PL356484A1 - Pochodne tiazoliloamidowe - Google Patents

Pochodne tiazoliloamidowe

Info

Publication number
PL356484A1
PL356484A1 PL00356484A PL35648400A PL356484A1 PL 356484 A1 PL356484 A1 PL 356484A1 PL 00356484 A PL00356484 A PL 00356484A PL 35648400 A PL35648400 A PL 35648400A PL 356484 A1 PL356484 A1 PL 356484A1
Authority
PL
Poland
Prior art keywords
amide derivatives
thiazolyl amide
thiazolyl
derivatives
amide
Prior art date
Application number
PL00356484A
Other languages
English (en)
Other versions
PL208707B1 (pl
Inventor
Rudiger Fischer
Gerald Kleymann
Ulrich Betz
Judith Baumeister
Wolfgang Bender
Peter Eckenberg
Gabriele Handke
Martin Henrix
Kerstin Henninger
Axel Jensen
Jorg Keldenich
Udo Schneider
Olaf Weber
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19962532A external-priority patent/DE19962532A1/de
Priority claimed from DE10039265A external-priority patent/DE10039265A1/de
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of PL356484A1 publication Critical patent/PL356484A1/pl
Publication of PL208707B1 publication Critical patent/PL208707B1/pl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • A61P31/22Antivirals for DNA viruses for herpes viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54Nitrogen and either oxygen or sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6536Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and sulfur atoms with or without oxygen atoms, as the only ring hetero atoms
    • C07F9/6539Five-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
PL356484A 1999-12-23 2000-12-12 Pochodne tiazoliloamidowe, sposób ich wytwarzania, kompozycje farmaceutyczne je zawierające i ich zastosowanie PL208707B1 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19962532A DE19962532A1 (de) 1999-12-23 1999-12-23 Thiazolylamid-Derivate
DE10039265A DE10039265A1 (de) 2000-08-11 2000-08-11 Thiazolylamid-Derivate
PCT/EP2000/012564 WO2001047904A1 (de) 1999-12-23 2000-12-12 Thiazolylamid-derivate

Publications (2)

Publication Number Publication Date
PL356484A1 true PL356484A1 (pl) 2004-06-28
PL208707B1 PL208707B1 (pl) 2011-05-31

Family

ID=26006669

Family Applications (1)

Application Number Title Priority Date Filing Date
PL356484A PL208707B1 (pl) 1999-12-23 2000-12-12 Pochodne tiazoliloamidowe, sposób ich wytwarzania, kompozycje farmaceutyczne je zawierające i ich zastosowanie

Country Status (26)

Country Link
US (1) US7105553B2 (pl)
EP (1) EP1244641B1 (pl)
JP (1) JP4726175B2 (pl)
KR (1) KR100768361B1 (pl)
CN (1) CN1235890C (pl)
AR (1) AR029210A1 (pl)
AT (1) ATE293104T1 (pl)
AU (1) AU784286B2 (pl)
BR (1) BR0017030B8 (pl)
CA (1) CA2396720C (pl)
CO (1) CO5261491A1 (pl)
DE (1) DE50010060D1 (pl)
DK (1) DK1244641T3 (pl)
DO (1) DOP2000000109A (pl)
ES (1) ES2240233T3 (pl)
IL (2) IL149897A0 (pl)
MX (1) MXPA02006243A (pl)
MY (1) MY134880A (pl)
NZ (1) NZ519701A (pl)
PE (1) PE20010964A1 (pl)
PL (1) PL208707B1 (pl)
PT (1) PT1244641E (pl)
SV (1) SV2002000249A (pl)
TW (1) TWI256951B (pl)
UY (1) UY26495A1 (pl)
WO (1) WO2001047904A1 (pl)

Families Citing this family (42)

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WO2001096874A1 (en) * 2000-06-15 2001-12-20 Bayer Aktiengesellschaft Method for identifying compounds with anti-herpes activity
DE10129714A1 (de) * 2001-06-22 2003-01-02 Bayer Ag Topische Anwendung von Thiazolylamiden
DE10131128A1 (de) * 2001-06-28 2003-01-16 Bayer Ag Sekundäre Sulfonamide
AR036873A1 (es) 2001-09-07 2004-10-13 Euro Celtique Sa Piridinas aril sustituidas a, composiciones farmaceuticas y el uso de las mismas para la preparacion de un medicamento
AR037233A1 (es) 2001-09-07 2004-11-03 Euro Celtique Sa Piridinas aril sustituidas, composiciones farmaceuticas y el uso de dichos compuestos para la elaboracion de un medicamento
PT1789084E (pt) * 2004-09-09 2011-02-22 Novartis Vaccines & Diagnostic Redução de riscos iatrogénicos pontenciais associados às vacinas contra a gripe
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BRPI0611187A2 (pt) * 2005-06-03 2010-08-24 Xenon Pharmaceuticals Inc derivados aminotiazàis como inibidores da estearoil-coa desaturase humana
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HUE029309T2 (en) * 2006-03-17 2017-02-28 Univ Johns Hopkins N-hydroxylsulfonamide derivatives as novel physiologically useful nitroxyl donors
JP2010510168A (ja) * 2006-11-22 2010-04-02 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 官能化窒化ホウ素ナノチューブ
EP2573086A1 (en) 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamide mesylate monohydrate
EP2573085A1 (en) 2011-09-26 2013-03-27 AiCuris GmbH & Co. KG N-[5-(aminosulfonyl)-4methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl] acetamide mesylate monohydrate having a specific particle size distribution range and a specific surface area range
WO2014124978A2 (en) * 2013-02-12 2014-08-21 Aicuris Gmbh & Co. Kg Helicase-primase inhibitors for use in a method of treating alzheimer's disease
US10052329B2 (en) * 2014-07-07 2018-08-21 Elian Llc Viral prophylaxis treatment methods and pre-exposure prophylaxis kits
GEP20207128B (en) 2016-04-06 2020-07-10 Molecules Gm Innovative Aminothiazole derivatives useful as antiviral agents
AR110251A1 (es) * 2016-11-28 2019-03-13 Aicuris Anti Infective Cures Gmbh Una sal maleato de la base libre de n-[5-(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]-acetamida, formulaciones farmacéuticas, métodos de fabricación y usos de la misma
WO2018095576A1 (en) 2016-11-28 2018-05-31 Aicuris Anti-Infective Cures Gmbh Topical pharmaceutical formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide
UY40935A (es) 2016-11-28 2024-10-31 Aicuris Gmbh & Co Kg Composición tópica de hemihidrato de la base libre de n-[5(aminosulfonil)-4-metil-1,3-tiazol-2-il]-n-metil-2-[4-(2-piridinil)-fenil]acetamida
EP3566749A4 (en) * 2017-01-09 2020-09-23 Medshine Discovery Inc. THIAZOLE DERIVATIVE AND USES OF IT
DK3692039T3 (da) * 2017-10-05 2023-03-13 Innovative Molecules Gmbh Enantiomerer af substituerede thiazoler som antivirale forbindelser
ES2982663T3 (es) * 2018-07-06 2024-10-17 Phaeno Therapeutics Co Ltd Formas cristalinas de un compuesto de tiazol y aplicación del mismo
EP4096632A1 (en) 2020-03-26 2022-12-07 AiCuris GmbH & Co. KG Ophthalmic formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3- thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl]acetamide hemihydrate
EP3925595A1 (en) 2020-06-17 2021-12-22 AiCuris GmbH & Co. KG Ophthalmic formulation comprising n-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-n-methyl-2-[4-(2-pyridinyl)phenyl] acetamide hemihydrate
MX2023004955A (es) 2020-10-29 2023-05-17 Innovative Molecules Gmbh Compuestos de aminotiazol deuterados como compuestos antiviricos.
IL314188A (en) 2022-01-17 2024-09-01 Innovative Molecules Gmbh Solid crystalline forms of helicase-primase inhibitors and process of preparation thereof
KR20250016217A (ko) 2022-05-20 2025-02-03 길리애드 사이언시즈, 인코포레이티드 항바이러스성 인돌리닐 화합물 및 이의 용도(antiviral indolinyl compounds and uses thereof)
AU2023333337A1 (en) 2022-08-29 2025-03-06 Assembly Biosciences, Inc. Cyclic urea thiazolyl compounds for treatment of hsv
EP4581030A1 (en) 2022-08-29 2025-07-09 Assembly Biosciences, Inc. A novel crystalline form of pritelivir
EP4581031A1 (en) 2022-08-29 2025-07-09 Assembly Biosciences, Inc. A novel crystalline form of pritelivir
CA3265860A1 (en) 2022-08-29 2024-03-07 Assembly Biosciences, Inc. Pharmaceutical compositions against the herpes virus
KR20250170707A (ko) 2023-04-26 2025-12-05 어셈블리 바이오사이언시스, 인크. 경구 제약 조성물
WO2025046457A1 (en) 2023-08-28 2025-03-06 Assembly Biosciences, Inc. A crystalline form of 2-(3-(2,,5'-difluoro-[1,1'-biphenyl]-4-yl)-2-oxotetrahydropyrimidin-1(2h)-yl)-4-methylthiazole-5-sulfonamide
WO2025046456A1 (en) 2023-08-28 2025-03-06 Assembly Biosciences, Inc. A crystalline form of 2-(3-(2,,5'-difluoro-[1,1'-biphenyl]-4-yl)-2-oxotetrahydropyrimidin-1(2h)-yl)-4-methylthiazole-5-sulfonamide
WO2025111598A1 (en) 2023-11-22 2025-05-30 Assembly Biosciences, Inc. Azetidine compounds for treatment of hsv
WO2025172927A1 (en) 2024-02-16 2025-08-21 Assembly Biosciences, Inc. Pharmaceutical compositions for herpes virus
WO2026015761A1 (en) 2024-07-12 2026-01-15 Assembly Biosciences, Inc. Cyclic urea thiazolyl compound for treatment of viral infections unresponsive to treatment with a first antiviral therapy
WO2026035901A1 (en) 2024-08-07 2026-02-12 Assembly Biosciences, Inc. Tricyclic compounds for treatment of hsv
WO2026035900A1 (en) 2024-08-07 2026-02-12 Assembly Biosciences, Inc. Tricyclic compounds for treatment of hsv
WO2026035899A1 (en) 2024-08-07 2026-02-12 Assembly Biosciences, Inc. Azetidine compounds for treatment of hsv
WO2026062572A1 (en) 2024-09-20 2026-03-26 Assembly Biosciences, Inc. Use of a helicase-primase inhibitor in a method of treatment of a herpes virus infection

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ATE229945T1 (de) 1998-03-19 2003-01-15 Upjohn Co Zur behandlung von cmv infektionen geeignete 1,3, 4-thiadiazole
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Also Published As

Publication number Publication date
AU3157401A (en) 2001-07-09
CO5261491A1 (es) 2003-03-31
CN1235890C (zh) 2006-01-11
MY134880A (en) 2007-12-31
US20040006076A1 (en) 2004-01-08
JP2003519134A (ja) 2003-06-17
DE50010060D1 (de) 2005-05-19
PE20010964A1 (es) 2001-11-10
KR20020067568A (ko) 2002-08-22
IL149897A0 (en) 2002-11-10
KR100768361B1 (ko) 2007-10-18
BR0017030A (pt) 2003-01-07
ES2240233T3 (es) 2005-10-16
BR0017030B8 (pt) 2021-05-25
JP4726175B2 (ja) 2011-07-20
TWI256951B (en) 2006-06-21
AR029210A1 (es) 2003-06-18
BR0017030B1 (pt) 2013-10-01
EP1244641A1 (de) 2002-10-02
PT1244641E (pt) 2005-08-31
CA2396720A1 (en) 2001-07-05
DK1244641T3 (da) 2005-07-11
MXPA02006243A (es) 2003-01-28
ATE293104T1 (de) 2005-04-15
AU784286B2 (en) 2006-03-02
NZ519701A (en) 2004-05-28
EP1244641B1 (de) 2005-04-13
WO2001047904A1 (de) 2001-07-05
CA2396720C (en) 2009-09-22
US7105553B2 (en) 2006-09-12
SV2002000249A (es) 2002-06-07
CN1434812A (zh) 2003-08-06
DOP2000000109A (es) 2002-08-30
IL149897A (en) 2008-08-07
PL208707B1 (pl) 2011-05-31
HK1057552A1 (en) 2004-04-08
UY26495A1 (es) 2001-07-31

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