|
US266710A
(en)
|
|
1882-10-31 |
|
Fastening for pocket-books |
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4275149A
(en)
|
1978-11-24 |
1981-06-23 |
Syva Company |
Macromolecular environment control in specific receptor assays
|
|
US4318980A
(en)
|
1978-04-10 |
1982-03-09 |
Miles Laboratories, Inc. |
Heterogenous specific binding assay employing a cycling reactant as label
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4419446A
(en)
|
1980-12-31 |
1983-12-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant DNA process utilizing a papilloma virus DNA as a vector
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
DD266710A3
(de)
|
1983-06-06 |
1989-04-12 |
Ve Forschungszentrum Biotechnologie |
Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4965199A
(en)
|
1984-04-20 |
1990-10-23 |
Genentech, Inc. |
Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
US4737456A
(en)
|
1985-05-09 |
1988-04-12 |
Syntex (U.S.A.) Inc. |
Reducing interference in ligand-receptor binding assays
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
DE68925971T2
(de)
|
1988-09-23 |
1996-09-05 |
Cetus Oncology Corp |
Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
EP0940468A1
(en)
|
1991-06-14 |
1999-09-08 |
Genentech, Inc. |
Humanized antibody variable domain
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
DE69303494T2
(de)
|
1992-11-13 |
1997-01-16 |
Idec Pharma Corp |
Therapeutische verwendung von chimerischen und markierten antikörper gegen menschlichen b lymphozyt beschränkter differenzierung antigen für die behandlung von b-zell-lymphoma
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
US6037454A
(en)
|
1996-11-27 |
2000-03-14 |
Genentech, Inc. |
Humanized anti-CD11a antibodies
|
|
US5888809A
(en)
|
1997-05-01 |
1999-03-30 |
Icos Corporation |
Hamster EF-1α transcriptional regulatory DNA
|
|
US6737056B1
(en)
*
|
1999-01-15 |
2004-05-18 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
|
DK1210428T3
(en)
|
1999-08-23 |
2015-06-15 |
Dana Farber Cancer Inst Inc |
PD-1, a receptor for B7-4 AND USE THEREOF
|
|
AR036993A1
(es)
|
2001-04-02 |
2004-10-20 |
Wyeth Corp |
Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas
|
|
EP1445264B1
(en)
|
2001-07-31 |
2011-09-14 |
Ono Pharmaceutical Co., Ltd. |
Substance specific to pd-1
|
|
WO2004056875A1
(en)
|
2002-12-23 |
2004-07-08 |
Wyeth |
Antibodies against pd-1 and uses therefor
|
|
EP1591527B1
(en)
|
2003-01-23 |
2015-08-26 |
Ono Pharmaceutical Co., Ltd. |
Substance specific to human pd-1
|
|
AU2005211725B2
(en)
|
2004-02-09 |
2010-07-15 |
Human Genome Sciences, Inc. |
Albumin fusion proteins
|
|
EP2418278A3
(en)
|
2005-05-09 |
2012-07-04 |
Ono Pharmaceutical Co., Ltd. |
Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics
|
|
WO2009026472A1
(en)
|
2007-08-21 |
2009-02-26 |
The General Hospital Corporation |
Methods for inducing tolerance
|
|
US8647822B2
(en)
|
2007-11-28 |
2014-02-11 |
Oregon Health & Science University |
Determining whether a test compound modulates PD-1 activity in activated immune cells using gene expression profiles
|
|
US8168757B2
(en)
|
2008-03-12 |
2012-05-01 |
Merck Sharp & Dohme Corp. |
PD-1 binding proteins
|
|
CA2736816C
(en)
*
|
2008-09-12 |
2018-05-22 |
Isis Innovation Limited |
Pd-1 specific antibodies and uses thereof
|
|
WO2010029435A1
(en)
|
2008-09-12 |
2010-03-18 |
Isis Innovation Limited |
Pd-1 specific antibodies and uses thereof
|
|
HUE030807T2
(en)
|
2008-09-26 |
2017-05-29 |
Dana Farber Cancer Inst Inc |
Human anti-PD-1, anti-PD-L1 and anti-PD-L2 antibodies and their applications
|
|
TW201134488A
(en)
*
|
2010-03-11 |
2011-10-16 |
Ucb Pharma Sa |
PD-1 antibodies
|
|
CN102892786B
(zh)
|
2010-03-11 |
2016-03-16 |
Ucb医药有限公司 |
Pd-1抗体
|
|
AR083044A1
(es)
*
|
2010-09-27 |
2013-01-30 |
Regeneron Pharma |
Anticuerpos anti-cd48 y usos de los mismos
|
|
AU2011352205B2
(en)
|
2010-12-31 |
2016-06-16 |
Bioatla, Llc |
Express humanization of antibodies
|
|
ES2893855T3
(es)
|
2011-08-11 |
2022-02-10 |
Ono Pharmaceutical Co |
Agente terapéutico para enfermedades autoinmunes que comprende agonista de PD-1
|
|
PT2992017T
(pt)
|
2013-05-02 |
2021-01-29 |
Anaptysbio Inc |
Anticorpos dirigidos contra a morte programada 1 (pd-1)
|
|
CN104250302B
(zh)
|
2013-06-26 |
2017-11-14 |
上海君实生物医药科技股份有限公司 |
抗pd‑1抗体及其应用
|
|
US10077305B2
(en)
|
2013-09-10 |
2018-09-18 |
Medimmune Limited |
Antibodies against PD-1 and uses thereof
|
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對pd-1的人類抗體
|
|
TWI680138B
(zh)
|
2014-01-23 |
2019-12-21 |
美商再生元醫藥公司 |
抗pd-l1之人類抗體
|
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
|
CN105330740B
(zh)
*
|
2014-07-30 |
2018-08-17 |
珠海市丽珠单抗生物技术有限公司 |
抗pd-1抗体及其应用
|
|
KR102357893B1
(ko)
|
2014-08-05 |
2022-02-04 |
맵퀘스트 에스아 |
Pd-1 에 결합하는 면역학적 시약
|
|
TWI595006B
(zh)
*
|
2014-12-09 |
2017-08-11 |
禮納特神經系統科學公司 |
抗pd-1抗體類和使用彼等之方法
|
|
EP3237446B1
(en)
|
2014-12-22 |
2021-05-05 |
PD-1 Acquisition Group, LLC |
Anti-pd-1 antibodies
|
|
AU2016281641B2
(en)
|
2015-06-23 |
2022-01-20 |
Eureka Therapeutics, Inc. |
Novel PD-1 immune modulating agents
|
|
CN106699888B
(zh)
|
2015-07-28 |
2020-11-06 |
上海昀怡健康科技发展有限公司 |
一种pd-1抗体及其制备方法和应用
|
|
KR20180054824A
(ko)
|
2015-09-29 |
2018-05-24 |
셀진 코포레이션 |
Pd-1 결합 단백질 및 이의 사용 방법
|
|
RU2746409C1
(ru)
|
2015-10-02 |
2021-04-13 |
Ф. Хоффманн-Ля Рош Аг |
Антитела к pd1 и способы их применения
|
|
JP6875385B2
(ja)
|
2015-10-02 |
2021-05-26 |
シムフォゲン・アクティーゼルスカブSymphogen A/S |
抗pd−1抗体および組成物
|
|
WO2017079080A1
(en)
|
2015-11-02 |
2017-05-11 |
The Johns Hopkins University |
Method of preventing organ transplant rejections using agonists to the pd-1 checkpoint pathway
|
|
CN106699889A
(zh)
|
2015-11-18 |
2017-05-24 |
礼进生物医药科技(上海)有限公司 |
抗pd-1抗体及其治疗用途
|
|
CN109069628A
(zh)
|
2016-01-14 |
2018-12-21 |
Bps生物科学有限公司 |
抗pd-1抗体及其用途
|
|
EP3448987A4
(en)
*
|
2016-04-29 |
2020-05-27 |
Voyager Therapeutics, Inc. |
COMPOSITIONS FOR TREATING A DISEASE
|
|
EP3470424B1
(en)
|
2016-06-08 |
2025-04-23 |
Shanghai Jiao Tong University School of Medicine |
Sequence of antibody heavy chain constant region for enhancing agonist antibody activity
|
|
RU2656181C1
(ru)
|
2016-07-13 |
2018-05-31 |
Закрытое Акционерное Общество "Биокад" |
Анти-pd-1-антитела, способ их получения и способ применения
|
|
JP7164528B2
(ja)
|
2016-09-14 |
2022-11-01 |
ベイジン・ハンミ・ファーマシューティカル・カンパニー・リミテッド |
Pd-1に特異的に結合する可能な抗体及びその機能的断片
|
|
ES2837755T3
(es)
*
|
2016-09-14 |
2021-07-01 |
Abbvie Biotherapeutics Inc |
Anticuerpos anti-PD-1
|
|
BR112019004733A2
(pt)
|
2016-09-19 |
2019-05-28 |
Celgene Corp |
métodos de tratamento de distúrbios imunes usando proteínas de ligação a pd-1
|
|
US10766958B2
(en)
|
2016-09-19 |
2020-09-08 |
Celgene Corporation |
Methods of treating vitiligo using PD-1 binding antibodies
|
|
CN107840887B
(zh)
|
2016-09-21 |
2022-03-25 |
基石药业(苏州)有限公司 |
一种新的pd-1单克隆抗体
|
|
DK3515938T3
(da)
|
2016-09-21 |
2025-04-07 |
Cstone Pharmaceuticals |
Monoklonale antistoffer mod programmeret død 1 (pd-1)
|
|
US11155624B2
(en)
|
2016-11-01 |
2021-10-26 |
Anaptysbio, Inc. |
Antibodies directed against programmed death-1 (PD-1)
|
|
BR112019008494A2
(pt)
|
2016-11-02 |
2019-07-09 |
Jounce Therapeutics Inc |
anticorpos para pd-1 e usos dos mesmos
|
|
EA201991214A1
(ru)
|
2016-11-18 |
2019-10-31 |
|
Антитела против pd-1 и их композиции
|
|
CN106519034B
(zh)
|
2016-12-22 |
2020-09-18 |
鲁南制药集团股份有限公司 |
抗pd-1抗体及其用途
|
|
EP3565841A1
(en)
|
2017-01-06 |
2019-11-13 |
Crescendo Biologics Limited |
Single domain antibodies to programmed cell death (pd-1)
|
|
CN110382545A
(zh)
|
2017-01-09 |
2019-10-25 |
泰萨罗公司 |
用抗pd-1抗体治疗癌症的方法
|
|
JP7105238B2
(ja)
|
2017-01-18 |
2022-07-22 |
ジェネンテック, インコーポレイテッド |
抗pd-l1抗体に対するイディオタイプ抗体及びそれらの使用
|
|
CN117586401A
(zh)
*
|
2017-01-20 |
2024-02-23 |
大有华夏生物医药集团有限公司 |
抗pd-1抗体及其用途
|
|
CN108341871A
(zh)
|
2017-01-24 |
2018-07-31 |
三生国健药业(上海)股份有限公司 |
抗pd-1单克隆抗体及其制备方法和应用
|
|
CA3055984A1
(en)
|
2017-03-29 |
2018-10-04 |
Celgene Corporation |
Formulations comprising pd-1 binding proteins and methods of making thereof
|
|
US11603407B2
(en)
|
2017-04-06 |
2023-03-14 |
Regeneron Pharmaceuticals, Inc. |
Stable antibody formulation
|
|
JOP20190260A1
(ar)
|
2017-05-02 |
2019-10-31 |
Merck Sharp & Dohme |
صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها
|
|
KR102692379B1
(ko)
|
2017-06-05 |
2024-08-05 |
얀센 바이오테크 인코포레이티드 |
Pd-1과 특이적으로 결합하는 항체 및 사용 방법
|
|
TW201902514A
(zh)
|
2017-06-05 |
2019-01-16 |
大陸商江蘇恆瑞醫藥股份有限公司 |
Pd-1抗體與vegf配體或vegf受體抑制劑聯合在製備治療腫瘤的藥物中的用途
|
|
TN2020000015A1
(en)
|
2017-08-03 |
2021-10-04 |
Amgen Inc |
Interleukin-21 muteins and methods of treatment
|
|
SG11202005605SA
(en)
|
2018-01-12 |
2020-07-29 |
Amgen Inc |
Anti-pd-1 antibodies and methods of treatment
|
|
TWI708787B
(zh)
|
2018-03-02 |
2020-11-01 |
美商美國禮來大藥廠 |
Pd-1促效劑抗體及其用途
|
|
IL277095B2
(en)
|
2018-03-07 |
2025-10-01 |
Pfizer |
Preparations containing anti-PD-1 antibody
|
|
GB201803745D0
(en)
|
2018-03-08 |
2018-04-25 |
Ultrahuman Eight Ltd |
PD1 binding agents
|
|
GB201803746D0
(en)
|
2018-03-08 |
2018-04-25 |
Ultrahuman Eight Ltd |
PD1 binding agents
|
|
WO2019179390A1
(en)
|
2018-03-19 |
2019-09-26 |
Wuxi Biologics (Shanghai) Co., Ltd. |
Novel bispecific pd-1/egfr antibody molecules
|
|
WO2019179391A1
(en)
|
2018-03-19 |
2019-09-26 |
Wuxi Biologics (Shanghai) Co., Ltd. |
Novel bispecific pd-1/ctla-4 antibody molecules
|
|
WO2019179421A1
(en)
|
2018-03-19 |
2019-09-26 |
Wuxi Biologics (Shanghai) Co., Ltd. |
Novel bispecific pd-1/ctla-4 antibody molecules
|
|
WO2019179434A1
(en)
|
2018-03-20 |
2019-09-26 |
Wuxi Biologics (Shanghai) Co., Ltd. |
Novel bispecific pd-1/cd47 antibody molecules
|
|
US12030941B2
(en)
|
2018-03-20 |
2024-07-09 |
WuXi Biologics Ireland Limited |
Anti-PD-1 antibodies
|
|
US11136394B2
(en)
|
2018-05-17 |
2021-10-05 |
Nanjing Leads Biolabs Co., Ltd. |
Antibody binding PD-1 and use thereof
|
|
CN112424231B
(zh)
|
2018-07-19 |
2022-09-13 |
大有华夏生物医药集团有限公司 |
抗pd-1抗体及其剂量和用途
|
|
CN113861295B
(zh)
*
|
2018-07-20 |
2024-05-24 |
厦门大学 |
抗pd-1抗体及其用途
|
|
EP3876978A4
(en)
|
2018-11-07 |
2022-09-28 |
Merck Sharp & Dohme Corp. |
STABLE FORMULATIONS OF PROGRAMMED DEATH RECEPTOR 1 (PD-1) ANTIBODIES AND METHODS OF USE THEREOF
|
|
WO2020116636A1
(ja)
|
2018-12-07 |
2020-06-11 |
小野薬品工業株式会社 |
免疫抑制剤
|
|
TW202509079A
(zh)
|
2019-04-04 |
2025-03-01 |
日商小野藥品工業股份有限公司 |
雙特異性抗體
|
|
CN110577599A
(zh)
|
2019-05-13 |
2019-12-17 |
深圳市润科生物科技有限公司 |
人源抗程序性死亡-1(pd-1)抗体及其应用
|
|
BR112021024507A2
(pt)
|
2019-06-05 |
2022-03-08 |
Anaptysbio Inc |
Agonista de pd-1 e método de uso do mesmo
|
|
WO2021011448A1
(en)
|
2019-07-12 |
2021-01-21 |
The Johns Hopkins University |
Compositions and methods for treating cerebral vasospasm
|
|
JP7771749B2
(ja)
|
2019-08-08 |
2025-11-18 |
小野薬品工業株式会社 |
二重特異性タンパク質
|
|
BR112022003163A2
(pt)
|
2019-08-19 |
2022-05-17 |
Pandion Operations Inc |
Imunotolerância alvejada com um agonista de pd-1
|
|
EP4076385B1
(en)
|
2019-12-20 |
2025-12-10 |
Formycon AG |
Formulations of anti-pd1 antibodies
|
|
CN113004408B
(zh)
|
2019-12-20 |
2022-07-01 |
广东菲鹏制药股份有限公司 |
抗人程序死亡因子-1单克隆抗体
|
|
CN110787292B
(zh)
|
2020-01-06 |
2020-04-24 |
上海复宏汉霖生物技术股份有限公司 |
一种细胞程序性死亡受体1抗体制剂及其用途
|
|
KR20210097882A
(ko)
|
2020-01-30 |
2021-08-10 |
삼성바이오에피스 주식회사 |
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