LT3609898T - Junginiai, naudingi kaip ret inhibitoriai - Google Patents
Junginiai, naudingi kaip ret inhibitoriaiInfo
- Publication number
- LT3609898T LT3609898T LTEPPCT/GB2018/050986T LT18050986T LT3609898T LT 3609898 T LT3609898 T LT 3609898T LT 18050986 T LT18050986 T LT 18050986T LT 3609898 T LT3609898 T LT 3609898T
- Authority
- LT
- Lithuania
- Prior art keywords
- compounds useful
- ret inhibitors
- ret
- inhibitors
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1705971.8A GB201705971D0 (en) | 2017-04-13 | 2017-04-13 | Inhibitor compounds |
| PCT/GB2018/050986 WO2018189553A1 (en) | 2017-04-13 | 2018-04-13 | Compounds useful as ret inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3609898T true LT3609898T (lt) | 2022-09-12 |
Family
ID=58744532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEPPCT/GB2018/050986T LT3609898T (lt) | 2017-04-13 | 2018-04-13 | Junginiai, naudingi kaip ret inhibitoriai |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US11352361B2 (lt) |
| EP (2) | EP3609898B1 (lt) |
| JP (3) | JP7277376B2 (lt) |
| CN (2) | CN110506043B (lt) |
| AU (3) | AU2018252251B2 (lt) |
| BR (1) | BR112019021231A2 (lt) |
| CA (1) | CA3059134A1 (lt) |
| DK (1) | DK3609898T3 (lt) |
| ES (1) | ES2925077T3 (lt) |
| GB (1) | GB201705971D0 (lt) |
| HR (1) | HRP20221040T1 (lt) |
| HU (1) | HUE059716T2 (lt) |
| LT (1) | LT3609898T (lt) |
| PL (1) | PL3609898T3 (lt) |
| PT (1) | PT3609898T (lt) |
| RS (1) | RS63514B1 (lt) |
| RU (1) | RU2760669C2 (lt) |
| SI (1) | SI3609898T1 (lt) |
| SM (1) | SMT202200345T1 (lt) |
| WO (1) | WO2018189553A1 (lt) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3371171B1 (en) | 2015-11-02 | 2023-10-25 | Blueprint Medicines Corporation | Inhibitors of ret |
| GB201705971D0 (en) * | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
| WO2019143977A1 (en) | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors |
| WO2019143991A1 (en) * | 2018-01-18 | 2019-07-25 | Array Biopharma Inc. | SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS |
| JP6997876B2 (ja) | 2018-01-18 | 2022-02-04 | アレイ バイオファーマ インコーポレイテッド | Ｒｅｔキナーゼ阻害剤としての置換ピラゾリル［４，３－ｃ］ピリジン化合物 |
| BR112020020273A2 (pt) | 2018-04-03 | 2021-04-06 | Blueprint Medicines Corporation | Inibidor de ret para uso no tratamento de câncer tendo uma alteração de ret |
| WO2020033838A2 (en) | 2018-08-10 | 2020-02-13 | Blueprint Medicines Corporation | Treatment of egfr-mutant cancer |
| WO2020094084A1 (zh) * | 2018-11-07 | 2020-05-14 | 南京明德新药研发有限公司 | 作为ret抑制剂的三并环衍生物 |
| CN111454268B (zh) * | 2019-01-18 | 2023-09-08 | 明慧医药（上海）有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
| WO2020200316A1 (zh) * | 2019-04-03 | 2020-10-08 | 南京明德新药研发有限公司 | 作为ret抑制剂的吡唑并吡啶类化合物及其应用 |
| EP4157829A1 (en) | 2020-05-29 | 2023-04-05 | Blueprint Medicines Corporation | Solid forms of pralsetinib |
| CN113214294A (zh) * | 2020-06-10 | 2021-08-06 | 深圳铂立健医药有限公司 | 三环化合物、药物组合物及其应用 |
| KR20230049668A (ko) * | 2020-08-07 | 2023-04-13 | 안텐진 디스커버리 리미티드 | Atr 억제제 및 이의 용도 |
| EP4194455A4 (en) * | 2020-09-29 | 2024-04-03 | Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. Baiyunshan Pharmaceutical General Factory | CRYSTALLINE FORMS OF PYRIDOPYRAZOLE COMPOUNDS AND PRODUCTION PROCESSES THEREOF |
| US12012398B2 (en) | 2021-07-12 | 2024-06-18 | Nido Biosciences, Inc. | Bicyclic compounds as androgen receptor modulators |
| CN117813308A (zh) * | 2021-09-14 | 2024-04-02 | 中国医药研究开发中心有限公司 | 含氮稠环类化合物及其制备方法和医药用途 |
| WO2023064843A1 (en) * | 2021-10-15 | 2023-04-20 | Stemline Therapeutics, Inc. | Inhibitors of mutant ret kinases for use in treating cancer |
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| EP0322779A3 (en) | 1987-12-29 | 1991-05-08 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzolactam compounds and pharmaceutical uses thereof |
| US5480883A (en) | 1991-05-10 | 1996-01-02 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| JP4471404B2 (ja) | 1996-02-13 | 2010-06-02 | アストラゼネカ ユーケイ リミテッド | Ｖｅｇｆインヒビターとしてのキナゾリン誘導体 |
| ATE211134T1 (de) | 1996-03-05 | 2002-01-15 | 4-anilinochinazolin derivate | |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| DK1553097T3 (da) | 1999-02-10 | 2010-12-13 | Astrazeneca Ab | Quinazolinderivat som angiogeneseinhibitor og mellemprodukter dertil |
| NZ522074A (en) | 2000-05-31 | 2004-06-25 | Astrazeneca Ab | Indole derivatives with vascular damaging activity |
| UA73993C2 (uk) | 2000-06-06 | 2005-10-17 | Астразенека Аб | Хіназолінові похідні для лікування пухлин та фармацевтична композиція |
| JP2004502766A (ja) | 2000-07-07 | 2004-01-29 | アンギオジェン・ファーマシューティカルズ・リミテッド | 血管損傷剤としてのコルヒノール誘導体 |
| CA2410562A1 (en) | 2000-07-07 | 2002-01-31 | Angiogene Pharmaceuticals Limited | Colchinol derivatives as angiogenesis inhibitors |
| US7119200B2 (en) | 2002-09-04 | 2006-10-10 | Schering Corporation | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7429596B2 (en) | 2003-06-20 | 2008-09-30 | The Regents Of The University Of California | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof |
| US9512125B2 (en) | 2004-11-19 | 2016-12-06 | The Regents Of The University Of California | Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents |
| US9271963B2 (en) | 2005-03-03 | 2016-03-01 | Universitat Des Saarlandes | Selective inhibitors of human corticosteroid synthases |
| AU2006316605B2 (en) | 2005-11-17 | 2012-04-26 | Osi Pharmaceuticals, Inc. | Fused bicyclic mTOR inhibitors |
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| US20110224223A1 (en) | 2008-07-08 | 2011-09-15 | The Regents Of The University Of California, A California Corporation | MTOR Modulators and Uses Thereof |
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| US8476431B2 (en) * | 2008-11-03 | 2013-07-02 | Itellikine LLC | Benzoxazole kinase inhibitors and methods of use |
| US20110269779A1 (en) | 2008-11-18 | 2011-11-03 | Intellikine, Inc. | Methods and compositions for treatment of ophthalmic conditions |
| KR101061599B1 (ko) | 2008-12-05 | 2011-09-02 | 한국과학기술연구원 | 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물 |
| PT2496567T (pt) | 2009-11-05 | 2017-11-15 | Rhizen Pharmaceuticals S A | Novos moduladores de quinase benzopiran |
| EP2528919B1 (en) | 2010-01-28 | 2016-11-02 | University of Washington | Compositions and methods for treating toxoplasmosis. cryptosporidiosis and other apicomplexan protozoan related diseases |
| US9765037B2 (en) | 2010-01-28 | 2017-09-19 | University Of Washington Through Its Center For Commercialization | Compositions and methods for treating toxoplasmosis, cryptosporidiosis, and other apicomplexan protozoan related diseases |
| WO2011153553A2 (en) | 2010-06-04 | 2011-12-08 | The Regents Of The University Of California | Methods and compositions for kinase inhibition |
| US20110304649A1 (en) * | 2010-06-10 | 2011-12-15 | Microsoft Corporation | Character selection |
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| AU2016211630B2 (en) | 2015-01-26 | 2021-03-25 | University Of Washington | Compositions and methods for treating toxoplasmosis, cryptosporidiosis and other apicomplexan protozoan related diseases |
| KR101766194B1 (ko) * | 2015-08-07 | 2017-08-10 | 한국과학기술연구원 | RET 키나아제 저해제인 신규 3-(이속사졸-3-일)-피라졸로[3,4-d]피리미딘-4-아민 화합물 |
| US10550124B2 (en) | 2015-08-13 | 2020-02-04 | San Diego State University Foundation | Atropisomerism for increased kinase inhibitor selectivity |
| TW201722958A (zh) * | 2015-09-15 | 2017-07-01 | 葛蘭素史克智慧財產（第二）有限公司 | 化學化合物 |
| WO2017160717A2 (en) | 2016-03-15 | 2017-09-21 | Memorial Sloan Kettering Cancer Center | Method of treating diseases using kinase modulators |
| SMT202200348T1 (it) | 2016-04-15 | 2022-11-18 | Cancer Research Tech Ltd | Composti eterociclici come inibitori della chinasi ret |
| IL297192A (en) | 2016-04-15 | 2022-12-01 | Cancer Research Tech Ltd | Heterocyclic compounds as ret kinase inhibitors |
| GB201705971D0 (en) * | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
-
2017
- 2017-04-13 GB GBGB1705971.8A patent/GB201705971D0/en not_active Ceased
-
2018
- 2018-04-13 LT LTEPPCT/GB2018/050986T patent/LT3609898T/lt unknown
- 2018-04-13 HR HRP20221040TT patent/HRP20221040T1/hr unknown
- 2018-04-13 CN CN201880024433.7A patent/CN110506043B/zh active Active
- 2018-04-13 JP JP2019555675A patent/JP7277376B2/ja active Active
- 2018-04-13 BR BR112019021231A patent/BR112019021231A2/pt not_active Application Discontinuation
- 2018-04-13 CA CA3059134A patent/CA3059134A1/en active Pending
- 2018-04-13 HU HUE18719276A patent/HUE059716T2/hu unknown
- 2018-04-13 RU RU2019132155A patent/RU2760669C2/ru active
- 2018-04-13 EP EP18719276.0A patent/EP3609898B1/en active Active
- 2018-04-13 RS RS20220789A patent/RS63514B1/sr unknown
- 2018-04-13 ES ES18719276T patent/ES2925077T3/es active Active
- 2018-04-13 PL PL18719276.0T patent/PL3609898T3/pl unknown
- 2018-04-13 US US16/604,332 patent/US11352361B2/en active Active
- 2018-04-13 SM SM20220345T patent/SMT202200345T1/it unknown
- 2018-04-13 AU AU2018252251A patent/AU2018252251B2/en active Active
- 2018-04-13 WO PCT/GB2018/050986 patent/WO2018189553A1/en not_active Ceased
- 2018-04-13 DK DK18719276.0T patent/DK3609898T3/da active
- 2018-04-13 SI SI201830743T patent/SI3609898T1/sl unknown
- 2018-04-13 EP EP22175240.5A patent/EP4105219A1/en not_active Withdrawn
- 2018-04-13 PT PT187192760T patent/PT3609898T/pt unknown
- 2018-04-13 CN CN202211253646.1A patent/CN115785100B/zh active Active
-
2022
- 2022-04-07 AU AU2022202325A patent/AU2022202325B2/en active Active
- 2022-05-06 US US17/738,278 patent/US11680068B2/en active Active
-
2023
- 2023-05-04 US US18/312,069 patent/US20240132504A1/en not_active Abandoned
- 2023-05-08 JP JP2023076767A patent/JP7536949B2/ja active Active
-
2024
- 2024-07-31 US US18/790,458 patent/US20250243202A1/en not_active Abandoned
- 2024-08-07 JP JP2024131113A patent/JP2024161432A/ja active Pending
- 2024-08-22 AU AU2024213175A patent/AU2024213175A1/en active Pending
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