PL3755684T3 - Pochodne alkoholowe jako substancje otwierające kanał potasowy kv7 - Google Patents
Pochodne alkoholowe jako substancje otwierające kanał potasowy kv7Info
- Publication number
- PL3755684T3 PL3755684T3 PL18708346.4T PL18708346T PL3755684T3 PL 3755684 T3 PL3755684 T3 PL 3755684T3 PL 18708346 T PL18708346 T PL 18708346T PL 3755684 T3 PL3755684 T3 PL 3755684T3
- Authority
- PL
- Poland
- Prior art keywords
- potassium channel
- alcohol derivatives
- channel openers
- openers
- derivatives
- Prior art date
Links
- 229940127315 Potassium Channel Openers Drugs 0.000 title 1
- 150000001298 alcohols Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18708346.4A EP3755684B1 (en) | 2018-02-20 | 2018-02-20 | Alcohol derivatives as kv7 potassium channel openers |
| PCT/EP2018/054057 WO2019161877A1 (en) | 2018-02-20 | 2018-02-20 | Alcohol derivatives as kv7 potassium channel openers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3755684T3 true PL3755684T3 (pl) | 2023-11-06 |
Family
ID=61557232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18708346.4T PL3755684T3 (pl) | 2018-02-20 | 2018-02-20 | Pochodne alkoholowe jako substancje otwierające kanał potasowy kv7 |
Country Status (11)
| Country | Link |
|---|---|
| EP (2) | EP4241843A3 (pl) |
| JP (1) | JP7121144B2 (pl) |
| CN (2) | CN116589375A (pl) |
| ES (1) | ES2951656T3 (pl) |
| HR (1) | HRP20230808T1 (pl) |
| HU (1) | HUE063567T2 (pl) |
| MA (1) | MA51881B1 (pl) |
| MD (1) | MD3755684T2 (pl) |
| PL (1) | PL3755684T3 (pl) |
| RS (1) | RS64479B1 (pl) |
| WO (1) | WO2019161877A1 (pl) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10590067B2 (en) | 2018-02-20 | 2020-03-17 | H. Lundbeck A/S | Alcohol derivatives of carboxamides as Kv7 potassium channel openers |
| CR20220028A (es) * | 2019-08-02 | 2022-03-02 | H Lundbeck As | DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7 |
| AR119521A1 (es) | 2019-08-02 | 2021-12-22 | H Lundbeck As | DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7 |
| CN114206328A (zh) * | 2019-08-02 | 2022-03-18 | H.隆德贝克有限公司 | 用于在癫痫或癫痫发作中使用的作为Kv7钾通道开放剂的醇衍生物 |
| CN115461327A (zh) | 2020-04-29 | 2022-12-09 | 爱杜西亚药品有限公司 | 螺脲衍生物 |
| EP4172140A1 (en) | 2020-06-25 | 2023-05-03 | Idorsia Pharmaceuticals Ltd | Cyclobutyl-urea derivatives |
| WO2024121779A1 (en) | 2022-12-09 | 2024-06-13 | Pfizer Inc. | Papain-like protease (plpro) inhibitors |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL152202A0 (en) | 2000-05-26 | 2003-05-29 | Bristol Myers Squibb Co | Human kcnq5 polypeptide and pharmaceutical compositions containing the same |
| WO2001096540A2 (en) | 2000-06-11 | 2001-12-20 | Dupont Pharmaceuticals Company | Hepatitis c protease exosite for inhibitor design |
| US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| KR20080096659A (ko) | 2006-02-07 | 2008-10-31 | 하. 룬트벡 아크티에 셀스카브 | 정신분열증 증상의 치료 또는 감소를 위한 ｋｃｎｑ개방제의 용도 |
| WO2007104717A1 (en) * | 2006-03-15 | 2007-09-20 | Neurosearch A/S | Quinazolinones and their use as potassium channels activators |
| MX2010001171A (es) | 2007-08-01 | 2010-03-01 | Lundbeck & Co As H | Uso de abridores de canales de potasio kcnq para reducir los sintomas o tratar desordenes o afecciones en las cuales se encuentra anulado el sistema dopaminergico. |
| TW201024286A (en) * | 2008-11-27 | 2010-07-01 | Neurosearch As | Novel compounds |
| WO2014090731A1 (en) | 2012-12-10 | 2014-06-19 | H. Lundbeck A/S | New positive allosteric modulators of nicotinic acetylcholine receptor |
| WO2014145852A2 (en) * | 2013-03-15 | 2014-09-18 | Knopp Biosciences Llc | Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators |
| DK3572405T3 (da) * | 2014-09-12 | 2023-10-16 | Biohaven Therapeutics Ltd | Benzoimidazol-1,2-yl-amider som kv7-kanalaktivatorer |
| JP2017095366A (ja) | 2015-11-18 | 2017-06-01 | 持田製薬株式会社 | 新規ビアリールアミド誘導体 |
| CN105663136A (zh) * | 2016-01-15 | 2016-06-15 | 河北中医学院 | 法舒地尔作为制备选择性Kv7离子通道激活剂药物的应用 |
-
2018
- 2018-02-20 JP JP2020566873A patent/JP7121144B2/ja active Active
- 2018-02-20 EP EP23176632.0A patent/EP4241843A3/en active Pending
- 2018-02-20 HR HRP20230808TT patent/HRP20230808T1/hr unknown
- 2018-02-20 EP EP18708346.4A patent/EP3755684B1/en active Active
- 2018-02-20 PL PL18708346.4T patent/PL3755684T3/pl unknown
- 2018-02-20 MD MDE20210001T patent/MD3755684T2/ro unknown
- 2018-02-20 CN CN202310501178.3A patent/CN116589375A/zh active Pending
- 2018-02-20 WO PCT/EP2018/054057 patent/WO2019161877A1/en unknown
- 2018-02-20 RS RS20230574A patent/RS64479B1/sr unknown
- 2018-02-20 MA MA51881A patent/MA51881B1/fr unknown
- 2018-02-20 HU HUE18708346A patent/HUE063567T2/hu unknown
- 2018-02-20 ES ES18708346T patent/ES2951656T3/es active Active
- 2018-02-20 CN CN201880089423.1A patent/CN111727182B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021519814A (ja) | 2021-08-12 |
| BR112019021960A2 (pt) | 2020-08-25 |
| EP4241843A3 (en) | 2023-09-27 |
| JP7121144B2 (ja) | 2022-08-17 |
| CN111727182B (zh) | 2023-05-26 |
| EP4241843A2 (en) | 2023-09-13 |
| ES2951656T3 (es) | 2023-10-24 |
| WO2019161877A1 (en) | 2019-08-29 |
| HUE063567T2 (hu) | 2024-01-28 |
| CN111727182A (zh) | 2020-09-29 |
| MD3755684T2 (ro) | 2023-11-30 |
| EP3755684B1 (en) | 2023-07-12 |
| MA51881B1 (fr) | 2023-08-31 |
| CN116589375A (zh) | 2023-08-15 |
| HRP20230808T1 (hr) | 2023-11-10 |
| RS64479B1 (sr) | 2023-09-29 |
| MA51881A (fr) | 2020-12-30 |
| EP3755684A1 (en) | 2020-12-30 |
| EP3755684C0 (en) | 2023-07-12 |
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