PL3700529T3 - Nowa kombinacja środków aktywnych w leczeniu śródmiąższowych chorób płuc z postępującym włóknieniem (pf-ild) - Google Patents
Nowa kombinacja środków aktywnych w leczeniu śródmiąższowych chorób płuc z postępującym włóknieniem (pf-ild)Info
- Publication number
- PL3700529T3 PL3700529T3 PL18785961.6T PL18785961T PL3700529T3 PL 3700529 T3 PL3700529 T3 PL 3700529T3 PL 18785961 T PL18785961 T PL 18785961T PL 3700529 T3 PL3700529 T3 PL 3700529T3
- Authority
- PL
- Poland
- Prior art keywords
- ild
- treatment
- active agents
- interstitial lung
- lung diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17197719 | 2017-10-23 | ||
| PCT/EP2018/077952 WO2019081235A1 (en) | 2017-10-23 | 2018-10-12 | NEW ASSOCIATION OF ACTIVE AGENTS FOR THE TREATMENT OF PROGRESSIVE FIBROSANT INTERSTITIAL PNEUMOPATHY (PF-ILD) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3700529T3 true PL3700529T3 (pl) | 2025-12-22 |
Family
ID=60162029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18785961.6T PL3700529T3 (pl) | 2017-10-23 | 2018-10-12 | Nowa kombinacja środków aktywnych w leczeniu śródmiąższowych chorób płuc z postępującym włóknieniem (pf-ild) |
Country Status (26)
| Country | Link |
|---|---|
| US (4) | US11406638B2 (pl) |
| EP (2) | EP4603094A2 (pl) |
| JP (1) | JP7196169B2 (pl) |
| KR (2) | KR102893133B1 (pl) |
| CN (1) | CN111278442B (pl) |
| AU (2) | AU2018357775B2 (pl) |
| BR (1) | BR112020003973A2 (pl) |
| CA (1) | CA3079299A1 (pl) |
| CL (1) | CL2020000627A1 (pl) |
| DK (1) | DK3700529T3 (pl) |
| EA (1) | EA202090977A1 (pl) |
| ES (1) | ES3041129T3 (pl) |
| FI (1) | FI3700529T3 (pl) |
| HR (1) | HRP20251042T1 (pl) |
| HU (1) | HUE072914T2 (pl) |
| IL (2) | IL273169B2 (pl) |
| LT (1) | LT3700529T (pl) |
| MA (1) | MA50441A (pl) |
| MX (1) | MX2020004173A (pl) |
| PH (1) | PH12020550452A1 (pl) |
| PL (1) | PL3700529T3 (pl) |
| PT (1) | PT3700529T (pl) |
| RS (1) | RS67241B1 (pl) |
| SI (1) | SI3700529T1 (pl) |
| TW (1) | TWI700088B (pl) |
| WO (1) | WO2019081235A1 (pl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW202210069A (zh) * | 2020-05-29 | 2022-03-16 | 美商諾沃麥迪斯有限責任公司 | 聯芳磺胺類及其醫藥組合物與彼等用於治療纖維化肺疾病之用途 |
| CN113116904B (zh) * | 2021-03-23 | 2022-11-29 | 深圳市泰力生物医药有限公司 | 尼达尼布-甘草次酸复方制剂和药物复方制剂及在制备治疗肺纤维化药物中的应用 |
| MX2024006270A (es) | 2021-12-09 | 2024-06-11 | Boehringer Ingelheim Int | Nueva composicion farmaceutica oral y regimen de dosificacion para la terapia de enfermedades pulmonares intersticiales fibrosantes progresivas. |
| TW202342050A (zh) * | 2021-12-09 | 2023-11-01 | 德商百靈佳殷格翰國際股份有限公司 | 用於治療進行性纖維化間質性肺病之新穎治療組合 |
| CA3254837A1 (en) * | 2022-05-28 | 2023-12-07 | Avalyn Pharma Inc. | Compositions of NINTEDANIB dry powder and NINTEDANIB combinations and uses |
| US20250326765A1 (en) * | 2022-06-02 | 2025-10-23 | Xizang Haisco Pharmaceutical Co., Ltd. | Pde4b inhibitor and use thereof |
| CN117247394A (zh) * | 2022-06-16 | 2023-12-19 | 武汉人福创新药物研发中心有限公司 | 作为pde4b抑制剂的含氮杂环类化合物 |
| EP4570804A1 (en) * | 2022-08-09 | 2025-06-18 | Xizang Haisco Pharmaceutical Co., Ltd. | Pde4b inhibitor and use thereof |
| WO2024068386A1 (en) | 2022-09-28 | 2024-04-04 | Boehringer Ingelheim International Gmbh | Use of biomarkers in the treatment of fibrotic conditions with a pde4b-inhibitor |
| KR20240159340A (ko) * | 2023-04-28 | 2024-11-05 | 한국원자력의학원 | 폐섬유화 예방 또는 치료를 위한 펙시다티닙 및 닌테다닙의 병용 요법 |
| KR20240159339A (ko) * | 2023-04-28 | 2024-11-05 | 한국원자력의학원 | 폐섬유화 예방 또는 치료를 위한 다코미티닙 및 닌테다닙의 병용 요법 |
| WO2025092985A1 (zh) * | 2023-11-03 | 2025-05-08 | 合肥医工医药股份有限公司 | 磷酸二酯酶4b抑制剂及其制备方法与用途 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1049411A (en) | 1972-12-18 | 1979-02-27 | Affiliated Medical Research | N-substituted pyridone and general method for preparing pyridones |
| CN1046939C (zh) | 1993-07-02 | 1999-12-01 | 比克·古尔顿·劳姆贝尔格化学公司 | 氟烷氧基取代的苯甲酰胺类及其制备方法和应用 |
| US6020358A (en) | 1998-10-30 | 2000-02-01 | Celgene Corporation | Substituted phenethylsulfones and method of reducing TNFα levels |
| UA75054C2 (uk) | 1999-10-13 | 2006-03-15 | Бьорінгер Інгельхайм Фарма Гмбх & Ко. Кг | Заміщені в положенні 6 індолінони, їх одержання та їх застосування як лікарського засобу |
| US6762180B1 (en) | 1999-10-13 | 2004-07-13 | Boehringer Ingelheim Pharma Kg | Substituted indolines which inhibit receptor tyrosine kinases |
| DE10233500A1 (de) | 2002-07-24 | 2004-02-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 3-Z-[1-(4-(N-((4-Methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylen]-6-methoxycarbonyl-2-indolinon-Monoethansulfonat und dessen Verwendung als Arzneimittel |
| DE102004057595A1 (de) | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| DE102004057645A1 (de) | 2004-11-29 | 2006-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| DE102004057594A1 (de) | 2004-11-29 | 2006-06-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substitueirte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| DE102004057618A1 (de) | 2004-11-29 | 2006-06-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Substituierte Pteridine zur Behandlung von entzündlichen Erkrankungen |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| CN101163706A (zh) | 2005-04-21 | 2008-04-16 | 贝林格尔·英格海姆国际有限公司 | 用于治疗炎性疾病的二氢噻吩并嘧啶 |
| EP1847543A1 (de) | 2006-04-19 | 2007-10-24 | Boehringer Ingelheim Pharma GmbH & Co. KG | Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen |
| EP1870400A1 (en) | 2006-06-08 | 2007-12-26 | Boehringer Ingelheim Pharma GmbH & Co. KG | Salts and crystalline salt forms of an 2-indolinone derivative |
| EP2610258B1 (de) | 2007-10-19 | 2014-08-27 | Boehringer Ingelheim International Gmbh | Substituierte Piperidino-Dihydrothienopyrimidine |
| RU2500681C2 (ru) | 2007-10-19 | 2013-12-10 | Берингер Ингельхайм Интернациональ Гмбх | Замещенные гетероциклом пиперазинодигидротиенопиримидины |
| PL2299987T3 (pl) | 2008-06-06 | 2018-08-31 | Boehringer Ingelheim International Gmbh | Farmaceutyczna postać dawkowania w formie kapsułki zawierająca formulację zwiesiny pochodnej indolinonu |
| UA107560C2 (uk) | 2008-06-06 | 2015-01-26 | Фармацевтична лікарська форма для негайного вивільнення похідної індолінону | |
| US9802954B2 (en) * | 2011-08-24 | 2017-10-31 | Boehringer Ingelheim International Gmbh | Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma |
| US20130059866A1 (en) | 2011-08-24 | 2013-03-07 | Boehringer Ingelheim International Gmbh | Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma |
| WO2014124860A1 (en) | 2013-02-14 | 2014-08-21 | Boehringer Ingelheim International Gmbh | Specific pde4b-inhibitors for the treatment of diabetes mellitus |
| WO2016173400A1 (zh) * | 2015-04-27 | 2016-11-03 | 江苏恒瑞医药股份有限公司 | 蛋白激酶抑制剂在制备治疗纤维化疾病的药物中的用途 |
| CZ308695B6 (cs) * | 2015-07-29 | 2021-03-03 | Zentiva, K.S. | Způsob přípravy methyl (Z)-3[[4-[methyl[2-(4-methyl-1piperazinyl)acetyl]amino]fenyl]amino]fenylmethylen)-oxindol-6karboxylátu (intedanibu, nintedanibu) |
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2018
- 2018-10-12 FI FIEP18785961.6T patent/FI3700529T3/fi active
- 2018-10-12 KR KR1020207014628A patent/KR102893133B1/ko active Active
- 2018-10-12 PL PL18785961.6T patent/PL3700529T3/pl unknown
- 2018-10-12 CA CA3079299A patent/CA3079299A1/en active Pending
- 2018-10-12 PT PT187859616T patent/PT3700529T/pt unknown
- 2018-10-12 RS RS20250904A patent/RS67241B1/sr unknown
- 2018-10-12 AU AU2018357775A patent/AU2018357775B2/en active Active
- 2018-10-12 IL IL273169A patent/IL273169B2/en unknown
- 2018-10-12 CN CN201880068509.6A patent/CN111278442B/zh active Active
- 2018-10-12 EP EP25180683.2A patent/EP4603094A2/en active Pending
- 2018-10-12 EA EA202090977A patent/EA202090977A1/ru unknown
- 2018-10-12 HU HUE18785961A patent/HUE072914T2/hu unknown
- 2018-10-12 IL IL309150A patent/IL309150B2/en unknown
- 2018-10-12 MX MX2020004173A patent/MX2020004173A/es unknown
- 2018-10-12 SI SI201831258T patent/SI3700529T1/sl unknown
- 2018-10-12 MA MA050441A patent/MA50441A/fr unknown
- 2018-10-12 KR KR1020257039551A patent/KR20250172732A/ko active Pending
- 2018-10-12 LT LTEPPCT/EP2018/077952T patent/LT3700529T/lt unknown
- 2018-10-12 HR HRP20251042TT patent/HRP20251042T1/hr unknown
- 2018-10-12 ES ES18785961T patent/ES3041129T3/es active Active
- 2018-10-12 JP JP2020522715A patent/JP7196169B2/ja active Active
- 2018-10-12 BR BR112020003973-0A patent/BR112020003973A2/pt unknown
- 2018-10-12 EP EP18785961.6A patent/EP3700529B1/en active Active
- 2018-10-12 DK DK18785961.6T patent/DK3700529T3/da active
- 2018-10-12 WO PCT/EP2018/077952 patent/WO2019081235A1/en not_active Ceased
- 2018-10-22 US US16/166,239 patent/US11406638B2/en active Active
- 2018-10-22 TW TW107137119A patent/TWI700088B/zh active
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2020
- 2020-03-11 CL CL2020000627A patent/CL2020000627A1/es unknown
- 2020-04-20 PH PH12020550452A patent/PH12020550452A1/en unknown
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2022
- 2022-07-12 US US17/811,914 patent/US11813266B2/en active Active
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2023
- 2023-06-29 US US18/343,792 patent/US12233068B2/en active Active
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2024
- 2024-05-08 AU AU2024203045A patent/AU2024203045A1/en active Pending
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2025
- 2025-01-21 US US19/032,760 patent/US20250241919A1/en active Pending
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