element analysis or CAD-CAM techniques using a positive or a negative model, e.g. moulds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2111/00—Mortars, concrete or artificial stone or mixtures to prepare them, characterised by specific function, property or use
    • C04B2111/00474—Uses not provided for elsewhere in C04B2111/00
    • C04B2111/00836—Uses not provided for elsewhere in C04B2111/00 for medical or dental applications
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/30—Constituents and secondary phases not being of a fibrous nature
    • C04B2235/32—Metal oxides, mixed metal oxides, or oxide-forming salts thereof, e.g. carbonates, nitrates, (oxy)hydroxides, chlorides
    • C04B2235/3205—Alkaline earth oxides or oxide forming salts thereof, e.g. beryllium oxide
    • C04B2235/3208—Calcium oxide or oxide-forming salts thereof, e.g. lime
    • C04B2235/3212—Calcium phosphates, e.g. hydroxyapatite
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/02—Composition of constituents of the starting material or of secondary phases of the final product
    • C04B2235/50—Constituents or additives of the starting mixture chosen for their shape or used because of their shape or their physical appearance
    • C04B2235/54—Particle size related information
    • C04B2235/5418—Particle size related information expressed by the size of the particles or aggregates thereof
    • C04B2235/5445—Particle size related information expressed by the size of the particles or aggregates thereof submicron sized, i.e. from 0,1 to 1 micron
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/60—Aspects relating to the preparation, properties or mechanical treatment of green bodies or pre-forms
    • C04B2235/602—Making the green bodies or pre-forms by moulding
    • C04B2235/6021—Extrusion moulding
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/60—Aspects relating to the preparation, properties or mechanical treatment of green bodies or pre-forms
    • C04B2235/606—Drying
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/65—Aspects relating to heat treatments of ceramic bodies such as green ceramics or pre-sintered ceramics, e.g. burning, sintering or melting processes
    • C04B2235/656—Aspects relating to heat treatments of ceramic bodies such as green ceramics or pre-sintered ceramics, e.g. burning, sintering or melting processes characterised by specific heating conditions during heat treatment
    • C04B2235/6562—Heating rate
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/65—Aspects relating to heat treatments of ceramic bodies such as green ceramics or pre-sintered ceramics, e.g. burning, sintering or melting processes
    • C04B2235/656—Aspects relating to heat treatments of ceramic bodies such as green ceramics or pre-sintered ceramics, e.g. burning, sintering or melting processes characterised by specific heating conditions during heat treatment
    • C04B2235/6565—Cooling rate
    • C—CHEMISTRY; METALLURGY
    • C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B2235/00—Aspects relating to ceramic starting mixtures or sintered ceramic products
    • C04B2235/70—Aspects relating to sintered or melt-casted ceramic products
    • C04B2235/96—Properties of ceramic products, e.g. mechanical properties such as strength, toughness, wear resistance
PT01953223T 2000-08-04 2001-07-27 Enxerto osseo sintetico poroso e processo para a sua fabricacao PT1305056E (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0019003.3A GB0019003D0 (en) 2000-08-04 2000-08-04 Porous synthetic bone graft and method of manufacture thereof
GB0030295A GB2365423A (en) 2000-08-04 2000-12-12 Artificial bone from ceramics

Publications (1)

Publication Number Publication Date
PT1305056E true PT1305056E (pt) 2006-05-31

Family

ID=26244784

Family Applications (1)

Application Number Title Priority Date Filing Date
PT01953223T PT1305056E (pt) 2000-08-04 2001-07-27 Enxerto osseo sintetico poroso e processo para a sua fabricacao

Country Status (12)

Country Link
US (1) US7094371B2 (pt)
EP (1) EP1305056B1 (pt)
JP (1) JP5154729B2 (pt)
CN (1) CN1209170C (pt)
AT (1) ATE313345T1 (pt)
AU (2) AU7571501A (pt)
CA (1) CA2417895C (pt)
DE (1) DE60116103T2 (pt)
DK (1) DK1305056T3 (pt)
ES (1) ES2256273T3 (pt)
PT (1) PT1305056E (pt)
WO (1) WO2002011781A1 (pt)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19940717A1 (de) * 1999-08-26 2001-03-01 Gerontocare Gmbh Resorblerbares Knochenersatz- und Knochenaufbaumaterial
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
JP3739715B2 (ja) * 2002-03-19 2006-01-25 オリンパス株式会社 人工骨および組織工学用担体
US7166133B2 (en) 2002-06-13 2007-01-23 Kensey Nash Corporation Devices and methods for treating defects in the tissue of a living being
KR100460452B1 (ko) * 2002-08-23 2004-12-08 한국화학연구원 순간 겔화법을 이용한 다공성 유·무기 복합체의 제조방법
EP1601632B1 (en) * 2003-01-23 2010-08-25 University Of Bath Bone substitute material
GB0311221D0 (en) 2003-05-15 2003-06-18 Orthogem Ltd Biomaterial
GB0318901D0 (en) 2003-08-12 2003-09-17 Univ Bath Improvements in or relating to bone substitute material
GB0502493D0 (en) * 2005-02-07 2005-03-16 Orthogem Ltd Bone cement
US7531190B2 (en) 2005-05-25 2009-05-12 Biomet Manufacturing Corp. Porous ceramic structure containing biologics
US20070116734A1 (en) * 2005-11-18 2007-05-24 Akash Akash Porous, load-bearing, ceramic or metal implant
US20090305882A1 (en) * 2006-02-03 2009-12-10 Saint-Gobain Ceramics & Plastics, Inc. Articles Comprising Tetragonal Zirconia and Methods of Making the Same
WO2007130648A2 (en) * 2006-05-05 2007-11-15 Ceramatec, Inc. Fully or partially bioresorbable orthopedic implant
GB0610333D0 (en) * 2006-05-24 2006-07-05 Orthogem Ltd Bone repair or augmentation device
AU2008206953A1 (en) * 2007-01-19 2008-07-24 Cinvention Ag Porous, non-degradable implant made by powder molding
US20080175885A1 (en) * 2007-01-19 2008-07-24 Cinvention Ag Porous, degradable implant made by powder molding
US8114336B2 (en) * 2007-03-16 2012-02-14 Board Of Regents Of The University Of Texas System Methods for increasing the strength and controlling the architecture and composition of ceramic articles
EP2014256A1 (en) 2007-07-12 2009-01-14 Straumann Holding AG Composite bone repair material
US8154376B2 (en) * 2007-09-17 2012-04-10 Littelfuse, Inc. Fuses with slotted fuse bodies
JP2009113477A (ja) * 2007-10-15 2009-05-28 Taiheiyo Randamu Kk セラミックス成形体とその製造方法
BRPI0906702A2 (pt) * 2008-01-09 2015-06-30 Innovative Health Technologies Llc Grânulos de implante e métodos para realizar a regeneração e preservação óssea
CN102036694A (zh) * 2008-05-30 2011-04-27 华沙整形外科股份有限公司 生物陶瓷和生物聚合物复合材料
US20090304775A1 (en) * 2008-06-04 2009-12-10 Joshi Ashok V Drug-Exuding Orthopedic Implant
US20100042213A1 (en) 2008-08-13 2010-02-18 Nebosky Paul S Drug delivery implants
US9700431B2 (en) 2008-08-13 2017-07-11 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
US10842645B2 (en) 2008-08-13 2020-11-24 Smed-Ta/Td, Llc Orthopaedic implant with porous structural member
WO2010019788A1 (en) 2008-08-13 2010-02-18 Smed-Ta/Td. Llc Drug delivery implants
US9616205B2 (en) 2008-08-13 2017-04-11 Smed-Ta/Td, Llc Drug delivery implants
JP5687622B2 (ja) 2008-08-29 2015-03-18 スメド−ティーエイ／ティーディー・エルエルシー 整形外科インプラント
US8709149B2 (en) 2008-11-12 2014-04-29 Ossdsign Ab Hydraulic cements, methods and products
US20110201704A1 (en) * 2010-02-18 2011-08-18 Doctors Research Group, Inc. Polymeric bone defect filler
US8338498B2 (en) * 2010-02-18 2012-12-25 Doctors Research Group, Inc. Polymeric bone defect filler
EP2544627B1 (en) 2010-03-10 2018-05-02 OssDsign AB Implants for correcting tissue defects
CA3048850A1 (en) 2010-05-11 2011-11-17 Howmedica Osteonics Corp. Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods
CN101913584B (zh) * 2010-08-27 2012-04-04 江苏永冠给排水设备有限公司 一种饮用水除氟滤料的生产方法
US9463046B2 (en) 2011-08-22 2016-10-11 Ossdsign Ab Implants and methods for using such implants to fill holes in bone tissue
WO2013035083A2 (en) * 2011-09-09 2013-03-14 Oss-Q Ab Storage stable premixed hydraulic cement compositions, cements, methods, and articles
US8591645B2 (en) 2011-09-09 2013-11-26 Ossdsign Ab Hydraulic cements with optimized grain size distribution, methods, articles and kits
US20130066327A1 (en) 2011-09-09 2013-03-14 Håkan Engqvist Hydraulic cement compositions with low ph methods, articles and kits
CN102492082B (zh) * 2011-12-03 2013-12-18 桂林理工大学 一种医用人造骨骼用材料的制备方法
CN102697548B (zh) * 2012-06-21 2014-07-23 闫宏伟 一种制备新型个体化可降解人工骨髓内支架的方法
ES2784859T3 (es) 2012-12-14 2020-10-01 Ossdsign Ab Composiciones formadoras de cemento, cementos de monetíta, implantes y métodos para corregir los defectos óseos
US10076416B2 (en) 2013-02-12 2018-09-18 Ossdsign Ab Mosaic implants, kits and methods for correcting bone defects
US10179834B2 (en) 2013-04-10 2019-01-15 The University Of Melbourne Biodegradable network polymers for regenerative medicine and tissue engineering
WO2014187969A1 (de) * 2013-05-23 2014-11-27 Ceramtec Gmbh Bauteil aus keramik mit porenkanälen
CN103691000B (zh) * 2013-12-12 2015-08-05 西南交通大学 微、纳米磷酸钙/儿茶酚基聚合物骨修复支架的制备方法
CN104771782A (zh) * 2014-01-10 2015-07-15 东莞博捷生物科技有限公司 一种骨修复用材料β-磷酸三钙及其制备方法
CN103922784B (zh) * 2014-03-25 2015-07-29 西安理工大学 微生物发酵低温成型制备多孔陶瓷的方法
AU2015302923B2 (en) 2014-08-14 2020-05-14 Ossdsign Ab Bone implants for correcting bone defects
JP6505406B2 (ja) * 2014-09-29 2019-04-24 富田製薬株式会社 リン酸カルシウムの繊維状成型体の製造方法
KR101889128B1 (ko) * 2014-12-24 2018-08-17 주식회사 바이오알파 인공 골조직의 제조 시스템 및 이의 제조 방법
CN105963789B (zh) * 2016-06-03 2019-09-27 昆明理工大学 一种骨组织工程支架材料的制备方法
US11141278B2 (en) 2017-03-29 2021-10-12 Vito Nv Surgical implants comprising graded porous structures
CN113135769B (zh) * 2021-04-09 2022-07-26 华南理工大学 表面包覆改性多孔磷酸钙陶瓷微球及其制备方法与应用
TWI804100B (zh) * 2021-12-13 2023-06-01 富爾哥頓生技股份有限公司 多孔複合材料的製造方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4073999A (en) * 1975-05-09 1978-02-14 Minnesota Mining And Manufacturing Company Porous ceramic or metallic coatings and articles
EP0335359A3 (en) * 1988-03-31 1989-11-29 Asahi Kogaku Kogyo Kabushiki Kaisha Porous ceramic material and production process thereof
US4973566A (en) * 1989-05-16 1990-11-27 Coors Ceramics Company Cordierite material useful in a heat source retainer and process for making the same
JP2766029B2 (ja) 1990-03-12 1998-06-18 日本碍子株式会社 セラミックグリーンシート材及び電気化学的素子並びにその製造方法
US5705118A (en) 1992-08-27 1998-01-06 Polyceramics, Inc. Process for producing a ceramic body
JPH06312375A (ja) * 1993-04-28 1994-11-08 Noritake Dia Kk 貫通気孔構造を有するレジンボンドホイールの製造方法とこれを用いた研削加工方法
JP3362267B2 (ja) * 1993-12-29 2003-01-07 日本特殊陶業株式会社 生体インプラント材料及びその製造方法
DE4403509A1 (de) * 1994-02-04 1995-08-10 Draenert Klaus Werkstoff und Verfahren zu seiner Herstellung
US6271278B1 (en) * 1997-05-13 2001-08-07 Purdue Research Foundation Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties
US6296667B1 (en) * 1997-10-01 2001-10-02 Phillips-Origen Ceramic Technology, Llc Bone substitutes
AU766735B2 (en) 1998-09-15 2003-10-23 Isotis N.V. Osteoinduction
GB9821663D0 (en) * 1998-10-05 1998-11-25 Abonetics Ltd Foamed ceramics
CA2285149A1 (en) * 1998-10-07 2000-04-07 Isotis B.V. Device for tissue engineering a bone equivalent
AU3242201A (en) 1999-12-16 2001-06-25 Isotis N.V. Porous ceramic body
AU778651B2 (en) 1999-12-16 2004-12-16 Isotis N.V. Porous ceramic body
CA2438801A1 (en) 2001-02-19 2002-08-29 Isotis N.V. Porous metals and metal coatings for implants

Also Published As

Publication number Publication date
CN1209170C (zh) 2005-07-06
DE60116103D1 (de) 2006-01-26
ATE313345T1 (de) 2006-01-15
AU7571501A (en) 2002-02-18
WO2002011781A1 (en) 2002-02-14
EP1305056B1 (en) 2005-12-21
JP5154729B2 (ja) 2013-02-27
JP2004505677A (ja) 2004-02-26
AU2001275715B2 (en) 2006-08-03
DE60116103T2 (de) 2006-08-24
EP1305056A1 (en) 2003-05-02
CN1446109A (zh) 2003-10-01
DK1305056T3 (da) 2008-01-02
CA2417895A1 (en) 2002-02-14
ES2256273T3 (es) 2006-07-16
US7094371B2 (en) 2006-08-22
US20030171822A1 (en) 2003-09-11
CA2417895C (en) 2011-09-27

Similar Documents

Publication Publication Date Title
PT1305056E (pt) Enxerto osseo sintetico poroso e processo para a sua fabricacao
ES476173A1 (es) Un procedimiento para la obtencion de un producto de whitlo-ckita
ES2147720T3 (es) Factor de celulas madre.
DK1357953T3 (da) Transplantater til reparation af osteochondrale defekter
DE59007610D1 (de) Keramische Verbundkörper und Verfahren zu ihrer Herstellung.
ES2194919T3 (es) Incorporacion de moleculas biologicamente activas en vidrios bioactivos.
EA200000711A1 (ru) 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, СПОСОБ ПОЛУЧЕНИЯ ФАРМАЦЕВТИЧЕСКИХ ПРЕПАРАТОВ, СОДЕРЖАЩИХ ЭТИ 11β-ГАЛОГЕН-7α-ЗАМЕЩЕННЫЕ ЭСТРАТРИЕНЫ, И ИХ ПРИМЕНЕНИЕ ДЛЯ ИЗГОТОВЛЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ
FR2627696B1 (fr) Nouvelle forme galenique du fenofibrate
WO2004062697A3 (en) Silk fibroin materials and use thereof
PT98889A (pt) Processo para a preparacao de material para proteses osseas a base de produtos ceramicos osseos
BR0008978A (pt) Método para preparação de 5-cianoftalida
BR9500280A (pt) Processo para preparar corpos verdes cerâmicos,e corpo verde cerâmico usinável
HN2001000217A (es) Nuevos tiadiazoles y oxadiazoles y su uso como inhibidores de fosfodiesterasa - 7
DE3853002D1 (de) Poröse keramische formen, zusammensetzungen zur herstellung und verfahren zur herstellung.
DE69433791D1 (de) Diamant-Sinterkörper, Hochdruckphasen-Bornitrid-Sinterkörper sowie Verfahren zur Herstellung dieser Sinterkörper
FR2832063B1 (fr) Procede de production de solutions stables de substances phenoliques et les solutions en resultant
DE69534595D1 (de) Methode zur proliferation und differenzierung von b-zellen und verwendungen dafür
BR8205649A (pt) Cimento ceramico moldavel de duas partes,processo para sua formacao e composicao adequada para uso como parte de um cimento ceramico moldavel
ATE43809T1 (de) Keramischer koerper sowie verfahren und form zur herstellung desselben.
HUT47601A (en) Process for releasing cell-mixtures and tissues from non-desirable population
DE69009379T2 (de) Sinterofen zur herstellung von quarz-basismaterial.
ES2180553T3 (es) Cemento para uso medico, procedimiento para fabricar el cemento y su utilizacion.
WO2001044141A3 (en) Porous ceramic body
ES2139101T3 (es) Compuestos de oro organicos con azufre, procedimiento para su preparacion y su uso.
BR0110881A (pt) Processo para a preparação de corpos sólidos inorg nicos porosos a partir de uma dispersão aquosa de partìculas, corpos sólidos inorg nicos porosos, e, uso de corpos sólidos inorg nicos porosos