PL88989B1 - - Google Patents
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- Publication number
- PL88989B1 PL88989B1 PL1972156883A PL15688372A PL88989B1 PL 88989 B1 PL88989 B1 PL 88989B1 PL 1972156883 A PL1972156883 A PL 1972156883A PL 15688372 A PL15688372 A PL 15688372A PL 88989 B1 PL88989 B1 PL 88989B1
- Authority
- PL
- Poland
- Prior art keywords
- protease
- general formula
- solution
- benzoyl
- value
- Prior art date
Links
- 239000000243 solution Substances 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 24
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims description 18
- 239000004365 Protease Substances 0.000 claims description 18
- 108091005804 Peptidases Proteins 0.000 claims description 14
- 150000003931 anilides Chemical class 0.000 claims description 13
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 11
- 239000002253 acid Substances 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
- 238000002360 preparation method Methods 0.000 claims description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 5
- 239000008366 buffered solution Substances 0.000 claims description 3
- 229910052739 hydrogen Inorganic materials 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 3
- 239000011707 mineral Substances 0.000 claims description 3
- 239000012188 paraffin wax Substances 0.000 claims description 2
- 125000003798 L-tyrosyl group Chemical class [H]N([H])[C@]([H])(C(=O)[*])C([H])([H])C1=C([H])C([H])=C(O[H])C([H])=C1[H] 0.000 claims 3
- YTRPTVLTUWVLKO-ZDUSSCGKSA-N Ficine Natural products CN1CCC[C@H]1C1=C(O)C=C(O)C2=C1OC(C=1C=CC=CC=1)=CC2=O YTRPTVLTUWVLKO-ZDUSSCGKSA-N 0.000 claims 1
- YTRPTVLTUWVLKO-UHFFFAOYSA-N ficine Chemical compound CN1CCCC1C1=C(O)C=C(O)C2=C1OC(C=1C=CC=CC=1)=CC2=O YTRPTVLTUWVLKO-UHFFFAOYSA-N 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 238000010626 work up procedure Methods 0.000 claims 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 39
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 21
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000000047 product Substances 0.000 description 10
- 239000007979 citrate buffer Substances 0.000 description 9
- 229960000583 acetic acid Drugs 0.000 description 7
- 239000012362 glacial acetic acid Substances 0.000 description 7
- 238000002844 melting Methods 0.000 description 7
- 230000008018 melting Effects 0.000 description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 6
- 239000012452 mother liquor Substances 0.000 description 6
- 238000010992 reflux Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 5
- 239000007858 starting material Substances 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
- XUJNEKJLAYXESH-UHFFFAOYSA-O cysteinium Chemical compound SCC([NH3+])C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-O 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 239000002244 precipitate Substances 0.000 description 4
- 239000001632 sodium acetate Substances 0.000 description 4
- 235000017281 sodium acetate Nutrition 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 108090000526 Papain Proteins 0.000 description 3
- 102000035195 Peptidases Human genes 0.000 description 3
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000002425 crystallisation Methods 0.000 description 3
- 230000008025 crystallization Effects 0.000 description 3
- 238000000354 decomposition reaction Methods 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 239000000706 filtrate Substances 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
- 235000019834 papain Nutrition 0.000 description 3
- 229940055729 papain Drugs 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 235000014101 wine Nutrition 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000005711 Benzoic acid Substances 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 235000010233 benzoic acid Nutrition 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 235000019419 proteases Nutrition 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- ODTCNJWUFHCFJB-CYBMUJFWSA-N (2r)-2-benzamido-3-(4-hydroxy-3-methoxyphenyl)propanoic acid Chemical compound C1=C(O)C(OC)=CC(C[C@@H](NC(=O)C=2C=CC=CC=2)C(O)=O)=C1 ODTCNJWUFHCFJB-CYBMUJFWSA-N 0.000 description 1
- IDRRCKUGGXLORG-FJXQXJEOSA-N (2s)-2-amino-3-(4-hydroxy-3-methoxyphenyl)propanoic acid;hydrate Chemical compound O.COC1=CC(C[C@H](N)C(O)=O)=CC=C1O IDRRCKUGGXLORG-FJXQXJEOSA-N 0.000 description 1
- ODTCNJWUFHCFJB-UHFFFAOYSA-N 2-benzamido-3-(4-hydroxy-3-methoxyphenyl)propanoic acid Chemical compound C1=C(O)C(OC)=CC(CC(NC(=O)C=2C=CC=CC=2)C(O)=O)=C1 ODTCNJWUFHCFJB-UHFFFAOYSA-N 0.000 description 1
- HYAINHWQBOEATF-UHFFFAOYSA-N 2-benzamido-3-(4-hydroxy-4-methoxycyclohexa-1,5-dien-1-yl)propanoic acid Chemical compound C(C1=CC=CC=C1)(=O)NC(CC1=CCC(C=C1)(O)OC)C(=O)O HYAINHWQBOEATF-UHFFFAOYSA-N 0.000 description 1
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- 108010004032 Bromelains Proteins 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 150000008553 L-tyrosines Chemical class 0.000 description 1
- 208000018737 Parkinson disease Diseases 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000004414 alkyl thio group Chemical group 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 235000019835 bromelain Nutrition 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
- -1 methoxyl group Chemical group 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 229960004441 tyrosine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
- C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2136675A DE2136675A1 (de) | 1971-07-22 | 1971-07-22 | Verfahren zur herstellung von l-3methoxytyrosin |
| DE19722200041 DE2200041A1 (de) | 1972-01-03 | 1972-01-03 | Verfahren zur herstellung von derivaten des l-tyrosins |
| DE19722216097 DE2216097A1 (de) | 1972-04-01 | 1972-04-01 | Verfahren zur herstellung von derivaten des l-m-tyrosins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL88989B1 true PL88989B1 (instruction) | 1976-10-30 |
Family
ID=27183578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL1972156883A PL88989B1 (instruction) | 1971-07-22 | 1972-07-21 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US3855062A (instruction) |
| JP (1) | JPS4828689A (instruction) |
| AT (1) | AT317815B (instruction) |
| AU (1) | AU469638B2 (instruction) |
| BE (1) | BE786577A (instruction) |
| BG (1) | BG24407A3 (instruction) |
| CA (1) | CA985649A (instruction) |
| CH (2) | CH585185A5 (instruction) |
| CS (1) | CS170191B2 (instruction) |
| DD (1) | DD100707A5 (instruction) |
| ES (1) | ES405006A1 (instruction) |
| FR (1) | FR2146458B1 (instruction) |
| GB (1) | GB1391309A (instruction) |
| HU (1) | HU167228B (instruction) |
| IE (1) | IE36685B1 (instruction) |
| IL (1) | IL39957A (instruction) |
| NL (1) | NL7210064A (instruction) |
| NO (1) | NO136789C (instruction) |
| PH (1) | PH10890A (instruction) |
| PL (1) | PL88989B1 (instruction) |
| RO (1) | RO68363A (instruction) |
| SE (1) | SE393799B (instruction) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU584502B2 (en) * | 1987-03-30 | 1989-05-25 | Shosuke Okamoto | Phenylalanine derivatives and proteinase inhibitor |
| EP1596808A4 (en) * | 2003-02-07 | 2007-04-04 | Yissum Res Dev Co | L-DOPA AMID DERIVATIVES AND THEIR USE |
-
0
- BE BE786577D patent/BE786577A/xx unknown
-
1972
- 1972-06-28 AT AT555772A patent/AT317815B/de not_active IP Right Cessation
- 1972-07-14 RO RO7271619A patent/RO68363A/ro unknown
- 1972-07-14 SE SE7209349A patent/SE393799B/xx unknown
- 1972-07-19 CH CH1079672A patent/CH585185A5/xx not_active IP Right Cessation
- 1972-07-19 US US00273202A patent/US3855062A/en not_active Expired - Lifetime
- 1972-07-19 CH CH1349576A patent/CH585186A5/xx not_active IP Right Cessation
- 1972-07-20 BG BG021011A patent/BG24407A3/xx unknown
- 1972-07-20 HU HUBO1386A patent/HU167228B/hu unknown
- 1972-07-20 NL NL7210064A patent/NL7210064A/xx unknown
- 1972-07-20 ES ES405006A patent/ES405006A1/es not_active Expired
- 1972-07-20 IL IL39957A patent/IL39957A/xx unknown
- 1972-07-20 DD DD164560A patent/DD100707A5/xx unknown
- 1972-07-21 JP JP47073317A patent/JPS4828689A/ja active Pending
- 1972-07-21 FR FR7226316A patent/FR2146458B1/fr not_active Expired
- 1972-07-21 CS CS5209A patent/CS170191B2/cs unknown
- 1972-07-21 AU AU44856/72A patent/AU469638B2/en not_active Expired
- 1972-07-21 PL PL1972156883A patent/PL88989B1/pl unknown
- 1972-07-21 NO NO2623/72A patent/NO136789C/no unknown
- 1972-07-21 CA CA147,643A patent/CA985649A/en not_active Expired
- 1972-07-21 GB GB3434772A patent/GB1391309A/en not_active Expired
- 1972-07-21 IE IE1027/72A patent/IE36685B1/xx unknown
- 1972-07-27 PH PH13750A patent/PH10890A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE36685L (en) | 1973-01-22 |
| IL39957A (en) | 1975-02-10 |
| GB1391309A (en) | 1975-04-23 |
| NO136789B (no) | 1977-08-01 |
| CA985649A (en) | 1976-03-16 |
| CH585185A5 (instruction) | 1977-02-28 |
| IE36685B1 (en) | 1977-02-02 |
| PH10890A (en) | 1977-09-30 |
| NL7210064A (instruction) | 1973-01-24 |
| SE393799B (sv) | 1977-05-23 |
| BG24407A3 (en) | 1978-02-10 |
| DD100707A5 (instruction) | 1973-10-05 |
| IL39957A0 (en) | 1972-09-28 |
| AU469638B2 (en) | 1976-02-19 |
| US3855062A (en) | 1974-12-17 |
| FR2146458A1 (instruction) | 1973-03-02 |
| HU167228B (instruction) | 1975-09-27 |
| AU4485672A (en) | 1974-01-24 |
| NO136789C (no) | 1977-11-09 |
| RO68363A (ro) | 1981-09-24 |
| BE786577A (fr) | 1973-01-22 |
| FR2146458B1 (instruction) | 1976-03-12 |
| CH585186A5 (instruction) | 1977-02-28 |
| JPS4828689A (instruction) | 1973-04-16 |
| CS170191B2 (instruction) | 1976-08-27 |
| SU450399A3 (ru) | 1974-11-15 |
| ES405006A1 (es) | 1976-01-01 |
| AT317815B (de) | 1974-09-10 |
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