PL3341016T3 - Sposoby i kompozycje do ochrony immunologicznej przed pozajelitowymi patogennymi e. coli - Google Patents
Sposoby i kompozycje do ochrony immunologicznej przed pozajelitowymi patogennymi e. coliInfo
- Publication number
- PL3341016T3 PL3341016T3 PL16760616.9T PL16760616T PL3341016T3 PL 3341016 T3 PL3341016 T3 PL 3341016T3 PL 16760616 T PL16760616 T PL 16760616T PL 3341016 T3 PL3341016 T3 PL 3341016T3
- Authority
- PL
- Poland
- Prior art keywords
- coli
- compositions
- methods
- protection against
- immune protection
- Prior art date
Links
- 241000588724 Escherichia coli Species 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000001717 pathogenic effect Effects 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Polymers & Plastics (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562209091P | 2015-08-24 | 2015-08-24 | |
| US201562210655P | 2015-08-27 | 2015-08-27 | |
| PCT/US2016/048278 WO2017035181A1 (en) | 2015-08-24 | 2016-08-24 | Methods and compositions for immune protection against extra-intestinal pathogenic e. coli |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3341016T3 true PL3341016T3 (pl) | 2023-11-13 |
Family
ID=56855827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16760616.9T PL3341016T3 (pl) | 2015-08-24 | 2016-08-24 | Sposoby i kompozycje do ochrony immunologicznej przed pozajelitowymi patogennymi e. coli |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US10583185B2 (pl) |
| EP (2) | EP3341016B9 (pl) |
| JP (1) | JP6872532B2 (pl) |
| KR (1) | KR102735147B1 (pl) |
| CN (1) | CN108430500B (pl) |
| AU (1) | AU2016312422B2 (pl) |
| BR (1) | BR112018003469A2 (pl) |
| EA (1) | EA037500B1 (pl) |
| ES (1) | ES2951408T3 (pl) |
| HR (1) | HRP20230947T1 (pl) |
| HU (1) | HUE063961T2 (pl) |
| IL (1) | IL257608B (pl) |
| MX (1) | MX2018002340A (pl) |
| PL (1) | PL3341016T3 (pl) |
| RS (1) | RS64449B1 (pl) |
| SM (1) | SMT202300220T1 (pl) |
| TW (1) | TWI715617B (pl) |
| WO (1) | WO2017035181A1 (pl) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130122810A (ko) * | 2005-06-27 | 2013-11-08 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 백신 제조 방법 |
| NZ707777A (en) | 2013-01-17 | 2019-12-20 | X4 Pharmaceuticals Austria Gmbh | Mdr e. coli specific antibody |
| RS65631B1 (sr) | 2014-02-24 | 2024-07-31 | Glaxosmithkline Biologicals Sa | Novi polisaharid i njegove upotrebe |
| TWI715617B (zh) | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
| AR109621A1 (es) | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
| US20190275135A1 (en) | 2018-03-12 | 2019-09-12 | Janssen Pharmaceuticals, Inc | Vaccines against intra-abdominal infections |
| US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| PE20212265A1 (es) | 2019-03-18 | 2021-11-30 | Janssen Pharmaceuticals Inc | Bioconjugados de antigenos-polisacaridos de e. coli, metodos de produccion y metodos de utilizacion de los mismos |
| IL286467B1 (en) | 2019-03-18 | 2025-10-01 | Janssen Pharmaceuticals Inc | Methods for producing bioconjugates of E. COLI O-antigen polysaccharides, preparations thereof and methods for using them |
| CN115038461A (zh) | 2020-01-16 | 2022-09-09 | 杨森制药公司 | FimH突变体、其组合物及其用途 |
| BR112022014555A2 (pt) * | 2020-02-23 | 2022-09-20 | Pfizer | Composições de escherichia coli e métodos das mesmas. |
| ES2984813T3 (es) | 2020-04-28 | 2024-10-31 | Janssen Pharmaceuticals Inc | Método para la identificación y la cuantificación de polisacáridos en composiciones de glicoconjugados complejas |
| BR112022023234A2 (pt) | 2020-06-25 | 2023-01-03 | Glaxosmithkline Biologicals Sa | Proteínas de exotoxina a modificada |
| EP4213870A1 (en) * | 2020-09-17 | 2023-07-26 | Janssen Pharmaceuticals, Inc. | Multivalent vaccine compositions and uses thereof |
| US12138302B2 (en) | 2020-10-27 | 2024-11-12 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
| JP7495578B2 (ja) * | 2020-11-30 | 2024-06-04 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | キャピラリーベースのイムノアッセイシステムを使用する複合糖質の分析方法 |
| US12357681B2 (en) | 2020-12-23 | 2025-07-15 | Pfizer Inc. | E. coli FimH mutants and uses thereof |
| WO2022153166A1 (en) | 2021-01-12 | 2022-07-21 | Janssen Pharmaceuticals, Inc. | Fimh mutants, compositions therewith and use thereof |
| US20220236283A1 (en) * | 2021-01-28 | 2022-07-28 | Janssen Pharmaceuticals, Inc. | Method for identification and quantification of polysaccharides in complex glycoconjugate compositions |
| WO2022178020A1 (en) | 2021-02-16 | 2022-08-25 | Duke University | Vaccine compositions and methods for the treatment and prevention of urinary tract infections |
| JP2024514074A (ja) | 2021-04-01 | 2024-03-28 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | Ｅ．ｃｏｌｉ ｏ１８バイオコンジュゲートの産生 |
| JP2024513914A (ja) | 2021-04-08 | 2024-03-27 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | バイオコンジュゲート生産のためのプロセス |
| AR131046A1 (es) * | 2022-11-15 | 2025-02-12 | Janssen Pharmaceuticals Inc | Composiciones de vacunas multivalentes y sus usos |
| EP4478050A1 (en) | 2023-06-12 | 2024-12-18 | Janssen Pharmaceuticals, Inc. | Method for quantifying bound acetate in glycoconjugates |
| WO2025172892A1 (en) | 2024-02-16 | 2025-08-21 | Glaxosmithkline Biologicals Sa | Modified proteins and methods |
| CN118286407B (zh) * | 2024-04-08 | 2025-04-01 | 江西省农业科学院畜牧兽医研究所 | 一种禽大肠杆菌病三价灭活疫苗及其制备方法 |
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| WO2001078787A2 (en) | 2000-04-18 | 2001-10-25 | Endobiologics, Incorporated | Lipopolysaccharide-conjugate vaccine for sepsis treatment |
| RU2189253C1 (ru) | 2001-04-09 | 2002-09-20 | Государственный научный центр прикладной микробиологии | Диагностикум для идентификации escherichia coli o157 : h7 и способ его получения |
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| WO2007109812A2 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Immunopotentiating compounds |
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| WO2010125565A2 (en) | 2009-04-27 | 2010-11-04 | Hadasit Medical Research Services And Development Ltd. | Anti-lps enriched immunoglobulin preparation for use in treatment and/or prophylaxis of a pathologic disorder |
| PL2501406T3 (pl) | 2009-11-19 | 2018-05-30 | Glaxosmithkline Biologicals S.A. | Biosyntetyczny układ wytwarzający immunogenne polisacharydy w komórkach prokariotycznych |
| EP3336225B1 (en) | 2010-07-16 | 2020-02-19 | Adimab, LLC | Antibody libraries |
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| JP2014526449A (ja) | 2011-09-06 | 2014-10-06 | グリコヴァキシン アーゲー | 原核細胞において製造されるバイオコンジュゲートワクチン |
| US9932598B2 (en) | 2012-08-02 | 2018-04-03 | The Regents Of The University Of California | Metabolic engineering of microbial organisms |
| HK1212249A1 (en) * | 2012-09-10 | 2016-06-10 | Glycovaxyn Ag | Bioconjugates comprising modified antigens and uses thereof |
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| EP2938363B1 (en) | 2012-12-27 | 2019-08-21 | GlaxoSmithKline Biologicals S.A. | Methods and compositions relating to crm197 |
| NZ707777A (en) | 2013-01-17 | 2019-12-20 | X4 Pharmaceuticals Austria Gmbh | Mdr e. coli specific antibody |
| ES2778074T3 (es) | 2013-10-11 | 2020-08-07 | Glaxosmithkline Biologicals Sa | Procedimientos de modificación de células hospedadoras |
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| RS65631B1 (sr) | 2014-02-24 | 2024-07-31 | Glaxosmithkline Biologicals Sa | Novi polisaharid i njegove upotrebe |
| SI3240895T1 (sl) | 2014-12-30 | 2022-04-29 | Glaxosmithkline Biologicals S.A. | Sestavki in postopki za glikozilacijo proteinov |
| TWI715617B (zh) | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
| AR109621A1 (es) | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
| GB201711635D0 (en) | 2017-07-19 | 2017-08-30 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
| IL286467B1 (en) | 2019-03-18 | 2025-10-01 | Janssen Pharmaceuticals Inc | Methods for producing bioconjugates of E. COLI O-antigen polysaccharides, preparations thereof and methods for using them |
| PE20212265A1 (es) | 2019-03-18 | 2021-11-30 | Janssen Pharmaceuticals Inc | Bioconjugados de antigenos-polisacaridos de e. coli, metodos de produccion y metodos de utilizacion de los mismos |
| FR3098334B1 (fr) | 2019-07-05 | 2021-07-23 | Airbus Operations Sas | Procédé et système de surveillance d’un état de conscience d’un opérateur dans un poste de pilotage d’un aéronef |
-
2016
- 2016-08-23 TW TW105126945A patent/TWI715617B/zh active
- 2016-08-24 RS RS20230664A patent/RS64449B1/sr unknown
- 2016-08-24 MX MX2018002340A patent/MX2018002340A/es unknown
- 2016-08-24 EP EP16760616.9A patent/EP3341016B9/en active Active
- 2016-08-24 CN CN201680062232.7A patent/CN108430500B/zh active Active
- 2016-08-24 PL PL16760616.9T patent/PL3341016T3/pl unknown
- 2016-08-24 KR KR1020187007898A patent/KR102735147B1/ko active Active
- 2016-08-24 WO PCT/US2016/048278 patent/WO2017035181A1/en not_active Ceased
- 2016-08-24 AU AU2016312422A patent/AU2016312422B2/en active Active
- 2016-08-24 HR HRP20230947TT patent/HRP20230947T1/hr unknown
- 2016-08-24 EA EA201890400A patent/EA037500B1/ru unknown
- 2016-08-24 SM SM20230220T patent/SMT202300220T1/it unknown
- 2016-08-24 JP JP2018510886A patent/JP6872532B2/ja active Active
- 2016-08-24 EP EP23176994.4A patent/EP4245320A3/en active Pending
- 2016-08-24 ES ES16760616T patent/ES2951408T3/es active Active
- 2016-08-24 US US15/754,867 patent/US10583185B2/en active Active
- 2016-08-24 HU HUE16760616A patent/HUE063961T2/hu unknown
- 2016-08-24 BR BR112018003469A patent/BR112018003469A2/pt not_active Application Discontinuation
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2018
- 2018-02-19 IL IL257608A patent/IL257608B/en unknown
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2020
- 2020-02-04 US US16/781,526 patent/US11484582B2/en active Active
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2022
- 2022-09-23 US US17/934,781 patent/US12076385B2/en active Active
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