PL327693A1 - Application of cellular na+/h+(nhe) ions exchanger inhibitors in production of a respiration stimulating drug - Google Patents

Application of cellular na+/h+(nhe) ions exchanger inhibitors in production of a respiration stimulating drug

Info

Publication number
PL327693A1
PL327693A1 PL96327693A PL32769396A PL327693A1 PL 327693 A1 PL327693 A1 PL 327693A1 PL 96327693 A PL96327693 A PL 96327693A PL 32769396 A PL32769396 A PL 32769396A PL 327693 A1 PL327693 A1 PL 327693A1
Authority
PL
Poland
Prior art keywords
nhe
cellular
production
application
stimulating drug
Prior art date
Application number
PL96327693A
Other languages
English (en)
Inventor
Klaus Wirth
Wolfgang Scholz
Hans-Willi Jansen
Hans Jochen Lang
Joachim Brendel
Heinz-Werner Kleemann
Jan-Robert Schwark
Andreas Weichert
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of PL327693A1 publication Critical patent/PL327693A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60L—PROPULSION OF ELECTRICALLY-PROPELLED VEHICLES; SUPPLYING ELECTRIC POWER FOR AUXILIARY EQUIPMENT OF ELECTRICALLY-PROPELLED VEHICLES; ELECTRODYNAMIC BRAKE SYSTEMS FOR VEHICLES IN GENERAL; MAGNETIC SUSPENSION OR LEVITATION FOR VEHICLES; MONITORING OPERATING VARIABLES OF ELECTRICALLY-PROPELLED VEHICLES; ELECTRIC SAFETY DEVICES FOR ELECTRICALLY-PROPELLED VEHICLES
    • B60L50/00—Electric propulsion with power supplied within the vehicle
    • B60L50/50—Electric propulsion with power supplied within the vehicle using propulsion power supplied by batteries or fuel cells
    • B60L50/60—Electric propulsion with power supplied within the vehicle using propulsion power supplied by batteries or fuel cells using power supplied by batteries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60L—PROPULSION OF ELECTRICALLY-PROPELLED VEHICLES; SUPPLYING ELECTRIC POWER FOR AUXILIARY EQUIPMENT OF ELECTRICALLY-PROPELLED VEHICLES; ELECTRODYNAMIC BRAKE SYSTEMS FOR VEHICLES IN GENERAL; MAGNETIC SUSPENSION OR LEVITATION FOR VEHICLES; MONITORING OPERATING VARIABLES OF ELECTRICALLY-PROPELLED VEHICLES; ELECTRIC SAFETY DEVICES FOR ELECTRICALLY-PROPELLED VEHICLES
    • B60L7/00—Electrodynamic brake systems for vehicles in general
    • B60L7/10—Dynamic electric regenerative braking
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B60—VEHICLES IN GENERAL
    • B60L—PROPULSION OF ELECTRICALLY-PROPELLED VEHICLES; SUPPLYING ELECTRIC POWER FOR AUXILIARY EQUIPMENT OF ELECTRICALLY-PROPELLED VEHICLES; ELECTRODYNAMIC BRAKE SYSTEMS FOR VEHICLES IN GENERAL; MAGNETIC SUSPENSION OR LEVITATION FOR VEHICLES; MONITORING OPERATING VARIABLES OF ELECTRICALLY-PROPELLED VEHICLES; ELECTRIC SAFETY DEVICES FOR ELECTRICALLY-PROPELLED VEHICLES
    • B60L7/00—Electrodynamic brake systems for vehicles in general
    • B60L7/10—Dynamic electric regenerative braking
    • B60L7/16—Dynamic electric regenerative braking for vehicles comprising converters between the power source and the motor
    • E—FIXED CONSTRUCTIONS
    • E01—CONSTRUCTION OF ROADS, RAILWAYS, OR BRIDGES
    • E01C—CONSTRUCTION OF, OR SURFACES FOR, ROADS, SPORTS GROUNDS, OR THE LIKE; MACHINES OR AUXILIARY TOOLS FOR CONSTRUCTION OR REPAIR
    • E01C19/00—Machines, tools or auxiliary devices for preparing or distributing paving materials, for working the placed materials, or for forming, consolidating, or finishing the paving
    • E01C19/22—Machines, tools or auxiliary devices for preparing or distributing paving materials, for working the placed materials, or for forming, consolidating, or finishing the paving for consolidating or finishing laid-down unset materials
    • E01C19/23—Rollers therefor; Such rollers usable also for compacting soil
    • E01C19/26—Rollers therefor; Such rollers usable also for compacting soil self-propelled or fitted to road vehicles
    • E—FIXED CONSTRUCTIONS
    • E01—CONSTRUCTION OF ROADS, RAILWAYS, OR BRIDGES
    • E01C—CONSTRUCTION OF, OR SURFACES FOR, ROADS, SPORTS GROUNDS, OR THE LIKE; MACHINES OR AUXILIARY TOOLS FOR CONSTRUCTION OR REPAIR
    • E01C19/00—Machines, tools or auxiliary devices for preparing or distributing paving materials, for working the placed materials, or for forming, consolidating, or finishing the paving
    • E01C19/22—Machines, tools or auxiliary devices for preparing or distributing paving materials, for working the placed materials, or for forming, consolidating, or finishing the paving for consolidating or finishing laid-down unset materials
    • E01C19/23—Rollers therefor; Such rollers usable also for compacting soil
    • E01C19/28—Vibrated rollers or rollers subjected to impacts, e.g. hammering blows

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Transportation (AREA)
  • Power Engineering (AREA)
  • Civil Engineering (AREA)
  • Architecture (AREA)
  • Structural Engineering (AREA)
  • Sustainable Energy (AREA)
  • Sustainable Development (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
PL96327693A 1995-12-27 1996-12-13 Application of cellular na+/h+(nhe) ions exchanger inhibitors in production of a respiration stimulating drug PL327693A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19548812A DE19548812A1 (de) 1995-12-27 1995-12-27 Verwendung von Inhibitoren des zellulären Na·+·/H·+·-Exchangers (NHE) zur Herstellung eines Medikaments zur Atemstimulation
PCT/EP1996/005614 WO1997024113A1 (de) 1995-12-27 1996-12-13 VERWENDUNG VON INHIBITOREN DES ZELLULÄREN Na+/H+-EXCHANGERS (NHE) ZUR HERSTELLUNG EINES MEDIKAMENTS ZUR ATEMSTIMULATION

Publications (1)

Publication Number Publication Date
PL327693A1 true PL327693A1 (en) 1998-12-21

Family

ID=7781474

Family Applications (1)

Application Number Title Priority Date Filing Date
PL96327693A PL327693A1 (en) 1995-12-27 1996-12-13 Application of cellular na+/h+(nhe) ions exchanger inhibitors in production of a respiration stimulating drug

Country Status (16)

Country Link
EP (1) EP0869779A1 (de)
KR (1) KR19990076802A (de)
CN (1) CN1207676A (de)
AU (1) AU717247B2 (de)
BR (1) BR9612287A (de)
CA (1) CA2241531A1 (de)
CZ (1) CZ202198DA3 (de)
DE (1) DE19548812A1 (de)
HU (1) HUP9900807A3 (de)
IL (1) IL125114A0 (de)
MX (1) MX9805141A (de)
NO (1) NO982989L (de)
PL (1) PL327693A1 (de)
SK (1) SK88398A3 (de)
TR (1) TR199801235T2 (de)
WO (1) WO1997024113A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9504537D0 (sv) * 1995-12-19 1995-12-19 Jan Hedner Sätt att behandla och diagnosticera andningsstörningar under sömn och medel för utförande av sättet
DE19945302A1 (de) * 1999-09-22 2001-03-29 Merck Patent Gmbh Biphenylderivate als NHE-3-Inhibitoren
DE10060292A1 (de) 2000-12-05 2002-06-20 Aventis Pharma Gmbh Verwendung substituierter Benzimidazole zur Herstellung eines Medikaments zur Behandlung von Krankheiten, welche durch Inhibierung des Na+/H+-Austauschers beeinflusst werden können und sie enthaltendes Medikament
DE10163239A1 (de) * 2001-12-21 2003-07-10 Aventis Pharma Gmbh Substituierte Imidazolidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie enthaltendes Medikament
WO2018129556A1 (en) 2017-01-09 2018-07-12 Ardelyx, Inc. Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
ES2657938T3 (es) 2008-12-31 2018-03-07 Ardelyx, Inc. Compuestos y métodos para inhibir el antipuerto mediado por NHE en el tratamiento de trastornos asociados a la retención de líquidos o a la sobrecarga de sales y trastornos del tracto gastrointestinal
US10376481B2 (en) 2012-08-21 2019-08-13 Ardelyx, Inc. Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders
CN104902930A (zh) 2012-08-21 2015-09-09 阿德利克斯公司 在治疗与液体潴留或盐分过载相关的疾病和胃肠道疾病中用于抑制nhe-介导的反向转运的化合物和方法
ES2735992T3 (es) 2013-04-12 2019-12-23 Ardelyx Inc Compuestos de unión a NHE3 y procedimientos para inhibir el transporte de fosfatos
LT3173408T (lt) 2014-07-25 2018-12-27 Taisho Pharmaceutical Co., Ltd. Fenilo tetrahidroizochinolino junginys, turintis heteroarilo pakaitų
EP3565808A1 (de) 2017-01-09 2019-11-13 Ardelyx, Inc. Verbindungen zur behandlung erkrankungen des magen-darm-traktes
EA201991676A1 (ru) 2017-01-09 2020-01-30 Арделикс, Инк. Ингибиторы nhe-опосредованного антипорта
BR112020002322A2 (pt) 2017-08-04 2020-09-01 Ardelyx, Inc. derivados de ácido glicirretinínico para o tratamento de hipercalemia
AU2020218255A1 (en) 2019-02-07 2021-09-09 Ardelyx, Inc. Glycyrrhetinic acid derivatives for use in treating hyperkalemia
JP2022533251A (ja) 2019-05-21 2022-07-21 アルデリックス， インコーポレイテッド 患者において血清リン酸塩を低下させるための組み合わせ

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4325822A1 (de) * 1993-07-31 1995-02-02 Hoechst Ag Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP0639573A1 (de) * 1993-08-03 1995-02-22 Hoechst Aktiengesellschaft Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament
DE4337609A1 (de) * 1993-11-04 1995-05-11 Boehringer Ingelheim Kg Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln
DE4415873A1 (de) * 1994-05-05 1995-11-09 Hoechst Ag Substituierte bizyklische Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament

Also Published As

Publication number Publication date
MX9805141A (es) 1998-10-31
SK88398A3 (en) 1999-03-12
NO982989D0 (no) 1998-06-26
DE19548812A1 (de) 1997-07-03
KR19990076802A (ko) 1999-10-15
HUP9900807A3 (en) 2000-11-28
CN1207676A (zh) 1999-02-10
EP0869779A1 (de) 1998-10-14
TR199801235T2 (xx) 1998-10-21
BR9612287A (pt) 2005-05-24
NO982989L (no) 1998-08-06
HUP9900807A2 (hu) 1999-07-28
CA2241531A1 (en) 1997-07-10
CZ202198DA3 (cs) 1998-11-11
AU1372097A (en) 1997-07-28
AU717247B2 (en) 2000-03-23
IL125114A0 (en) 1999-01-26
WO1997024113A1 (de) 1997-07-10

Similar Documents

Publication Publication Date Title
CZ202198DA3 (cs) Použití inhibitorů výměny Na+/H+ k přípravě léčiva k léčení narušené stimulace dýchání
PL322613A1 (en) Application of derivatives of vitamins d2 or d4 in production of a drug for treating secondary hyperparathyroidism
PL312064A1 (en) Soft gelatinous form of pharmaceutical dose
PL325363A1 (en) Novel 1,4-benzothiazepin 1,1-dioxides, method of obtaining them, pharmaceutic agent, therapeutic process employing them and their application in production of a pharmaceutic agent
PL330412A1 (en) Application of cellular na/h ion exchanger (nhe) in production of a drug serving to normalise the level of lipoids in blood serum
GB9411488D0 (en) Method of magnetically stimulating neural cells
ZA953006B (en) Human bone stimulating factor
IL78980A0 (en) Nasal pharmaceutical compositions and their production
IL74561A0 (en) Medicinal plasters and their production
HUT64540A (en) New biologically active eburnamine derivatives and method for producing them
EP0196546A3 (en) Pharmaceutical tableting method
PL312693A1 (en) Oxathiolanes, method of their production and pharmaceutical compounds containing them
PL311257A1 (en) New compounds and method of their production as well as pharmaceutical compounds and method of its production
CS938384A1 (en) Pharmaceutical agent for breathlesness therapy and method of its production
PL324656A1 (en) Inhibition of cellular respiration and production of made interfile plants
HUP9802589A3 (en) Bone stimulating factor
GB2304977B (en) Production of electrodes
EP0568300A3 (en) Interleukin-4 as a stimulator of bone formation
GR970300040T1 (en) A ranitidine tablet having a hydroxypropylmethylcellulose containing coating and a method for producing said coating
IS3984A (is) Aðferð við framleiðslu á lyfjablöndu sem ætluð ertil staðbundinnar meðferðar við liðagigt og notkun á henni
GB2306739B (en) Improvements relating to computerized correction of numeric data
PL328265A1 (en) Application of na/h ion exchanger inhibitor in production of a pharmaceutic agent, method of obtaining a pharmaceutic agent and pharmaceutic agent as such
PL328366A1 (en) Application of na /h ion exchanger inhibitors in production of a pharmaceutic agent, method of obtaining such agent and pharmaceutic agent obtained thereby
GB9524942D0 (en) Drug therapy
PL326844A1 (en) Novel derivatives of quinosalinodione, their production and implementation in drugs