PL3277682T3 - Pochodne 6-morfolinylo-2-pirazolylo-9h-puryny i ich zastosowanie jako inhibitory pi3k - Google Patents
Pochodne 6-morfolinylo-2-pirazolylo-9h-puryny i ich zastosowanie jako inhibitory pi3kInfo
- Publication number
- PL3277682T3 PL3277682T3 PL16718910T PL16718910T PL3277682T3 PL 3277682 T3 PL3277682 T3 PL 3277682T3 PL 16718910 T PL16718910 T PL 16718910T PL 16718910 T PL16718910 T PL 16718910T PL 3277682 T3 PL3277682 T3 PL 3277682T3
- Authority
- PL
- Poland
- Prior art keywords
- morpholinyl
- pyrazolyl
- purine derivatives
- pi3k inhibitors
- pi3k
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN878DE2015 | 2015-03-30 | ||
| EP16718910.9A EP3277682B1 (en) | 2015-03-30 | 2016-03-29 | 6-morpholinyl-2-pyrazolyl-9h-purine derivatives and their use as pi3k inhibitors |
| PCT/IB2016/051762 WO2016157074A1 (en) | 2015-03-30 | 2016-03-29 | 6-morpholinyl-2-pyrazolyl-9h-purine derivatives and their use as pi3k inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3277682T3 true PL3277682T3 (pl) | 2019-09-30 |
Family
ID=55854760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL16718910T PL3277682T3 (pl) | 2015-03-30 | 2016-03-29 | Pochodne 6-morfolinylo-2-pirazolylo-9h-puryny i ich zastosowanie jako inhibitory pi3k |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US10174035B2 (pl) |
| EP (1) | EP3277682B1 (pl) |
| JP (1) | JP6669417B2 (pl) |
| KR (1) | KR20170131444A (pl) |
| CN (1) | CN107428756B (pl) |
| AU (1) | AU2016242080B2 (pl) |
| BR (1) | BR112017020818A2 (pl) |
| CA (1) | CA2980517C (pl) |
| CO (1) | CO2017011020A2 (pl) |
| CY (1) | CY1122018T1 (pl) |
| DK (1) | DK3277682T3 (pl) |
| ES (1) | ES2733505T3 (pl) |
| HK (1) | HK1250161B (pl) |
| HR (1) | HRP20190998T1 (pl) |
| HU (1) | HUE045192T2 (pl) |
| IL (1) | IL254688B (pl) |
| LT (1) | LT3277682T (pl) |
| MX (1) | MX2017012390A (pl) |
| MY (1) | MY185268A (pl) |
| PH (1) | PH12017501750A1 (pl) |
| PL (1) | PL3277682T3 (pl) |
| PT (1) | PT3277682T (pl) |
| RS (1) | RS59213B1 (pl) |
| RU (1) | RU2710549C2 (pl) |
| SG (1) | SG11201706509QA (pl) |
| SI (1) | SI3277682T1 (pl) |
| SM (1) | SMT201900405T1 (pl) |
| TR (1) | TR201910941T4 (pl) |
| TW (1) | TWI689508B (pl) |
| WO (1) | WO2016157074A1 (pl) |
| ZA (1) | ZA201705530B (pl) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2018062382A1 (ja) * | 2016-09-29 | 2019-07-11 | 第一三共株式会社 | ［２−（１−メチル−１ｈ−ピラゾール−４−イル）−６−（モルホリン−４−イル）−９ｈ−プリン−８−イル］［４−（モルホリン−４−イル）ピペリジン−１−イル］メタノン及びその製薬上許容される塩の結晶 |
| CN107163061A (zh) * | 2017-04-14 | 2017-09-15 | 江西科技师范大学 | 含吡唑啉结构的噻吩并嘧啶类化合物的制备及应用 |
| CN110963955A (zh) * | 2018-09-30 | 2020-04-07 | 南京富润凯德生物医药有限公司 | 一种单氟代螺环化合物的合成方法及其中间体 |
| CN111087336A (zh) * | 2018-10-24 | 2020-05-01 | 南京富润凯德生物医药有限公司 | 一种双氟代螺环化合物的合成方法及其中间体 |
| CN110577515B (zh) * | 2019-09-02 | 2022-05-17 | 南通大学 | 一种4-(氮杂环丁烷-3-基)-1-甲基哌嗪-2-酮二盐酸盐的合成方法 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4768265B2 (ja) | 2002-10-15 | 2011-09-07 | シンタ ファーマシューティカルズ コーポレーション | 新規化合物 |
| TW200510394A (en) | 2003-05-29 | 2005-03-16 | Synta Pharmaceuticals Corp | Heterocyclic compounds for preventing and treating disorders associated with excessive bone loss |
| GB2431156A (en) | 2005-10-11 | 2007-04-18 | Piramed Ltd | 1-cyclyl-3-substituted- -benzenes and -azines as inhibitors of phosphatidylinositol 3-kinase |
| PL2041139T3 (pl) * | 2006-04-26 | 2012-05-31 | Hoffmann La Roche | Związki farmaceutyczne |
| MX2008013583A (es) * | 2006-04-26 | 2008-10-31 | Genentech Inc | Compuestos del inhibidor de fosfoinositido 3-cinasa y composiciones farmaceuticas que los contienen. |
| US20080233127A1 (en) | 2007-03-21 | 2008-09-25 | Wyeth | Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors |
| WO2009034386A1 (en) | 2007-09-13 | 2009-03-19 | Astrazeneca Ab | Derivatives of adenine and 8-aza-adenine and uses thereof-796 |
| WO2009045174A1 (en) | 2007-10-05 | 2009-04-09 | S*Bio Pte Ltd | 2-morpholinylpurines as inhibitors of pi3k |
| CN104119336B (zh) | 2007-10-05 | 2016-08-24 | 维拉斯通股份有限公司 | 嘧啶取代的嘌呤衍生物 |
| ES2537624T3 (es) | 2007-10-26 | 2015-06-10 | F. Hoffmann-La Roche Ag | Derivados purina útiles como inhibidores de la quinasa PI3 |
| EP2244709A4 (en) | 2008-02-07 | 2012-02-29 | Synta Pharmaceuticals Corp | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS |
| CA2721851A1 (en) | 2008-05-30 | 2009-12-03 | Genentech, Inc. | Purine pi3k inhibitor compounds and methods of use |
| CA2730271A1 (en) | 2008-07-07 | 2010-01-14 | Xcovery Holding Company Llc | Pi3k isoform selective inhibitors |
| TWI378933B (en) | 2008-10-14 | 2012-12-11 | Daiichi Sankyo Co Ltd | Morpholinopurine derivatives |
| WO2010114494A1 (en) | 2009-04-03 | 2010-10-07 | S*Bio Pte Ltd | 8-substituted-2-morpholino purines for use as pi3k and/or mtor inhibitors in the treatment of proliferative disorders |
| WO2010136491A1 (en) | 2009-05-27 | 2010-12-02 | F. Hoffmann-La Roche Ag | Bicyclic indole-pyrimidine pi3k inhibitor compounds selective for p110 delta, and methods of use |
| US8173650B2 (en) * | 2009-05-27 | 2012-05-08 | Genentech, Inc. | Bicyclic pyrimidine PI3K inhibitor compounds selective for P110 delta, and methods of use |
| MX2012005463A (es) | 2009-11-12 | 2012-09-12 | Hoffmann La Roche | Compuestos de purina n/9 sustituida, composiciones y metodos de uso. |
| CA2802808A1 (en) | 2010-07-14 | 2012-01-19 | F. Hoffmann-La Roche Ag | Purine compounds selective for pi3k p110 delta, and methods of use |
| JP5954838B2 (ja) | 2010-09-14 | 2016-07-20 | エクセリクシス， インク． | Ｐｉ３ｋ−デルタの阻害剤ならびにそれらの使用法および製造法 |
| CA2820078C (en) | 2010-12-16 | 2019-02-12 | F. Hoffmann-La Roche Ag | Tricyclic pi3k inhibitor compounds and methods of use |
| MX343706B (es) | 2011-01-31 | 2016-11-18 | Novartis Ag | Derivados heterocíclicos novedosos. |
| JP5766820B2 (ja) | 2011-02-09 | 2015-08-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｐｉ３キナーゼ阻害剤としての複素環化合物 |
-
2016
- 2016-03-29 KR KR1020177026959A patent/KR20170131444A/ko not_active Withdrawn
- 2016-03-29 HU HUE16718910A patent/HUE045192T2/hu unknown
- 2016-03-29 HR HRP20190998TT patent/HRP20190998T1/hr unknown
- 2016-03-29 HK HK18109578.1A patent/HK1250161B/en not_active IP Right Cessation
- 2016-03-29 LT LTEP16718910.9T patent/LT3277682T/lt unknown
- 2016-03-29 MY MYPI2017001151A patent/MY185268A/en unknown
- 2016-03-29 AU AU2016242080A patent/AU2016242080B2/en not_active Ceased
- 2016-03-29 WO PCT/IB2016/051762 patent/WO2016157074A1/en not_active Ceased
- 2016-03-29 EP EP16718910.9A patent/EP3277682B1/en active Active
- 2016-03-29 TW TW105109845A patent/TWI689508B/zh not_active IP Right Cessation
- 2016-03-29 SM SM20190405T patent/SMT201900405T1/it unknown
- 2016-03-29 US US15/560,466 patent/US10174035B2/en active Active
- 2016-03-29 BR BR112017020818-0A patent/BR112017020818A2/pt not_active IP Right Cessation
- 2016-03-29 PL PL16718910T patent/PL3277682T3/pl unknown
- 2016-03-29 RU RU2017134110A patent/RU2710549C2/ru active
- 2016-03-29 SI SI201630267T patent/SI3277682T1/sl unknown
- 2016-03-29 CA CA2980517A patent/CA2980517C/en not_active Expired - Fee Related
- 2016-03-29 ES ES16718910T patent/ES2733505T3/es active Active
- 2016-03-29 JP JP2017545934A patent/JP6669417B2/ja not_active Expired - Fee Related
- 2016-03-29 SG SG11201706509QA patent/SG11201706509QA/en unknown
- 2016-03-29 TR TR2019/10941T patent/TR201910941T4/tr unknown
- 2016-03-29 MX MX2017012390A patent/MX2017012390A/es active IP Right Grant
- 2016-03-29 PT PT16718910T patent/PT3277682T/pt unknown
- 2016-03-29 RS RSP20190941 patent/RS59213B1/sr unknown
- 2016-03-29 DK DK16718910.9T patent/DK3277682T3/da active
- 2016-03-29 CN CN201680019892.7A patent/CN107428756B/zh not_active Expired - Fee Related
-
2017
- 2017-08-15 ZA ZA2017/05530A patent/ZA201705530B/en unknown
- 2017-09-25 PH PH12017501750A patent/PH12017501750A1/en unknown
- 2017-09-25 IL IL254688A patent/IL254688B/en active IP Right Grant
- 2017-10-27 CO CONC2017/0011020A patent/CO2017011020A2/es unknown
-
2019
- 2019-07-19 CY CY20191100773T patent/CY1122018T1/el unknown
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