PL354094A1 - Pyrrolo[2,3-d]pyrimidine nucleoside analogs - Google Patents
Pyrrolo[2,3-d]pyrimidine nucleoside analogsInfo
- Publication number
- PL354094A1 PL354094A1 PL00354094A PL35409400A PL354094A1 PL 354094 A1 PL354094 A1 PL 354094A1 PL 00354094 A PL00354094 A PL 00354094A PL 35409400 A PL35409400 A PL 35409400A PL 354094 A1 PL354094 A1 PL 354094A1
- Authority
- PL
- Poland
- Prior art keywords
- pyrrolo
- nucleoside analogs
- pyrimidine nucleoside
- pyrimidine
- analogs
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Oncology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15123399P | 1999-08-27 | 1999-08-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL354094A1 true PL354094A1 (en) | 2003-12-29 |
Family
ID=22537871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL00354094A PL354094A1 (en) | 1999-08-27 | 2000-08-17 | Pyrrolo[2,3-d]pyrimidine nucleoside analogs |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP1212326A4 (sl) |
JP (1) | JP2003511454A (sl) |
KR (1) | KR20020092904A (sl) |
CN (1) | CN1384834A (sl) |
AU (1) | AU769578B2 (sl) |
BR (1) | BR0013642A (sl) |
CA (1) | CA2381297A1 (sl) |
HR (1) | HRP20020163A2 (sl) |
HU (1) | HUP0301875A2 (sl) |
IL (1) | IL147908A0 (sl) |
MX (1) | MXPA02001753A (sl) |
NO (1) | NO20020931D0 (sl) |
PL (1) | PL354094A1 (sl) |
RU (1) | RU2002103501A (sl) |
SI (1) | SI20819A (sl) |
SK (1) | SK1772002A3 (sl) |
WO (1) | WO2001027114A1 (sl) |
ZA (1) | ZA200201567B (sl) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6455508B1 (en) * | 2000-02-15 | 2002-09-24 | Kanda S. Ramasamy | Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides |
US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
JP2003183283A (ja) * | 2001-12-18 | 2003-07-03 | Takeda Chem Ind Ltd | 縮合インドール化合物、その製造法および用途 |
US20050182252A1 (en) | 2004-02-13 | 2005-08-18 | Reddy K. R. | Novel 2'-C-methyl nucleoside derivatives |
CN101851241B (zh) * | 2010-07-02 | 2012-05-23 | 西安交通大学 | 一种抗肿瘤化合物及其制备方法和其用途 |
CN103209987B (zh) | 2010-09-22 | 2017-06-06 | 艾丽奥斯生物制药有限公司 | 取代的核苷酸类似物 |
CN102286048A (zh) * | 2011-06-24 | 2011-12-21 | 吉林大学 | 4-氨基-6-(3-(3-溴苯基)苯基)-5-氰基-7-(β-L-呋喃木糖)吡咯并[2, 3-d]嘧啶、同类衍生物及用于制备抗肿瘤药物 |
AU2012358804B2 (en) | 2011-12-22 | 2018-04-19 | Alios Biopharma, Inc. | Substituted phosphorothioate nucleotide analogs |
US9073960B2 (en) | 2011-12-22 | 2015-07-07 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
WO2013142124A1 (en) | 2012-03-21 | 2013-09-26 | Vertex Pharmaceuticals Incorporated | Solid forms of a thiophosphoramidate nucleotide prodrug |
USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
EP2827876A4 (en) | 2012-03-22 | 2015-10-28 | Alios Biopharma Inc | PHARMACEUTICAL COMBINATIONS WITH A THIONUCLEOTIDE ANALOG |
AU2015217221A1 (en) | 2014-02-13 | 2016-08-11 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and their uses |
EP3164136A4 (en) | 2014-07-02 | 2018-04-04 | Ligand Pharmaceuticals, Inc. | Prodrug compounds and uses therof |
AR104326A1 (es) * | 2015-05-04 | 2017-07-12 | Lilly Co Eli | Compuestos nucleósidos 5-sustituidos |
WO2017053216A2 (en) * | 2015-09-23 | 2017-03-30 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors and preparations thereof |
AU2019207625A1 (en) | 2018-01-09 | 2020-07-30 | Ligand Pharmaceuticals, Inc. | Acetal compounds and therapeutic uses thereof |
DK3794012T3 (da) | 2018-05-15 | 2024-01-08 | Illumina Inc | Sammensætninger og fremgangsmåder til kemisk spaltning og afbeskyttelse af overfladebundne oligonukleotider |
SG11202110742TA (en) | 2019-04-02 | 2021-10-28 | Aligos Therapeutics Inc | Compounds targeting prmt5 |
KR102639275B1 (ko) * | 2021-06-08 | 2024-02-21 | 퓨쳐메디신 주식회사 | 다중 표적 인산화효소 저해 활성을 갖는 뉴클레오사이드 유도체 및 이를 포함하는 암의 예방 및 치료용 약학적 조성물 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3988338A (en) * | 1974-04-24 | 1976-10-26 | Wisconsin Alumni Research Foundation | 4-Substituted amino-2-substituted thio-pyrrolo-[2,3-d]pyrimidine derivatives |
US4892865A (en) * | 1987-12-01 | 1990-01-09 | The Regents Of The University Of Michigan | Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents |
US5674998A (en) * | 1989-09-15 | 1997-10-07 | Gensia Inc. | C-4' modified adenosine kinase inhibitors |
EP0684953A4 (en) * | 1993-02-03 | 1999-12-22 | Gensia Inc | ADENOSINE KINASE INHIBITORS COMPRISING LYXOFURANOSYL DERIVATIVES. |
US5665721A (en) * | 1995-06-07 | 1997-09-09 | Abbott Laboratories | Heterocyclic substituted cyclopentane compounds |
CN1233254A (zh) * | 1996-10-16 | 1999-10-27 | Icn药品公司 | 嘌呤l-核苷、其类似物及其用途 |
-
2000
- 2000-08-17 AU AU70618/00A patent/AU769578B2/en not_active Ceased
- 2000-08-17 MX MXPA02001753A patent/MXPA02001753A/es unknown
- 2000-08-17 HU HU0301875A patent/HUP0301875A2/hu unknown
- 2000-08-17 EP EP00959267A patent/EP1212326A4/en not_active Withdrawn
- 2000-08-17 RU RU2002103501/04A patent/RU2002103501A/ru not_active Application Discontinuation
- 2000-08-17 BR BR0013642-5A patent/BR0013642A/pt not_active IP Right Cessation
- 2000-08-17 WO PCT/US2000/022674 patent/WO2001027114A1/en not_active Application Discontinuation
- 2000-08-17 SK SK177-2002A patent/SK1772002A3/sk unknown
- 2000-08-17 SI SI200020035A patent/SI20819A/sl not_active IP Right Cessation
- 2000-08-17 CA CA002381297A patent/CA2381297A1/en not_active Abandoned
- 2000-08-17 PL PL00354094A patent/PL354094A1/xx not_active Application Discontinuation
- 2000-08-17 JP JP2001530332A patent/JP2003511454A/ja not_active Withdrawn
- 2000-08-17 IL IL14790800A patent/IL147908A0/xx unknown
- 2000-08-17 CN CN00814992A patent/CN1384834A/zh active Pending
- 2000-08-17 KR KR1020027002570A patent/KR20020092904A/ko not_active Application Discontinuation
-
2002
- 2002-02-22 HR HR20020163A patent/HRP20020163A2/hr not_active Application Discontinuation
- 2002-02-25 ZA ZA200201567A patent/ZA200201567B/en unknown
- 2002-02-26 NO NO20020931A patent/NO20020931D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HRP20020163A2 (en) | 2004-02-29 |
IL147908A0 (en) | 2002-08-14 |
MXPA02001753A (es) | 2002-10-23 |
EP1212326A4 (en) | 2003-08-20 |
SK1772002A3 (en) | 2002-10-08 |
ZA200201567B (en) | 2003-07-30 |
CA2381297A1 (en) | 2001-04-19 |
AU769578B2 (en) | 2004-01-29 |
EP1212326A1 (en) | 2002-06-12 |
WO2001027114A1 (en) | 2001-04-19 |
HUP0301875A2 (hu) | 2003-09-29 |
NO20020931L (no) | 2002-02-26 |
KR20020092904A (ko) | 2002-12-12 |
SI20819A (sl) | 2002-08-31 |
RU2002103501A (ru) | 2003-09-10 |
AU7061800A (en) | 2001-04-23 |
NO20020931D0 (no) | 2002-02-26 |
CN1384834A (zh) | 2002-12-11 |
JP2003511454A (ja) | 2003-03-25 |
BR0013642A (pt) | 2002-05-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REFS | Decisions on refusal to grant patents (taken after the publication of the particulars of the applications) |