PL3359522T3 - Sposób wytwarzania n-boc-bifenyloalaninolu - Google Patents
Sposób wytwarzania n-boc-bifenyloalaninoluInfo
- Publication number
- PL3359522T3 PL3359522T3 PL16853064T PL16853064T PL3359522T3 PL 3359522 T3 PL3359522 T3 PL 3359522T3 PL 16853064 T PL16853064 T PL 16853064T PL 16853064 T PL16853064 T PL 16853064T PL 3359522 T3 PL3359522 T3 PL 3359522T3
- Authority
- PL
- Poland
- Prior art keywords
- preparation
- alaninol
- boc
- boc biphenyl
- biphenyl alaninol
- Prior art date
Links
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 title 2
- BKMMTJMQCTUHRP-VKHMYHEASA-N (S)-2-aminopropan-1-ol Chemical compound C[C@H](N)CO BKMMTJMQCTUHRP-VKHMYHEASA-N 0.000 title 1
- 235000010290 biphenyl Nutrition 0.000 title 1
- 239000004305 biphenyl Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
- C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510654835.3A CN105198775B (zh) | 2015-10-10 | 2015-10-10 | 一种手性N‑Boc联苯丙氨醇的制备方法 |
| EP16853064.0A EP3359522B1 (en) | 2015-10-10 | 2016-09-09 | Process for preparation of n-boc biphenyl alaninol |
| PCT/CN2016/098517 WO2017059759A1 (en) | 2015-10-10 | 2016-09-09 | Process for preparation of n-boc biphenyl alaninol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3359522T3 true PL3359522T3 (pl) | 2020-09-21 |
Family
ID=54946776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16853064T PL3359522T3 (pl) | 2015-10-10 | 2016-09-09 | Sposób wytwarzania n-boc-bifenyloalaninolu |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US10183909B2 (e) |
| EP (1) | EP3359522B1 (e) |
| CN (1) | CN105198775B (e) |
| DK (1) | DK3359522T3 (e) |
| ES (1) | ES2788673T3 (e) |
| HR (1) | HRP20200830T1 (e) |
| PL (1) | PL3359522T3 (e) |
| PT (1) | PT3359522T (e) |
| SI (1) | SI3359522T1 (e) |
| WO (1) | WO2017059759A1 (e) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105198775B (zh) | 2015-10-10 | 2017-11-14 | 凯瑞斯德生化(苏州)有限公司 | 一种手性N‑Boc联苯丙氨醇的制备方法 |
| CN105622460B (zh) * | 2016-01-08 | 2017-12-05 | 浙江大学 | (r)‑n‑叔丁氧羰基联苯丙氨醇的合成方法 |
| CN105884656B (zh) * | 2016-04-20 | 2017-09-19 | 沧州那瑞化学科技有限公司 | 一种lcz696中间体的制备方法 |
| US20190256454A1 (en) | 2016-07-05 | 2019-08-22 | Novartis Ag | New process for early sacubitril intermediates |
| JP6945619B2 (ja) | 2016-08-17 | 2021-10-06 | ノバルティス アーゲー | Ｎｅｐ阻害剤合成のための新規な方法および中間体 |
| JP7138106B2 (ja) | 2016-12-23 | 2022-09-15 | ノバルティス アーゲー | 初期サクビトリル中間体のための新規な方法 |
| CN109053495B (zh) * | 2018-07-23 | 2021-05-28 | 江苏宇田医药有限公司 | 一种lcz696中间体的合成方法 |
| CN110041214A (zh) * | 2019-05-06 | 2019-07-23 | 凯瑞斯德生化(苏州)有限公司 | 一种Melphalan中间体及其制备方法 |
| CN110054563A (zh) * | 2019-06-10 | 2019-07-26 | 江西隆莱生物制药有限公司 | 丁内酯类化合物的制备方法及其中间体 |
| CN114853811A (zh) * | 2022-04-29 | 2022-08-05 | 新乡市润宇新材料科技有限公司 | 一种合成磷中心手性苯并磷杂五元环的方法 |
| CN118619995A (zh) * | 2024-04-16 | 2024-09-10 | 凯特立斯（深圳）科技有限公司 | 一种富电子双膦配体、制备及其应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2437078A (en) * | 2006-04-11 | 2007-10-17 | Portela & Ca Sa | 10-Acyloxy-5H-dibenzo[b,f]azepine-5-carboxamides & their asymmetric hydrogenation to the chiral 10,11-dihydro derivatives |
| US8980833B2 (en) | 2007-05-10 | 2015-03-17 | R&D-Biopharmaceuticals Gmbh | Tubulysine derivatives |
| US8278486B2 (en) * | 2008-12-31 | 2012-10-02 | Chiral Quest, Inc. | Process and intermediates for the preparation of N-acylated-4-aryl beta-amino acid derivatives |
| CN101774941A (zh) | 2009-01-13 | 2010-07-14 | 浙江九洲药业股份有限公司 | 2-酰基氨基-3-联苯基丙酸的制备及拆分方法 |
| JP5735977B2 (ja) * | 2009-12-14 | 2015-06-17 | ヘルムホルツ−ツェントルム フュア インフェクツィオンスフォルシュンク ゲーエムベーハー | ｐ２７のプロテアソーム分解の阻害因子である、アルギリン及びその誘導体等の大員環の製造の中間体を製造する改善された方法 |
| EP2560493B1 (en) * | 2010-04-20 | 2018-06-06 | Chiral Quest, Inc. | An enantioselective process for cycloalkenyl b-substituted alanines |
| CN102276491B (zh) * | 2010-06-11 | 2014-03-05 | 凯瑞斯德生化(苏州)有限公司 | 一种雷沙吉兰的中间体的制备方法 |
| CN102382033B (zh) * | 2010-08-31 | 2013-04-03 | 凯瑞斯德生化(苏州)有限公司 | 一种光学活性米格列奈酯及米格列奈盐的制备方法 |
| CN106977418A (zh) | 2011-08-19 | 2017-07-25 | Dpx精细化学奥地利两合公司 | R‑联苯丙氨醇的合成 |
| AR092278A1 (es) | 2012-08-31 | 2015-04-08 | Novartis Ag | Proceso de obtencion de derivados n-acilicos de bifenil-alanina e intermediarios relacionados |
| JP2016513718A (ja) * | 2013-03-14 | 2016-05-16 | ヴィスタゲン セラピューティクス、インコーポレイテッド | キラルキヌレニン化合物及び中間体の合成 |
| WO2015024991A1 (en) * | 2013-08-21 | 2015-02-26 | Dpx Holdings B.V. | Synthesis of biphenylalaninol via novel intermediates |
| WO2015037460A1 (ja) | 2013-09-10 | 2015-03-19 | 住友化学株式会社 | 光学活性な３－（ビフェニル－４－イル）－２－［（ｔ－ブトキシカルボニル）アミノ］プロパン－１－オールの製造方法 |
| CN105198775B (zh) * | 2015-10-10 | 2017-11-14 | 凯瑞斯德生化(苏州)有限公司 | 一种手性N‑Boc联苯丙氨醇的制备方法 |
-
2015
- 2015-10-10 CN CN201510654835.3A patent/CN105198775B/zh active Active
-
2016
- 2016-09-09 PT PT168530640T patent/PT3359522T/pt unknown
- 2016-09-09 US US15/766,979 patent/US10183909B2/en active Active
- 2016-09-09 HR HRP20200830TT patent/HRP20200830T1/hr unknown
- 2016-09-09 PL PL16853064T patent/PL3359522T3/pl unknown
- 2016-09-09 ES ES16853064T patent/ES2788673T3/es active Active
- 2016-09-09 DK DK16853064.0T patent/DK3359522T3/da active
- 2016-09-09 EP EP16853064.0A patent/EP3359522B1/en active Active
- 2016-09-09 SI SI201630749T patent/SI3359522T1/sl unknown
- 2016-09-09 WO PCT/CN2016/098517 patent/WO2017059759A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP3359522A4 (en) | 2018-09-26 |
| PT3359522T (pt) | 2020-05-28 |
| EP3359522B1 (en) | 2020-02-26 |
| WO2017059759A1 (en) | 2017-04-13 |
| EP3359522A1 (en) | 2018-08-15 |
| ES2788673T3 (es) | 2020-10-22 |
| CN105198775B (zh) | 2017-11-14 |
| DK3359522T3 (da) | 2020-06-02 |
| SI3359522T1 (sl) | 2020-07-31 |
| HRP20200830T1 (hr) | 2020-08-07 |
| CN105198775A (zh) | 2015-12-30 |
| US10183909B2 (en) | 2019-01-22 |
| US20180297941A1 (en) | 2018-10-18 |
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