PL4249073T3 - Pirymidyny do degradacji kinazy tyrozynowej Brutona - Google Patents

Pirymidyny do degradacji kinazy tyrozynowej Brutona

Info

Publication number
PL4249073T3
PL4249073T3 PL23162731.6T PL23162731T PL4249073T3 PL 4249073 T3 PL4249073 T3 PL 4249073T3 PL 23162731 T PL23162731 T PL 23162731T PL 4249073 T3 PL4249073 T3 PL 4249073T3
Authority
PL
Poland
Prior art keywords
bruton
pyrimidines
degrading
tyrosine kinase
tyrosine
Prior art date
Application number
PL23162731.6T
Other languages
English (en)
Inventor
Zhiguo BIAN
Jason Burke
Zhaozhong Jia
Xingyu Jiang
Matthew Katcher
Venkat Reddy Mali
Violeta Marin
Elizabeth Noey
Akinori Okano
Alexey Rivkin
Spencer Scholz
Kevin Woller
Xianrui Zhao
Ashley ADAMS
Berenger BIANNIC
Shahab MORTEZAEI
Joshua Payette
Jeffery Zablocki
Original Assignee
Abbvie Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Inc. filed Critical Abbvie Inc.
Publication of PL4249073T3 publication Critical patent/PL4249073T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PL23162731.6T 2022-03-22 2023-03-17 Pirymidyny do degradacji kinazy tyrozynowej Brutona PL4249073T3 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202263322505P 2022-03-22 2022-03-22

Publications (1)

Publication Number Publication Date
PL4249073T3 true PL4249073T3 (pl) 2025-03-17

Family

ID=85776045

Family Applications (1)

Application Number Title Priority Date Filing Date
PL23162731.6T PL4249073T3 (pl) 2022-03-22 2023-03-17 Pirymidyny do degradacji kinazy tyrozynowej Brutona

Country Status (22)

Country Link
US (2) US12172992B2 (pl)
EP (2) EP4480482A3 (pl)
JP (2) JP7805983B2 (pl)
KR (1) KR20240163634A (pl)
CN (1) CN119072475A (pl)
AR (1) AR128842A1 (pl)
AU (1) AU2023237882A1 (pl)
CO (1) CO2024012427A2 (pl)
DK (1) DK4249073T3 (pl)
ES (1) ES3014292T3 (pl)
FI (1) FI4249073T3 (pl)
HR (1) HRP20241722T1 (pl)
HU (1) HUE070665T2 (pl)
IL (1) IL314260A (pl)
LT (1) LT4249073T (pl)
MX (1) MX2024011120A (pl)
PL (1) PL4249073T3 (pl)
PT (1) PT4249073T (pl)
RS (1) RS66349B1 (pl)
SI (1) SI4249073T1 (pl)
TW (1) TW202346287A (pl)
WO (1) WO2023183811A1 (pl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022424178A1 (en) * 2021-12-30 2024-07-11 Beone Medicines I Gmbh Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use
WO2026021570A1 (en) * 2024-07-26 2026-01-29 Ascentage Pharma (Suzhou) Co., Ltd. Btk degrader and use thereof

Family Cites Families (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578550A (en) 1993-10-08 1996-11-26 American Cyanamid Company Herbicidal oxadiazole carbonamide compounds
JP3402153B2 (ja) 1997-10-01 2003-04-28 凸版印刷株式会社 耐水性および剛性に優れた含浸紙
US7214487B2 (en) 1998-06-26 2007-05-08 Sunesis Pharmaceuticals, Inc. Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates
US6998233B2 (en) 1998-06-26 2006-02-14 Sunesis Pharmaceuticals, Inc. Methods for ligand discovery
AU2573102A (en) 2000-11-21 2002-06-03 Sunesis Pharmaceuticals Inc An extended tethering approach for rapid identification of ligands
US9157875B2 (en) 2001-05-16 2015-10-13 Benjamin P. Warner Drug development and manufacturing
US20080220441A1 (en) 2001-05-16 2008-09-11 Birnbaum Eva R Advanced drug development and manufacturing
EP1908520A4 (en) 2005-06-28 2009-06-10 Sumitomo Chemical Co PEROXIDE-DEGRADABLE CATALYST
EP2511844B1 (en) 2006-10-10 2015-08-12 XRpro Sciences, Inc. X-ray microscope
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
AR078793A1 (es) 2009-10-27 2011-12-07 Orion Corp Derivados de carboxamidas no esteroidales y acil hidrazona moduladores de receptores androgenicos de tejido selectivo (sarm), composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento del cancer de prostata entre otros
MX2013001872A (es) 2010-08-16 2013-09-02 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrieno.
US8580829B2 (en) 2010-08-26 2013-11-12 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
TWI732259B (zh) 2010-12-16 2021-07-01 美商建南德克公司 關於th2抑制作用之診斷及治療
AR089853A1 (es) 2012-02-01 2014-09-24 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso
AR092790A1 (es) 2012-02-01 2015-05-06 Euro Celtique Sa Derivados bencimidazolicos del acido hidroxamico
AU2013250726B2 (en) 2012-04-20 2017-01-05 Advinus Therapeutics Limited Substituted hetero-bicyclic compounds, compositions and medicinal applications thereof
MX2015002975A (es) 2012-10-26 2015-06-22 Hoffmann La Roche Inhibidores de la tirosina cinasa de bruton.
EP3099717B1 (en) 2014-01-31 2019-03-27 Novartis AG Antibody molecules to tim-3 and uses thereof
US20150259420A1 (en) 2014-03-14 2015-09-17 Novartis Ag Antibody molecules to lag-3 and uses thereof
KR102359214B1 (ko) 2014-04-04 2022-02-07 델 마 파마슈티컬스 폐의 비소세포 암종 및 난소암을 치료하기 위한 디안하이드로갈락티톨 및 이의 유사체 또는 유도체
KR101582834B1 (ko) 2014-04-14 2016-01-08 한국세라믹기술원 비수계 그래핀 코팅액 제조 방법
KR101635848B1 (ko) 2014-04-14 2016-07-05 한국세라믹기술원 탄소 비결합성 금속 나노입자가 함유된 잉크 기제 제조 방법 및 금속 나노입자가 분산된 잉크
ES2907622T3 (es) 2014-10-06 2022-04-25 Merck Patent Gmbh Compuestos de heteroarilo como inhibidores de BTK y usos de estos
US9694084B2 (en) 2014-12-23 2017-07-04 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
GB201506871D0 (en) 2015-04-22 2015-06-03 Glaxosmithkline Ip Dev Ltd Novel compounds
CA2988436A1 (en) 2015-07-13 2017-01-19 Arvinas, Inc. Alanine-based modulators of proteolysis and associated methods of use
EP3458101B1 (en) 2016-05-20 2020-12-30 H. Hoffnabb-La Roche Ag Protac antibody conjugates and methods of use
GB201610147D0 (en) 2016-06-10 2016-07-27 Glaxosmithkline Ip Dev Ltd Novel compounds
AU2017312970B2 (en) 2016-08-16 2021-08-12 Merck Patent Gmbh 2-oxo-imidazopyridines as reversible BTK inhibitors and uses thereof
GB201614134D0 (en) 2016-08-18 2016-10-05 Glaxosmithkline Ip Dev Ltd Novel compounds
KR20190080956A (ko) 2016-11-22 2019-07-08 다나-파버 캔서 인스티튜트 인크. E3 리가아제 리간드와 브루톤 티로신 키나아제(btk) 억제제의 컨쥬게이션에 의한 btk의 분해 및 사용 방법
US10842878B2 (en) 2016-11-22 2020-11-24 Dana-Farber Cancer Institute, Inc. Degradation of Bruton's tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand and methods of use
UY37559A (es) 2017-01-06 2018-05-31 Pharmacyclics Llc Pirazolo[3,4-b]piridina y pirrolo[2,3-b]piridina como inhibidores de la tirosina quinasa de bruton
RU2763898C9 (ru) 2017-01-24 2022-03-18 Цспц Чжунци Фармасьютикал Текнолоджи (Шицзячжуан) Ко., Лтд. Ингибитор lsd1, а также способ его получения и его применение
JP7145874B2 (ja) 2017-04-14 2022-10-03 バイオジェン・エムエイ・インコーポレイテッド ブルトン型チロシンキナーゼの阻害剤としてのベンゾアゼピン類似体
FI3645001T3 (fi) 2017-06-29 2024-09-25 G1 Therapeutics Inc Git38:n morfisia muotoja ja niiden valmistusmenetelmiä
CN109422752B (zh) 2017-09-03 2023-04-07 上海美志医药科技有限公司 一类具有抑制并降解布鲁顿酪氨酸蛋白激酶Btk活性的化合物
WO2019084030A1 (en) 2017-10-24 2019-05-02 Genentech, Inc. (4-HYDROXYPYRROLIDIN-2-YL) -HYDROXAMATE COMPOUNDS AND METHODS OF USE
EP3700901A1 (en) 2017-10-24 2020-09-02 Genentech, Inc. (4-hydroxypyrrolidin-2-yl)-heterocyclic compounds and methods of use thereof
CA3083228A1 (en) 2017-12-14 2019-06-20 Dana-Farber Cancer Institute, Inc. Small molecule degraders that recruit dcaft15
EP3746426A4 (en) 2018-01-29 2021-12-29 Dana Farber Cancer Institute, Inc. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use
WO2019160915A1 (en) 2018-02-14 2019-08-22 Dana-Farber Cancer Institute, Inc. Irak degraders and uses thereof
WO2019161224A1 (en) 2018-02-15 2019-08-22 GiraFpharma LLC Heterocyclic compounds as kinase inhibitors
US11028088B2 (en) 2018-03-10 2021-06-08 Yale University Modulators of BTK proteolysis and methods of use
US20200121684A1 (en) 2018-03-10 2020-04-23 Yale University Modulators of btk proteolysis and methods of use
WO2019183523A1 (en) 2018-03-23 2019-09-26 Genentech, Inc. Hetero-bifunctional degrader compounds and their use as modulators of targeted ubiquination (vhl)
EP3774808A1 (en) 2018-03-26 2021-02-17 Novartis AG 3-hydroxy-n-(3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)pyrrolidine-1-carboxamide derivatives
EP3774804A1 (en) 2018-03-26 2021-02-17 Novartis AG N-(3-(7h-pyrrolo[2,3-d]pyrimidin-4-yl)phenyl)benzamide derivatives
CN108379591B (zh) 2018-04-03 2022-03-29 深圳大学 免疫激动剂靶向化合物的合成及其应用
US10899753B2 (en) 2018-05-14 2021-01-26 Biogen Ma Inc. Inhibiting agents for Bruton's tyrosine kinase
CA3102996A1 (en) 2018-07-20 2020-01-23 Dana-Farber Cancer Institute, Inc. Degraders that target proteins via keap1
US12415803B2 (en) 2018-08-28 2025-09-16 Merck Patent Gmbh Fused imidazopyridines as reversible inhibitors of Brutons Tyrosine Kinase (BTK)
JP7600123B2 (ja) 2018-10-15 2024-12-16 ニューリックス セラピューティクス,インコーポレイテッド ユビキチンプロテオソーム経路を介してbtkを分解するための二官能性化合物
JP7623943B2 (ja) 2018-11-30 2025-01-29 カイメラ セラピューティクス, インコーポレイテッド Irak分解剤およびそれらの使用
BR112021012027A2 (pt) 2018-12-21 2021-11-03 Ose Immunotherapeutics Molécula bifuncional direcionada contra pd-1 humano
CN113614109A (zh) 2018-12-21 2021-11-05 Ose免疫疗法公司 双功能抗pd-1/il-7分子
AU2019409805A1 (en) 2018-12-21 2021-07-22 Ose Immunotherapeutics Bifunctional anti-PD-1/SIRPA molecule
WO2020167518A1 (en) 2019-02-13 2020-08-20 Nurix Therapeutics, Inc. Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
WO2020165374A1 (en) 2019-02-14 2020-08-20 Ose Immunotherapeutics Bifunctional molecule comprising il-15ra
CN113727973B (zh) 2019-02-15 2025-08-29 百时美施贵宝公司 可用作类法尼醇x受体调节剂的取代酰胺化合物
WO2020206035A1 (en) 2019-04-01 2020-10-08 G1 Therapeutics, Inc. Treatment of cdk4/6 inhibitor resistant neoplastic disorders
WO2020232330A1 (en) 2019-05-15 2020-11-19 Biogen Ma Inc. Inhibiting agents for bruton's tyrosine kinase
WO2020252397A1 (en) 2019-06-12 2020-12-17 Baylor College Of Medicine Small molecule proteolysis-targeting chimeras and methods of use thereof
AU2020301399B2 (en) 2019-06-24 2025-12-18 Dana-Farber Cancer Institute, Inc. HCK degraders and uses thereof
WO2021018018A1 (en) 2019-07-26 2021-02-04 Beigene, Ltd. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inidbitors with e3 ligase ligand and methods of use
JP7785663B2 (ja) 2019-09-16 2025-12-15 ノバルティス アーゲー 二機能性分解誘導薬及びそれらの使用方法
WO2021087112A1 (en) 2019-10-30 2021-05-06 Biogen Ma Inc. Condensed bi-heterocycles as inhibiting agents for bruton's tyrosine kinase
EP4081514A1 (en) 2019-12-23 2022-11-02 Biogen MA Inc. Btk inhibitors
WO2021180103A1 (en) 2020-03-11 2021-09-16 Beigene, Ltd. Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use
CN115485278A (zh) 2020-04-30 2022-12-16 百济神州有限公司 通过缀合btk抑制剂与e3连接酶配体降解布鲁顿氏酪氨酸激酶(btk)及其使用方法
EP4192587A1 (en) 2020-08-07 2023-06-14 Biogen MA Inc. Btk inhibitors
US20240246977A1 (en) 2020-12-31 2024-07-25 Beigene Switzerland Gmbh Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and method of use
KR20240017814A (ko) 2021-05-05 2024-02-08 바이오젠 엠에이 인코포레이티드 브루톤 티로신 키나제의 분해를 표적으로 하는 화합물
IL309528A (en) 2021-06-21 2024-02-01 Beigene Switzerland Gmbh (R)-glutrimide CRBN ligands and methods of use
PL4192813T3 (pl) 2021-06-30 2024-12-23 Zedira Gmbh Inhibitory transglutaminaz
WO2023110138A1 (en) 2021-12-17 2023-06-22 Zedira Gmbh Inhibitors of transglutaminases
AU2022301517A1 (en) 2021-06-30 2023-12-14 Zedira Gmbh Inhibitors of transglutaminases
KR20240028466A (ko) 2021-06-30 2024-03-05 제디라 게엠베하 트랜스글루타미나아제 억제제
AU2022370021B2 (en) 2021-10-22 2026-04-16 Gluetacs Therapeutics (Shanghai) Co., Ltd. Crbn e3 ligase ligand compound, protein degrading agent developed on the basis of ligand compound, and their applications
EP4429770A1 (en) 2021-11-10 2024-09-18 Biogen MA Inc. Btk inhibitors
AU2022405474A1 (en) 2021-12-08 2024-07-18 Gluetacs Therapeutics (Shanghai) Co., Ltd. E3 ubiquitin ligase ligand compound, protein degrader developed based thereon and their applications
AU2022424178A1 (en) 2021-12-30 2024-07-11 Beone Medicines I Gmbh Degradation of bruton's tyrosine kinase (btk) by conjugation of btk inhibitors with e3 ligase ligand and methods of use
JP2025503463A (ja) 2021-12-30 2025-02-04 ベイジーン スウィッツァーランド ゲーエムベーハー ブルトン型チロシンキナーゼ(btk)阻害剤をe3リガーゼリガンドにコンジュゲートすることによるbtkの分解及び使用方法

Also Published As

Publication number Publication date
DK4249073T3 (da) 2025-01-02
KR20240163634A (ko) 2024-11-19
SI4249073T1 (sl) 2025-02-28
US12172992B2 (en) 2024-12-24
ES3014292T3 (en) 2025-04-21
JP2026063166A (ja) 2026-04-10
EP4480482A3 (en) 2025-03-26
US20240109877A1 (en) 2024-04-04
WO2023183811A1 (en) 2023-09-28
JP7805983B2 (ja) 2026-01-26
HRP20241722T1 (hr) 2025-02-28
CN119072475A (zh) 2024-12-03
CO2024012427A2 (es) 2024-09-30
AU2023237882A1 (en) 2024-08-01
US20250304568A1 (en) 2025-10-02
PT4249073T (pt) 2025-01-06
AR128842A1 (es) 2024-06-19
MX2024011120A (es) 2024-09-18
EP4480482A2 (en) 2024-12-25
JP2023140319A (ja) 2023-10-04
IL314260A (en) 2024-09-01
LT4249073T (lt) 2025-01-27
EP4249073B1 (en) 2024-12-11
HUE070665T2 (hu) 2025-06-28
EP4249073A1 (en) 2023-09-27
RS66349B1 (sr) 2025-01-31
TW202346287A (zh) 2023-12-01
FI4249073T3 (fi) 2025-02-03

Similar Documents

Publication Publication Date Title
IL308219A (en) Compounds to Target Broton Tyrosine Kinase Degradation
HUE070805T2 (hu) [1,3]diazino[5,4-D]pirimidenek, mint HER2-gátlók
IL314260A (en) Pyrimidines for Broton's tyrosine kinase degradation
MX2025013699A (es) Una 7-h-pirrolo[2,3-d]pirimidina inhibidora de jak
IL266741A (en) Broton tyrosine kinase inhibitors
TW200736249A (en) Aminopyrimidines useful as kinase inhibitors
AU2009270856A8 (en) Inhibitors of Bruton's tyrosine kinase for the treatment of solid tumors
WO2003042172A3 (en) C-5 modified indazolylpyrrolotriazines
ATE508126T1 (de) Als kinaseinhibitoren geeignete aminopyrimidine
ZA200707342B (en) Pyrrolopyrimidines useful as inhibitors of protein kinase
UA99597C2 (ru) Пиримидилциклопентаны как ингибиторы акт протеинкиназ
MX2009013403A (es) Metabolitos del inhibidor de janus cinasa (r)-3-(4-(7h-pirrolo[2,3 -d]pirimidin-4-il)-1h-pirazol-1-il)-3-ciclopentilpropanitrilo.
MX2009010037A (es) Aminopirimidinas utiles como inhibidores de cinasas.
MX2009006690A (es) Aminopirimidinas utiles como inhibidores de proteinas cinasas.
MX2009011811A (es) Aminopirimidinas utiles como inhibidores de cinasa.
EP3601264A4 (en) BRUTON TYROSINE KINASE INHIBITORS
IL284916A (en) Cyclic molecules as Bruton's tyrosine kinase inhibitors
WO2003032911A3 (en) Anti-angiogenic and cytotoxic fused pyrimidines
UA84929C2 (en) Prodrugs of pyrrolylpyrimidine erk protein kinase inhibitors
EP4069689A4 (en) SUBSTITUTED IMIDAZOLECARBOXAMIDE AS BRUTON TYROSINKINASE INHIBITORS
HK40107548A (en) Compounds for targeting degradation of bruton's tyrosine kinase
MA55964A (fr) Agents inhibiteurs de la tyrosine kinase de bruton
WO2005009384A3 (en) Egfr tyrosine kinase inhibitors
GB202103176D0 (en) Pyrroloquinoline compounds as modulators of Bruton's tyrosine kinase (BTK).
UA97235C2 (ru) Производные хиназолина и конденсированного пиримидина в качестве ингибитора erbb