PL2616486T3 - Warianty czynnika viii mające zmniejszony wychwyt komórkowy - Google Patents

Warianty czynnika viii mające zmniejszony wychwyt komórkowy

Info

Publication number
PL2616486T3
PL2616486T3 PL11769805T PL11769805T PL2616486T3 PL 2616486 T3 PL2616486 T3 PL 2616486T3 PL 11769805 T PL11769805 T PL 11769805T PL 11769805 T PL11769805 T PL 11769805T PL 2616486 T3 PL2616486 T3 PL 2616486T3
Authority
PL
Poland
Prior art keywords
factor viii
cellular uptake
decreased cellular
viii variants
variants
Prior art date
Application number
PL11769805T
Other languages
English (en)
Polish (pl)
Inventor
Henriët MEEMS
Alexander Benjamin Meijer
Koenraad Mertens
Ole Hvilsted Olsen
Kasper Lamberth
Peder Lisby Noerby
Laust Bruun Johnsen
Marianne Kjalke
Henning Ralf Stennicke
Johannes Jacobus Voorberg
Maartje Van Den Biggelaar
Original Assignee
Stichting Sanquin Bloedvoorziening
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stichting Sanquin Bloedvoorziening filed Critical Stichting Sanquin Bloedvoorziening
Publication of PL2616486T3 publication Critical patent/PL2616486T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PL11769805T 2010-09-15 2011-09-14 Warianty czynnika viii mające zmniejszony wychwyt komórkowy PL2616486T3 (pl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
EP10176731 2010-09-15
US38473110P 2010-09-21 2010-09-21
EP11173768 2011-07-13
US201161507666P 2011-07-14 2011-07-14
PCT/EP2011/065913 WO2012035050A2 (en) 2010-09-15 2011-09-14 Factor viii variants having a decreased cellular uptake
EP11769805.0A EP2616486B1 (en) 2010-09-15 2011-09-14 Factor viii variants having a decreased cellular uptake

Publications (1)

Publication Number Publication Date
PL2616486T3 true PL2616486T3 (pl) 2019-05-31

Family

ID=45832010

Family Applications (1)

Application Number Title Priority Date Filing Date
PL11769805T PL2616486T3 (pl) 2010-09-15 2011-09-14 Warianty czynnika viii mające zmniejszony wychwyt komórkowy

Country Status (7)

Country Link
US (4) US9321827B2 (enExample)
EP (2) EP3466968A1 (enExample)
JP (2) JP6042335B2 (enExample)
CN (2) CN103209992A (enExample)
AU (1) AU2011303916A1 (enExample)
PL (1) PL2616486T3 (enExample)
WO (1) WO2012035050A2 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2742949A1 (en) * 2009-11-13 2014-06-18 Puget Sound Blood Center Factor VIII B cell epitope variants having reduced immunogenicity
WO2013160005A1 (en) 2012-04-24 2013-10-31 Novo Nordisk A/S Pharmaceutical composition suitable for treatment of haemophilia
JP2015515482A (ja) 2012-04-24 2015-05-28 ノヴォ ノルディスク アー／エス 血友病の治療に適する化合物
CN104661685A (zh) 2012-10-15 2015-05-27 诺和诺德保健Ag（股份有限公司） 因子vii缀合物
BR112015014753B8 (pt) 2012-12-20 2020-03-03 Basf Agro Bv composições, uso de uma composição, método para o combate de fungos fitopatogênicos e uso dos componentes
BR122019013926B1 (pt) 2013-01-09 2019-10-29 Basf Agro Bv processo para preparar um composto de triazol de fórmula i
UA118265C2 (uk) 2013-07-08 2018-12-26 Басф Агро Б.В. Композиції, що містять триазольну сполуку і біопестицид
BR112016008039A2 (pt) 2013-10-15 2017-10-17 Novo Nordisk Healthcare Ag polipeptídeos do fator vii da coagulação
WO2015132724A1 (en) 2014-03-05 2015-09-11 Pfizer Inc. Improved muteins of clotting factor viii
UA119672C2 (uk) 2014-06-25 2019-07-25 Басф Агро Б.В. Пестицидні композиції
JP7261739B2 (ja) * 2017-04-27 2023-04-20 中外製薬株式会社 薬物動態が改善された血液凝固第ｉｘ因子
AU2019366942B2 (en) * 2018-10-23 2025-10-30 The Children's Hospital Of Philadelphia Compositions and methods for modulating factor VIII function
MY206180A (en) 2019-04-17 2024-12-03 Novo Nordisk As Bispecific antibodies
EP4147056A1 (en) * 2020-05-08 2023-03-15 UCB Biopharma SRL Arrays and methods for identifying binding sites on a protein
CN113248594B (zh) * 2021-04-26 2022-08-30 北京美康基免生物科技有限公司 一种重组凝血因子viii及其应用
WO2025164792A1 (ja) * 2024-02-02 2025-08-07 学校法人自治医科大学 高比活性／高分泌発現型の第ｖｉｉｉ因子改変体、高発現型の第ｖｉｉｉ因子コード核酸及びそれらの用途
WO2025168826A1 (en) 2024-02-08 2025-08-14 Hemab Aps Methods of treating coagulopathy

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2645588A (en) 1987-12-04 1989-06-15 Scripps Clinic And Research Foundation The von willebrand factor binding domain of factor viii
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
AU6029594A (en) * 1993-01-15 1994-08-15 Enzon, Inc. Factor viii - polymeric conjugates
SE504074C2 (sv) * 1993-07-05 1996-11-04 Pharmacia Ab Proteinberedning för subkutan, intramuskulär eller intradermal administrering
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
CN100335503C (zh) 1998-04-28 2007-09-05 应用研究系统Ars股份公司 多元醇干扰素β偶联物
US6759216B1 (en) 1998-11-06 2004-07-06 Emory University Glycosylated, low antigenicity low immunogenicity factor VIII
AU775529B2 (en) 1998-11-10 2004-08-05 Stichting Sanquin Bloedvoorziening A factor VIII-polypeptide with factor VIII:C-activity
ES2411007T3 (es) * 2001-10-10 2013-07-04 Novo Nordisk A/S Remodelación y glicoconjugación de péptidos
JP4758608B2 (ja) * 2001-11-07 2011-08-31 ネクター セラピューティックス 分枝ポリマーおよびそれらの結合体
US20040249134A1 (en) * 2001-11-30 2004-12-09 Lollar John S. Factor viii c2 domain variants
AU2003227687B2 (en) 2002-04-29 2009-10-15 Stichting Sanquin Bloedvoorziening Antagonists of factor VIII interaction with low-density lipoprotein receptor-related protein
US7645860B2 (en) 2006-03-31 2010-01-12 Baxter Healthcare S.A. Factor VIII polymer conjugates
US20100056428A1 (en) 2006-09-01 2010-03-04 Novo Nordisk Health Care Ag Modified proteins
WO2008151258A2 (en) * 2007-06-04 2008-12-11 Neose Technologies, Inc. O-linked glycosylation using n-acetylglucosaminyl transferases
RU2573587C2 (ru) 2008-02-27 2016-01-20 Ново Нордиск А/С Конъюгированные молекулы фактора viii
EP2742949A1 (en) 2009-11-13 2014-06-18 Puget Sound Blood Center Factor VIII B cell epitope variants having reduced immunogenicity

Also Published As

Publication number Publication date
EP2616486B1 (en) 2019-01-02
EP2616486A2 (en) 2013-07-24
CN104788557A (zh) 2015-07-22
JP2016180002A (ja) 2016-10-13
US20170066813A1 (en) 2017-03-09
CN103209992A (zh) 2013-07-17
WO2012035050A3 (en) 2012-06-14
AU2011303916A1 (en) 2013-03-21
US20160002314A1 (en) 2016-01-07
JP6042335B2 (ja) 2016-12-14
US10906960B2 (en) 2021-02-02
US10047142B2 (en) 2018-08-14
US20180327479A1 (en) 2018-11-15
EP3466968A1 (en) 2019-04-10
US9321827B2 (en) 2016-04-26
WO2012035050A2 (en) 2012-03-22
US20140057848A1 (en) 2014-02-27
JP2013541521A (ja) 2013-11-14
JP6336522B2 (ja) 2018-06-06

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