PL364414A1 - Nie-nukleozydowe inhibitory odwrotnej transkryptazy - Google Patents
Nie-nukleozydowe inhibitory odwrotnej transkryptazyInfo
- Publication number
- PL364414A1 PL364414A1 PL02364414A PL36441402A PL364414A1 PL 364414 A1 PL364414 A1 PL 364414A1 PL 02364414 A PL02364414 A PL 02364414A PL 36441402 A PL36441402 A PL 36441402A PL 364414 A1 PL364414 A1 PL 364414A1
- Authority
- PL
- Poland
- Prior art keywords
- cyclopropaheterocycles
- reverse transcriptase
- transcriptase inhibitors
- nucleoside reverse
- nucleoside
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
- C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
- C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
- C07C245/18—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
- C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0100733A SE0100733D0 (sv) | 2001-03-05 | 2001-03-05 | Non-nucleoside reverse transcriptase inhibitors |
| PCT/EP2002/002328 WO2002070516A2 (en) | 2001-03-05 | 2002-03-04 | Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PL364414A1 true PL364414A1 (pl) | 2004-12-13 |
| PL207392B1 PL207392B1 (pl) | 2010-12-31 |
Family
ID=20283208
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL364414A PL207392B1 (pl) | 2001-03-05 | 2002-03-04 | Związek (-) -cis-1-(5-cyjanopirydyn-2-ylo)-3-(4,7-difluoro-1,1a,2,7b-tetrahydrocyklopropa [c] chromen-1-ylo) mocznik, jego zastosowanie oraz kompozycja farmaceutyczna |
Country Status (22)
| Country | Link |
|---|---|
| US (3) | US6716850B2 (pl) |
| EP (1) | EP1373261B1 (pl) |
| JP (2) | JP4463478B2 (pl) |
| KR (1) | KR100884494B1 (pl) |
| CN (2) | CN1264839C (pl) |
| AR (1) | AR035941A1 (pl) |
| AT (1) | ATE508128T1 (pl) |
| AU (1) | AU2002308231B2 (pl) |
| BR (1) | BR0207886A (pl) |
| CA (1) | CA2438524C (pl) |
| DE (1) | DE60239924D1 (pl) |
| DK (1) | DK1373261T3 (pl) |
| ES (1) | ES2364926T3 (pl) |
| HK (2) | HK1063784A1 (pl) |
| IL (2) | IL157543A0 (pl) |
| MX (1) | MXPA03008040A (pl) |
| MY (1) | MY137083A (pl) |
| PL (1) | PL207392B1 (pl) |
| RU (1) | RU2281284C2 (pl) |
| SE (1) | SE0100733D0 (pl) |
| TW (1) | TWI228990B (pl) |
| WO (1) | WO2002070516A2 (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE413174T1 (de) | 2002-09-05 | 2008-11-15 | Medivir Ab | Nicht-nucleoside revers-transcriptase inhibitoren |
| EP1680431A1 (en) * | 2003-10-17 | 2006-07-19 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors |
| SE0400021D0 (sv) * | 2004-01-08 | 2004-01-08 | Medivir Ab | Non-nucleoside reverse transcriptase inhibitors |
| US7915295B2 (en) | 2004-01-08 | 2011-03-29 | Medivir Ab | Non-nucleotide reverse transcriptase inhibitors |
| GB0608876D0 (en) | 2006-05-05 | 2006-06-14 | Medivir Ab | Combination therapy |
| EP2021327B1 (en) | 2006-05-15 | 2012-04-04 | Merck Sharp & Dohme Corp. | Antidiabetic bicyclic compounds |
| JP6380862B2 (ja) | 2013-06-28 | 2018-08-29 | ベイジーン リミテッド | 複数種類のキナーゼの阻害剤としての縮合三環式アミド系化合物 |
| DK3013798T3 (en) * | 2013-06-28 | 2018-10-15 | Beigene Ltd | Condensed tricyclic urea compounds such as RAF kinase and / or RAF kinase dimer inhibitors |
| WO2015089842A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Novel tricyclic calcium sensing receptor antagonists for the treatment of osteoporosis |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3803175A (en) | 1969-08-22 | 1974-04-09 | Universal Oil Prod Co | Preparation of coumarin compounds |
| GB1311171A (en) * | 1969-08-22 | 1973-03-21 | Universal Oil Prod Co | Vinylation of aromatic compounds |
| US4931221A (en) * | 1988-12-30 | 1990-06-05 | Ppg Industries, Inc. | Photochromic spiropyran compounds |
| IL102548A (en) | 1991-08-02 | 1998-08-16 | Medivir Ab | Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds |
| ATE173466T1 (de) | 1993-08-24 | 1998-12-15 | Medivir Ab | Verbindungen und methoden zur inhibition von hiv und verwandten viren |
| CZ299387B6 (cs) * | 1998-01-16 | 2008-07-09 | Medivir Ab | Antivirové slouceniny |
| US5998411A (en) | 1998-03-17 | 1999-12-07 | Hughes Institute | Heterocyclic nonnucleoside inhibitors of reverse transcriptase |
| WO1999051613A1 (en) | 1998-04-03 | 1999-10-14 | Medivir Ab | Prodrugs of phosphorous-containing pharmaceuticals |
| US6136335A (en) | 1998-12-31 | 2000-10-24 | Hughes Institute | Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity |
| US7186736B1 (en) | 1999-03-20 | 2007-03-06 | Parker Hughes Institute | NNI for treatment of multi-drug resistant HIV |
| US6469034B1 (en) | 1999-06-23 | 2002-10-22 | Parker Hughes Institute | Cyclohexenyl-ethyl-thiourea compounds for inhibiting HIV reverse transcriptase |
| US6124324A (en) | 1999-06-23 | 2000-09-26 | Hughes Institute | Thiophene-ethyl thiourea compounds and use |
| US6207688B1 (en) | 1999-06-23 | 2001-03-27 | Parker Hughes Institute | Phenethyl-thiourea compounds and use |
-
2001
- 2001-03-05 SE SE0100733A patent/SE0100733D0/xx unknown
-
2002
- 2002-02-25 TW TW091103297A patent/TWI228990B/zh not_active IP Right Cessation
- 2002-03-01 MY MYPI20020739A patent/MY137083A/en unknown
- 2002-03-04 JP JP2002569836A patent/JP4463478B2/ja not_active Expired - Fee Related
- 2002-03-04 EP EP02748329A patent/EP1373261B1/en not_active Expired - Lifetime
- 2002-03-04 DE DE60239924T patent/DE60239924D1/de not_active Expired - Lifetime
- 2002-03-04 BR BR0207886-4A patent/BR0207886A/pt not_active IP Right Cessation
- 2002-03-04 DK DK02748329.6T patent/DK1373261T3/da active
- 2002-03-04 PL PL364414A patent/PL207392B1/pl not_active IP Right Cessation
- 2002-03-04 AU AU2002308231A patent/AU2002308231B2/en not_active Ceased
- 2002-03-04 MX MXPA03008040A patent/MXPA03008040A/es active IP Right Grant
- 2002-03-04 WO PCT/EP2002/002328 patent/WO2002070516A2/en active IP Right Grant
- 2002-03-04 RU RU2003129513/04A patent/RU2281284C2/ru not_active IP Right Cessation
- 2002-03-04 CA CA2438524A patent/CA2438524C/en not_active Expired - Fee Related
- 2002-03-04 AT AT02748329T patent/ATE508128T1/de not_active IP Right Cessation
- 2002-03-04 ES ES02748329T patent/ES2364926T3/es not_active Expired - Lifetime
- 2002-03-04 IL IL15754302A patent/IL157543A0/xx unknown
- 2002-03-04 CN CNB02806027XA patent/CN1264839C/zh not_active Expired - Fee Related
- 2002-03-04 CN CN200610082490XA patent/CN101081843B/zh not_active Expired - Fee Related
- 2002-03-04 KR KR1020037011616A patent/KR100884494B1/ko not_active IP Right Cessation
- 2002-03-05 US US10/092,752 patent/US6716850B2/en not_active Expired - Fee Related
- 2002-03-05 AR ARP020100797A patent/AR035941A1/es unknown
-
2003
- 2003-02-28 US US10/377,057 patent/US6894177B2/en not_active Expired - Fee Related
- 2003-08-21 IL IL157543A patent/IL157543A/en not_active IP Right Cessation
-
2004
- 2004-08-31 HK HK04106555A patent/HK1063784A1/xx not_active IP Right Cessation
-
2005
- 2005-03-02 US US11/071,675 patent/US7405310B2/en not_active Expired - Fee Related
-
2008
- 2008-05-26 HK HK08105844.9A patent/HK1111155A1/xx not_active IP Right Cessation
-
2009
- 2009-02-10 JP JP2009028717A patent/JP2009102436A/ja active Pending
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| LAPS | Decisions on the lapse of the protection rights |
Effective date: 20130304 |