IL144349A0 - Non-nucleoside reverse transcriptase inhibitors - Google Patents

Non-nucleoside reverse transcriptase inhibitors

Info

Publication number
IL144349A0
IL144349A0 IL14434999A IL14434999A IL144349A0 IL 144349 A0 IL144349 A0 IL 144349A0 IL 14434999 A IL14434999 A IL 14434999A IL 14434999 A IL14434999 A IL 14434999A IL 144349 A0 IL144349 A0 IL 144349A0
Authority
IL
Israel
Prior art keywords
reverse transcriptase
transcriptase inhibitors
nucleoside reverse
nucleoside
inhibitors
Prior art date
Application number
IL14434999A
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/249,317 external-priority patent/US6458772B1/en
Application filed by Medivir Ab filed Critical Medivir Ab
Publication of IL144349A0 publication Critical patent/IL144349A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4075—Esters with hydroxyalkyl compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
IL14434999A 1999-02-12 1999-08-18 Non-nucleoside reverse transcriptase inhibitors IL144349A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/249,317 US6458772B1 (en) 1909-10-07 1999-02-12 Prodrugs
PCT/SE1999/000194 WO1999041275A1 (en) 1998-02-13 1999-02-15 Prodrugs
PCT/SE1999/001403 WO2000047561A1 (en) 1999-02-12 1999-08-18 Non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
IL144349A0 true IL144349A0 (en) 2002-05-23

Family

ID=22942958

Family Applications (1)

Application Number Title Priority Date Filing Date
IL14434999A IL144349A0 (en) 1999-02-12 1999-08-18 Non-nucleoside reverse transcriptase inhibitors

Country Status (3)

Country Link
JP (1) JP2002536435A (en)
IL (1) IL144349A0 (en)
WO (2) WO1999051613A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) * 1909-10-07 2002-10-01 Medivir Ab Prodrugs
SE0100733D0 (en) 2001-03-05 2001-03-05 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
WO2003008425A1 (en) * 2001-07-16 2003-01-30 Universite Paris 13 Novel bisphosphonate derivatives, their preparation methods and uses
FR2837490B1 (en) * 2002-03-21 2009-04-17 Univ Paris 13 NOVEL DERIVATIVES OF BISPHOSPHONATES, THEIR PREPARATIONS AND USES
SE0102867D0 (en) 2001-08-28 2001-08-28 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
JP5042444B2 (en) 2002-03-22 2012-10-03 エーザイ・アール・アンド・ディー・マネジメント株式会社 Hemiasterine derivatives and their use in the treatment of cancer
EP1534276B1 (en) 2002-09-05 2008-11-05 Medivir AB Non-nucleoside reverse transcriptase inhibitors
EA009700B1 (en) * 2004-01-08 2008-02-28 Медивир Аб Non-nucleotide reverse transcriptase inhibitors
CA2552319C (en) 2004-01-30 2012-08-21 Medivir Ab Hcv ns-3 serine protease inhibitors
TW200600492A (en) 2004-05-18 2006-01-01 Achillion Pharmaceuticals Inc Substituted aryl acylthioureas and related compounds; inhibitors of viral replication
AR049199A1 (en) 2004-06-04 2006-07-05 Aventis Pharma Inc DERIVATIVES OF SUBSTITUTED PROPANE-PHOSPHINIC ACID
EP1828186A1 (en) 2004-12-13 2007-09-05 Sunesis Pharmaceuticals, Inc. Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as raf kinase inhibitors
PE20070211A1 (en) 2005-07-29 2007-05-12 Medivir Ab MACROCYCLIC COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS
ES2930848T3 (en) 2015-09-23 2022-12-22 Xwpharma Ltd Gamma-hydroxybutyric acid prodrugs, compositions and uses thereof
KR102378845B1 (en) 2017-03-30 2022-03-24 엑스더블유파마 리미티드 Bicyclic heteroaryl derivatives and their preparation and use
WO2018236221A2 (en) * 2017-06-03 2018-12-27 Can Holding B.V. Neurodegenerative peptide deposit dissolution
WO2020063824A1 (en) * 2018-09-29 2020-04-02 江苏亚虹医药科技有限公司 Nitroxoline prodrug and use thereof
CN114042070A (en) 2018-09-30 2022-02-15 凯瑞康宁生物工程（武汉）有限公司 Compounds as neuronal histamine receptor-3 antagonists and uses thereof
WO2021127461A1 (en) 2019-12-20 2021-06-24 Xw Laboratories Limited Methods of synthesizing 4-valyloxybutyric acid
AU2021293941B2 (en) 2020-06-18 2024-03-28 XWPharma Ltd. Pharmaceutical granulations of water-soluble active pharmaceutical ingredients
CN117618393A (en) 2020-06-18 2024-03-01 凯瑞康宁生物工程（武汉）有限公司 Controlled release granulation of water-soluble active pharmaceutical ingredient
CN116261451A (en) 2020-07-24 2023-06-13 凯瑞康宁生物工程有限公司 Pharmaceutical compositions and pharmacokinetics of gamma-hydroxybutyric acid derivatives
KR20230058151A (en) 2020-10-05 2023-05-02 엑스더블유파마 리미티드 Modified release compositions of gamma-hydroxybutyric acid derivatives
EP4308086A1 (en) 2021-03-19 2024-01-24 XWPharma Ltd. Pharmacokinetics of combined release formulations of a gamma-hydroxybutyric acid derivative

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6458772B1 (en) * 1909-10-07 2002-10-01 Medivir Ab Prodrugs
DE68922903T2 (en) * 1988-12-19 1995-11-23 Wellcome Found Antiviral pyrimidine and purine compounds, processes for their preparation and pharmaceutical preparations containing them.
US5411947A (en) * 1989-06-28 1995-05-02 Vestar, Inc. Method of converting a drug to an orally available form by covalently bonding a lipid to the drug
US5227506A (en) * 1989-09-06 1993-07-13 Merck & Co., Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
US5177064A (en) * 1990-07-13 1993-01-05 University Of Florida Targeted drug delivery via phosphonate derivatives
IL100874A (en) * 1991-02-08 1996-01-19 Pro Neuron Inc Oxypurine nucleosides and related compounds for use as medicaments their preparation and pharmaceutical compositions containing them
US5484911A (en) * 1993-04-01 1996-01-16 Health Research, Inc. Nucleoside 5'-diphosphate conjugates of ether lipids
EP0706514B1 (en) * 1993-08-24 1998-11-18 Medivir Ab Compounds and methods for inhibition of hiv and related viruses
DE4418690A1 (en) * 1994-05-28 1996-01-11 Boehringer Mannheim Gmbh Nucleoside 5'-mono-phosphate ester(s) of glyceryl di:ether derivs.
PE32296A1 (en) * 1994-07-28 1996-08-07 Hoffmann La Roche L-MONOVALINE ESTER DERIVED FROM 2- (2-AMINO-1,6-DIHYDRO-6-OXO-PURIN-9-IL) METOXI-1,3-PROPANDIOL AND ITS PHARMACEUTICALLY ACCEPTABLE SALTS
US5696277A (en) * 1994-11-15 1997-12-09 Karl Y. Hostetler Antiviral prodrugs
AU5511196A (en) * 1995-04-21 1996-11-07 Centre National De La Recherche Scientifique (Cnrs) Acyclovir derivatives as antiviral agents
JP2001503767A (en) * 1996-11-12 2001-03-21 メディヴィル・アクチボラグ Nucleoside
NZ505543A (en) * 1998-01-16 2002-09-27 Medivir Ab N-[cis-2-(6-halo, 2-hydroxy, 3-propionylphenyl)-cyclopropyl]-N'-pyrid-2-yl-urea derivatives and salts, prodrugs, pharmaceuticals thereof; useful for the treatment or prophylaxis of HIV

Also Published As

Publication number Publication date
WO2000047561A1 (en) 2000-08-17
WO1999051613A1 (en) 1999-10-14
JP2002536435A (en) 2002-10-29

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