PL334293A1 - Enzymatic separation of benzodiazepinacetic esters by means of lipase - Google Patents
Enzymatic separation of benzodiazepinacetic esters by means of lipaseInfo
- Publication number
- PL334293A1 PL334293A1 PL97334293A PL33429397A PL334293A1 PL 334293 A1 PL334293 A1 PL 334293A1 PL 97334293 A PL97334293 A PL 97334293A PL 33429397 A PL33429397 A PL 33429397A PL 334293 A1 PL334293 A1 PL 334293A1
- Authority
- PL
- Poland
- Prior art keywords
- benzodiazepinacetic
- lipase
- esters
- enzymatic separation
- enzymatic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
- C12P17/165—Heterorings having nitrogen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3385396P | 1996-12-27 | 1996-12-27 | |
| PCT/GB1997/003522 WO1998029561A1 (en) | 1996-12-27 | 1997-12-23 | Enzymatic resolution of benzodiazepine-acetic acid esters with a lipase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL334293A1 true PL334293A1 (en) | 2000-02-14 |
Family
ID=21872833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL97334293A PL334293A1 (en) | 1996-12-27 | 1997-12-23 | Enzymatic separation of benzodiazepinacetic esters by means of lipase |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0964928A1 (pt) |
| JP (1) | JP2001507231A (pt) |
| KR (1) | KR20000069705A (pt) |
| CN (1) | CN1246157A (pt) |
| AR (1) | AR010860A1 (pt) |
| AU (1) | AU730064B2 (pt) |
| BR (1) | BR9714099A (pt) |
| CA (1) | CA2276134A1 (pt) |
| CO (1) | CO4930272A1 (pt) |
| HU (1) | HUP0002825A3 (pt) |
| IL (1) | IL130580A0 (pt) |
| NO (1) | NO993174L (pt) |
| NZ (1) | NZ336376A (pt) |
| PL (1) | PL334293A1 (pt) |
| TR (1) | TR199901487T2 (pt) |
| WO (1) | WO1998029561A1 (pt) |
| ZA (1) | ZA9711566B (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69914458T2 (de) | 1998-02-17 | 2004-10-28 | G.D. Searle & Co., Chicago | Verfahren zur enzymatischen auflösung von laktamen |
| WO2001092553A1 (en) * | 2000-06-01 | 2001-12-06 | Sk Corporation | Method for optically resolving a racemic alpha-substituted heterocyclic carboxylic acid using enzyme |
| KR100378741B1 (ko) * | 2000-06-01 | 2003-04-07 | 에스케이 주식회사 | 효소를 이용하여 R-폼 또는 S-폼의 α-치환 헤테로싸이클릭 카르복실산 및 이와 상반되는 광학특성을 갖는 α-치환 헤테로싸이클릭 카르복실산 에스테르를 제조하는 방법 |
| KR100379756B1 (ko) * | 2000-10-02 | 2003-04-11 | 한국과학기술연구원 | 이성질체 분할방법 |
| US6828119B2 (en) * | 2001-01-04 | 2004-12-07 | Bristol Myers Squibb Company | Enzymatic deprotection of amines and hydroxides |
| FR2853327B1 (fr) * | 2003-04-04 | 2012-07-27 | Solvay | Procede pour la fabrication de derives de beta-aminoacides enantiopurs et derives de beta-aminoacides enantiopurs |
| KR100650798B1 (ko) * | 2004-07-19 | 2006-11-27 | (주)제이코통상 | 광학활성 카복실산의 제조방법 |
| FR2876102A1 (fr) * | 2004-10-04 | 2006-04-07 | Solvay | Compose heterocyclique enantiopur |
| KR100650797B1 (ko) * | 2005-12-12 | 2006-11-27 | (주)케미코월드 | 광학활성 사이클로프로판 카복사미드의 제조방법 |
| FR2986804A1 (fr) * | 2012-02-09 | 2013-08-16 | Servier Lab | Procede de synthese enzymatique de l'acide (7s) 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene 7-carboxylique ou de ses esters, et application a la synthese de l'ivabradine et de ses sels |
| CN117363683A (zh) * | 2023-10-09 | 2024-01-09 | 江苏惠利生物科技有限公司 | 一种脂酶苯并二氮杂-乙酸酯的酶拆分方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA924760B (en) * | 1991-06-28 | 1993-03-31 | Smithkline Beecham Corp | Bicyclic fibrinogen antagonists |
| DE69332860T2 (de) * | 1992-12-21 | 2004-03-11 | Smithkline Beecham Corp. | Bicyklische fibrinogen antagoniste |
| MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
| US5529929A (en) * | 1995-06-07 | 1996-06-25 | Seprachem, Inc. | Optical resolution of alkyl 1,4-benzodioxan-2-carboxylates using esterase from serratia marcescens |
-
1997
- 1997-12-23 CA CA002276134A patent/CA2276134A1/en not_active Abandoned
- 1997-12-23 WO PCT/GB1997/003522 patent/WO1998029561A1/en not_active Application Discontinuation
- 1997-12-23 JP JP52974298A patent/JP2001507231A/ja active Pending
- 1997-12-23 EP EP97950309A patent/EP0964928A1/en not_active Withdrawn
- 1997-12-23 HU HU0002825A patent/HUP0002825A3/hu unknown
- 1997-12-23 AU AU53314/98A patent/AU730064B2/en not_active Ceased
- 1997-12-23 TR TR1999/01487T patent/TR199901487T2/xx unknown
- 1997-12-23 CN CN97181853A patent/CN1246157A/zh active Pending
- 1997-12-23 NZ NZ336376A patent/NZ336376A/xx unknown
- 1997-12-23 KR KR1019997005777A patent/KR20000069705A/ko not_active Application Discontinuation
- 1997-12-23 ZA ZA9711566A patent/ZA9711566B/xx unknown
- 1997-12-23 AR ARP970106167A patent/AR010860A1/es not_active Application Discontinuation
- 1997-12-23 IL IL13058097A patent/IL130580A0/xx unknown
- 1997-12-23 PL PL97334293A patent/PL334293A1/xx unknown
- 1997-12-23 BR BR9714099A patent/BR9714099A/pt not_active IP Right Cessation
- 1997-12-26 CO CO97075096A patent/CO4930272A1/es unknown
-
1999
- 1999-06-25 NO NO993174A patent/NO993174L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20000069705A (ko) | 2000-11-25 |
| WO1998029561A1 (en) | 1998-07-09 |
| HUP0002825A3 (en) | 2002-09-30 |
| JP2001507231A (ja) | 2001-06-05 |
| EP0964928A1 (en) | 1999-12-22 |
| CN1246157A (zh) | 2000-03-01 |
| NZ336376A (en) | 2000-11-24 |
| TR199901487T2 (xx) | 1999-11-22 |
| HUP0002825A2 (hu) | 2000-12-28 |
| AU730064B2 (en) | 2001-02-22 |
| AR010860A1 (es) | 2000-07-12 |
| CA2276134A1 (en) | 1998-07-09 |
| BR9714099A (pt) | 2000-03-21 |
| CO4930272A1 (es) | 2000-06-27 |
| NO993174D0 (no) | 1999-06-25 |
| IL130580A0 (en) | 2000-06-01 |
| NO993174L (no) | 1999-06-25 |
| AU5331498A (en) | 1998-07-31 |
| ZA9711566B (en) | 1998-06-29 |
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