PL2686334T5 - Chromatografia jonowymienna o ulepszonej selektywności do rozdzielania monomerów, agregatów i fragmentów polipeptydowych przez modulację fazy ruchomej - Google Patents

Chromatografia jonowymienna o ulepszonej selektywności do rozdzielania monomerów, agregatów i fragmentów polipeptydowych przez modulację fazy ruchomej

Info

Publication number
PL2686334T5
PL2686334T5 PL12708546T PL12708546T PL2686334T5 PL 2686334 T5 PL2686334 T5 PL 2686334T5 PL 12708546 T PL12708546 T PL 12708546T PL 12708546 T PL12708546 T PL 12708546T PL 2686334 T5 PL2686334 T5 PL 2686334T5
Authority
PL
Poland
Prior art keywords
aggregates
fragments
modulation
separation
ion exchange
Prior art date
Application number
PL12708546T
Other languages
English (en)
Other versions
PL2686334T3 (pl
Inventor
Sebastian Neumann
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45819216&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL2686334(T5) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of PL2686334T3 publication Critical patent/PL2686334T3/pl
Publication of PL2686334T5 publication Critical patent/PL2686334T5/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Mycology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL12708546T 2011-03-16 2012-03-14 Chromatografia jonowymienna o ulepszonej selektywności do rozdzielania monomerów, agregatów i fragmentów polipeptydowych przez modulację fazy ruchomej PL2686334T5 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11158523 2011-03-16
PCT/EP2012/054449 WO2012123488A1 (en) 2011-03-16 2012-03-14 Ion exchange chromatography with improved selectivity for the separation of polypeptide monomers, aggregates and fragments by modulation of the mobile phase
EP12708546.2A EP2686334B2 (en) 2011-03-16 2012-03-14 Ion exchange chromatography with improved selectivity for the separation of polypeptide monomers, aggregates and fragments by modulation of the mobile phase

Publications (2)

Publication Number Publication Date
PL2686334T3 PL2686334T3 (pl) 2018-03-30
PL2686334T5 true PL2686334T5 (pl) 2020-10-19

Family

ID=45819216

Family Applications (2)

Application Number Title Priority Date Filing Date
PL17201391T PL3318571T3 (pl) 2011-03-16 2012-03-14 Chromatografia jonowymienna o ulepszonej selektywności do rozdzielania monomerów, agregatów i fragmentów polipeptydowych przez modulację fazy ruchomej
PL12708546T PL2686334T5 (pl) 2011-03-16 2012-03-14 Chromatografia jonowymienna o ulepszonej selektywności do rozdzielania monomerów, agregatów i fragmentów polipeptydowych przez modulację fazy ruchomej

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PL17201391T PL3318571T3 (pl) 2011-03-16 2012-03-14 Chromatografia jonowymienna o ulepszonej selektywności do rozdzielania monomerów, agregatów i fragmentów polipeptydowych przez modulację fazy ruchomej

Country Status (9)

Country Link
US (3) US9394337B2 (pl)
EP (2) EP3318571B1 (pl)
JP (3) JP5984854B2 (pl)
ES (2) ES2656167T5 (pl)
HR (2) HRP20180028T4 (pl)
PL (2) PL3318571T3 (pl)
SG (1) SG193378A1 (pl)
SI (2) SI3318571T1 (pl)
WO (1) WO2012123488A1 (pl)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2656167T5 (es) 2011-03-16 2021-03-26 Hoffmann La Roche Cromatografía de intercambio iónico con selectividad mejorada para la separación de monómeros, agregados y fragmentos polipeptídicos mediante la modulación de la fase móvil
US9573810B2 (en) * 2012-07-21 2017-02-21 K-Technologies, Inc. Processes for the removal and recovery of minor elements in wet-process phosphoric acid
DK2970379T3 (da) 2013-03-14 2019-07-22 Emd Millipore Corp Fremgangsmåder til forhøjelse af proteinrenhed ved anvendelse af protein a-baseret kromatografi
GB2516808A (en) * 2013-05-31 2015-02-11 Innova Biosciences Ltd Antibody composition and buffer system therefor
WO2015024896A1 (en) * 2013-08-19 2015-02-26 F. Hoffmann-La Roche Ag Separation of bispecific antibodies and bispecific antibody production side products using hydroxyapatite chromatography
CA3156648A1 (en) * 2019-10-04 2021-04-08 Merck Patent Gmbh Elution of monoclonal antibodies in protein a affinity chromatography
CN116745609A (zh) * 2020-12-20 2023-09-12 瑞泽恩制药公司 鉴定生物分子中乱序二硫键的方法
CN113388026B (zh) * 2021-08-03 2022-09-27 江西理工大学 一种螺旋藻藻蓝蛋白和藻油的同步提取方法

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US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
ES2228052T3 (es) 1998-06-01 2005-04-01 Genentech, Inc. Separacion demonomeros de anticuerpos de sus multimeros utilizando cromatografia de intercambio de iones.
DK2272870T3 (da) * 1998-06-09 2013-08-05 Csl Behring Ag Fremgangsmåde til fremstilling af immunoglobuliner med henblik på intravenøs indgivelse og andre immunoglobulin-lignende produkter.
ES2229784T3 (es) 1998-06-09 2005-04-16 Statens Serum Institut Proceso de produccion de inmunoglobulinas para administracion intravenosa y otros productos de inmunoglobulina.
DE19836213A1 (de) * 1998-08-11 2000-02-24 Gerhard Harry Scholz Verfahren zur Elution von Biomolekülen von Chromatographie-Materialien
WO2004013162A2 (en) 2002-08-06 2004-02-12 Akzo Nobel Nv. Increased dynamic binding capacity in ion exchange chromatography by addition of polyethylene glycol
CN1208346C (zh) 2003-04-09 2005-06-29 中国科学院过程工程研究所 血红蛋白－人血清白蛋白偶联物制备血液代用品及其制备方法
SE0400886D0 (sv) 2004-04-02 2004-04-02 Amersham Biosciences Ab Process of purification
KR100554481B1 (ko) * 2004-06-30 2006-03-03 씨제이 주식회사 반코마이신 염산염의 정제방법
TWI320788B (en) * 2005-05-25 2010-02-21 Hoffmann La Roche Method for the purification of antibodies
WO2007143121A2 (en) * 2006-06-01 2007-12-13 President And Fellows Of Harvard College Purification of a bivalently active antibody using a non-chromatographic method
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EP2182943B1 (en) * 2007-07-23 2016-10-26 Janssen Biotech, Inc. Methods and compositions for treating fibrosis related disorders using il-17 antagonists
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WO2009092014A1 (en) 2008-01-18 2009-07-23 Gagnon Peter S Enhanced purification of antibodies and antibody fragments by apatite chromatography
CA2726823A1 (en) * 2008-06-03 2009-12-10 Patrys Limited Process for purification of antibodies
KR101318549B1 (ko) 2008-09-29 2013-10-16 로슈 글리카트 아게 인간 ｉｌ17 에 대한 항체 및 이의 용도
US8268314B2 (en) 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
HUE040636T2 (hu) 2009-06-16 2019-03-28 Genzyme Corp Javított eljárások rekombináns AAV-vektorok tisztítására
US8394922B2 (en) * 2009-08-03 2013-03-12 Medarex, Inc. Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
AR080793A1 (es) * 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
ES2656167T5 (es) 2011-03-16 2021-03-26 Hoffmann La Roche Cromatografía de intercambio iónico con selectividad mejorada para la separación de monómeros, agregados y fragmentos polipeptídicos mediante la modulación de la fase móvil

Also Published As

Publication number Publication date
EP2686334A1 (en) 2014-01-22
EP3318571A1 (en) 2018-05-09
EP2686334B1 (en) 2017-11-15
HRP20180028T1 (hr) 2018-02-09
JP2017019805A (ja) 2017-01-26
US9394337B2 (en) 2016-07-19
US20200148719A1 (en) 2020-05-14
SG193378A1 (en) 2013-10-30
SI3318571T1 (sl) 2021-08-31
JP6523491B2 (ja) 2019-06-05
SI2686334T2 (sl) 2020-10-30
HRP20180028T4 (hr) 2020-10-02
JP5984854B2 (ja) 2016-09-06
SI2686334T1 (en) 2018-03-30
WO2012123488A1 (en) 2012-09-20
ES2656167T5 (es) 2021-03-26
EP3318571B1 (en) 2021-02-17
US10377793B2 (en) 2019-08-13
HRP20210588T1 (hr) 2021-05-28
ES2865449T3 (es) 2021-10-15
JP6273326B2 (ja) 2018-01-31
ES2656167T3 (es) 2018-02-23
PL3318571T3 (pl) 2021-07-05
JP2018058900A (ja) 2018-04-12
US20140081000A1 (en) 2014-03-20
EP2686334B2 (en) 2020-07-01
PL2686334T3 (pl) 2018-03-30
JP2014511829A (ja) 2014-05-19
US20170107249A1 (en) 2017-04-20

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