PL355975A1 - Pochodne spiro (2H-1-benzopirano-2,4'-piperydyny)jako inhibitory transportu glicyny - Google Patents

Pochodne spiro (2H-1-benzopirano-2,4'-piperydyny)jako inhibitory transportu glicyny

Info

Publication number
PL355975A1
PL355975A1 PL00355975A PL35597500A PL355975A1 PL 355975 A1 PL355975 A1 PL 355975A1 PL 00355975 A PL00355975 A PL 00355975A PL 35597500 A PL35597500 A PL 35597500A PL 355975 A1 PL355975 A1 PL 355975A1
Authority
PL
Poland
Prior art keywords
benzopyran
derivates
spiro
piperidine
transport inhibitors
Prior art date
Application number
PL00355975A
Other languages
English (en)
Other versions
PL206071B1 (pl
Inventor
Samuel George Gibson
David John Miller
Original Assignee
Akzo Nobel N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel N.V. filed Critical Akzo Nobel N.V.
Publication of PL355975A1 publication Critical patent/PL355975A1/pl
Publication of PL206071B1 publication Critical patent/PL206071B1/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL355975A 1999-11-17 2000-11-13 Pochodna spiro (2H-1-benzopirano-2,4’-piperydyny), jej zastosowanie i zawierająca ją kompozycja farmaceutyczna PL206071B1 (pl)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99309137 1999-11-17

Publications (2)

Publication Number Publication Date
PL355975A1 true PL355975A1 (pl) 2004-05-31
PL206071B1 PL206071B1 (pl) 2010-06-30

Family

ID=8241739

Family Applications (1)

Application Number Title Priority Date Filing Date
PL355975A PL206071B1 (pl) 1999-11-17 2000-11-13 Pochodna spiro (2H-1-benzopirano-2,4’-piperydyny), jej zastosowanie i zawierająca ją kompozycja farmaceutyczna

Country Status (29)

Country Link
US (2) US6645973B1 (pl)
EP (1) EP1232160B1 (pl)
JP (1) JP4825386B2 (pl)
KR (1) KR100776226B1 (pl)
CN (1) CN1199974C (pl)
AR (1) AR026487A1 (pl)
AT (1) ATE398622T1 (pl)
AU (1) AU779518B2 (pl)
BR (1) BR0015586A (pl)
CA (1) CA2389491C (pl)
CO (1) CO5261618A1 (pl)
CY (1) CY1108339T1 (pl)
CZ (1) CZ293920B6 (pl)
DE (1) DE60039247D1 (pl)
DK (1) DK1232160T3 (pl)
ES (1) ES2307536T3 (pl)
HK (1) HK1047282B (pl)
HU (1) HUP0204162A3 (pl)
IL (2) IL149286A0 (pl)
NO (1) NO327743B1 (pl)
NZ (1) NZ518671A (pl)
PE (1) PE20010750A1 (pl)
PL (1) PL206071B1 (pl)
PT (1) PT1232160E (pl)
RU (1) RU2250211C2 (pl)
SK (1) SK287040B6 (pl)
TW (1) TWI243173B (pl)
WO (1) WO2001036423A1 (pl)
ZA (1) ZA200203320B (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
FR2842804B1 (fr) * 2002-07-29 2004-09-03 Sanofi Synthelabo Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique
NZ593444A (en) 2003-10-01 2012-12-21 Adolor Corp 4-[(2-N,N-diethylaminocarbonyl)pyrid-5-yl]-spiro[1,2-dihydronaphthalene-2,4'-piperidine] and methods of its use
KR100783836B1 (ko) * 2004-01-08 2007-12-10 에프. 호프만-라 로슈 아게 글라이신 트랜스포터 1 및 글라이신 트랜스포터 2의억제제로서의 다이아자-스피로피페리딘 유도체
EP1720873B1 (en) * 2004-01-08 2011-02-23 F. Hoffmann-La Roche AG Diaza-spiropiperidine derivatives
WO2005092442A2 (en) * 2004-03-22 2005-10-06 Apkarian Vania A Method and compositions for treatment of chronic neuropathic pain
US7598261B2 (en) * 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
CN101184749B (zh) * 2005-03-31 2012-12-05 阿得罗公司 螺环杂环衍生物及其使用方法
US7576207B2 (en) * 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP2024370A1 (en) * 2006-05-05 2009-02-18 Boehringer Ingelheim International GmbH Spiro- (tho) benzopyran-2, 4' -piperidine-and cyclohexane derivatives as inhibitors of specific cell cycle enzymes
WO2008033299A2 (en) * 2006-09-12 2008-03-20 Adolor Corporation Use of n-containing spirocompounds for the enhancement of cognitive function
TWI366565B (en) 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
KR100888468B1 (ko) * 2007-08-31 2009-03-11 한국화학연구원 항암활성을 갖는1'-알킬피페리딘-4'-스피로-2-6-(아미도)-2ｈ-벤조피란유도체
US20100317679A1 (en) * 2007-09-21 2010-12-16 Ligand Pharmaceuticals, Inc. Substituted aryl-fused spirocyclic amines
EP2380595A1 (en) 2010-04-19 2011-10-26 Nlife Therapeutics S.L. Compositions and methods for selective delivery of oligonucleotide molecules to specific neuron types
TW201643169A (zh) * 2010-07-09 2016-12-16 艾伯維股份有限公司 作為s1p調節劑的螺-哌啶衍生物
US20170143681A1 (en) 2015-11-02 2017-05-25 Apkarian Technologies Llc Methods and compositions for treating pain
CN116621187B (zh) * 2023-07-24 2023-09-22 江苏泓顺硅基半导体科技有限公司 一种用于高温氯化提纯石英砂的设备

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
FR2689509B1 (fr) * 1992-04-01 1994-06-03 Adir Nouveaux derives spiraniques du 3-amino chromane, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
DK78692D0 (da) 1992-06-12 1992-06-12 Lundbeck & Co As H Dimere piperidin- og piperazinderivater
IL107881A0 (en) * 1992-12-05 1994-04-12 Fisons Corp Furanone derivatives and pharmaceutical compositions containing them
US5698566A (en) * 1993-02-12 1997-12-16 Merck & Co., Inc. Nitrogen-containing spirocycles
US5484923A (en) * 1993-06-10 1996-01-16 Merck & Co., Inc. Process of making spirocycles and analogs thereof
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
GB9421003D0 (en) * 1994-10-18 1994-12-07 Smithkline Beecham Plc Novel compounds
US5654316A (en) 1995-06-06 1997-08-05 Schering Corporation Piperidine derivatives as neurokinin antagonists
PT871440E (pt) 1995-12-07 2006-07-31 Daniel C Javitt Tratamento de sintomas negativos e cognitivos de esquizofrenia com antagonistas da captacao de glicina
HUP9600928A3 (en) * 1996-04-10 1999-03-29 Richter Gedeon Vegyeszet Use of spiro[2h-1-benzopyran-2,4'-piperidin]-4(3h)-one derivatives for the preparation of pharmaceutical compositions treating dementia, novel derivatives and process for their preparation
CA2619901A1 (en) 1996-05-31 1997-12-04 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
AU737095B2 (en) 1996-05-31 2001-08-09 Nps Pharmaceuticals, Inc. Pharmaceutical for treating of neurological and neuropsychiatric disorders
US5919653A (en) 1996-08-20 1999-07-06 Allelix Neuroscience Inc. Nucleic acids encoding a human glycine transporter
AU2030999A (en) 1998-01-09 1999-07-26 Allelix Neuroscience, Inc. Glycine transport inhibitors
TW555757B (en) 1998-07-31 2003-10-01 Akzo Nobel Nv Aminomethylcarboxylic acid derivatives
TWI243173B (en) * 1999-11-17 2005-11-11 Akzo Nobel Nv Spiro[2H-1-benzopyran-2,4'-piperidine] derivatives
CN1249057C (zh) * 2000-04-27 2006-04-05 巴斯利尔药物股份公司 用作抗菌剂的色烯基甲基嘧啶二胺

Also Published As

Publication number Publication date
NO20022320L (no) 2002-05-15
US20040029904A1 (en) 2004-02-12
CZ293920B6 (cs) 2004-08-18
PT1232160E (pt) 2008-09-30
HUP0204162A2 (hu) 2003-04-28
TWI243173B (en) 2005-11-11
NO327743B1 (no) 2009-09-14
HK1047282A1 (en) 2003-02-14
DE60039247D1 (de) 2008-07-31
EP1232160B1 (en) 2008-06-18
EP1232160A1 (en) 2002-08-21
DK1232160T3 (da) 2008-10-06
JP2003527340A (ja) 2003-09-16
ATE398622T1 (de) 2008-07-15
NO20022320D0 (no) 2002-05-15
KR100776226B1 (ko) 2007-11-16
BR0015586A (pt) 2002-07-09
SK287040B6 (sk) 2009-10-07
CY1108339T1 (el) 2014-02-12
JP4825386B2 (ja) 2011-11-30
US7507824B2 (en) 2009-03-24
CA2389491C (en) 2010-11-02
CN1199974C (zh) 2005-05-04
IL149286A (en) 2008-08-07
HK1047282B (zh) 2008-08-29
HUP0204162A3 (en) 2006-01-30
PL206071B1 (pl) 2010-06-30
AR026487A1 (es) 2003-02-12
AU779518B2 (en) 2005-01-27
CO5261618A1 (es) 2003-03-31
US6645973B1 (en) 2003-11-11
WO2001036423A1 (en) 2001-05-25
ES2307536T3 (es) 2008-12-01
IL149286A0 (en) 2002-11-10
CN1390221A (zh) 2003-01-08
PE20010750A1 (es) 2001-07-19
CZ20021724A3 (cs) 2002-08-14
NZ518671A (en) 2003-10-31
RU2250211C2 (ru) 2005-04-20
SK8432002A3 (en) 2002-10-08
CA2389491A1 (en) 2001-05-25
AU1521901A (en) 2001-05-30
KR20020050287A (ko) 2002-06-26
ZA200203320B (en) 2003-08-27

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Legal Events

Date Code Title Description
LAPS Decisions on the lapse of the protection rights

Effective date: 20101113