PT1049699E - Pirazolotriazinas como antagonistas de flc - Google Patents
Pirazolotriazinas como antagonistas de flcInfo
- Publication number
- PT1049699E PT1049699E PT99904382T PT99904382T PT1049699E PT 1049699 E PT1049699 E PT 1049699E PT 99904382 T PT99904382 T PT 99904382T PT 99904382 T PT99904382 T PT 99904382T PT 1049699 E PT1049699 E PT 1049699E
- Authority
- PT
- Portugal
- Prior art keywords
- antagonists
- pirazolotriazinas
- flc
- crf
- psychiatric
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 2
- 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 abstract 2
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 abstract 2
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010020751 Hypersensitivity Diseases 0.000 abstract 1
- 208000012902 Nervous system disease Diseases 0.000 abstract 1
- 208000025966 Neurological disease Diseases 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 230000000112 colonic effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000009610 hypersensitivity Effects 0.000 abstract 1
- 230000001900 immune effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Virology (AREA)
- Reproductive Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Addiction (AREA)
- Gynecology & Obstetrics (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/014,734 US6313124B1 (en) | 1997-07-23 | 1998-01-28 | Tetrazine bicyclic compounds |
| US09/015,001 US6060478A (en) | 1996-07-24 | 1998-01-28 | Azolo triazines and pyrimidines |
| US09/015,002 US6191131B1 (en) | 1997-07-23 | 1998-01-28 | Azolo triazines and pyrimidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1049699E true PT1049699E (pt) | 2004-08-31 |
Family
ID=27360164
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT99904382T PT1049699E (pt) | 1998-01-28 | 1999-01-28 | Pirazolotriazinas como antagonistas de flc |
| PT03075887T PT1344779E (pt) | 1998-01-28 | 1999-01-28 | Azolo-pirimidinas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT03075887T PT1344779E (pt) | 1998-01-28 | 1999-01-28 | Azolo-pirimidinas |
Country Status (19)
| Country | Link |
|---|---|
| EP (2) | EP1344779B1 (da) |
| JP (1) | JP4228332B2 (da) |
| KR (1) | KR100574313B1 (da) |
| CN (2) | CN1542010A (da) |
| AT (2) | ATE264860T1 (da) |
| AU (1) | AU748818C (da) |
| BR (1) | BR9908206A (da) |
| CA (2) | CA2314613C (da) |
| DE (2) | DE69916578T2 (da) |
| DK (2) | DK1049699T3 (da) |
| ES (2) | ES2218991T3 (da) |
| IL (1) | IL137019A0 (da) |
| NZ (2) | NZ505079A (da) |
| PL (1) | PL200939B1 (da) |
| PT (2) | PT1049699E (da) |
| SG (1) | SG111076A1 (da) |
| SI (2) | SI1049699T1 (da) |
| TW (1) | TW520372B (da) |
| WO (1) | WO1999038868A1 (da) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4331500A (en) | 1999-04-06 | 2000-10-23 | Du Pont Pharmaceuticals Company | Pyrazolotriazines as crf antagonists |
| US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
| KR20020047198A (ko) | 1999-09-30 | 2002-06-21 | 해피 페너 ; 해리 에이치. 페너 2세 | 특정 알킬렌 디아민-치환된피라졸로[1,5-ａ]-1,5-피리미딘 및피라졸로[1,5-ａ]-1,3,5-트리아진 |
| OA12050A (en) * | 1999-09-30 | 2006-05-02 | Neurogen Corp | Certain alkylene diamine-substituted heterocycles. |
| US6525067B1 (en) | 1999-11-23 | 2003-02-25 | Pfizer Inc | Substituted heterocyclic derivatives |
| WO2001087889A1 (en) * | 2000-05-18 | 2001-11-22 | Neurocrine Biosciences, Inc. | Crf receptor antagonists and methods relating thereto |
| EP1305637A2 (en) * | 2000-08-02 | 2003-05-02 | Malope Company Limited | Diagnosis and treatment of non-ulcer dyspepsia based on hypothalamic-pituitary-adrenal axis abnormality |
| JP4549630B2 (ja) * | 2001-03-13 | 2010-09-22 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | コルチコトロピン放出因子受容体リガンドとしての、４−（２−ブチルアミノ）−２，７−ジメチル−８−（２−メチル−６−メトキシピリド−３−イル）ピラゾロ−［１，５−ａ］−１，３，５−トリアジン、その鏡像異性体および薬学的に許容できる塩類 |
| FR2842809A1 (fr) * | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
| US7034023B2 (en) * | 2003-04-04 | 2006-04-25 | Pfizer Inc | Pyrrolo[1,2-B]pyridazine compounds and their uses |
| US7056920B2 (en) | 2003-04-04 | 2006-06-06 | Pfizer Inc | Pyrrolo[1,2-B]pyridazine compounds and their uses |
| NZ547990A (en) * | 2003-12-22 | 2010-04-30 | Smithkline Beecham Cork Ltd | CRF receptor antagonists and methods relating thereto |
| EP1697369A1 (en) * | 2003-12-22 | 2006-09-06 | SB Pharmco Puerto Rico Inc | Crf receptor antagonists and methods relating thereto |
| JP2008503444A (ja) * | 2004-02-13 | 2008-02-07 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | Ｃｒｆ受容体アンタゴニスト、その調製法、その医薬組成物およびその使用 |
| GB0519957D0 (en) | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
| PE20070855A1 (es) * | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
| US7851468B2 (en) * | 2006-05-15 | 2010-12-14 | Cephalon, Inc. | Substituted pyrazolo[3,4-d]pyrimidines |
| WO2007149938A2 (en) | 2006-06-21 | 2007-12-27 | The Salk Institute Biological Studies | Methods for promoting hair growth |
| EP2114941B1 (en) | 2006-12-22 | 2015-03-25 | Astex Therapeutics Limited | Bicyclic heterocyclic compounds as fgfr inhibitors |
| JP5442449B2 (ja) | 2006-12-22 | 2014-03-12 | アステックス、セラピューティックス、リミテッド | 新規化合物 |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| WO2014078568A1 (en) | 2012-11-14 | 2014-05-22 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| CN104876935B (zh) * | 2015-05-18 | 2017-04-19 | 南方医科大学 | 2‑氨基吡咯并[1,2‑f][1,2,4]三嗪类化合物、合成方法及应用 |
| WO2016206999A1 (en) * | 2015-06-24 | 2016-12-29 | Apodemus Ab | Pyrazolo[1,5-a]triazin-4-amine derivatives useful in therapy |
| MX2019015318A (es) * | 2017-08-14 | 2020-07-20 | Spruce Biosciences Inc | Antagonistas del receptor del factor liberador de corticotropina. |
| KR20250022913A (ko) | 2017-08-14 | 2025-02-17 | 스프루스 바이오사이언시스 인코포레이티드 | 코티코트로핀 방출 인자 수용체 길항제 |
| CN112479956A (zh) * | 2019-07-30 | 2021-03-12 | 杭州阿诺生物医药科技有限公司 | 一种用于制备腺苷受体抑制剂中间体的方法 |
| MX2023001688A (es) | 2020-08-12 | 2023-02-22 | Spruce Biosciences Inc | Metodos y composiciones para tratar el sindrome de ovario poliquistico. |
| US11708372B2 (en) | 2021-11-19 | 2023-07-25 | Spruce Biosciences, Inc. | Crystalline composition of tildacerfont and methods of use and preparation thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW574214B (en) * | 1994-06-08 | 2004-02-01 | Pfizer | Corticotropin releasing factor antagonists |
| JPH10506126A (ja) * | 1995-05-12 | 1998-06-16 | ニューロゲン コーポレイション | 新規なデアザプリン誘導体；ｃｒｆ１特異性リガンドの新規なクラス |
| WO1997029109A1 (en) * | 1996-02-07 | 1997-08-14 | Janssen Pharmaceutica N.V. | Pyrazolopyrimidines as crf receptor antagonists |
| HU229024B1 (en) * | 1996-07-24 | 2013-07-29 | Bristol Myers Squibb Pharma Co | Azolo-pyridimidines, pharmaceutical compositions containing the same and use thereof |
| TR199900389T2 (xx) * | 1996-08-28 | 2000-06-21 | Pfizer Inc. | �kame edilmi� 6,5-hetero-bisiklik t�revleri. |
-
1999
- 1999-01-28 PL PL342183A patent/PL200939B1/pl unknown
- 1999-01-28 CA CA002314613A patent/CA2314613C/en not_active Expired - Fee Related
- 1999-01-28 EP EP03075887A patent/EP1344779B1/en not_active Expired - Lifetime
- 1999-01-28 DE DE69916578T patent/DE69916578T2/de not_active Expired - Lifetime
- 1999-01-28 DK DK99904382T patent/DK1049699T3/da active
- 1999-01-28 DK DK03075887T patent/DK1344779T3/da active
- 1999-01-28 CN CNA2003101225466A patent/CN1542010A/zh active Pending
- 1999-01-28 AU AU24787/99A patent/AU748818C/en not_active Ceased
- 1999-01-28 SI SI9930578T patent/SI1049699T1/xx unknown
- 1999-01-28 NZ NZ505079A patent/NZ505079A/en not_active IP Right Cessation
- 1999-01-28 WO PCT/US1999/001824 patent/WO1999038868A1/en not_active Ceased
- 1999-01-28 PT PT99904382T patent/PT1049699E/pt unknown
- 1999-01-28 CA CA2614603A patent/CA2614603C/en not_active Expired - Fee Related
- 1999-01-28 DE DE69926665T patent/DE69926665T2/de not_active Expired - Lifetime
- 1999-01-28 SI SI9930817T patent/SI1344779T1/sl unknown
- 1999-01-28 AT AT99904382T patent/ATE264860T1/de active
- 1999-01-28 CN CNB998023639A patent/CN1137123C/zh not_active Expired - Fee Related
- 1999-01-28 PT PT03075887T patent/PT1344779E/pt unknown
- 1999-01-28 KR KR1020007008188A patent/KR100574313B1/ko not_active Expired - Fee Related
- 1999-01-28 IL IL13701999A patent/IL137019A0/xx unknown
- 1999-01-28 JP JP2000529335A patent/JP4228332B2/ja not_active Expired - Fee Related
- 1999-01-28 ES ES99904382T patent/ES2218991T3/es not_active Expired - Lifetime
- 1999-01-28 EP EP99904382A patent/EP1049699B1/en not_active Expired - Lifetime
- 1999-01-28 SG SG200204556A patent/SG111076A1/en unknown
- 1999-01-28 NZ NZ524842A patent/NZ524842A/en not_active IP Right Cessation
- 1999-01-28 ES ES03075887T patent/ES2247478T3/es not_active Expired - Lifetime
- 1999-01-28 BR BR9908206-3A patent/BR9908206A/pt not_active Application Discontinuation
- 1999-01-28 AT AT03075887T patent/ATE301657T1/de active
- 1999-02-23 TW TW088102636A patent/TW520372B/zh not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2218991T3 (es) | Pirazolotriazinas como antagonistas de crf. | |
| LV12292A (lv) | Triazinu un pirimidinu azoloatvasinajumi | |
| DE69726724D1 (de) | Tetrahydropteridine und pyridylpiperazine zur behandlung von neurologischen störungen | |
| BR9814458A (pt) | Composto, composição farmacêutica e método de tratamento de disfunções afetivas | |
| MY132871A (en) | Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders | |
| PT1140929E (pt) | 1h-imidazo¬4,5-d|piridazin-7-onas 3h-imidazo¬4,5-c|piridin-4-onas e as tionas correspondentes como ligandos receptores do factor de libertacao de corticotrofina (flc) | |
| BR9307646A (pt) | Pirrolopirimidinas como antagonistas de crf | |
| KR100521829B1 (en) | Compositions and Methods for the Treatment of Alzheimer's Disease, Central Nervous System Injury, and Inflammatory Diseases | |
| CY1106607T1 (el) | 4-(2-βουτυλαμιονο)-2,7-διμεθυλ-8-(2-μεθυλ-6-μεθοξυπυριδ-3-υλ) πυραζολο-1,5-αι-1,3,5-τριαζινη, τα εναντιομορα και φαρμακευτικως παραδεκτα αλατα αυτης ως συναρμοτες του υποδοχεα του παραγοντος απελευθερωσης κορτικοτροπινης | |
| ES2150482T3 (es) | Pirazolopirimidinas como antagonistas del factor liberador de corticotropina. | |
| BR0209575A (pt) | Pirazinonas, piridinas e pirimidinas substituìdas como ligantes do fator liberador de corticotropina | |
| ATE198895T1 (de) | Verwendung von bindungsreagenzien gegen cd23 in der behandlung von autoimmunkrankheiten | |
| WO2002004453A3 (en) | PYRROLO[3,4-d]PYRIMIDINES AS CORTICOTROPIN RELEASING FACTOR (CRF) ANTAGONISTS | |
| ATE113591T1 (de) | 4-benzyl-5-phenyl-2,4-dihydro-3h-1,2,4-triazol- - one und ihre verwendung als antikonvulsiva. | |
| MY141752A (en) | Pyrazolotriazines as crf antagonists | |
| MY141976A (en) | Azolo triazines and pyrimidines | |
| MY141511A (en) | Azolo triazines and pyrimidines | |
| CA2532925A1 (en) | Azolo triazines and pyrimidines | |
| Manelis et al. | Neuropsychological model of brain organization of higher psychic functions in children suffering bronchial asthma |