PL3125894T3 - Proleki inhibitorów odwrotnej transkryptazy hiv - Google Patents
Proleki inhibitorów odwrotnej transkryptazy hivInfo
- Publication number
- PL3125894T3 PL3125894T3 PL15774282T PL15774282T PL3125894T3 PL 3125894 T3 PL3125894 T3 PL 3125894T3 PL 15774282 T PL15774282 T PL 15774282T PL 15774282 T PL15774282 T PL 15774282T PL 3125894 T3 PL3125894 T3 PL 3125894T3
- Authority
- PL
- Poland
- Prior art keywords
- prodrugs
- reverse transcriptase
- transcriptase inhibitors
- hiv reverse
- hiv
- Prior art date
Links
- 108010078851 HIV Reverse Transcriptase Proteins 0.000 title 1
- 229940002612 prodrug Drugs 0.000 title 1
- 239000000651 prodrug Substances 0.000 title 1
- 239000003419 rna directed dna polymerase inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/22—Nitrogen and oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461973689P | 2014-04-01 | 2014-04-01 | |
| PCT/US2015/022868 WO2015153304A1 (en) | 2014-04-01 | 2015-03-27 | Prodrugs of hiv reverse transcriptase inhibitors |
| EP15774282.6A EP3125894B1 (en) | 2014-04-01 | 2015-03-27 | Prodrugs of hiv reverse transcriptase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3125894T3 true PL3125894T3 (pl) | 2021-02-08 |
Family
ID=54241131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL15774282T PL3125894T3 (pl) | 2014-04-01 | 2015-03-27 | Proleki inhibitorów odwrotnej transkryptazy hiv |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10004740B2 (pl) |
| EP (2) | EP3125894B1 (pl) |
| JP (1) | JP6342011B2 (pl) |
| KR (1) | KR102440843B1 (pl) |
| CN (1) | CN106456639B (pl) |
| AU (1) | AU2015241247B2 (pl) |
| BR (1) | BR112016022722B8 (pl) |
| CA (1) | CA2944187C (pl) |
| CY (1) | CY1123582T1 (pl) |
| DK (1) | DK3125894T3 (pl) |
| ES (1) | ES2828951T3 (pl) |
| HR (1) | HRP20201780T1 (pl) |
| HU (1) | HUE051848T2 (pl) |
| LT (1) | LT3125894T (pl) |
| MX (1) | MX2016012915A (pl) |
| PL (1) | PL3125894T3 (pl) |
| PT (1) | PT3125894T (pl) |
| RS (1) | RS61016B1 (pl) |
| RU (1) | RU2693622C2 (pl) |
| SI (1) | SI3125894T1 (pl) |
| WO (1) | WO2015153304A1 (pl) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| CA2944187C (en) | 2014-04-01 | 2018-06-19 | Merck Sharp & Dohme Corp. | Prodrugs of hiv reverse transcriptase inhibitors |
| CN106008362B (zh) * | 2016-05-24 | 2018-08-10 | 杰达维（上海）医药科技发展有限公司 | 一种嘧啶衍生物的制备方法 |
| AU2018390284A1 (en) | 2017-12-22 | 2020-06-11 | Sumitomo Chemical Company, Limited | Heterocyclic compound and harmful arthropod controlling agent containing same |
| AU2019402998B2 (en) * | 2018-12-18 | 2022-12-15 | Merck Sharp & Dohme Llc | Pyrimidone derivatives as selective cytotoxic agents against HIV infected cells |
| WO2020171129A1 (ja) | 2019-02-20 | 2020-08-27 | 住友化学株式会社 | エーテル化合物及びそれを含有する有害節足動物防除組成物 |
| KR20220011673A (ko) * | 2019-05-22 | 2022-01-28 | 머크 샤프 앤드 돔 코포레이션 | Hiv 감염된 세포에 대한 선택적 세포독성제로서의 피리디논 유도체 |
| US20230167082A1 (en) * | 2019-07-16 | 2023-06-01 | Bristol-Myers Squibb Company | Prodrugs in the modulation of interleukin |
| WO2022208370A1 (en) | 2021-03-31 | 2022-10-06 | Pi Industries Ltd. | Fused heterocyclic compounds and their use as pest control agents |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5665720A (en) | 1992-08-07 | 1997-09-09 | Merck & Co., Inc. | Benzoxazinones as inhibitors of HIV reverse transcriptase |
| IT1305313B1 (it) * | 1998-07-17 | 2001-05-04 | Colla Paolo | 3,4 - diidro- 6- benzil-4-oxopirimidine sostituite e relativo processodi produzione e impiego nella terapia delle infezioni da hiv-1. |
| SE9904045D0 (sv) | 1999-11-09 | 1999-11-09 | Astra Ab | Compounds |
| US20070021449A1 (en) | 2003-02-07 | 2007-01-25 | Jan Heeres | Pyrimidine derivatives for the prevention of hiv infection |
| TW200423930A (en) | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
| MXPA05010081A (es) | 2003-03-24 | 2005-11-23 | Hoffmann La Roche | Bencil-piridazinonas como inhibidores de transcriptasa inversa. |
| TW200505441A (en) | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
| US7790734B2 (en) | 2003-09-08 | 2010-09-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US7288942B2 (en) * | 2003-10-02 | 2007-10-30 | Naoyuki Sato | Plasma potential measuring method and apparatus, and plasma potential measuring probe |
| KR20060124701A (ko) | 2004-01-12 | 2006-12-05 | 길리애드 사이언시즈, 인코포레이티드 | 피리미딜 포스포네이트 항바이러스성 화합물 및 그의 사용방법 |
| JP4627315B2 (ja) | 2004-03-23 | 2011-02-09 | エフ．ホフマン−ラ ロシュ アーゲー | 非ヌクレオシド逆転写酵素阻害剤としてのベンジルピリダジノン誘導体 |
| US7166738B2 (en) | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| ES2333802T3 (es) | 2004-04-23 | 2010-03-01 | F. Hoffmann-La Roche Ag | Inhibidores no nucleicos de transcriptasa inversa. |
| US20090264425A1 (en) | 2004-12-22 | 2009-10-22 | Pfizer Limited | Chemical compounds |
| AR057455A1 (es) | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| AU2006303368B2 (en) | 2005-10-19 | 2011-05-26 | F. Hoffmann-La Roche Ag | Non-Nucleoside Reverse Transcriptase Inhibitors |
| CA2625039A1 (en) | 2005-10-19 | 2007-04-26 | F. Hoffmann-La Roche Ag | N-phenyl phenylacetamide non-nucleoside reverse transcriptase inihibitors |
| CA2670404A1 (en) | 2006-11-24 | 2008-05-29 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound and use thereof |
| US7803940B2 (en) | 2006-11-24 | 2010-09-28 | Takeda Pharmaceutical Company Limited | Heteromonocyclic compound or a salt thereof having strong antihypertensive action, insulin sensitizing activity and the like production thereof and use thereof for prophylaxis or treatment of cardiovascular diseases, metabolic diseases and/or central nervous system diseases |
| TW200831085A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Non-nucleoside reverse transcriptase inhibitors |
| US8404253B2 (en) | 2006-12-28 | 2013-03-26 | Newport Laboratories, Inc. | Modified live (JMSO strain) Haemophilus parasuis vaccine |
| DE102007032507A1 (de) * | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| RU2010125220A (ru) * | 2007-11-20 | 2011-12-27 | Мерк Шарп Энд Домэ Корп. (Us) | Ненуклеозидные ингибиторы обратной транскриптазы |
| JP5564435B2 (ja) | 2008-01-08 | 2014-07-30 | メルク・シャープ・アンド・ドーム・コーポレーション | Ｎ−置換ヒドロキシピリミジノンカルボキサミドの製造方法 |
| DK2924034T3 (en) | 2010-03-30 | 2017-02-06 | Merck Canada Inc | PHARMACEUTICAL COMPOSITION CONTAINING A NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR |
| EP2558093A4 (en) | 2010-04-08 | 2013-10-02 | Merck Sharp & Dohme | PRODRUGS OF HIV INVERTER TRANSCRIPTASE INHIBITOR |
| JO3470B1 (ar) | 2012-10-08 | 2020-07-05 | Merck Sharp & Dohme | مشتقات 5- فينوكسي-3h-بيريميدين-4-أون واستخدامها كمثبطات ناسخ عكسي ل hiv |
| CA2944187C (en) | 2014-04-01 | 2018-06-19 | Merck Sharp & Dohme Corp. | Prodrugs of hiv reverse transcriptase inhibitors |
-
2015
- 2015-03-27 CA CA2944187A patent/CA2944187C/en active Active
- 2015-03-27 LT LTEP15774282.6T patent/LT3125894T/lt unknown
- 2015-03-27 EP EP15774282.6A patent/EP3125894B1/en active Active
- 2015-03-27 RS RS20201323A patent/RS61016B1/sr unknown
- 2015-03-27 AU AU2015241247A patent/AU2015241247B2/en active Active
- 2015-03-27 RU RU2016142611A patent/RU2693622C2/ru active
- 2015-03-27 JP JP2016559867A patent/JP6342011B2/ja active Active
- 2015-03-27 HR HRP20201780TT patent/HRP20201780T1/hr unknown
- 2015-03-27 DK DK15774282.6T patent/DK3125894T3/da active
- 2015-03-27 WO PCT/US2015/022868 patent/WO2015153304A1/en not_active Ceased
- 2015-03-27 BR BR112016022722A patent/BR112016022722B8/pt active IP Right Grant
- 2015-03-27 CN CN201580029171.XA patent/CN106456639B/zh active Active
- 2015-03-27 HU HUE15774282A patent/HUE051848T2/hu unknown
- 2015-03-27 PL PL15774282T patent/PL3125894T3/pl unknown
- 2015-03-27 EP EP20194453.5A patent/EP3785714A1/en active Pending
- 2015-03-27 PT PT157742826T patent/PT3125894T/pt unknown
- 2015-03-27 MX MX2016012915A patent/MX2016012915A/es active IP Right Grant
- 2015-03-27 SI SI201531408T patent/SI3125894T1/sl unknown
- 2015-03-27 US US15/300,405 patent/US10004740B2/en active Active
- 2015-03-27 ES ES15774282T patent/ES2828951T3/es active Active
- 2015-03-27 KR KR1020167030064A patent/KR102440843B1/ko active Active
-
2020
- 2020-11-11 CY CY20201101068T patent/CY1123582T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL287113A (en) | smyd inhibitors | |
| IL247923A0 (en) | 4-substituted nucleotide derivatives as HIV reverse transcriptase inhibitors | |
| IL251584A0 (en) | Dihydropyrrolopyridines ror-gamma inhibitors | |
| IL246902A0 (en) | Dihydropyrrolopyridine ror–gamma inhibitors | |
| ZA201604272B (en) | Inhibitors of glutaminase | |
| IL248895A0 (en) | Phosphatidylinositol 3-kinase inhibitors | |
| PT3125894T (pt) | Profármacos de inibidores da transcriptase reversa do vih | |
| EP3494971C0 (en) | SALTS OF ERK INHIBITORS | |
| GB201521059D0 (en) | Inhibitors of metallo-beta-lactamases | |
| LT3226888T (lt) | Selektyvaus il-6-trans-signalinio inhibitoriaus skyrimas | |
| GB201402169D0 (en) | Viral inhibitors | |
| GB201407822D0 (en) | Use of a composition | |
| GB201401005D0 (en) | Inhibitor | |
| HUP1500506A2 (en) | Salts of palbociclib | |
| GB201417347D0 (en) | Prodrugs of delanzomib | |
| GB201417348D0 (en) | Prodrugs of lxazomib | |
| TH1501005447A (th) | สารยับยั้ง ido | |
| GB201417192D0 (en) | Deposition of graphene | |
| GB201418154D0 (en) | Inhibitors |