PL375883A1 - Alkanale polimerowe rozpuszczalne w wodzie - Google Patents
Alkanale polimerowe rozpuszczalne w wodzieInfo
- Publication number
- PL375883A1 PL375883A1 PL03375883A PL37588303A PL375883A1 PL 375883 A1 PL375883 A1 PL 375883A1 PL 03375883 A PL03375883 A PL 03375883A PL 37588303 A PL37588303 A PL 37588303A PL 375883 A1 PL375883 A1 PL 375883A1
- Authority
- PL
- Poland
- Prior art keywords
- water
- soluble polymer
- polymer alkanals
- alkanals
- soluble
- Prior art date
Links
- 229920003169 water-soluble polymer Polymers 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/30—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with halogen containing compounds, e.g. hypohalogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C47/00—Compounds having —CHO groups
- C07C47/02—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen
- C07C47/198—Saturated compounds having —CHO groups bound to acyclic carbon atoms or to hydrogen containing ether groups, groups, groups, or groups
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/26—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds
- C08G65/2603—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring from cyclic ethers and other compounds the other compounds containing oxygen
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
- C08G65/32—Polymers modified by chemical after-treatment
- C08G65/329—Polymers modified by chemical after-treatment with organic compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
- C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
- C08G65/48—Polymers modified by chemical after-treatment
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L2203/00—Applications
- C08L2203/02—Applications for biomedical use
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Polyethers (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Peptides Or Proteins (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Polyesters Or Polycarbonates (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40925102P | 2002-09-09 | 2002-09-09 | |
US45658003P | 2003-03-19 | 2003-03-19 | |
PCT/US2003/028221 WO2004022630A2 (en) | 2002-09-09 | 2003-09-09 | Water-soluble polymer alkanals |
Publications (1)
Publication Number | Publication Date |
---|---|
PL375883A1 true PL375883A1 (pl) | 2005-12-12 |
Family
ID=31981629
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL03375883A PL375883A1 (pl) | 2002-09-09 | 2003-09-09 | Alkanale polimerowe rozpuszczalne w wodzie |
Country Status (22)
Country | Link |
---|---|
US (5) | US7157546B2 (pl) |
EP (1) | EP1546235B1 (pl) |
JP (2) | JP4764630B2 (pl) |
KR (2) | KR20050093856A (pl) |
AP (2) | AP2005003246A0 (pl) |
AU (1) | AU2003270454B2 (pl) |
BR (1) | BR0314172A (pl) |
CA (1) | CA2498167C (pl) |
EA (1) | EA200500475A1 (pl) |
EC (1) | ECSP055654A (pl) |
ES (1) | ES2897470T3 (pl) |
GE (1) | GEP20074193B (pl) |
HR (2) | HRP20050319A2 (pl) |
IS (1) | IS7789A (pl) |
MA (1) | MA27401A1 (pl) |
MX (1) | MXPA05002620A (pl) |
NO (2) | NO20051077L (pl) |
NZ (2) | NZ540490A (pl) |
PL (1) | PL375883A1 (pl) |
RS (2) | RS20050202A (pl) |
UA (1) | UA80838C2 (pl) |
WO (1) | WO2004022630A2 (pl) |
Families Citing this family (52)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7053150B2 (en) | 2000-12-18 | 2006-05-30 | Nektar Therapeutics Al, Corporation | Segmented polymers and their conjugates |
EP3669887A1 (en) | 2002-01-18 | 2020-06-24 | Biogen MA Inc. | Polyalkylene polymer compounds and uses thereof |
DE10209821A1 (de) | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung von Proteinen an ein modifiziertes Polysaccharid |
DE10209822A1 (de) * | 2002-03-06 | 2003-09-25 | Biotechnologie Ges Mittelhesse | Kopplung niedermolekularer Substanzen an ein modifiziertes Polysaccharid |
MXPA05002620A (es) | 2002-09-09 | 2005-05-05 | Nektar Therapeutics Al Corp | Alcanales polimericos solubles en agua. |
KR101174510B1 (ko) | 2002-09-11 | 2012-08-16 | 프레제니우스 카비 도이치란트 게엠베하 | 하이드록시알킬전분화 폴리펩티드, 특히 하이드록시알킬전분화 에리트로포이에틴 |
TWI364295B (en) * | 2002-12-26 | 2012-05-21 | Mountain View Pharmaceuticals | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
AU2003303635B2 (en) * | 2002-12-26 | 2009-07-23 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of interferon-beta with enhanced biological potency |
CN102139114A (zh) * | 2003-02-26 | 2011-08-03 | 尼克塔治疗公司 | 聚合物-因子viii部分缀合物 |
US7947261B2 (en) | 2003-05-23 | 2011-05-24 | Nektar Therapeutics | Conjugates formed from polymer derivatives having particular atom arrangements |
GB0314472D0 (en) | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
SG145746A1 (en) * | 2003-08-08 | 2008-09-29 | Fresenius Kabi De Gmbh | Conjugates of hydroxyalkyl starch and g-csf |
WO2005014655A2 (en) | 2003-08-08 | 2005-02-17 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyalkyl starch and a protein |
EP2336192A1 (en) * | 2004-03-11 | 2011-06-22 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyalkyl starch and a protein, prepared by reductive amination |
ES2390885T3 (es) * | 2004-03-11 | 2012-11-19 | Fresenius Kabi Deutschland Gmbh | Conjugados de hidroxialquilalmidón y una proteína |
WO2005089805A2 (en) * | 2004-03-15 | 2005-09-29 | Nektar Therapeutics Al, Corporation | Polymer-based compositions and conjugates of hiv entry inhibitors |
CA2560289A1 (en) * | 2004-03-23 | 2005-10-13 | Amgen Inc. | Chemically modified protein compositions and methods |
AU2005275108B2 (en) * | 2004-07-16 | 2011-05-12 | Nektar Therapeutics | Conjugates of a GM-CSF moiety and a polymer |
KR20070042567A (ko) * | 2004-08-31 | 2007-04-23 | 파마시아 앤드 업존 캄파니 엘엘씨 | 글리세롤 분지쇄 폴리에틸렌 글리콜 인간 성장 호르몬공액체, 이의 제조 방법 및 이의 사용 방법 |
JP4920593B2 (ja) * | 2004-10-25 | 2012-04-18 | インテザイン テクノロジーズ, インコーポレイテッド | ヘテロ二官能性ポリ(エチレングリコール)およびそれらの使用 |
AU2006222187A1 (en) * | 2005-03-11 | 2006-09-14 | Fresenius Kabi Deutschland Gmbh | Production of bioactive glycoproteins from inactive starting material by conjugation with hydroxyalkylstarch |
WO2007010552A2 (en) * | 2005-03-17 | 2007-01-25 | Serum Institute Of India Limited | N- terminal peg conjugate of erythropoietin |
WO2006102659A2 (en) * | 2005-03-23 | 2006-09-28 | Nektar Therapeutics Al, Corporation | CONJUGATES OF AN hGH MOIETY AND A POLYMER |
EP1762250A1 (en) * | 2005-09-12 | 2007-03-14 | Fresenius Kabi Deutschland GmbH | Conjugates of hydroxyalkyl starch and an active substance, prepared by chemical ligation via thiazolidine |
US8293869B2 (en) | 2005-12-16 | 2012-10-23 | Nektar Therapeutics | Polymer conjugates of GLP-1 |
EP1834963A1 (en) * | 2006-03-13 | 2007-09-19 | Siegfried Ltd. | Di-polymer protein conjugates and processes for their preparation |
CA2861601A1 (en) * | 2006-04-27 | 2007-11-08 | Intezyne Technologies, Inc. | Poly (ethylene glycol) containing chemically disparate endgroups |
CL2008002399A1 (es) | 2007-08-16 | 2009-01-02 | Pharmaessentia Corp | Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c. |
EP2070951A1 (en) * | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Method for producing a hydroxyalkyl starch derivatives with two linkers |
EP2070950A1 (en) | 2007-12-14 | 2009-06-17 | Fresenius Kabi Deutschland GmbH | Hydroxyalkyl starch derivatives and process for their preparation |
WO2009099670A2 (en) * | 2008-02-08 | 2009-08-13 | Nektar Therapeutics Al, Corporation | Oligomer-cannabinoid conjugates |
KR100967833B1 (ko) * | 2008-05-20 | 2010-07-05 | 아이디비켐(주) | 고순도의 폴리에틸렌글리콜 알데하이드 유도체의 제조방법 |
JP5639585B2 (ja) * | 2008-07-31 | 2014-12-10 | ファーマエッセンティア コーポレイション | ペプチド−ポリマー共役体 |
US8492503B2 (en) | 2008-09-11 | 2013-07-23 | Nektar Therapeutics | Polymeric alpha-hydroxy aldehyde and ketone reagents and conjugation method |
EP2350118B1 (en) * | 2008-09-19 | 2016-03-30 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
US20110171312A1 (en) * | 2008-09-19 | 2011-07-14 | Nektar Therapeutics | Modified therapeutic peptides, methods of their preparation and use |
GB0823309D0 (en) | 2008-12-19 | 2009-01-28 | Univ Bath | Functionalising reagents and their uses |
PE20120570A1 (es) | 2009-07-14 | 2012-05-19 | Irm Llc | Diferenciacion de celulas madre mesenquimales |
EP2571896A4 (en) | 2010-05-17 | 2014-01-08 | Cebix Inc | PEGYLATED C-PEPTIDE |
RU2447083C1 (ru) * | 2010-07-20 | 2012-04-10 | Закрытое Акционерное Общество "Биокад" | НОВЫЙ ФУНКЦИОНАЛЬНО АКТИВНЫЙ ВЫСОКООЧИЩЕННЫЙ СТАБИЛЬНЫЙ КОНЪЮГАТ ИНТЕРФЕРОНА α С ПОЛИЭТИЛЕНГЛИКОЛЕМ, ПРЕДСТАВЛЕННЫЙ ОДНИМ ПОЗИЦИОННЫМ ИЗОМЕРОМ ПЭГ-NαH-ИФН, С УМЕНЬШЕННОЙ ИММУНОГЕННОСТЬЮ, С ПРОЛОНГИРОВАННЫМ БИОЛОГИЧЕСКИМ ДЕЙСТВИЕМ, ПРИГОДНЫЙ ДЛЯ МЕДИЦИНСКОГО ПРИМЕНЕНИЯ, И ИММУНОБИОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ |
WO2012054822A1 (en) | 2010-10-22 | 2012-04-26 | Nektar Therapeutics | Pharmacologically active polymer-glp-1 conjugates |
CA3144697A1 (en) * | 2010-11-12 | 2012-05-18 | Nektar Therapeutics | Conjugates of an il-2 moiety and a polymer |
US8765113B2 (en) | 2011-06-27 | 2014-07-01 | Greatbatch Ltd. | Peptide based antimicrobial coating |
EP2592103A1 (en) * | 2011-11-08 | 2013-05-15 | Adriacell S.p.A. | Polymer aldehyde derivatives |
JP5999659B2 (ja) * | 2011-12-14 | 2016-09-28 | 国立大学法人 筑波大学 | 新規分岐ポリエチレングリコール及びその用途 |
MA38369B1 (fr) | 2013-03-08 | 2018-10-31 | Novartis Ag | Peptides et compositions pour le traitement d'une lesion de l'articulation |
UY35368A (es) | 2013-03-08 | 2014-10-31 | Irm Llc | Péptidos y composiciones para el tratamiento de daño articular |
JP6106104B2 (ja) | 2014-01-16 | 2017-03-29 | 信越化学工業株式会社 | 末端にアミノ基を有する狭分散ポリアルキレングリコール誘導体の製造方法 |
JP6106103B2 (ja) * | 2014-01-16 | 2017-03-29 | 信越化学工業株式会社 | 末端にアミノ基を有する狭分散ポリアルキレングリコール誘導体の製造方法、並びにこれに用いる新規なアセタール基含有アルコール化合物及びそのアルカリ金属塩 |
GB201419108D0 (en) | 2014-10-27 | 2014-12-10 | Glythera Ltd | Materials and methods relating to linkers for use in antibody drug conjugates |
CA2964390A1 (en) | 2014-11-06 | 2016-05-12 | Pharmaessentia Corporation | Dosage regimen for pegylated interferon |
AR116566A1 (es) | 2018-10-03 | 2021-05-19 | Novartis Ag | Administración sostenida de polipéptidos similares a la angiopoyetina 3 |
Family Cites Families (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
JPS5695142A (en) * | 1979-12-28 | 1981-08-01 | T Hasegawa Co Ltd | Preparation of aliphatic aldehyde |
US5037969A (en) | 1986-07-03 | 1991-08-06 | Takeda Chemical Industries, Ltd. | Glycosyl derivatives and use thereof |
JPS63152393A (ja) * | 1986-07-03 | 1988-06-24 | Takeda Chem Ind Ltd | グリコシル誘導体 |
US5510418A (en) | 1988-11-21 | 1996-04-23 | Collagen Corporation | Glycosaminoglycan-synthetic polymer conjugates |
AU4660789A (en) | 1988-11-23 | 1990-06-12 | Genentech Inc. | Polypeptide derivatives |
US5252714A (en) * | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
JPH06233816A (ja) | 1993-02-12 | 1994-08-23 | Toyobo Co Ltd | 血液浄化吸着材 |
US5840900A (en) | 1993-10-20 | 1998-11-24 | Enzon, Inc. | High molecular weight polymer-based prodrugs |
US5919455A (en) | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
US5627662A (en) * | 1994-04-28 | 1997-05-06 | Xerox Corporation | Digital imaging system using two-dimensional input sensor array and output light valve |
FR2724459B1 (fr) | 1994-09-14 | 1997-05-09 | Univ Compiegne Tech | Electrophorese capillaire d'affinite, matrice d'affinite pour la mise en oeuvre de cette electrophorese et son procede de fabrication |
US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
US5672662A (en) | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
US5736543A (en) | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
US5990237A (en) | 1997-05-21 | 1999-11-23 | Shearwater Polymers, Inc. | Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines |
JPH11322916A (ja) | 1998-05-11 | 1999-11-26 | Kazunori Kataoka | ビオチン残基を片末端に有するヘテロテレケリツクポリマー |
US6420555B1 (en) * | 1998-06-16 | 2002-07-16 | Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S. | Imidazolyl derivatives |
WO2000024697A1 (en) | 1998-10-26 | 2000-05-04 | University Of Utah Research Foundation | Method for preparation of polyethylene glycol aldehyde derivatives |
JP2002531089A (ja) | 1998-11-30 | 2002-09-24 | イーライ・リリー・アンド・カンパニー | 赤血球産生性化合物 |
JP2000303090A (ja) * | 1999-04-20 | 2000-10-31 | T Hasegawa Co Ltd | 香料組成物 |
AU781839B2 (en) | 1999-12-22 | 2005-06-16 | Nektar Therapeutics | Sterically hindered derivatives of water soluble polymers |
TW593427B (en) | 2000-12-18 | 2004-06-21 | Nektar Therapeutics Al Corp | Synthesis of high molecular weight non-peptidic polymer derivatives |
US7026440B2 (en) | 2001-11-07 | 2006-04-11 | Nektar Therapeutics Al, Corporation | Branched polymers and their conjugates |
US20030171285A1 (en) | 2001-11-20 | 2003-09-11 | Finn Rory F. | Chemically-modified human growth hormone conjugates |
PL374354A1 (pl) | 2001-11-20 | 2005-10-17 | Pharmacia Corporation | Koniugaty chemicznie modyfikowanego ludzkiego hormonu wzrostu |
US6916962B2 (en) | 2001-12-11 | 2005-07-12 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
EP1507755A4 (en) * | 2001-12-11 | 2006-05-17 | Sun Bio Inc | NOVEL MONOFUNCTIONAL POLYETHYLENE GLYCOL ALDEHYDES |
US6956135B2 (en) | 2001-12-11 | 2005-10-18 | Sun Bio, Inc. | Monofunctional polyethylene glycol aldehydes |
EP3669887A1 (en) | 2002-01-18 | 2020-06-24 | Biogen MA Inc. | Polyalkylene polymer compounds and uses thereof |
US7364014B2 (en) * | 2002-04-26 | 2008-04-29 | Prime Polymer Co., Ltd. | Sound absorbing body, sound absorbing structural body, and method of manufacturing these bodies |
CA2493221C (en) * | 2002-07-24 | 2008-11-18 | F. Hoffmann-La Roche Ag | Polyethylene glycol aldehyde derivatives |
MXPA05002620A (es) * | 2002-09-09 | 2005-05-05 | Nektar Therapeutics Al Corp | Alcanales polimericos solubles en agua. |
PA8588901A1 (es) | 2002-11-20 | 2005-02-04 | Pharmacia Corp | Conjugados de hormona de crecimiento humana pegilados n-terminales y proceso para su preparacion |
US20040142870A1 (en) | 2002-11-20 | 2004-07-22 | Finn Rory F. | N-terminally monopegylated human growth hormone conjugates, process for their preparation, and methods of use thereof |
US6961962B1 (en) * | 2004-09-09 | 2005-11-08 | Morning Pride Manufacturing, L.L.C. | Combined closure and liner zippers employing common zipper tapes and protective garment employing said combined zippers |
JP5084245B2 (ja) | 2006-06-07 | 2012-11-28 | 関西ペイント株式会社 | 澱粉系塗料組成物 |
-
2003
- 2003-09-09 MX MXPA05002620A patent/MXPA05002620A/es active IP Right Grant
- 2003-09-09 PL PL03375883A patent/PL375883A1/pl not_active Application Discontinuation
- 2003-09-09 CA CA2498167A patent/CA2498167C/en not_active Expired - Lifetime
- 2003-09-09 ES ES03752147T patent/ES2897470T3/es not_active Expired - Lifetime
- 2003-09-09 KR KR1020057014173A patent/KR20050093856A/ko not_active Application Discontinuation
- 2003-09-09 AP AP2005003246A patent/AP2005003246A0/xx unknown
- 2003-09-09 EP EP03752147.3A patent/EP1546235B1/en not_active Expired - Lifetime
- 2003-09-09 JP JP2004534787A patent/JP4764630B2/ja not_active Expired - Lifetime
- 2003-09-09 AU AU2003270454A patent/AU2003270454B2/en not_active Expired
- 2003-09-09 US US10/659,734 patent/US7157546B2/en not_active Expired - Lifetime
- 2003-09-09 RS YUP-2005/0202A patent/RS20050202A/sr unknown
- 2003-09-09 GE GEAP20038670A patent/GEP20074193B/en unknown
- 2003-09-09 NZ NZ540490A patent/NZ540490A/en unknown
- 2003-09-09 KR KR1020057004009A patent/KR100974843B1/ko active IP Right Grant
- 2003-09-09 EA EA200500475A patent/EA200500475A1/ru unknown
- 2003-09-09 NZ NZ538624A patent/NZ538624A/xx unknown
- 2003-09-09 UA UAA200503295A patent/UA80838C2/xx unknown
- 2003-09-09 WO PCT/US2003/028221 patent/WO2004022630A2/en active Application Filing
- 2003-09-09 AP AP2005003249A patent/AP2005003249A0/xx unknown
- 2003-09-09 BR BR0314172-1A patent/BR0314172A/pt not_active IP Right Cessation
-
2005
- 2005-02-28 NO NO20051077A patent/NO20051077L/no not_active Application Discontinuation
- 2005-02-28 NO NO20051078A patent/NO20051078L/no not_active Application Discontinuation
- 2005-03-07 RS YUP-2005/0203A patent/RS20050203A/sr unknown
- 2005-03-09 EC EC2005005654A patent/ECSP055654A/es unknown
- 2005-04-06 MA MA28203A patent/MA27401A1/fr unknown
- 2005-04-07 HR HR20050319A patent/HRP20050319A2/xx not_active Application Discontinuation
- 2005-04-07 HR HR20050320A patent/HRP20050320A2/xx not_active Application Discontinuation
- 2005-04-08 IS IS7789A patent/IS7789A/is unknown
- 2005-06-08 JP JP2005168925A patent/JP2005350470A/ja not_active Withdrawn
-
2006
- 2006-03-13 US US11/375,698 patent/US7511094B2/en not_active Expired - Lifetime
-
2009
- 2009-01-28 US US12/361,427 patent/US7838595B2/en not_active Expired - Lifetime
-
2010
- 2010-10-20 US US12/908,266 patent/US8076412B2/en not_active Expired - Lifetime
-
2011
- 2011-11-21 US US13/301,715 patent/US8853325B2/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
AP2005003246A0 (en) | Water-soluble polymer alkanals | |
HK1224185A1 (zh) | 聚亞烷基化合物及其用途 | |
EP1608688A4 (en) | BRANCHED WATER-SOLUBLE POLYMERS AND CONJUGATES THEREOF | |
HK1072950A1 (zh) | 遇水膨脹的聚合物 | |
AU2003211925A1 (en) | Block copolymer | |
AU2003902496A0 (en) | Garment | |
AU2003241279A8 (en) | Antimicrobial polymer conjugates | |
GB0321383D0 (en) | Polymer circuits | |
DE60333033D1 (en) | Pulverförmiges thermoplastisches polymer | |
AU2002225394A1 (en) | Block copolymer | |
HK1079226A1 (en) | Side-chain -modified copolymer waxes | |
EP1686681A4 (en) | POLYMER ACTUATOR | |
AU2003267540A8 (en) | Biodegradable polymer | |
GB2393446B (en) | Polymer | |
AU2003272053A8 (en) | Polymer microneedles | |
ZA200502507B (en) | Water-soluble polymer alkanals. | |
GB2398790B (en) | Polymer compositions | |
AU2003244788A1 (en) | Polymeric based complex | |
GB0200505D0 (en) | Highly functional polymers | |
GB0201593D0 (en) | Ferromagnetic polymer | |
GB0104284D0 (en) | Polymer | |
GB0113194D0 (en) | Polymer | |
GB0115348D0 (en) | Polymer | |
AU2003905949A0 (en) | Valley iron | |
AU2003229630A8 (en) | Polymer composition |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) | ||
DISD | Decisions on discontinuance of the proceedings of a derived patent or utility model |
Ref document number: 375884 Country of ref document: PL |