PL328228A1 - 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous system - Google Patents

1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous system

Info

Publication number
PL328228A1
PL328228A1 PL97328228A PL32822897A PL328228A1 PL 328228 A1 PL328228 A1 PL 328228A1 PL 97328228 A PL97328228 A PL 97328228A PL 32822897 A PL32822897 A PL 32822897A PL 328228 A1 PL328228 A1 PL 328228A1
Authority
PL
Poland
Prior art keywords
piperidines
indol
pyrazol
ethyl
nervous system
Prior art date
Application number
PL97328228A
Other languages
English (en)
Inventor
Henning Boettcher
Joachim Maerz
Gerd Bartoszyk
Hartmut Greiner
Juergen Harting
Christoph Seyfried
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of PL328228A1 publication Critical patent/PL328228A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PL97328228A 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous system PL328228A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19602505A DE19602505A1 (de) 1996-01-25 1996-01-25 1-(Pyrazol-4-Indol-3-yl)-Piperidine
PCT/EP1997/000187 WO1997027186A1 (de) 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidine als das zentralnervensystem beeinflussende mittel

Publications (1)

Publication Number Publication Date
PL328228A1 true PL328228A1 (en) 1999-01-18

Family

ID=7783568

Family Applications (1)

Application Number Title Priority Date Filing Date
PL97328228A PL328228A1 (en) 1996-01-25 1997-01-17 1-(pyrazol-3-yl-ethyl)-4-(indol-3-yl)-piperidines as agents influencing the central nervous system

Country Status (16)

Country Link
EP (1) EP0879234A1 (cs)
JP (1) JP2000503972A (cs)
KR (1) KR19990081970A (cs)
CN (1) CN1209807A (cs)
AR (1) AR005549A1 (cs)
AU (1) AU715785B2 (cs)
BR (1) BR9707467A (cs)
CA (1) CA2244136A1 (cs)
CZ (1) CZ231898A3 (cs)
DE (1) DE19602505A1 (cs)
HU (1) HUP9900980A2 (cs)
NO (1) NO983439L (cs)
PL (1) PL328228A1 (cs)
SK (1) SK99298A3 (cs)
WO (1) WO1997027186A1 (cs)
ZA (1) ZA97572B (cs)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001021614A1 (en) * 1999-09-09 2001-03-29 H. Lundbeck A/S 5-aminoalkyl and 5-aminocarbonyl substituted indoles
CZ20021604A3 (cs) 1999-11-10 2002-09-11 Takeda Chemical Industries, Ltd. Pětičlenné N-heterocyklické sloučeniny, farmaceutický přípravek a činidlo je obsahující a jejich použití
US7309703B2 (en) 2000-08-14 2007-12-18 Ortho Mcneil Pharmaceutical, Inc. Substituted pyrazoles
US7332494B2 (en) 2000-08-14 2008-02-19 Janssen Pharmaceutica, N.V. Method for treating allergies using substituted pyrazoles
US20050026927A1 (en) * 2001-11-14 2005-02-03 Henning Boettcher Pyrazole derivatives as psychopharmaceuticals
BRPI0617204A2 (pt) 2005-10-11 2011-07-19 Hoffmann La Roche derivados de imidazo benzodiazepina
EP1945213A4 (en) * 2005-10-24 2009-12-02 Janssen Pharmaceutica Nv MODULATORS OF THE R3-PIPERIDINE-4-YL-INDOLE ORL-1 RECEPTOR
TWI548630B (zh) 2011-04-06 2016-09-11 Ｌｇ生命科學有限公司 １－（３－氰基－１－異丙基－吲哚－５－基）吡唑－４－羧酸結晶型及其製造方法
US20240000750A1 (en) * 2020-11-04 2024-01-04 Lg Chem, Ltd. Method for preparing crystalline particles of 1-(3-cyano-1-isopropyl-indole-5-yl)pyrazole-4-carboxylic acid, and pharmaceutical composition comprising same
WO2025021120A1 (zh) * 2023-07-24 2025-01-30 上海翊石医药科技有限公司 一类5-ht2a受体激动剂及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2060816C3 (de) * 1970-12-10 1980-09-04 Merck Patent Gmbh, 6100 Darmstadt 4-Phenylpiperidinderivate Verfahren zu ihrer Herstellung und pharmazeutische Zubereitungen enthaltend diese Verbindungen
DE2258033A1 (de) * 1972-11-27 1974-05-30 Merck Patent Gmbh Verfahren zur herstellung von pyrazolderivaten
GB8719167D0 (en) * 1987-08-13 1987-09-23 Glaxo Group Ltd Chemical compounds
US5045550A (en) * 1990-09-20 1991-09-03 Warner-Lambert Co. Substituted tetrahydropyridines as central nervous system agents
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine

Also Published As

Publication number Publication date
KR19990081970A (ko) 1999-11-15
CZ231898A3 (cs) 1998-10-14
NO983439D0 (no) 1998-07-24
ZA97572B (en) 1997-08-04
AU1443297A (en) 1997-08-20
CA2244136A1 (en) 1997-07-31
SK99298A3 (en) 1999-01-11
DE19602505A1 (de) 1997-07-31
NO983439L (no) 1998-09-25
BR9707467A (pt) 1999-07-20
AR005549A1 (es) 1999-06-23
WO1997027186A1 (de) 1997-07-31
HUP9900980A2 (hu) 1999-07-28
AU715785B2 (en) 2000-02-10
CN1209807A (zh) 1999-03-03
EP0879234A1 (de) 1998-11-25
JP2000503972A (ja) 2000-04-04

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