PL3355915T3 - Szczepionki zawierające cząstki wirusopodobne (VLP) parwowirusa psów (CPV) i ich zastosowania - Google Patents

Szczepionki zawierające cząstki wirusopodobne (VLP) parwowirusa psów (CPV) i ich zastosowania

Info

Publication number
PL3355915T3
PL3355915T3 PL16771050.8T PL16771050T PL3355915T3 PL 3355915 T3 PL3355915 T3 PL 3355915T3 PL 16771050 T PL16771050 T PL 16771050T PL 3355915 T3 PL3355915 T3 PL 3355915T3
Authority
PL
Poland
Prior art keywords
cpv
vlp
vaccines
virus
particle
Prior art date
Application number
PL16771050.8T
Other languages
English (en)
Inventor
Frederic David
Zahia HANNAS-DJEBBARA
Herve Poulet
Jules Maarten Minke
Original Assignee
Boehringer Ingelheim Animal Health USA Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Animal Health USA Inc. filed Critical Boehringer Ingelheim Animal Health USA Inc.
Publication of PL3355915T3 publication Critical patent/PL3355915T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/23Parvoviridae, e.g. feline panleukopenia virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/125Picornaviridae, e.g. calicivirus
    • A61K39/135Foot- and mouth-disease virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/20Antivirals for DNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5258Virus-like particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/70Multivalent vaccine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14311Parvovirus, e.g. minute virus of mice
    • C12N2750/14323Virus like particles [VLP]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14311Parvovirus, e.g. minute virus of mice
    • C12N2750/14334Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14311Parvovirus, e.g. minute virus of mice
    • C12N2750/14371Demonstrated in vivo effect
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32111Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32123Virus like particles [VLP]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/32011Picornaviridae
    • C12N2770/32111Aphthovirus, e.g. footandmouth disease virus
    • C12N2770/32134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL16771050.8T 2015-09-29 2016-09-14 Szczepionki zawierające cząstki wirusopodobne (VLP) parwowirusa psów (CPV) i ich zastosowania PL3355915T3 (pl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562234196P 2015-09-29 2015-09-29
PCT/US2016/051736 WO2017058521A1 (en) 2015-09-29 2016-09-14 Canine parvovirus (cpv) virus-like particle (vlp) vaccines and uses thereof

Publications (1)

Publication Number Publication Date
PL3355915T3 true PL3355915T3 (pl) 2024-03-25

Family

ID=57003591

Family Applications (1)

Application Number Title Priority Date Filing Date
PL16771050.8T PL3355915T3 (pl) 2015-09-29 2016-09-14 Szczepionki zawierające cząstki wirusopodobne (VLP) parwowirusa psów (CPV) i ich zastosowania

Country Status (26)

Country Link
US (2) US10080798B2 (pl)
EP (2) EP3355915B1 (pl)
JP (1) JP6818748B2 (pl)
CN (1) CN108348594B (pl)
AR (1) AR106026A1 (pl)
AU (1) AU2016332037B2 (pl)
BR (1) BR112018006567A2 (pl)
CA (1) CA3000352A1 (pl)
CL (1) CL2018000820A1 (pl)
CO (1) CO2018003460A2 (pl)
DK (1) DK3355915T5 (pl)
ES (1) ES2974666T3 (pl)
FI (1) FI3355915T3 (pl)
HR (1) HRP20231630T1 (pl)
HU (1) HUE065661T2 (pl)
LT (1) LT3355915T (pl)
MA (1) MA43016A (pl)
MX (1) MX2018004016A (pl)
NZ (1) NZ741875A (pl)
PL (1) PL3355915T3 (pl)
PT (1) PT3355915T (pl)
RS (1) RS65084B1 (pl)
RU (1) RU2710854C1 (pl)
SI (1) SI3355915T1 (pl)
WO (1) WO2017058521A1 (pl)
ZA (1) ZA201802117B (pl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA43016A (fr) * 2015-09-29 2018-08-08 Merial Inc Vaccins à particules pseudo-virales (vlp) de parvovirus canin (cpv) et utilisations associées
AR113124A1 (es) 2017-09-23 2020-01-29 Boehringer Ingelheim Vetmedica Gmbh Sistema de expresión de paramyxoviridae
CN108273055A (zh) * 2018-01-03 2018-07-13 复旦大学 犬细小病毒疫苗组合物及其制备方法与应用
KR102117810B1 (ko) * 2018-11-29 2020-06-02 대한민국(농림축산식품부 농림축산검역본부장) 재조합 개파보바이러스 2c 항원 단백질 및 이의 용도
CN110157687A (zh) * 2019-05-25 2019-08-23 青岛易邦生物工程有限公司 一种犬细小病毒三价亚单位疫苗
WO2022152939A1 (en) 2021-01-18 2022-07-21 Conserv Bioscience Limited Coronavirus immunogenic compositions, methods and uses thereof
CN114317459B (zh) * 2021-12-31 2024-02-23 长春西诺生物科技有限公司 一种犬瘟热病毒株和基于犬瘟热病毒和犬细小病毒的二联疫苗及应用
CN114957406B (zh) * 2022-05-26 2024-02-02 吉林大学 一种犬细小病毒的三价抗原和三价病毒样颗粒以及应用
CN116376981A (zh) * 2023-04-21 2023-07-04 西北农林科技大学 一种重组犬细小病毒假病毒

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2909462A (en) 1955-12-08 1959-10-20 Bristol Myers Co Acrylic acid polymer laxative compositions
US5505941A (en) 1981-12-24 1996-04-09 Health Research, Inc. Recombinant avipox virus and method to induce an immune response
EP0138854B1 (en) 1983-03-08 1992-11-04 Chiron Mimotopes Pty. Ltd. Antigenically active amino acid sequences
EP0173552B1 (en) 1984-08-24 1991-10-09 The Upjohn Company Recombinant dna compounds and the expression of polypeptides such as tpa
US5168062A (en) 1985-01-30 1992-12-01 University Of Iowa Research Foundation Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence
US4968615A (en) 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
US4963481A (en) 1985-12-18 1990-10-16 Genetics Institute Inc Promoter system
IE872455L (en) 1986-09-12 1988-03-12 Lanstrase Ltd Improved recombinant expression
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
DE3743138A1 (de) 1987-12-18 1989-09-14 Mayr Christian Gmbh & Co Kg Schleifringlose, elektromagnetische ueberlastkupplung
US4971793A (en) 1988-05-09 1990-11-20 Boyce Thompson Institute For Plant Research, Inc. Subunit canine parvovirus vaccine
US6204044B1 (en) 1989-09-14 2001-03-20 Caroline Sarah Brown Human parvovirus B19 proteins and virus-like particles, their production and their use in diagnostic assays and vaccines
AU672359B2 (en) 1991-03-07 1996-10-03 Virogenetics Corporation Genetically engineered vaccine strain
CA2214029A1 (en) 1995-04-25 1996-10-31 Magda Marquet Single-vial formulations of dna/lipid complexes
US5846946A (en) 1996-06-14 1998-12-08 Pasteur Merieux Serums Et Vaccins Compositions and methods for administering Borrelia DNA
FR2751225B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique aviaire
FR2751227B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique contre les pathologies canines, notamment les pathologies respiratoires et digestives
FR2751229B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique notamment contre la pathologie respiratoire des bovins
FR2751228B1 (fr) 1996-07-19 1998-11-20 Rhone Merieux Vaccin polynucleotidique bovin pour voie intradermique
FR2751226B1 (fr) 1996-07-19 1998-11-27 Rhone Merieux Formule de vaccin polynucleotidique contre les pathologies du cheval
FR2751224B1 (fr) 1996-07-19 1998-11-20 Rhone Merieux Formule de vaccin polynucleotidique contre les pathologies respiratoires et de reproduction des porcs
ATE292980T1 (de) 1996-10-11 2005-04-15 Univ California Immunostimulierende oligonucleotidekonjugate
CA2223029A1 (en) 1997-02-12 1998-08-12 Akzo Nobel Nv Canine parvovirus dna vaccines
DE69826124T3 (de) 1997-06-30 2007-10-11 Institut Gustave Roussy Verabreichung der nukleinsäure in den quergestreiften muskel
FR2778858B1 (fr) 1998-05-20 2000-06-16 Oreal Emulsion e/h/e stable et son utilisation comme composition cosmetique et/ou dermatologique
FR2801607B1 (fr) 1999-11-26 2001-12-28 Merial Sas Pneumovirus du canard et vaccins correspondants
US6852705B2 (en) 2000-01-21 2005-02-08 Merial DNA vaccines for farm animals, in particular bovines and porcines
US7179456B2 (en) 2003-04-30 2007-02-20 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Use of parvovirus for brain tumor therapy
WO2005009462A2 (en) 2003-07-24 2005-02-03 Merial Limited Vaccine formulations comprising an oil-in-water emulsion
EP2488634A4 (en) 2009-10-14 2013-04-03 Univ Oklahoma State ISOLATION OF A VIRUS RELATED TO DOG PARVOVIRUS 2 IN A WASHBASIN
US9744228B2 (en) 2010-04-07 2017-08-29 Norvartis Ag Method for generating a parvovirus B19 virus-like particle
US20120052082A1 (en) * 2010-04-09 2012-03-01 Zetra Biologicals, LLC Cross-protective influenza vaccine
CN104812408A (zh) * 2012-07-24 2015-07-29 赛诺菲巴斯德有限公司 用于防止登革热病毒感染的疫苗组合物
CN103387996B (zh) * 2013-08-19 2015-07-15 长春西诺生物科技有限公司 犬细小病毒病毒样颗粒、其制备方法及应用
CN103409377B (zh) * 2013-08-28 2015-12-23 中国农业科学院兰州兽医研究所 犬细小病毒病毒样颗粒的制备及用途
MA43016A (fr) * 2015-09-29 2018-08-08 Merial Inc Vaccins à particules pseudo-virales (vlp) de parvovirus canin (cpv) et utilisations associées

Also Published As

Publication number Publication date
EP3355915B1 (en) 2023-11-01
NZ741875A (en) 2019-08-30
CO2018003460A2 (es) 2018-06-20
CN108348594A (zh) 2018-07-31
AU2016332037A1 (en) 2018-05-10
MX2018004016A (es) 2018-11-29
PT3355915T (pt) 2023-12-19
AR106026A1 (es) 2017-12-06
RU2710854C1 (ru) 2020-01-14
CN108348594B (zh) 2022-09-09
CA3000352A1 (en) 2017-04-06
AU2016332037B2 (en) 2019-06-27
FI3355915T3 (fi) 2024-01-12
ZA201802117B (en) 2019-01-30
SI3355915T1 (sl) 2024-03-29
US10537632B2 (en) 2020-01-21
EP4286002A3 (en) 2024-02-28
BR112018006567A2 (pt) 2018-12-11
CL2018000820A1 (es) 2019-03-01
RS65084B1 (sr) 2024-02-29
EP4286002A2 (en) 2023-12-06
JP6818748B2 (ja) 2021-01-20
LT3355915T (lt) 2024-01-25
HUE065661T2 (hu) 2024-06-28
US20190000965A1 (en) 2019-01-03
ES2974666T3 (es) 2024-07-01
HRP20231630T1 (hr) 2024-03-15
US10080798B2 (en) 2018-09-25
JP2018529718A (ja) 2018-10-11
EP3355915A1 (en) 2018-08-08
DK3355915T3 (da) 2024-01-29
DK3355915T5 (da) 2024-09-30
WO2017058521A1 (en) 2017-04-06
MA43016A (fr) 2018-08-08
US20170087244A1 (en) 2017-03-30

Similar Documents

Publication Publication Date Title
HUE065661T2 (hu) Kutya parvovírus (CPV) vírusszerû részecske (VLP) vakcinák és alkalmazásuk
HK1255847A1 (zh) 針對乙型肝炎病毒的疫苗
HK1255670A1 (zh) Cmv的修飾病毒樣顆粒
HK1246654A1 (zh) 具有有效表位顯示的病毒樣顆粒
ZA201700165B (en) Influenza virus vaccines and uses thereof
LT3718565T (lt) Kvėpavimo takų virusų vakcinos
HK1259274A1 (zh) 基於人呼吸道合胞病毒(hrsv)病毒樣顆粒(vlps)的疫苗
SG11201610443WA (en) Influenza virus vaccines and uses thereof
EP2968517A4 (en) Specific multivalent virus-like particle vaccines and uses thereof
IL263550A (en) Infectious bronchitis virus vaccine
SG11201702116VA (en) Viral rna segments as immunomodulatory agents and vaccine components
GB201701573D0 (en) Virus-like particle
IL247185B (en) Tilapia virus vaccines
SG11201912454SA (en) Virus-like particles comprising zika antigen
HK1253030A1 (zh) 基於piv5的擴增病毒樣顆粒
EP3403671C0 (en) VACCINE WITH IMMOBILIZED VIRUS PARTICLES
EP3240568A4 (en) Recombinant influenza virus vaccines for influenza and respiratory syncytial virus
EP3347044A4 (en) BIRD FLUID VACCINE COMBINATION WITH VIRUS-RELATED PARTICLES AND NOVEL AUXILIARY SUBSTANCES
EP3170509A4 (en) Vaccine containing virus-like particles
EP3545973A4 (en) COMPOSITION OF VACCINE CONTAINING PARTICLES OF THE HEPATITIS B VIRUS TYPE USED AS AN ADJUVANT
EP3487527A4 (en) PARTICLES OF VEGETABLE OR VIRAL-LIKE PARTICLES
IL249705B (en) Influenza virus vaccines and their uses
IL249704A0 (en) Influenza virus vaccines and their uses
AU2014902031A0 (en) Immunogenic vaccines and uses thereof