|
BE788516A
(fr)
|
1971-09-10 |
1973-03-07 |
Lonza Ag |
Procede de fabrication d'esters alcoxyacetylacetiques
|
|
GB1528382A
(en)
|
1974-12-26 |
1978-10-11 |
Teijin Ltd |
Cyclopentene diols and acyl esters thereof and processes for their preparation
|
|
DE2658401A1
(de)
|
1976-12-23 |
1978-07-06 |
Merck Patent Gmbh |
Cyclopentan-1-amine, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel
|
|
US4575694A
(en)
|
1984-03-05 |
1986-03-11 |
Allied Corporation |
Coaxial connector
|
|
DE3900736A1
(de)
|
1989-01-12 |
1990-07-26 |
Hoechst Ag |
Positiv arbeitendes strahlungsempfindliches gemisch enthaltend einen mehrfunktionellen (alpha)-diazo-(beta)-ketoester, verfahren zu dessen herstellung und strahlungsempfindliches aufzeichnungsmaterial enthaltend dieses gemisch
|
|
US6703396B1
(en)
|
1990-02-01 |
2004-03-09 |
Emory University |
Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
|
|
US5204466A
(en)
|
1990-02-01 |
1993-04-20 |
Emory University |
Method and compositions for the synthesis of bch-189 and related compounds
|
|
US5914331A
(en)
|
1990-02-01 |
1999-06-22 |
Emory University |
Antiviral activity and resolution of 2-hydroxymethyl-5-(5-fluorocytosin-1-yl)-1,3-oxathiolane
|
|
DE4014649A1
(de)
|
1990-05-08 |
1991-11-14 |
Hoechst Ag |
Neue mehrfunktionelle verbindungen mit (alpha)-diazo-ss-ketoester- und sulfonsaeureester-einheiten, verfahren zu ihrer herstellung und deren verwendung
|
|
GB9301000D0
(en)
|
1993-01-20 |
1993-03-10 |
Glaxo Group Ltd |
Chemical compounds
|
|
US5922695A
(en)
|
1996-07-26 |
1999-07-13 |
Gilead Sciences, Inc. |
Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
|
|
SE9702772D0
(sv)
|
1997-07-22 |
1997-07-22 |
Astra Pharma Prod |
Novel compounds
|
|
US5935946A
(en)
|
1997-07-25 |
1999-08-10 |
Gilead Sciences, Inc. |
Nucleotide analog composition and synthesis method
|
|
WO1999025345A1
(en)
|
1997-11-14 |
1999-05-27 |
Merck & Co., Inc. |
Alpha-1a adrenergic receptor antagonists
|
|
DE69926148D1
(en)
|
1998-11-09 |
2005-08-18 |
Black James Foundation |
Gastrin und cholecystokinin rezeptor ligande
|
|
GB2345058A
(en)
|
1998-12-01 |
2000-06-28 |
Cerebrus Pharm Ltd |
Hydroxypyridone compounds useful in the treatment of oxidative damage to the central nervous system
|
|
WO2000039086A1
(en)
|
1998-12-25 |
2000-07-06 |
Shionogi & Co., Ltd. |
Aromatic heterocycle compounds having hiv integrase inhibiting activities
|
|
EP1297834A4
(en)
|
2000-06-14 |
2007-05-09 |
Shionogi & Co |
ENZYME INHIBITOR HAVING TWO DIVALENT METAL IONS AS ACTIVE CENTERS
|
|
ES2383262T3
(es)
|
2001-08-10 |
2012-06-19 |
Shionogi & Co., Ltd. |
Agente antiviral
|
|
WO2003030897A1
(en)
|
2001-10-03 |
2003-04-17 |
Ucb, S.A. |
Pyrrolidinone derivatives
|
|
EP1441735B1
(en)
|
2001-10-26 |
2006-02-22 |
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. |
N-substituted hydroxypyrimidinone carboxamide inhibitors of hiv integrase
|
|
DE60231425D1
(de)
|
2001-11-13 |
2009-04-16 |
Shiseido Co Ltd |
Azabicycloverbindung, matrixmetallproteaseinhibitor und zubereitung für haut
|
|
AU2003248872A1
(en)
|
2002-07-09 |
2004-01-23 |
Bristol-Myers Squibb Company |
Hiv integrase inhibitors
|
|
US7517532B2
(en)
|
2002-09-11 |
2009-04-14 |
Merck & Co., Inc. |
Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors
|
|
SI1564210T1
(sl)
|
2002-11-20 |
2010-01-29 |
Japan Tobacco Inc |
4-oksokinolinske spojine in njihova uporaba kot inhibitorji HIV integraze
|
|
KR20080032014A
(ko)
|
2003-01-14 |
2008-04-11 |
길리애드 사이언시즈, 인코포레이티드 |
복합 항바이러스 치료를 위한 조성물 및 방법
|
|
TW200510425A
(en)
|
2003-08-13 |
2005-03-16 |
Japan Tobacco Inc |
Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
|
|
TW200528440A
(en)
|
2003-10-31 |
2005-09-01 |
Fujisawa Pharmaceutical Co |
2-cyanopyrrolidinecarboxamide compound
|
|
WO2005074513A2
(en)
|
2004-01-30 |
2005-08-18 |
Merck & Co., Inc. |
N-benzyl-3,4-dihyroxypyridine-2-carboxamide and n-benzyl-2,3-dihydroxypyridine-4-carboxamide compounds useful as hiv integrase inhibitors
|
|
JP2007528396A
(ja)
|
2004-03-09 |
2007-10-11 |
メルク エンド カムパニー インコーポレーテッド |
Hivインテグラーゼ阻害薬
|
|
EP1755586A2
(en)
|
2004-04-29 |
2007-02-28 |
The Regents of the University of California |
Hydroxypyridinone, hydroxypyridinethione, pyrone, and thiopyrone metalloprotein inhibitors
|
|
WO2005110399A2
(en)
|
2004-04-29 |
2005-11-24 |
The Regents Of The University Of California |
Zinc-binding groups for metalloprotein inhibitors
|
|
US7538112B2
(en)
|
2004-05-07 |
2009-05-26 |
Merck & Co., Inc. |
HIV integrase inhibitors
|
|
US7273859B2
(en)
|
2004-05-12 |
2007-09-25 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors: cyclic pyrimidinone compounds
|
|
WO2005113509A1
(en)
|
2004-05-20 |
2005-12-01 |
Japan Tobacco Inc. |
Novel 4-oxoquinoline compound and use thereof as hiv integrase inhibitor
|
|
MY134672A
(en)
|
2004-05-20 |
2007-12-31 |
Japan Tobacco Inc |
Stable crystal of 4-oxoquinoline compound
|
|
EP3287130A1
(en)
|
2004-05-21 |
2018-02-28 |
Japan Tobacco Inc. |
Combinations comprising a 4-isoquinolone derivative and protease inhibitors
|
|
CN101014572B
(zh)
|
2004-09-15 |
2011-07-06 |
盐野义制药株式会社 |
具有hiv整合酶抑制活性的氨基甲酰基吡啶酮衍生物
|
|
EP1973906A1
(en)
|
2004-12-23 |
2008-10-01 |
Virochem Pharma Inc. |
Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase
|
|
EP1852434B1
(en)
|
2005-02-21 |
2011-07-13 |
Shionogi Co., Ltd. |
Bicyclic carbamoylpyridone derivative having hiv integrase inhibiting activity
|
|
MX302718B
(es)
|
2005-04-28 |
2012-08-27 |
Smithkline Beecham Corp |
Derivado de carbamoilpiridona policiclico que tiene actividad inhibidora de la integrasa de hiv.
|
|
US20070072831A1
(en)
|
2005-05-16 |
2007-03-29 |
Gilead Sciences, Inc. |
Integrase inhibitor compounds
|
|
EP1906971A2
(en)
|
2005-07-27 |
2008-04-09 |
Gilead Sciences, Inc. |
Antiviral compounds
|
|
EA200801144A1
(ru)
|
2005-10-27 |
2008-10-30 |
Сионоги Энд Ко., Лтд. |
Полициклическое карбамоилпиридоновое производное, обладающее ингибиторной активностью в отношении интегразы вич
|
|
SG170796A1
(en)
|
2005-12-30 |
2011-05-30 |
Gilead Sciences Inc Us |
Methods for improving the pharmacokinetics of hiv integrase inhibitors
|
|
US7601844B2
(en)
|
2006-01-27 |
2009-10-13 |
Bristol-Myers Squibb Company |
Piperidinyl derivatives as modulators of chemokine receptor activity
|
|
EP1978960A4
(en)
|
2006-02-01 |
2009-12-02 |
Japan Tobacco Inc |
USE OF 6- (3-CHLORO-2-FLUORBENZYL) -1 - [(2S) -1-HYDROXY-3-METHYLBUTAN-2-YL [-7-METHOXY-4-OXO-1,4-DIHYDROCHINOLINE-3- CARBOXYLIC ACID OR SALT THEREOF FOR THE TREATMENT OF RETROVIRUS INFECTION
|
|
CN101437801B
(zh)
|
2006-03-06 |
2013-02-06 |
日本烟草产业株式会社 |
制备4-氧代喹啉化合物的方法
|
|
JP4669040B2
(ja)
|
2006-03-06 |
2011-04-13 |
日本たばこ産業株式会社 |
4−オキソキノリン化合物の製造方法
|
|
US7893055B2
(en)
|
2006-06-28 |
2011-02-22 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
|
EP2046328A4
(en)
|
2006-07-19 |
2009-10-28 |
Univ Georgia Res Found |
PYRIDINONE DIKETOIC ACIDS: INHIBITORS OF HIV REPLICATION IN COMBINATION THERAPY
|
|
CA2662628C
(en)
|
2006-09-07 |
2016-02-09 |
Industrial Research Limited |
Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
|
|
EP2069280B1
(en)
|
2006-09-12 |
2015-03-25 |
Gilead Sciences, Inc. |
Process and intermediates for preparing HIV integrase inhibitors
|
|
CA2665538A1
(en)
|
2006-10-18 |
2008-04-24 |
Merck & Co., Inc. |
Hiv integrase inhibitors
|
|
EP2118082B1
(en)
|
2007-02-23 |
2014-10-01 |
Gilead Sciences, Inc. |
Modulators of pharmacokinetic properties of therapeutics
|
|
US20080280945A1
(en)
|
2007-05-09 |
2008-11-13 |
Sachin Lohani |
Crystalline forms of an HIV integrase inhibitor
|
|
MX2009013828A
(es)
|
2007-06-29 |
2010-03-10 |
Gilead Sciences Inc |
Composiciones terapeuticas y su uso.
|
|
JP5547066B2
(ja)
|
2007-06-29 |
2014-07-09 |
ギリアード サイエンシーズ, インコーポレイテッド |
治療用組成物およびその使用
|
|
CA2693340A1
(en)
|
2007-07-31 |
2009-02-05 |
Limerick Biopharma, Inc. |
Pyrone analog compositions and methods
|
|
AR068403A1
(es)
|
2007-09-11 |
2009-11-18 |
Gilead Sciences Inc |
Proceso e intermediarios para la preparacion de inhibidores de integrasa
|
|
KR20100097156A
(ko)
|
2007-11-16 |
2010-09-02 |
베링거 인겔하임 인터내셔날 게엠베하 |
사람 면역결핍 바이러스 복제의 억제제
|
|
GB0803019D0
(en)
|
2008-02-19 |
2008-03-26 |
Btg Int Ltd |
Fluorinated compounds
|
|
US8129398B2
(en)
|
2008-03-19 |
2012-03-06 |
Bristol-Myers Squibb Company |
HIV integrase inhibitors
|
|
WO2010011813A1
(en)
|
2008-07-23 |
2010-01-28 |
Alkermes, Inc. |
Complex of trospium and pharmaceutical compositions thereof
|
|
HRP20140223T2
(hr)
|
2008-07-25 |
2014-08-01 |
Viiv Healthcare Company |
Prolijekovi dolutegravir
|
|
KR101695807B1
(ko)
|
2008-07-25 |
2017-01-13 |
비이브 헬쓰케어 컴퍼니 |
화합물
|
|
ES2395705T3
(es)
|
2008-07-25 |
2013-02-14 |
Glaxosmithkline Llc |
Compuestos químicos
|
|
WO2010011818A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
WO2010011819A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
WO2010011815A1
(en)
|
2008-07-25 |
2010-01-28 |
Smithkline Beecham Corporation |
Chemical compounds
|
|
EP3617194B1
(en)
|
2008-12-11 |
2023-11-08 |
VIIV Healthcare Company |
Processes and intermediates for carbamoylpyridone hiv integrase inhibitors
|
|
MX2011006241A
(es)
|
2008-12-11 |
2011-06-28 |
Shionogi & Co |
Sintesis de inhibidores de integrasa de vih de carbamoil-piridona e intermediarios.
|
|
JP5697163B2
(ja)
|
2009-03-26 |
2015-04-08 |
塩野義製薬株式会社 |
置換された3−ヒドロキシ−4−ピリドン誘導体
|
|
TWI518084B
(zh)
|
2009-03-26 |
2016-01-21 |
鹽野義製藥股份有限公司 |
哌喃酮與吡啶酮衍生物之製造方法
|
|
US8338441B2
(en)
|
2009-05-15 |
2012-12-25 |
Gilead Sciences, Inc. |
Inhibitors of human immunodeficiency virus replication
|
|
JP5737691B2
(ja)
|
2009-06-15 |
2015-06-17 |
塩野義製薬株式会社 |
置換された多環性カルバモイルピリドン誘導体
|
|
KR101280198B1
(ko)
|
2009-09-02 |
2013-06-28 |
이화여자대학교 산학협력단 |
피라졸 유도체, 이의 제조방법 및 이를 포함하는 골다공증 예방 및 치료용 조성물
|
|
LT3494972T
(lt)
|
2010-01-27 |
2024-03-12 |
Viiv Healthcare Company |
Dolutegraviro ir lamivudino kompozicija živ infekcijai gydyti
|
|
NZ601847A
(en)
|
2010-02-26 |
2014-03-28 |
Japan Tobacco Inc |
1,3,4,8-tetrahydro-2h-pyrido[1,2-a]pyrazine derivative and use of same as hiv integrase inhibitor
|
|
TWI582097B
(zh)
|
2010-03-23 |
2017-05-11 |
Viiv醫療保健公司 |
製備胺甲醯吡啶酮衍生物及中間體之方法
|
|
WO2011139637A1
(en)
|
2010-05-03 |
2011-11-10 |
Philadelphia Health & Education Corporation |
Small-molecule modulators of hiv-1 capsid stability and methods thereof
|
|
US9102614B2
(en)
|
2010-07-02 |
2015-08-11 |
Gilead Sciences, Inc. |
Naphth-2-ylacetic acid derivatives to treat AIDS
|
|
NZ604716A
(en)
|
2010-07-02 |
2014-12-24 |
Gilead Sciences Inc |
2-quinolinyl-acetic acid derivatives as hiv antiviral compounds
|
|
US20130210809A1
(en)
|
2010-07-14 |
2013-08-15 |
Christelle Boléa |
Novel 2-amino-4-pyrazolyl-thiazole derivatives and their use as allosteric modulators of metabotropic glutamate receptors
|
|
BR112013002461A2
(pt)
|
2010-08-05 |
2016-05-24 |
Shionogi & Co |
método para produzir um composto, e, cristal de um composto
|
|
RU2608519C2
(ru)
|
2010-09-24 |
2017-01-19 |
Шионоги энд Ко. Лтд. |
Пролекарственная форма замещенного полициклического производного карбамоилпиридона
|
|
WO2012106534A2
(en)
|
2011-02-02 |
2012-08-09 |
The Regents Of The University Of California |
Hiv integrase inhibitors
|
|
US9006229B2
(en)
|
2011-04-21 |
2015-04-14 |
Gilead Sciences, Inc. |
Benzothiazole compounds and their pharmaceutical use
|
|
WO2012151361A1
(en)
|
2011-05-03 |
2012-11-08 |
Concert Pharmaceuticals Inc. |
Carbamoylpyridone derivatives
|
|
WO2012151567A1
(en)
|
2011-05-05 |
2012-11-08 |
St. Jude Children's Research Hospital |
Pyrimidinone compounds and methods for preventing and treating influenza
|
|
CA2840095A1
(en)
|
2011-07-06 |
2013-01-10 |
Gilead Sciences, Inc. |
Compounds for the treatment of hiv
|
|
CN102863512B
(zh)
|
2011-07-07 |
2016-04-20 |
上海泓博智源医药技术有限公司 |
抗病毒化合物
|
|
PL2742051T3
(pl)
|
2011-09-14 |
2017-06-30 |
Mapi Pharma Limited |
Amorficzna postać soli sodowej dolutegrawiru
|
|
CN103974957A
(zh)
|
2011-10-12 |
2014-08-06 |
盐野义制药株式会社 |
具有整合酶抑制活性的多环吡啶酮衍生物
|
|
CN104114559B
(zh)
|
2011-12-12 |
2016-08-24 |
拜耳知识产权有限责任公司 |
氨基取代的咪唑并哒嗪
|
|
RU2014115227A
(ru)
|
2012-04-20 |
2015-10-27 |
Джилид Сайэнс, Инк. |
Производные бензотиазол-6-ил уксусной кислоты и их примение для лечения вич-инфекции
|
|
WO2014008636A1
(en)
|
2012-07-11 |
2014-01-16 |
Merck Sharp & Dohme Corp. |
Macrocyclic compounds as hiv integrase inhibitors
|
|
US20150166520A1
(en)
|
2012-07-20 |
2015-06-18 |
Merck Sharp & Dohme Corp. |
Amido-substituted pyrimidinone derivatives useful for the treatment of hiv infection
|
|
EP2877469A4
(en)
|
2012-07-25 |
2016-04-06 |
Merck Sharp & Dohme |
SUBSTITUTED NAPHTHYRIDEINDION DERIVATIVES AS HIV INTEGRASE INHIBITORS
|
|
JP6147856B2
(ja)
|
2012-08-03 |
2017-06-14 |
ギリアード サイエンシーズ, インコーポレイテッド |
インテグラーゼインヒビターを調製するためのプロセスおよび中間体
|
|
AU2013341200A1
(en)
|
2012-11-08 |
2015-07-02 |
Bristol-Myers Squibb Company |
Heteroaryl substituted pyridyl compounds useful as kinase modulators
|
|
EA201590862A1
(ru)
|
2012-12-14 |
2016-05-31 |
ГЛАКСОСМИТКЛАЙН ЭлЭлСи |
Фармацевтические композиции
|
|
EP2931730B1
(en)
*
|
2012-12-17 |
2019-08-07 |
Merck Sharp & Dohme Corp. |
4-pyridinonetriazine derivatives as hiv integrase inhibitors
|
|
US20160000721A1
(en)
|
2012-12-21 |
2016-01-07 |
Merck Sharp & Dohme Corp. |
Gastro-retentive formulations
|
|
PT3067358T
(pt)
|
2012-12-21 |
2019-11-18 |
Gilead Sciences Inc |
Compostos carbamoílpiridona policíclicos e sua utilização farmacêutica
|
|
US20140221355A1
(en)
|
2012-12-21 |
2014-08-07 |
Gilead Sciences, Inc. |
Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
|
|
RU2015131006A
(ru)
|
2012-12-27 |
2017-01-30 |
Джапан Тобакко Инк. |
ЗАМЕЩЕННОЕ ПРОИЗВОДНОЕ СПИРОПИРИДО[1,2-a]ПИРАЗИНА И ЕГО ПРИМЕНЕНИЕ В МЕДИЦИНЕ В КАЧЕСТВЕ ИНГИБИТОРА ИНТЕГРАЗЫ ВИРУСА ИММУНОДЕФИЦИТА ЧЕЛОВЕКА (ВИЧ)
|
|
US9951079B2
(en)
|
2013-06-13 |
2018-04-24 |
Merck Sharp & Dohme Corp. |
Fused tricyclic heterocyclic compounds as HIV integrase inhibitors
|
|
AU2014286993B2
(en)
*
|
2013-07-12 |
2018-10-25 |
Gilead Sciences, Inc. |
Polycyclic-carbamoylpyridone compounds and their use for the treatment of HIV infections
|
|
NO2865735T3
(index.php)
|
2013-07-12 |
2018-07-21 |
|
|
|
WO2015039348A1
(en)
*
|
2013-09-23 |
2015-03-26 |
Merck Sharp & Dohme Corp. |
Tetracyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
US9861620B2
(en)
|
2013-09-27 |
2018-01-09 |
Merck Sharp & Dohme Corp. |
Substituted quinolizine derivatives useful as HIV integrase inhibitors
|
|
US20150146340A1
(en)
|
2013-11-26 |
2015-05-28 |
Qualcomm Incorporated |
Multilayer ceramic capacitor including at least one slot
|
|
WO2015089847A1
(en)
|
2013-12-20 |
2015-06-25 |
Merck Sharp & Dohme Corp. |
Spirocyclic heterocycle compounds useful as hiv integrase inhibitors
|
|
IN2014CH00247A
(index.php)
|
2014-01-21 |
2015-08-14 |
Laurus Labs Private Ltd |
|