PL3755684T3 - Pochodne alkoholowe jako substancje otwierające kanał potasowy kv7 - Google Patents
Pochodne alkoholowe jako substancje otwierające kanał potasowy kv7Info
- Publication number
- PL3755684T3 PL3755684T3 PL18708346.4T PL18708346T PL3755684T3 PL 3755684 T3 PL3755684 T3 PL 3755684T3 PL 18708346 T PL18708346 T PL 18708346T PL 3755684 T3 PL3755684 T3 PL 3755684T3
- Authority
- PL
- Poland
- Prior art keywords
- potassium channel
- alcohol derivatives
- channel openers
- openers
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18708346.4A EP3755684B1 (en) | 2018-02-20 | 2018-02-20 | Alcohol derivatives as kv7 potassium channel openers |
| PCT/EP2018/054057 WO2019161877A1 (en) | 2018-02-20 | 2018-02-20 | Alcohol derivatives as kv7 potassium channel openers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3755684T3 true PL3755684T3 (pl) | 2023-11-06 |
Family
ID=61557232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18708346.4T PL3755684T3 (pl) | 2018-02-20 | 2018-02-20 | Pochodne alkoholowe jako substancje otwierające kanał potasowy kv7 |
Country Status (12)
| Country | Link |
|---|---|
| EP (2) | EP4241843B1 (pl) |
| JP (1) | JP7121144B2 (pl) |
| CN (2) | CN111727182B (pl) |
| ES (2) | ES3032221T3 (pl) |
| HR (1) | HRP20230808T1 (pl) |
| HU (1) | HUE063567T2 (pl) |
| MA (1) | MA51881B1 (pl) |
| MD (1) | MD3755684T2 (pl) |
| PL (1) | PL3755684T3 (pl) |
| RS (1) | RS64479B1 (pl) |
| SM (1) | SMT202300235T1 (pl) |
| WO (1) | WO2019161877A1 (pl) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10590067B2 (en) | 2018-02-20 | 2020-03-17 | H. Lundbeck A/S | Alcohol derivatives of carboxamides as Kv7 potassium channel openers |
| US12508239B2 (en) * | 2019-08-02 | 2025-12-30 | H. Lundbeck A/S | Alcohol derivatives as Kv7 potassium channel openers for use in epilepsy or seizures |
| ES2989376T3 (es) * | 2019-08-02 | 2024-11-26 | H Lundbeck As | Derivados de alcohol como abridores del canal de potasio Kv7 |
| AR119521A1 (es) | 2019-08-02 | 2021-12-22 | H Lundbeck As | DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7 |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| CA3155812A1 (en) * | 2019-11-08 | 2021-05-14 | Cynthia Louise HARDEN | Methods of treating depressive disorders |
| JP2023523402A (ja) | 2020-04-29 | 2023-06-05 | イドーシア ファーマシューティカルズ リミテッド | スピロウレア誘導体 |
| JP2023531500A (ja) | 2020-06-25 | 2023-07-24 | イドーシア ファーマシューティカルズ リミテッド | シクロブチル－ウレア誘導体 |
| WO2024121779A1 (en) | 2022-12-09 | 2024-06-13 | Pfizer Inc. | Papain-like protease (plpro) inhibitors |
| AU2024310446A1 (en) * | 2023-06-27 | 2026-01-22 | Saniona A/S | Kv7 modulators |
| WO2026132415A1 (en) * | 2024-12-20 | 2026-06-25 | Saniona A/S | Kv7 modulators |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6893858B2 (en) | 2000-05-26 | 2005-05-17 | Bristol-Myers Squibb Company | Human kcnq5 potassium channel, methods and compositions thereof |
| WO2001096540A2 (en) | 2000-06-11 | 2001-12-20 | Dupont Pharmaceuticals Company | Hepatitis c protease exosite for inhibitor design |
| EP1565190A4 (en) * | 2002-11-22 | 2006-04-26 | Bristol Myers Squibb Co | ARYLCYCLOPROPYLCARBOXYLIC ACID AMIDE AS A KALIUM CHANNEL OPENER |
| US7790770B2 (en) * | 2005-11-23 | 2010-09-07 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| US20090118285A1 (en) | 2006-02-07 | 2009-05-07 | H. Lundbeck A/S | Use of kcnq-openers for treating or reducing the symptoms of schizophrenia |
| WO2007104717A1 (en) * | 2006-03-15 | 2007-09-20 | Neurosearch A/S | Quinazolinones and their use as potassium channels activators |
| CN101790374A (zh) | 2007-08-01 | 2010-07-28 | H.隆德贝克有限公司 | Kcnq钾通道开放剂用于减轻多巴胺能系统受到干扰的障碍或病症的症状或治疗这种障碍或病症的用途 |
| TW201024286A (en) * | 2008-11-27 | 2010-07-01 | Neurosearch As | Novel compounds |
| US8883812B2 (en) * | 2010-07-08 | 2014-11-11 | Pfizer Inc. | Piperidinyl pyrimidine amides as Kv7 potassium channel openers |
| EP2928860A1 (en) | 2012-12-10 | 2015-10-14 | H. Lundbeck A/S | New positive allosteric modulators of nicotinic acetylcholine receptor |
| WO2014145852A2 (en) * | 2013-03-15 | 2014-09-18 | Knopp Biosciences Llc | Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators |
| ES2749103T3 (es) * | 2014-09-12 | 2020-03-19 | Knopp Biosciences Llc | Benzoimidazol-1,2-ilamidas como activadores del canal Kv7 |
| JP2017095366A (ja) | 2015-11-18 | 2017-06-01 | 持田製薬株式会社 | 新規ビアリールアミド誘導体 |
| CN105663136A (zh) * | 2016-01-15 | 2016-06-15 | 河北中医学院 | 法舒地尔作为制备选择性Kv7离子通道激活剂药物的应用 |
-
2018
- 2018-02-20 ES ES23176632T patent/ES3032221T3/es active Active
- 2018-02-20 CN CN201880089423.1A patent/CN111727182B/zh active Active
- 2018-02-20 WO PCT/EP2018/054057 patent/WO2019161877A1/en not_active Ceased
- 2018-02-20 MA MA51881A patent/MA51881B1/fr unknown
- 2018-02-20 HR HRP20230808TT patent/HRP20230808T1/hr unknown
- 2018-02-20 RS RS20230574A patent/RS64479B1/sr unknown
- 2018-02-20 PL PL18708346.4T patent/PL3755684T3/pl unknown
- 2018-02-20 SM SM20230235T patent/SMT202300235T1/it unknown
- 2018-02-20 HU HUE18708346A patent/HUE063567T2/hu unknown
- 2018-02-20 JP JP2020566873A patent/JP7121144B2/ja active Active
- 2018-02-20 EP EP23176632.0A patent/EP4241843B1/en active Active
- 2018-02-20 ES ES18708346T patent/ES2951656T3/es active Active
- 2018-02-20 MD MDE20210001T patent/MD3755684T2/ro unknown
- 2018-02-20 CN CN202310501178.3A patent/CN116589375A/zh active Pending
- 2018-02-20 EP EP18708346.4A patent/EP3755684B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES3032221T3 (en) | 2025-07-16 |
| JP7121144B2 (ja) | 2022-08-17 |
| EP4241843B1 (en) | 2025-05-21 |
| CN111727182B (zh) | 2023-05-26 |
| EP3755684A1 (en) | 2020-12-30 |
| HUE063567T2 (hu) | 2024-01-28 |
| EP3755684C0 (en) | 2023-07-12 |
| HRP20230808T1 (hr) | 2023-11-10 |
| SMT202300235T1 (it) | 2023-11-13 |
| MD3755684T2 (ro) | 2023-11-30 |
| RS64479B1 (sr) | 2023-09-29 |
| CN116589375A (zh) | 2023-08-15 |
| EP4241843A2 (en) | 2023-09-13 |
| CN111727182A (zh) | 2020-09-29 |
| JP2021519814A (ja) | 2021-08-12 |
| BR112019021960A2 (pt) | 2020-08-25 |
| WO2019161877A1 (en) | 2019-08-29 |
| MA51881A (fr) | 2020-12-30 |
| EP4241843A3 (en) | 2023-09-27 |
| EP3755684B1 (en) | 2023-07-12 |
| MA51881B1 (fr) | 2023-08-31 |
| EP4241843C0 (en) | 2025-05-21 |
| ES2951656T3 (es) | 2023-10-24 |
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