PL3125894T3 - Proleki inhibitorów odwrotnej transkryptazy hiv - Google Patents
Proleki inhibitorów odwrotnej transkryptazy hivInfo
- Publication number
- PL3125894T3 PL3125894T3 PL15774282T PL15774282T PL3125894T3 PL 3125894 T3 PL3125894 T3 PL 3125894T3 PL 15774282 T PL15774282 T PL 15774282T PL 15774282 T PL15774282 T PL 15774282T PL 3125894 T3 PL3125894 T3 PL 3125894T3
- Authority
- PL
- Poland
- Prior art keywords
- prodrugs
- reverse transcriptase
- transcriptase inhibitors
- hiv reverse
- hiv
- Prior art date
Links
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461973689P | 2014-04-01 | 2014-04-01 | |
| EP15774282.6A EP3125894B1 (en) | 2014-04-01 | 2015-03-27 | Prodrugs of hiv reverse transcriptase inhibitors |
| PCT/US2015/022868 WO2015153304A1 (en) | 2014-04-01 | 2015-03-27 | Prodrugs of hiv reverse transcriptase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3125894T3 true PL3125894T3 (pl) | 2021-02-08 |
Family
ID=54241131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15774282T PL3125894T3 (pl) | 2014-04-01 | 2015-03-27 | Proleki inhibitorów odwrotnej transkryptazy hiv |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10004740B2 (pl) |
| EP (2) | EP3125894B1 (pl) |
| JP (1) | JP6342011B2 (pl) |
| KR (1) | KR102440843B1 (pl) |
| CN (1) | CN106456639B (pl) |
| AU (1) | AU2015241247B2 (pl) |
| BR (1) | BR112016022722B8 (pl) |
| CA (1) | CA2944187C (pl) |
| CY (1) | CY1123582T1 (pl) |
| DK (1) | DK3125894T3 (pl) |
| ES (1) | ES2828951T3 (pl) |
| HR (1) | HRP20201780T1 (pl) |
| HU (1) | HUE051848T2 (pl) |
| LT (1) | LT3125894T (pl) |
| MX (1) | MX2016012915A (pl) |
| PL (1) | PL3125894T3 (pl) |
| PT (1) | PT3125894T (pl) |
| RS (1) | RS61016B1 (pl) |
| RU (1) | RU2693622C2 (pl) |
| SI (1) | SI3125894T1 (pl) |
| WO (1) | WO2015153304A1 (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| RU2693622C2 (ru) | 2014-04-01 | 2019-07-03 | Мерк Шарп И Доум Корп. | Пролекарственные средства ингибиторов обратной транскриптазы вич |
| CN106008362B (zh) * | 2016-05-24 | 2018-08-10 | 杰达维（上海）医药科技发展有限公司 | 一种嘧啶衍生物的制备方法 |
| MX2020006527A (es) | 2017-12-22 | 2020-09-17 | Sumitomo Chemical Co | Compuesto heterociclico y agente para controlar artropodos perjudiciales que contienen el mismo. |
| PH12021551408A1 (en) | 2018-12-18 | 2022-05-16 | Merck Sharp & Dohme Llc | Pyrimidone derivatives as selective cytotoxic agents against hiv infected cells |
| BR112021016488A2 (pt) | 2019-02-20 | 2021-10-26 | Sumitomo Chemical Company, Limited | Composto de éter e composição de controle de artrópode nocivo contendo o mesmo |
| CN114026081B (zh) * | 2019-05-22 | 2025-02-11 | 默沙东有限责任公司 | 作为针对hiv感染的细胞的选择性细胞毒性剂的吡啶酮衍生物 |
| WO2021011513A1 (en) * | 2019-07-16 | 2021-01-21 | Bristol-Myers Squibb Company | Prodrugs in the modulation of interleukin |
| TW202304919A (zh) | 2021-03-31 | 2023-02-01 | 印度商皮埃企業有限公司 | 稠合雜環化合物及其作為害蟲控制劑之用途 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5519021A (en) | 1992-08-07 | 1996-05-21 | Merck & Co., Inc. | Benzoxazinones as inhibitors of HIV reverse transcriptase |
| IT1305313B1 (it) * | 1998-07-17 | 2001-05-04 | Colla Paolo | 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. |
| SE9904045D0 (sv) | 1999-11-09 | 1999-11-09 | Astra Ab | Compounds |
| JP5602333B2 (ja) | 2003-02-07 | 2014-10-08 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｈｉｖ感染の予防のためのピリミジン誘導体 |
| TW200423930A (en) | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
| WO2004085406A1 (en) | 2003-03-24 | 2004-10-07 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
| TW200505441A (en) | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
| WO2005026148A1 (en) * | 2003-09-08 | 2005-03-24 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
| US7288942B2 (en) * | 2003-10-02 | 2007-10-30 | Naoyuki Sato | Plasma potential measuring method and apparatus, and plasma potential measuring probe |
| BRPI0506786A (pt) | 2004-01-12 | 2007-05-22 | Gilead Sciences Inc | compostos antivirais de fosfonato de pirimidila e processos de uso |
| JP4627315B2 (ja) | 2004-03-23 | 2011-02-09 | エフ．ホフマン−ラ ロシュ アーゲー | 非ヌクレオシド逆転写酵素阻害剤としてのベンジルピリダジノン誘導体 |
| EP1742908B1 (en) | 2004-04-23 | 2009-11-11 | F.Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
| US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| CA2592092A1 (en) | 2004-12-22 | 2006-06-29 | Pfizer Limited | Nonnucleoside inhibitors of hiv-1 reverse transcriptase |
| AR057455A1 (es) | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| JP2009515826A (ja) | 2005-10-19 | 2009-04-16 | エフ．ホフマン−ラ ロシュ アーゲー | フェニル−アセトアミドｎｎｒｔ阻害剤 |
| RU2008119412A (ru) | 2005-10-19 | 2009-11-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | N-фенил-фенилацетамидные ненуклеозидные ингибиторы обратной транскриптазы |
| US7803940B2 (en) | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
| US20100056526A1 (en) | 2006-11-24 | 2010-03-04 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound and use thereof |
| TW200831085A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
| US8404253B2 (en) | 2006-12-28 | 2013-03-26 | Newport Laboratories, Inc. | Modified live (JMSO strain) Haemophilus parasuis vaccine |
| DE102007032507A1 (de) * | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| EP2222661B1 (en) * | 2007-11-20 | 2016-04-20 | Merck Sharp & Dohme Corp. | Non-nucleoside reverse transcriptase inhibitors |
| AU2008346833B2 (en) | 2008-01-08 | 2014-07-17 | Merck Sharp & Dohme Corp. | Process for preparing N-substituted hydroxypyrimidinone carboxamides |
| US8486975B2 (en) | 2010-03-30 | 2013-07-16 | Merck Canada Inc. | Non-nucleoside reverse transcriptase inhibitors |
| WO2011126969A1 (en) | 2010-04-08 | 2011-10-13 | Merck Sharp & Dohme Corp. | Prodrugs of an hiv reverse transcriptase inhibitor |
| JO3470B1 (ar) * | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| RU2693622C2 (ru) | 2014-04-01 | 2019-07-03 | Мерк Шарп И Доум Корп. | Пролекарственные средства ингибиторов обратной транскриптазы вич |
-
2015
- 2015-03-27 RU RU2016142611A patent/RU2693622C2/ru active
- 2015-03-27 ES ES15774282T patent/ES2828951T3/es active Active
- 2015-03-27 RS RS20201323A patent/RS61016B1/sr unknown
- 2015-03-27 JP JP2016559867A patent/JP6342011B2/ja active Active
- 2015-03-27 DK DK15774282.6T patent/DK3125894T3/da active
- 2015-03-27 CA CA2944187A patent/CA2944187C/en active Active
- 2015-03-27 BR BR112016022722A patent/BR112016022722B8/pt active IP Right Grant
- 2015-03-27 LT LTEP15774282.6T patent/LT3125894T/lt unknown
- 2015-03-27 HR HRP20201780TT patent/HRP20201780T1/hr unknown
- 2015-03-27 HU HUE15774282A patent/HUE051848T2/hu unknown
- 2015-03-27 CN CN201580029171.XA patent/CN106456639B/zh active Active
- 2015-03-27 MX MX2016012915A patent/MX2016012915A/es active IP Right Grant
- 2015-03-27 EP EP15774282.6A patent/EP3125894B1/en active Active
- 2015-03-27 SI SI201531408T patent/SI3125894T1/sl unknown
- 2015-03-27 PL PL15774282T patent/PL3125894T3/pl unknown
- 2015-03-27 US US15/300,405 patent/US10004740B2/en active Active
- 2015-03-27 WO PCT/US2015/022868 patent/WO2015153304A1/en not_active Ceased
- 2015-03-27 PT PT157742826T patent/PT3125894T/pt unknown
- 2015-03-27 AU AU2015241247A patent/AU2015241247B2/en active Active
- 2015-03-27 EP EP20194453.5A patent/EP3785714A1/en active Pending
- 2015-03-27 KR KR1020167030064A patent/KR102440843B1/ko active Active
-
2020
- 2020-11-11 CY CY20201101068T patent/CY1123582T1/el unknown
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