PL58297B1 - - Google Patents

Info

Publication number

PL58297B1

PL58297B1 PL121307A PL12130767A PL58297B1 PL 58297 B1 PL58297 B1 PL 58297B1 PL 121307 A PL121307 A PL 121307A PL 12130767 A PL12130767 A PL 12130767A PL 58297 B1 PL58297 B1 PL 58297B1

Authority

PL

Poland

Prior art keywords

viomycin

salt

substituted

treated

acid

Prior art date

1967-06-23

Links

• Espacenet
• Global Dossier
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• GXFAIFRPOKBQRV-GHXCTMGLSA-N viomycin Chemical class N1C(=O)\C(=C\NC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C[C@@H](N)CCCN)CNC(=O)[C@@H]1[C@@H]1NC(=N)N[C@@H](O)C1 GXFAIFRPOKBQRV-GHXCTMGLSA-N 0.000 claims description 20
• 229950001272 viomycin Drugs 0.000 claims description 15
• 238000000034 method Methods 0.000 claims description 14
• OZKXLOZHHUHGNV-UHFFFAOYSA-N Viomycin Natural products NCCCC(N)CC(=O)NC1CNC(=O)C(=CNC(=O)N)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(NC1=O)C2CC(O)NC(=N)N2 OZKXLOZHHUHGNV-UHFFFAOYSA-N 0.000 claims description 13
• 108010015940 Viomycin Proteins 0.000 claims description 13
• -1 aliphatic monocarboxylic acid Chemical class 0.000 claims description 5
• 229910019142 PO4 Inorganic materials 0.000 claims description 4
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
• 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 4
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 4
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 4
• 239000010452 phosphate Substances 0.000 claims description 4
• 239000002244 precipitate Substances 0.000 claims description 4
• 239000000047 product Substances 0.000 claims description 4
• 150000004649 carbonic acid derivatives Chemical class 0.000 claims description 3
• 238000006243 chemical reaction Methods 0.000 claims description 3
• 229910052751 metal Inorganic materials 0.000 claims description 3
• 239000002184 metal Substances 0.000 claims description 3
• 238000002360 preparation method Methods 0.000 claims description 3
• 150000003839 salts Chemical class 0.000 claims description 3
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
• 239000002253 acid Substances 0.000 claims description 2
• 125000003545 alkoxy group Chemical group 0.000 claims description 2
• 229910052791 calcium Inorganic materials 0.000 claims description 2
• 239000011575 calcium Substances 0.000 claims description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
• 125000005843 halogen group Chemical group 0.000 claims description 2
• 150000004679 hydroxides Chemical class 0.000 claims description 2
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
• 229910021645 metal ion Inorganic materials 0.000 claims description 2
• 150000002739 metals Chemical class 0.000 claims description 2
• 125000005341 metaphosphate group Chemical group 0.000 claims description 2
• 239000012429 reaction media Substances 0.000 claims description 2
• 229910052712 strontium Inorganic materials 0.000 claims description 2
• CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 2
• RQPZNWPYLFFXCP-UHFFFAOYSA-L barium dihydroxide Chemical class [OH-].[OH-].[Ba+2] RQPZNWPYLFFXCP-UHFFFAOYSA-L 0.000 claims 1
• 238000001914 filtration Methods 0.000 claims 1
• 239000002002 slurry Substances 0.000 claims 1
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 13
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
• TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 6
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
• 239000000706 filtrate Substances 0.000 description 4
• AQONYROJHRNYQQ-QMAPKBLTSA-N (3s)-3,6-diamino-n-[(3s,6z,9s,12s,15s)-3-[(4s,6r)-2-amino-4-hydroxy-1,4,5,6-tetrahydropyrimidin-6-yl]-6-[(carbamoylamino)methylidene]-9,12-bis(hydroxymethyl)-2,5,8,11,14-pentaoxo-1,4,7,10,13-pentazacyclohexadec-15-yl]hexanamide;sulfuric acid Chemical compound OS(O)(=O)=O.N1C(=O)\C(=C\NC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)C[C@@H](N)CCCN)CNC(=O)[C@@H]1[C@@H]1NC(N)=N[C@@H](O)C1 AQONYROJHRNYQQ-QMAPKBLTSA-N 0.000 description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
• GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 2
• 230000007059 acute toxicity Effects 0.000 description 2
• 231100000403 acute toxicity Toxicity 0.000 description 2
• 238000012792 lyophilization process Methods 0.000 description 2
• 239000000243 solution Substances 0.000 description 2
• 238000003756 stirring Methods 0.000 description 2
• 229910021653 sulphate ion Inorganic materials 0.000 description 2
• OURWKHLDAVYMGO-UHFFFAOYSA-N 7-thiophen-2-ylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid Chemical compound C=1C=NC2=C(C(=O)O)C=NN2C=1C1=CC=CS1 OURWKHLDAVYMGO-UHFFFAOYSA-N 0.000 description 1
• 102000005701 Calcium-Binding Proteins Human genes 0.000 description 1
• 108010045403 Calcium-Binding Proteins Proteins 0.000 description 1
• GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
• 239000005909 Kieselgur Substances 0.000 description 1
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 229960005070 ascorbic acid Drugs 0.000 description 1
• 235000010323 ascorbic acid Nutrition 0.000 description 1
• 239000011668 ascorbic acid Substances 0.000 description 1
• ITHZDDVSAWDQPZ-UHFFFAOYSA-L barium acetate Chemical compound [Ba+2].CC([O-])=O.CC([O-])=O ITHZDDVSAWDQPZ-UHFFFAOYSA-L 0.000 description 1
• HLKMEIITONDPGG-UHFFFAOYSA-L barium(2+);2-hydroxypropanoate Chemical compound [Ba+2].CC(O)C([O-])=O.CC(O)C([O-])=O HLKMEIITONDPGG-UHFFFAOYSA-L 0.000 description 1
• AYJRCSIUFZENHW-DEQYMQKBSA-L barium(2+);oxomethanediolate Chemical compound [Ba+2].[O-][14C]([O-])=O AYJRCSIUFZENHW-DEQYMQKBSA-L 0.000 description 1
• 150000001875 compounds Chemical class 0.000 description 1
• 230000001419 dependent effect Effects 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 231100000086 high toxicity Toxicity 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• 231100001231 less toxic Toxicity 0.000 description 1
• 231100000053 low toxicity Toxicity 0.000 description 1
• 239000000203 mixture Substances 0.000 description 1
• 150000002763 monocarboxylic acids Chemical class 0.000 description 1
• 229940055726 pantothenic acid Drugs 0.000 description 1
• 235000019161 pantothenic acid Nutrition 0.000 description 1
• 239000011713 pantothenic acid Substances 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical class OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 description 1
• 239000013049 sediment Substances 0.000 description 1
• 238000002791 soaking Methods 0.000 description 1
• 231100000419 toxicity Toxicity 0.000 description 1
• 230000001988 toxicity Effects 0.000 description 1
• 238000005406 washing Methods 0.000 description 1