PT1083881E - Composicao de liposomas contendo um derivado de quinolona e uso da mesma como agente antibacteriano - Google Patents
Composicao de liposomas contendo um derivado de quinolona e uso da mesma como agente antibacterianoInfo
- Publication number
- PT1083881E PT1083881E PT99916160T PT99916160T PT1083881E PT 1083881 E PT1083881 E PT 1083881E PT 99916160 T PT99916160 T PT 99916160T PT 99916160 T PT99916160 T PT 99916160T PT 1083881 E PT1083881 E PT 1083881E
- Authority
- PT
- Portugal
- Prior art keywords
- composition
- same
- antibacterial agent
- liposomes containing
- quinolone derivative
- Prior art date
Links
- 239000002502 liposome Substances 0.000 title abstract 3
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 150000007660 quinolones Chemical class 0.000 title 1
- MYSWGUAQZAJSOK-UHFFFAOYSA-N ciprofloxacin Chemical compound C12=CC(N3CCNCC3)=C(F)C=C2C(=O)C(C(=O)O)=CN1C1CC1 MYSWGUAQZAJSOK-UHFFFAOYSA-N 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 229960003405 ciprofloxacin Drugs 0.000 abstract 1
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- 229920001477 hydrophilic polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0038—Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/054,857 US5972379A (en) | 1995-02-14 | 1998-04-02 | Liposome composition and method for administering a quinolone |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1083881E true PT1083881E (pt) | 2004-11-30 |
Family
ID=21993954
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99916160T PT1083881E (pt) | 1998-04-02 | 1999-03-24 | Composicao de liposomas contendo um derivado de quinolona e uso da mesma como agente antibacteriano |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5972379A (https=) |
| EP (1) | EP1083881B1 (https=) |
| JP (1) | JP2002510611A (https=) |
| KR (1) | KR100617921B1 (https=) |
| CN (1) | CN1149978C (https=) |
| AT (1) | ATE274342T1 (https=) |
| AU (1) | AU763989B2 (https=) |
| CA (1) | CA2326497A1 (https=) |
| DE (1) | DE69919698T2 (https=) |
| DK (1) | DK1083881T3 (https=) |
| ES (1) | ES2226371T3 (https=) |
| IL (1) | IL138685A0 (https=) |
| NZ (1) | NZ506970A (https=) |
| PT (1) | PT1083881E (https=) |
| WO (1) | WO1999051202A2 (https=) |
| ZA (1) | ZA200005333B (https=) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7311924B2 (en) | 1999-04-01 | 2007-12-25 | Hana Biosciences, Inc. | Compositions and methods for treating cancer |
| US20030147944A1 (en) * | 1999-12-10 | 2003-08-07 | Mayer Lawrence D | Lipid carrier compositions with protected surface reactive functions |
| JP2004501955A (ja) * | 2000-06-30 | 2004-01-22 | アイネックス ファーマシューティカルズ コーポレイション | リポソーム抗新生物薬剤およびその使用 |
| US7452550B2 (en) | 2000-06-30 | 2008-11-18 | Hana Biosciences, Inc. | Liposomal antineoplastic drugs and uses thereof |
| EP1355634B8 (en) | 2000-11-09 | 2009-03-04 | Neopharm, Inc. | Sn-38 lipid complexes and methods of use |
| WO2003030864A1 (en) | 2001-05-29 | 2003-04-17 | Neopharm, Inc. | Liposomal formulation of irinotecan |
| PL369455A1 (en) * | 2001-06-01 | 2005-04-18 | Yamanouchi Europe B.V. | Lipid-polymer-conjugates |
| AU2002334358B2 (en) * | 2001-09-06 | 2008-02-07 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | A method for preparing liposome formulations with a predefined release profile |
| US20040219201A1 (en) * | 2001-12-06 | 2004-11-04 | Yechezkel Barenholz | Tempamine compositions and methods of use |
| WO2003077842A2 (en) * | 2002-03-12 | 2003-09-25 | Bristol-Myers Squibb Company | Palatable oral suspension and method |
| PT1581236E (pt) * | 2002-10-29 | 2013-12-24 | Insmed Inc | Libertação prolongada de anti-infecciosos |
| US7718189B2 (en) | 2002-10-29 | 2010-05-18 | Transave, Inc. | Sustained release of antiinfectives |
| EP1628637A2 (en) * | 2003-05-30 | 2006-03-01 | Alza Corporation | Method of pulmonary administration of an agent |
| CN100431525C (zh) * | 2003-07-17 | 2008-11-12 | 台湾东洋药品工业股份有限公司 | 脂质体悬浮液制造方法及含该法所制脂质体悬浮液的产物 |
| US8173840B2 (en) * | 2003-07-29 | 2012-05-08 | Signature R&D Holdings, Llc | Compounds with high therapeutic index |
| US7589233B2 (en) * | 2003-07-29 | 2009-09-15 | Signature R&D Holdings, Llc | L-Threonine derivatives of high therapeutic index |
| AU2004289174B2 (en) * | 2003-07-29 | 2011-05-19 | Signature R&D Holdings, Lcc | Amino acid prodrugs |
| US7915223B2 (en) * | 2004-09-27 | 2011-03-29 | Technion Research & Development Foundation Ltd. | Antimicrobial agents |
| WO2006039369A1 (en) * | 2004-09-29 | 2006-04-13 | Alza Corporation | Microparticles and nanoparticles containing a lipopolymer |
| TW200618820A (en) * | 2004-11-05 | 2006-06-16 | Alza Corp | Liposome formulations of boronic acid compounds |
| CN100403535C (zh) * | 2005-05-18 | 2008-07-16 | 崇贸科技股份有限公司 | 可控制触发电压的静电放电装置 |
| EP3067047B1 (en) | 2005-12-08 | 2022-04-20 | Insmed Incorporated | Lipid-based compositions of antiinfectives for treating pulmonary infections |
| US8071127B2 (en) | 2006-10-24 | 2011-12-06 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| US8268347B1 (en) | 2006-10-24 | 2012-09-18 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| US8119156B2 (en) | 2006-10-24 | 2012-02-21 | Aradigm Corporation | Dual action, inhaled formulations providing both an immediate and sustained release profile |
| KR100916160B1 (ko) * | 2007-02-21 | 2009-09-08 | (주)바이오버드 | 약제학적 항암 조성물 |
| EP2152289A1 (en) * | 2007-04-30 | 2010-02-17 | Technion Research & Development Foundation Ltd. | Novel antimicrobial agents |
| US20100173832A1 (en) * | 2007-04-30 | 2010-07-08 | Technion Research & Development Foundation Ltd. | Anticancerous polymeric agents |
| WO2008137717A1 (en) | 2007-05-04 | 2008-11-13 | Transave, Inc. | Compositions of multicationic drugs for reducing interactions with polyanionic biomolecules and methods and uses thereof |
| US9114081B2 (en) | 2007-05-07 | 2015-08-25 | Insmed Incorporated | Methods of treating pulmonary disorders with liposomal amikacin formulations |
| US9119783B2 (en) | 2007-05-07 | 2015-09-01 | Insmed Incorporated | Method of treating pulmonary disorders with liposomal amikacin formulations |
| US10143652B2 (en) | 2009-09-23 | 2018-12-04 | Curirx Inc. | Methods for the preparation of liposomes |
| CA2781527C (en) * | 2009-09-23 | 2017-10-24 | Indu Javeri | Methods for the preparation of liposomes |
| CN102309448B (zh) * | 2010-06-29 | 2014-07-09 | 中国人民解放军军事医学科学院毒物药物研究所 | 一种肺部给药的环丙沙星药用组合物及其制备方法 |
| CN102188430B (zh) * | 2011-04-06 | 2012-08-15 | 广东如来医药进出口有限公司 | 司帕沙星化合物的组合物制剂及其制备方法 |
| PL2852391T3 (pl) | 2012-05-21 | 2022-04-11 | Insmed Incorporated | Układy do leczenia infekcji płuc |
| MX2015005992A (es) | 2012-11-20 | 2016-03-07 | Spectrum Pharmaceuticals Inc | Metodo mejorado para la preparacion de la vincristina liposomal encapsulada para el uso terapeutico. |
| US10124066B2 (en) | 2012-11-29 | 2018-11-13 | Insmed Incorporated | Stabilized vancomycin formulations |
| WO2015061025A1 (en) | 2013-10-22 | 2015-04-30 | Aradigm Corporation | Inhaled surfactant-modified liposomal formulations providing both an immediate and sustained release profile |
| LT3466432T (lt) | 2014-05-15 | 2020-12-28 | Insmed Incorporated | Būdai, skirti plaučių netuberkuliozinėms mikobakterinėms infekcijoms gydyti |
| EP2957561A1 (en) * | 2014-06-18 | 2015-12-23 | Université Paris 6 Pierre et Marie Curie UPMC | Novel fluoroquinolones and use thereof to treat bacterial infections |
| TWI678213B (zh) | 2015-07-22 | 2019-12-01 | 美商史倍壯製藥公司 | 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物 |
| GB2552301A (en) * | 2016-07-11 | 2018-01-24 | Evox Therapeutics Ltd | Metabolic drug loading of EVs |
| US20170172921A1 (en) * | 2016-12-14 | 2017-06-22 | Mahmoud Reza Jaafari | Polyphenolic compounds encapsualated in long circulating liposomes and use thereof |
| TWI728255B (zh) * | 2017-07-24 | 2021-05-21 | 國邑藥品科技股份有限公司 | 包含弱酸藥物之脂質體組成物及其用途 |
| CN109305987B (zh) * | 2017-07-27 | 2021-04-20 | 济南大学 | 环丙沙星金属配合物及其制备方法和应用 |
| EP3773505B1 (en) | 2018-03-30 | 2026-04-29 | Insmed Incorporated | Methods for continuous manufacture of liposomal drug products |
| JP7449275B2 (ja) | 2018-05-02 | 2024-03-13 | インスメッド インコーポレイテッド | リポソーム薬物製剤の製造方法 |
| AU2019339401B9 (en) * | 2018-09-14 | 2022-11-03 | Pharmosa Biopharm Inc. | Pharmaceutical composition for controlled release of weak acid drugs and uses thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5077056A (en) * | 1984-08-08 | 1991-12-31 | The Liposome Company, Inc. | Encapsulation of antineoplastic agents in liposomes |
| ATE63124T1 (de) * | 1986-03-14 | 1991-05-15 | Fujisawa Pharmaceutical Co | Prodrugverbindungen, verfahren zu deren herstellung und diese enthaltende zubereitungen mit verzoegerter freisetzung. |
| US5057523A (en) * | 1988-09-22 | 1991-10-15 | Abbott Laboratories | Dipeptide quinolone derivatives |
| IL91664A (en) * | 1988-09-28 | 1993-05-13 | Yissum Res Dev Co | Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release |
| WO1991009616A1 (en) * | 1989-12-22 | 1991-07-11 | Yale University | Quinolone antibiotics encapsulated in lipid vesicles |
| DK0555229T3 (da) * | 1990-07-31 | 1996-08-19 | Liposome Co Inc | Akkumulation af aminosyrer og peptider i liposomer |
| CA2101241C (en) * | 1993-07-23 | 1998-12-22 | Jonathan P. Wong | Liposome-encapsulated ciprofloxacin |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US5741516A (en) * | 1994-06-20 | 1998-04-21 | Inex Pharmaceuticals Corporation | Sphingosomes for enhanced drug delivery |
| AU4981896A (en) * | 1995-02-14 | 1996-09-04 | Sequus Pharmaceuticals, Inc. | Liposome composition and method for administering liposome-loadable drugs |
| US5800833A (en) * | 1995-02-27 | 1998-09-01 | University Of British Columbia | Method for loading lipid vesicles |
| ATE252372T1 (de) * | 1996-08-23 | 2003-11-15 | Sequus Pharm Inc | Liposome enthaltend cisplatin |
| US5837282A (en) * | 1996-10-30 | 1998-11-17 | University Of British Columbia | Ionophore-mediated liposome loading |
-
1998
- 1998-04-02 US US09/054,857 patent/US5972379A/en not_active Expired - Lifetime
-
1999
- 1999-03-24 AT AT99916160T patent/ATE274342T1/de not_active IP Right Cessation
- 1999-03-24 JP JP2000541974A patent/JP2002510611A/ja active Pending
- 1999-03-24 CN CNB998046558A patent/CN1149978C/zh not_active Expired - Fee Related
- 1999-03-24 EP EP99916160A patent/EP1083881B1/en not_active Expired - Lifetime
- 1999-03-24 AU AU34533/99A patent/AU763989B2/en not_active Ceased
- 1999-03-24 IL IL13868599A patent/IL138685A0/xx unknown
- 1999-03-24 PT PT99916160T patent/PT1083881E/pt unknown
- 1999-03-24 DE DE69919698T patent/DE69919698T2/de not_active Expired - Fee Related
- 1999-03-24 WO PCT/US1999/006500 patent/WO1999051202A2/en not_active Ceased
- 1999-03-24 ES ES99916160T patent/ES2226371T3/es not_active Expired - Lifetime
- 1999-03-24 KR KR1020007010987A patent/KR100617921B1/ko not_active Expired - Lifetime
- 1999-03-24 DK DK99916160T patent/DK1083881T3/da active
- 1999-03-24 NZ NZ506970A patent/NZ506970A/en unknown
- 1999-03-24 CA CA002326497A patent/CA2326497A1/en not_active Abandoned
-
2000
- 2000-10-02 ZA ZA200005333A patent/ZA200005333B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HK1035331A1 (en) | 2001-11-23 |
| DE69919698D1 (de) | 2004-09-30 |
| ES2226371T3 (es) | 2005-03-16 |
| KR20010034727A (ko) | 2001-04-25 |
| ZA200005333B (en) | 2001-10-31 |
| CN1149978C (zh) | 2004-05-19 |
| WO1999051202A3 (en) | 1999-11-18 |
| IL138685A0 (en) | 2001-10-31 |
| NZ506970A (en) | 2003-07-25 |
| ATE274342T1 (de) | 2004-09-15 |
| CN1295465A (zh) | 2001-05-16 |
| EP1083881B1 (en) | 2004-08-25 |
| AU3453399A (en) | 1999-10-25 |
| DK1083881T3 (da) | 2005-01-03 |
| JP2002510611A (ja) | 2002-04-09 |
| WO1999051202A2 (en) | 1999-10-14 |
| EP1083881A2 (en) | 2001-03-21 |
| KR100617921B1 (ko) | 2006-08-30 |
| US5972379A (en) | 1999-10-26 |
| CA2326497A1 (en) | 1999-10-14 |
| AU763989B2 (en) | 2003-08-07 |
| DE69919698T2 (de) | 2005-05-25 |
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