PL4151637T3 - Środki kontrastowe na bazie PCTA zawierające gadolin - Google Patents
Środki kontrastowe na bazie PCTA zawierające gadolinInfo
- Publication number
- PL4151637T3 PL4151637T3 PL22205189.8T PL22205189T PL4151637T3 PL 4151637 T3 PL4151637 T3 PL 4151637T3 PL 22205189 T PL22205189 T PL 22205189T PL 4151637 T3 PL4151637 T3 PL 4151637T3
- Authority
- PL
- Poland
- Prior art keywords
- pcta
- gadolinium
- bearing
- contrast agents
- based contrast
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
- A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18187422 | 2018-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL4151637T3 true PL4151637T3 (pl) | 2025-04-28 |
Family
ID=63165233
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20193824.8T PL3770160T3 (pl) | 2018-08-06 | 2019-08-06 | Środki kontrastowe na bazie PCTA zawierające gadolin |
| PL19753296T PL3687994T3 (pl) | 2018-08-06 | 2019-08-06 | Środki kontrastowe na bazie pcta zawierające gadolin |
| PL22205189.8T PL4151637T3 (pl) | 2018-08-06 | 2019-08-06 | Środki kontrastowe na bazie PCTA zawierające gadolin |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL20193824.8T PL3770160T3 (pl) | 2018-08-06 | 2019-08-06 | Środki kontrastowe na bazie PCTA zawierające gadolin |
| PL19753296T PL3687994T3 (pl) | 2018-08-06 | 2019-08-06 | Środki kontrastowe na bazie pcta zawierające gadolin |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US10973934B2 (pl) |
| EP (4) | EP4491199A3 (pl) |
| JP (2) | JP7558146B2 (pl) |
| KR (2) | KR20250079243A (pl) |
| CN (4) | CN119954806A (pl) |
| AU (1) | AU2019319599B2 (pl) |
| BR (1) | BR112021001102B1 (pl) |
| CA (1) | CA3105610C (pl) |
| DK (3) | DK4151637T3 (pl) |
| ES (3) | ES2938015T3 (pl) |
| FI (2) | FI3770160T3 (pl) |
| PL (3) | PL3770160T3 (pl) |
| PT (3) | PT3687994T (pl) |
| WO (1) | WO2020030618A1 (pl) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020030618A1 (en) * | 2018-08-06 | 2020-02-13 | Bracco Imaging Spa | Gadolinium bearing pcta-based contrast agents |
| US11426470B2 (en) | 2019-01-17 | 2022-08-30 | Guerbet | Complex of gadolinium and a chelating ligand derived of a diastereoisomerically enriched PCTA and synthesis method |
| FR3091873B1 (fr) | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
| US11370804B2 (en) | 2019-01-17 | 2022-06-28 | Guerbet | Complex of gadolinium and a chelating ligand derived from a diastereoisomerically enriched PCTA and preparation and purification process |
| FR3091872B1 (fr) * | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese |
| PT4025259T (pt) * | 2019-09-03 | 2025-01-24 | Ge Healthcare As | Isómeros do quelato de manganês |
| HUE064567T2 (hu) * | 2020-07-16 | 2024-03-28 | Guerbet Sa | Eljárás 2-bróm-glutársav-diészterek elõállítására |
| US20230339945A1 (en) * | 2020-07-17 | 2023-10-26 | Guerbet | Method for preparing a chelating ligand derived from pcta |
| WO2022165424A1 (en) | 2021-02-01 | 2022-08-04 | Inventure, LLC | Synthesis methods and compositions of low intermediate and low dichelate intermediate contrast agents |
| US20260087709A1 (en) | 2022-08-30 | 2026-03-26 | Bayer Aktiengesellschaft | Generation of synthetic radiological images |
| WO2024046831A1 (de) | 2022-08-30 | 2024-03-07 | Bayer Aktiengesellschaft | Erzeugen von synthetischen radiologischen aufnahmen |
| WO2024046832A1 (de) | 2022-08-30 | 2024-03-07 | Bayer Aktiengesellschaft | Erzeugen von synthetischen radiologischen aufnahmen |
| JP7895667B2 (ja) * | 2022-09-01 | 2026-07-28 | テラノキュア カンパニー リミテッド | 新規化合物、およびこれを含むｍｒｉ造影剤 |
| KR102845061B1 (ko) * | 2022-09-01 | 2025-08-13 | 주식회사 테라노큐어 | 신규한 화합물 및 이를 포함하는 mri 조영제 |
| CN119816744B (zh) | 2022-09-05 | 2025-09-26 | 拜耳公司 | 生成人工对比度增强的放射图像 |
| WO2024083466A1 (de) | 2022-10-17 | 2024-04-25 | Bayer Aktiengesellschaft | Automatisches analysieren von radiologischen aufnahmen |
| EP4369353A1 (de) | 2022-11-12 | 2024-05-15 | Bayer Aktiengesellschaft | Erzeugung von künstlichen kontrastmittelverstärkten radiologischen aufnahmen |
| EP4471710B1 (de) | 2023-05-30 | 2025-12-17 | Bayer Aktiengesellschaft | Erkennen von artefakten in synthetischen medizinischen aufnahmen |
| EP4475137B1 (de) | 2023-06-05 | 2025-12-03 | Bayer Aktiengesellschaft | Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen |
| WO2024251601A1 (de) | 2023-06-05 | 2024-12-12 | Bayer Aktiengesellschaft | Erzeugen von künstlichen kontrastverstärkten radiologischen aufnahmen |
| US20250045926A1 (en) | 2023-07-25 | 2025-02-06 | Bayer Aktiengesellschaft | Detection of artifacts in synthetic images |
| CN121666388A (zh) | 2023-09-01 | 2026-03-13 | 江苏恒瑞医药股份有限公司 | 一种大环化合物及其用途 |
| EP4567716B1 (en) | 2023-12-06 | 2026-05-13 | Bayer Aktiengesellschaft | Generating synthetic representations |
| EP4567715B1 (en) | 2023-12-06 | 2026-05-13 | Bayer Aktiengesellschaft | Generating synthetic representations |
| WO2025190828A1 (en) | 2024-03-15 | 2025-09-18 | Bayer Aktiengesellschaft | Correction of an mri image |
| EP4664393A1 (de) | 2024-06-10 | 2025-12-17 | Bayer Aktiengesellschaft | Erzeugen von synthetischen kontrastverstärkten radiologischen aufnahmen |
| WO2026027591A1 (en) | 2024-07-31 | 2026-02-05 | Bracco Imaging Spa | Synthesis of an intermediate of a gadolinium-based contrast agent |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0992245A1 (en) | 1998-09-16 | 2000-04-12 | Goldham Bioglan Pharma GmbH | Radio-contrast agents |
| FR2794744B1 (fr) | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| FR2836916B1 (fr) * | 2002-03-05 | 2004-06-11 | Guerbet Sa | Oligomeres de chelates de gadolinium, leur application comme produits de contraste en imagerie par resonance magnetique et leurs intermediaires de synthese |
| FR2883562B1 (fr) * | 2005-03-24 | 2009-02-27 | Guerbet Sa | Chelates lipophiles et leur utilisation en imagerie |
| FR2891830B1 (fr) * | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| KR102231121B1 (ko) * | 2013-04-26 | 2021-03-23 | 게르브 | 조영제 제형 및 이와 관련된 제조 방법 |
| WO2020030618A1 (en) * | 2018-08-06 | 2020-02-13 | Bracco Imaging Spa | Gadolinium bearing pcta-based contrast agents |
| FR3091873B1 (fr) | 2019-01-17 | 2020-12-25 | Guerbet Sa | Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification |
-
2019
- 2019-08-06 WO PCT/EP2019/071075 patent/WO2020030618A1/en not_active Ceased
- 2019-08-06 KR KR1020257017484A patent/KR20250079243A/ko active Pending
- 2019-08-06 EP EP24217012.4A patent/EP4491199A3/en active Pending
- 2019-08-06 AU AU2019319599A patent/AU2019319599B2/en active Active
- 2019-08-06 US US16/766,619 patent/US10973934B2/en active Active
- 2019-08-06 ES ES20193824T patent/ES2938015T3/es active Active
- 2019-08-06 PT PT197532963T patent/PT3687994T/pt unknown
- 2019-08-06 EP EP20193824.8A patent/EP3770160B1/en active Active
- 2019-08-06 DK DK22205189.8T patent/DK4151637T3/da active
- 2019-08-06 EP EP22205189.8A patent/EP4151637B1/en active Active
- 2019-08-06 ES ES19753296T patent/ES2841070T3/es active Active
- 2019-08-06 EP EP19753296.3A patent/EP3687994B1/en active Active
- 2019-08-06 ES ES22205189T patent/ES3015456T3/es active Active
- 2019-08-06 FI FIEP20193824.8T patent/FI3770160T3/fi active
- 2019-08-06 FI FIEP22205189.8T patent/FI4151637T3/fi active
- 2019-08-06 CA CA3105610A patent/CA3105610C/en active Active
- 2019-08-06 KR KR1020217003707A patent/KR102815156B1/ko active Active
- 2019-08-06 CN CN202510106265.8A patent/CN119954806A/zh active Pending
- 2019-08-06 CN CN201980052546.2A patent/CN112533921B/zh active Active
- 2019-08-06 CN CN202510106257.3A patent/CN119930615A/zh active Pending
- 2019-08-06 JP JP2021506481A patent/JP7558146B2/ja active Active
- 2019-08-06 DK DK20193824.8T patent/DK3770160T3/da active
- 2019-08-06 PL PL20193824.8T patent/PL3770160T3/pl unknown
- 2019-08-06 DK DK19753296.3T patent/DK3687994T3/da active
- 2019-08-06 PL PL19753296T patent/PL3687994T3/pl unknown
- 2019-08-06 BR BR112021001102-1A patent/BR112021001102B1/pt active IP Right Grant
- 2019-08-06 PT PT201938248T patent/PT3770160T/pt unknown
- 2019-08-06 CN CN202410642657.1A patent/CN119039292A/zh active Pending
- 2019-08-06 PT PT222051898T patent/PT4151637T/pt unknown
- 2019-08-06 PL PL22205189.8T patent/PL4151637T3/pl unknown
-
2021
- 2021-03-11 US US17/199,122 patent/US12036289B2/en active Active
-
2024
- 2024-06-05 US US18/734,341 patent/US20240366802A1/en active Pending
- 2024-09-17 JP JP2024160004A patent/JP7841044B2/ja active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT3770160T (pt) | Agentes de contraste à base de pcta que suportam gadolínio | |
| IL272643A (en) | Binders | |
| GB201814169D0 (en) | Blockchain autonoumous agents | |
| IL259121B (en) | Long-lived gadolinium based tumor targeted imaging and therapy agents | |
| PL3386954T3 (pl) | Dimeryczne środki kontrastowe | |
| GB201707342D0 (en) | Imaging agents and methods | |
| IL268288A (en) | Binders | |
| IL277749A (en) | Palladianolide compounds and their use | |
| GB201706179D0 (en) | Bearing arrangement | |
| GB201913756D0 (en) | Contrast agent | |
| GB201801102D0 (en) | New compounds and uses | |
| GB201710949D0 (en) | Magnetic Bearing | |
| IL265680B (en) | Dimeric contrast agents | |
| SG11202012965YA (en) | External-use composition | |
| GB201807286D0 (en) | New use | |
| ZA202103578B (en) | Dna-cutting agent | |
| ZA202103582B (en) | Dna-cutting agent | |
| GB2546989B (en) | Bearing arrangements | |
| GB201806349D0 (en) | New compounds and uses | |
| GB201714777D0 (en) | Agent | |
| GB201717551D0 (en) | Antimicrobial agents | |
| GB201705679D0 (en) | Imaging agent | |
| PT3357849T (pt) | Suporte de fixação e sua utilização | |
| ZA202102200B (en) | Center bearing | |
| HUE065220T2 (hu) | Rögzítõszerkezet |