PL3609898T3 - Związki przydatne jako inhibitory ret - Google Patents
Związki przydatne jako inhibitory retInfo
- Publication number
- PL3609898T3 PL3609898T3 PL18719276.0T PL18719276T PL3609898T3 PL 3609898 T3 PL3609898 T3 PL 3609898T3 PL 18719276 T PL18719276 T PL 18719276T PL 3609898 T3 PL3609898 T3 PL 3609898T3
- Authority
- PL
- Poland
- Prior art keywords
- compounds useful
- ret inhibitors
- ret
- inhibitors
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1705971.8A GB201705971D0 (en) | 2017-04-13 | 2017-04-13 | Inhibitor compounds |
| PCT/GB2018/050986 WO2018189553A1 (en) | 2017-04-13 | 2018-04-13 | Compounds useful as ret inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3609898T3 true PL3609898T3 (pl) | 2022-09-26 |
Family
ID=58744532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL18719276.0T PL3609898T3 (pl) | 2017-04-13 | 2018-04-13 | Związki przydatne jako inhibitory ret |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US11352361B2 (pl) |
| EP (2) | EP3609898B1 (pl) |
| JP (3) | JP7277376B2 (pl) |
| CN (2) | CN110506043B (pl) |
| AU (3) | AU2018252251B2 (pl) |
| BR (1) | BR112019021231A2 (pl) |
| CA (1) | CA3059134A1 (pl) |
| DK (1) | DK3609898T3 (pl) |
| ES (1) | ES2925077T3 (pl) |
| GB (1) | GB201705971D0 (pl) |
| HR (1) | HRP20221040T1 (pl) |
| HU (1) | HUE059716T2 (pl) |
| LT (1) | LT3609898T (pl) |
| PL (1) | PL3609898T3 (pl) |
| PT (1) | PT3609898T (pl) |
| RS (1) | RS63514B1 (pl) |
| RU (1) | RU2760669C2 (pl) |
| SI (1) | SI3609898T1 (pl) |
| SM (1) | SMT202200345T1 (pl) |
| WO (1) | WO2018189553A1 (pl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI757256B (zh) | 2015-11-02 | 2022-03-11 | 美商纜圖藥品公司 | 轉染過程重排之抑制劑 |
| GB201705971D0 (en) * | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
| CN111971286B (zh) | 2018-01-18 | 2023-04-14 | 阿雷生物药品公司 | 作为RET激酶抑制剂的取代的吡咯并[2,3-d]嘧啶化合物 |
| WO2019143994A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrazolyl[4,3-c]pyridinecompounds as ret kinase inhibitors |
| TW201938169A (zh) * | 2018-01-18 | 2019-10-01 | 美商亞雷生物製藥股份有限公司 | 作為RET激酶抑制劑之經取代吡唑并[3,4-d]嘧啶化合物 |
| JP7422084B2 (ja) | 2018-04-03 | 2024-01-25 | ブループリント メディシンズ コーポレイション | Ret変化を有する癌の処置において使用するためのret阻害剤 |
| EP3833372A4 (en) | 2018-08-10 | 2022-06-08 | Blueprint Medicines Corporation | TREATMENT OF EGFR MUTANT CANCER |
| WO2020094084A1 (zh) * | 2018-11-07 | 2020-05-14 | 南京明德新药研发有限公司 | 作为ret抑制剂的三并环衍生物 |
| CN111454268B (zh) * | 2019-01-18 | 2023-09-08 | 明慧医药(上海)有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
| US12297197B2 (en) | 2019-04-03 | 2025-05-13 | Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory | Pyrazolopyridine compound as RET inhibitor and application thereof |
| CA3183728A1 (en) | 2020-05-29 | 2021-12-02 | Blueprint Medicines Corporation | Solid forms of pralsetinib |
| CN113214294A (zh) * | 2020-06-10 | 2021-08-06 | 深圳铂立健医药有限公司 | 三环化合物、药物组合物及其应用 |
| TW202220993A (zh) * | 2020-08-07 | 2022-06-01 | 香港商德琪研發有限公司 | Atr抑制劑及其用途 |
| JP7590550B2 (ja) * | 2020-09-29 | 2024-11-26 | 広州白雲山医薬集団股▲フン▼有限公司白雲山制薬総廠 | ピラゾロピリジン系化合物の結晶及びその調製方法 |
| WO2023287704A1 (en) * | 2021-07-12 | 2023-01-19 | Nido Biosciences, Inc. | Bicyclic compounds as androgen receptor modulators |
| JP2024539641A (ja) * | 2021-10-15 | 2024-10-29 | ステムライン セラピューティクス,インコーポレーテッド | 癌の治療に使用するための変異retキナーゼの阻害剤 |
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| CA2242425C (en) | 1996-02-13 | 2006-07-18 | Zeneca Limited | Quinazoline derivatives as vegf inhibitors |
| DE69709319T2 (de) | 1996-03-05 | 2002-08-14 | Astrazeneca Ab, Soedertaelje | 4-anilinochinazolin derivate |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| EE05345B1 (et) | 1999-02-10 | 2010-10-15 | Astrazeneca Ab | Kinasoliini derivaadid angiogeneesi inhibiitoritena |
| CN1431999A (zh) | 2000-05-31 | 2003-07-23 | 阿斯特拉曾尼卡有限公司 | 具有血管损伤活性的吲哚衍生物 |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| JP2004502766A (ja) | 2000-07-07 | 2004-01-29 | アンギオジェン・ファーマシューティカルズ・リミテッド | 血管損傷剤としてのコルヒノール誘導体 |
| RU2003103603A (ru) | 2000-07-07 | 2004-08-20 | Энджиоджен Фармасьютикалз Лимитед (Gb) | Производные колхинола в качестве ингибиторов ангиогенеза |
| US7119200B2 (en) | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7429596B2 (en) | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
| JP2008520744A (ja) | 2004-11-19 | 2008-06-19 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 抗炎症性ピラゾロピリミジン |
| WO2006092430A1 (de) | 2005-03-03 | 2006-09-08 | Universität des Saarlandes | Selektive hemmstoffe humaner corticoidsynthasen |
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| PT2201840E (pt) | 2006-09-22 | 2012-02-14 | Pharmacyclics Inc | Inibidores da tirosina quinase de bruton |
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| DK2240451T3 (da) | 2008-01-04 | 2017-11-20 | Intellikine Llc | Isoquinolinonderivater substitueret med en purin, der er anvendelig som pi3k-inhibitorer |
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| US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
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| US8476282B2 (en) * | 2008-11-03 | 2013-07-02 | Intellikine Llc | Benzoxazole kinase inhibitors and methods of use |
| WO2010059593A1 (en) | 2008-11-18 | 2010-05-27 | Intellikine, Inc. | Methods and compositions for treatment of ophthalmic conditions |
| KR101061599B1 (ko) | 2008-12-05 | 2011-09-02 | 한국과학기술연구원 | 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물 |
| AP2012006294A0 (en) | 2009-11-05 | 2012-06-30 | Rhizen Pharmaceuticals Sa | Novel kinase modulators. |
| WO2011094628A1 (en) | 2010-01-28 | 2011-08-04 | University Of Washington | Compositions and methods for treating toxoplasmosis. cryptosporidiosis and other apicomplexan protozoan related diseases |
| US9765037B2 (en) | 2010-01-28 | 2017-09-19 | University Of Washington Through Its Center For Commercialization | Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases |
| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
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| JP6130305B2 (ja) | 2011-02-23 | 2017-05-17 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせおよびそれらの使用 |
| WO2012151562A1 (en) | 2011-05-04 | 2012-11-08 | Intellikine, Llc | Combination pharmaceutical compositions and uses thereof |
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| TW201722958A (zh) * | 2015-09-15 | 2017-07-01 | 葛蘭素史克智慧財產(第二)有限公司 | 化學化合物 |
| WO2017160717A2 (en) | 2016-03-15 | 2017-09-21 | Memorial Sloan Kettering Cancer Center | Method of treating diseases using kinase modulators |
| RS62322B1 (sr) | 2016-04-15 | 2021-10-29 | Cancer Research Tech Ltd | Heterociklična jedinjenja kao inhibitori ret kinaze |
| PT3442535T (pt) | 2016-04-15 | 2022-09-05 | Cancer Research Tech Ltd | Compostos heterocíclicos como inibidores da ret quinase |
| GB201705971D0 (en) * | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
-
2017
- 2017-04-13 GB GBGB1705971.8A patent/GB201705971D0/en not_active Ceased
-
2018
- 2018-04-13 EP EP18719276.0A patent/EP3609898B1/en active Active
- 2018-04-13 HU HUE18719276A patent/HUE059716T2/hu unknown
- 2018-04-13 PL PL18719276.0T patent/PL3609898T3/pl unknown
- 2018-04-13 RU RU2019132155A patent/RU2760669C2/ru active
- 2018-04-13 JP JP2019555675A patent/JP7277376B2/ja active Active
- 2018-04-13 SI SI201830743T patent/SI3609898T1/sl unknown
- 2018-04-13 AU AU2018252251A patent/AU2018252251B2/en active Active
- 2018-04-13 CN CN201880024433.7A patent/CN110506043B/zh active Active
- 2018-04-13 US US16/604,332 patent/US11352361B2/en active Active
- 2018-04-13 ES ES18719276T patent/ES2925077T3/es active Active
- 2018-04-13 RS RS20220789A patent/RS63514B1/sr unknown
- 2018-04-13 CA CA3059134A patent/CA3059134A1/en active Pending
- 2018-04-13 BR BR112019021231A patent/BR112019021231A2/pt not_active Application Discontinuation
- 2018-04-13 HR HRP20221040TT patent/HRP20221040T1/hr unknown
- 2018-04-13 SM SM20220345T patent/SMT202200345T1/it unknown
- 2018-04-13 CN CN202211253646.1A patent/CN115785100B/zh active Active
- 2018-04-13 PT PT187192760T patent/PT3609898T/pt unknown
- 2018-04-13 DK DK18719276.0T patent/DK3609898T3/da active
- 2018-04-13 EP EP22175240.5A patent/EP4105219A1/en active Pending
- 2018-04-13 WO PCT/GB2018/050986 patent/WO2018189553A1/en not_active Ceased
- 2018-04-13 LT LTEPPCT/GB2018/050986T patent/LT3609898T/lt unknown
-
2022
- 2022-04-07 AU AU2022202325A patent/AU2022202325B2/en active Active
- 2022-05-06 US US17/738,278 patent/US11680068B2/en active Active
-
2023
- 2023-05-04 US US18/312,069 patent/US20240132504A1/en not_active Abandoned
- 2023-05-08 JP JP2023076767A patent/JP7536949B2/ja active Active
-
2024
- 2024-07-31 US US18/790,458 patent/US20250243202A1/en not_active Abandoned
- 2024-08-07 JP JP2024131113A patent/JP2024161432A/ja active Pending
- 2024-08-22 AU AU2024213175A patent/AU2024213175A1/en active Pending
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