PL3325011T6 - Białka fuzyjne fragmentów białka ludzkiego do tworzenia uporządkowanych multimeryzowanych kompozycji Fc immunoglobuliny o wzmocnionym wiązaniu dopełniacza - Google Patents

Białka fuzyjne fragmentów białka ludzkiego do tworzenia uporządkowanych multimeryzowanych kompozycji Fc immunoglobuliny o wzmocnionym wiązaniu dopełniacza

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Publication number
PL3325011T6
PL3325011T6 PL16831166.0T PL16831166T PL3325011T6 PL 3325011 T6 PL3325011 T6 PL 3325011T6 PL 16831166 T PL16831166 T PL 16831166T PL 3325011 T6 PL3325011 T6 PL 3325011T6
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PL
Poland
Prior art keywords
compositions
fusion proteins
human protein
protein fragments
complement binding
Prior art date
Application number
PL16831166.0T
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English (en)
Other versions
PL3325011T3 (pl
Inventor
David S. Block
Henrik Olsen
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Gliknik Inc.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=57885189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3325011(T6) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gliknik Inc. filed Critical Gliknik Inc.
Publication of PL3325011T3 publication Critical patent/PL3325011T3/pl
Publication of PL3325011T6 publication Critical patent/PL3325011T6/pl

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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1774Immunoglobulin superfamily (e.g. CD2, CD4, CD8, ICAM molecules, B7 molecules, Fc-receptors, MHC-molecules)
    • AHUMAN NECESSITIES
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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
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    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35Valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
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    • C07ORGANIC CHEMISTRY
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    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/524CH2 domain
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    • C07K2317/526CH3 domain
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    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734Complement-dependent cytotoxicity [CDC]
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    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
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    • C07K2319/00Fusion polypeptide
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    • C07ORGANIC CHEMISTRY
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    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/73Fusion polypeptide containing domain for protein-protein interaction containing coiled-coiled motif (leucine zippers)

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PL16831166.0T 2015-07-24 2016-07-22 Białka fuzyjne fragmentów białka ludzkiego do tworzenia uporządkowanych multimeryzowanych kompozycji Fc immunoglobuliny o wzmocnionym wiązaniu dopełniacza PL3325011T6 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562196478P 2015-07-24 2015-07-24
EP16831166.0A EP3325011B3 (en) 2015-07-24 2016-07-22 Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin fc compositions with enhanced complement binding
PCT/US2016/043746 WO2017019565A2 (en) 2015-07-24 2016-07-22 Fusion proteins of human protein fragments to create orderly multimerized immunoglobulin fc compositions with enhanced complement binding

Publications (2)

Publication Number Publication Date
PL3325011T3 PL3325011T3 (pl) 2021-05-17
PL3325011T6 true PL3325011T6 (pl) 2023-06-26

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ID=57885189

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Application Number Title Priority Date Filing Date
PL16831166.0T PL3325011T6 (pl) 2015-07-24 2016-07-22 Białka fuzyjne fragmentów białka ludzkiego do tworzenia uporządkowanych multimeryzowanych kompozycji Fc immunoglobuliny o wzmocnionym wiązaniu dopełniacza

Country Status (23)

Country Link
US (1) US20180244772A1 (pl)
EP (2) EP3828204A1 (pl)
JP (2) JP6937737B2 (pl)
KR (2) KR102649702B1 (pl)
CN (2) CN107847599B (pl)
AU (2) AU2016297862C1 (pl)
BR (1) BR112017028550A2 (pl)
CA (1) CA2991254A1 (pl)
CY (1) CY1123719T1 (pl)
DK (1) DK3325011T6 (pl)
ES (1) ES2846024T7 (pl)
FI (1) FI3325011T6 (pl)
HK (1) HK1254447A1 (pl)
HU (1) HUE053062T2 (pl)
IL (2) IL309260A (pl)
LT (1) LT3325011T (pl)
MX (2) MX2018000587A (pl)
PL (1) PL3325011T6 (pl)
PT (1) PT3325011T (pl)
RU (2) RU2737378C2 (pl)
SI (1) SI3325011T1 (pl)
TW (2) TWI812951B (pl)
WO (1) WO2017019565A2 (pl)

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EP3464347B1 (en) 2016-06-07 2023-05-31 Gliknik Inc. Cysteine-optimized stradomers
CN109641048A (zh) 2016-07-22 2019-04-16 格利克尼克股份有限公司 产生具有增强的Fc受体结合的经有序多聚化的免疫球蛋白Fc组合物的人蛋白片段的融合蛋白
CN110022898B (zh) * 2016-12-09 2023-07-04 格利克尼克股份有限公司 用多价Fc化合物治疗炎性疾病的方法
US11155574B2 (en) 2016-12-09 2021-10-26 Gliknik Inc. Manufacturing optimization of GL-2045, a multimerizing stradomer
EP3723791B1 (en) 2017-12-14 2024-02-21 CSL Behring Lengnau AG Recombinant igg fc multimers for the treatment of neuromyelitis optica
KR20220062084A (ko) 2019-09-13 2022-05-13 체에스엘 베링 렝나우 아게 면역 복합체 매개된 콩팥 장애의 치료를 위한 재조합 IgG Fc 다량체
JPWO2021193870A1 (pl) * 2020-03-26 2021-09-30
CN114478741B (zh) * 2021-12-31 2023-03-07 苏州大学 contactin 6蛋白突变体及其编码基因、表达载体与应用

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EP0307434B2 (en) * 1987-03-18 1998-07-29 Scotgen Biopharmaceuticals, Inc. Altered antibodies
EP0590060B1 (en) 1991-06-21 1997-09-17 University Of Cincinnati Orally administrable therapeutic proteins and method of making
US6194551B1 (en) * 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US20060235208A1 (en) * 2002-09-27 2006-10-19 Xencor, Inc. Fc variants with optimized properties
US20150071948A1 (en) * 2003-09-26 2015-03-12 Gregory Alan Lazar Novel immunoglobulin variants
WO2008114011A2 (en) * 2007-03-19 2008-09-25 Medimmune Limited Fc polypeptide variants obtained by ribosome display methodology
ES2565834T3 (es) 2007-06-01 2016-04-07 University Of Maryland, Baltimore Agentes de unión a receptor de Fc de región constante de inmunoglobulina
WO2011091078A2 (en) * 2010-01-19 2011-07-28 Xencor, Inc. Antibody fc variants with enhanced complement activity
MX368531B (es) * 2010-07-28 2019-10-07 Gliknik Inc Proteinas de fusion de fragmentos de proteinas humanas naturales para crear composiciones de fc de inmunoglobulinas multimerizadas ordenadamente.
CN103429620B (zh) * 2010-11-05 2018-03-06 酵活有限公司 在Fc结构域中具有突变的稳定异源二聚的抗体设计
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JP6851200B2 (ja) 2014-03-05 2021-03-31 ユーシービー バイオファルマ エスアールエル 多量体Fcタンパク質

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TW202134433A (zh) 2021-09-16
JP6937737B2 (ja) 2021-09-22
US20180244772A1 (en) 2018-08-30
ES2846024T7 (es) 2023-06-22
JP2021167325A (ja) 2021-10-21
WO2017019565A3 (en) 2017-03-09
PL3325011T3 (pl) 2021-05-17
TWI812951B (zh) 2023-08-21
FI3325011T6 (fi) 2023-05-11
BR112017028550A2 (pt) 2018-09-04
SI3325011T1 (sl) 2021-02-26
HUE053062T2 (hu) 2021-06-28
IL309260A (en) 2024-02-01
MX2018000587A (es) 2018-05-02
AU2016297862A1 (en) 2018-02-01
IL256879B1 (en) 2024-01-01
AU2016297862C1 (en) 2022-12-15
CN116063510A (zh) 2023-05-05
TW201713697A (zh) 2017-04-16
KR102649702B1 (ko) 2024-03-21
EP3325011B3 (en) 2023-03-15
CN107847599B (zh) 2022-10-04
RU2737378C2 (ru) 2020-11-27
LT3325011T (lt) 2021-01-25
RU2018106332A (ru) 2019-08-26
ES2846024T3 (es) 2021-07-28
KR20240042137A (ko) 2024-04-01
CY1123719T1 (el) 2022-05-27
PT3325011T (pt) 2021-01-27
EP3325011A4 (en) 2019-03-13
IL256879B2 (en) 2024-05-01
CA2991254A1 (en) 2017-02-02
AU2016297862B2 (en) 2022-06-09
DK3325011T6 (da) 2023-05-15
JP2018528167A (ja) 2018-09-27
EP3828204A1 (en) 2021-06-02
MX2022008337A (es) 2022-08-04
EP3325011A2 (en) 2018-05-30
RU2018106332A3 (pl) 2019-11-13
DK3325011T3 (da) 2020-12-14
KR20180031676A (ko) 2018-03-28
EP3325011B1 (en) 2020-11-18
RU2020138007A (ru) 2020-12-17
IL256879A (en) 2018-03-29
TWI729993B (zh) 2021-06-11
CN107847599A (zh) 2018-03-27
JP7122440B2 (ja) 2022-08-19
WO2017019565A2 (en) 2017-02-02
AU2022224791A1 (en) 2022-10-06
HK1254447A1 (zh) 2019-07-19

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