JP6042335B2 - 細胞取込みが低下した第ｖｉｉｉ因子変異体 - Google Patents
細胞取込みが低下した第ｖｉｉｉ因子変異体 Download PDFInfo
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- 230000003389 potentiating effect Effects 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 239000003805 procoagulant Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000003134 recirculating effect Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000011435 rock Substances 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 230000003393 splenic effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 238000012032 thrombin generation assay Methods 0.000 description 1
- 239000003868 thrombin inhibitor Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000001195 ultra high performance liquid chromatography Methods 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 210000004269 weibel-palade body Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Diabetes (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10176731 | 2010-09-15 | ||
| EP10176731.7 | 2010-09-15 | ||
| US38473110P | 2010-09-21 | 2010-09-21 | |
| US61/384,731 | 2010-09-21 | ||
| EP11173768.0 | 2011-07-13 | ||
| EP11173768 | 2011-07-13 | ||
| US201161507666P | 2011-07-14 | 2011-07-14 | |
| US61/507,666 | 2011-07-14 | ||
| PCT/EP2011/065913 WO2012035050A2 (en) | 2010-09-15 | 2011-09-14 | Factor viii variants having a decreased cellular uptake |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016134866A Division JP6336522B2 (ja) | 2010-09-15 | 2016-07-07 | 細胞取込みが低下した第ｖｉｉｉ因子変異体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013541521A JP2013541521A (ja) | 2013-11-14 |
| JP2013541521A5 JP2013541521A5 (enExample) | 2014-11-06 |
| JP6042335B2 true JP6042335B2 (ja) | 2016-12-14 |
Family
ID=45832010
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013528649A Expired - Fee Related JP6042335B2 (ja) | 2010-09-15 | 2011-09-14 | 細胞取込みが低下した第ｖｉｉｉ因子変異体 |
| JP2016134866A Expired - Fee Related JP6336522B2 (ja) | 2010-09-15 | 2016-07-07 | 細胞取込みが低下した第ｖｉｉｉ因子変異体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016134866A Expired - Fee Related JP6336522B2 (ja) | 2010-09-15 | 2016-07-07 | 細胞取込みが低下した第ｖｉｉｉ因子変異体 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US9321827B2 (enExample) |
| EP (2) | EP3466968A1 (enExample) |
| JP (2) | JP6042335B2 (enExample) |
| CN (2) | CN103209992A (enExample) |
| AU (1) | AU2011303916A1 (enExample) |
| PL (1) | PL2616486T3 (enExample) |
| WO (1) | WO2012035050A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2742949A1 (en) * | 2009-11-13 | 2014-06-18 | Puget Sound Blood Center | Factor VIII B cell epitope variants having reduced immunogenicity |
| WO2013160005A1 (en) | 2012-04-24 | 2013-10-31 | Novo Nordisk A/S | Pharmaceutical composition suitable for treatment of haemophilia |
| JP2015515482A (ja) | 2012-04-24 | 2015-05-28 | ノヴォ ノルディスク アー／エス | 血友病の治療に適する化合物 |
| CN104661685A (zh) | 2012-10-15 | 2015-05-27 | 诺和诺德保健Ag（股份有限公司） | 因子vii缀合物 |
| BR112015014753B8 (pt) | 2012-12-20 | 2020-03-03 | Basf Agro Bv | composições, uso de uma composição, método para o combate de fungos fitopatogênicos e uso dos componentes |
| BR122019013926B1 (pt) | 2013-01-09 | 2019-10-29 | Basf Agro Bv | processo para preparar um composto de triazol de fórmula i |
| UA118265C2 (uk) | 2013-07-08 | 2018-12-26 | Басф Агро Б.В. | Композиції, що містять триазольну сполуку і біопестицид |
| BR112016008039A2 (pt) | 2013-10-15 | 2017-10-17 | Novo Nordisk Healthcare Ag | polipeptídeos do fator vii da coagulação |
| WO2015132724A1 (en) | 2014-03-05 | 2015-09-11 | Pfizer Inc. | Improved muteins of clotting factor viii |
| UA119672C2 (uk) | 2014-06-25 | 2019-07-25 | Басф Агро Б.В. | Пестицидні композиції |
| JP7261739B2 (ja) * | 2017-04-27 | 2023-04-20 | 中外製薬株式会社 | 薬物動態が改善された血液凝固第ｉｘ因子 |
| AU2019366942B2 (en) * | 2018-10-23 | 2025-10-30 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor VIII function |
| MY206180A (en) | 2019-04-17 | 2024-12-03 | Novo Nordisk As | Bispecific antibodies |
| EP4147056A1 (en) * | 2020-05-08 | 2023-03-15 | UCB Biopharma SRL | Arrays and methods for identifying binding sites on a protein |
| CN113248594B (zh) * | 2021-04-26 | 2022-08-30 | 北京美康基免生物科技有限公司 | 一种重组凝血因子viii及其应用 |
| WO2025164792A1 (ja) * | 2024-02-02 | 2025-08-07 | 学校法人自治医科大学 | 高比活性／高分泌発現型の第ｖｉｉｉ因子改変体、高発現型の第ｖｉｉｉ因子コード核酸及びそれらの用途 |
| WO2025168826A1 (en) | 2024-02-08 | 2025-08-14 | Hemab Aps | Methods of treating coagulopathy |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2645588A (en) | 1987-12-04 | 1989-06-15 | Scripps Clinic And Research Foundation | The von willebrand factor binding domain of factor viii |
| SE465222C5 (sv) * | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
| AU6029594A (en) * | 1993-01-15 | 1994-08-15 | Enzon, Inc. | Factor viii - polymeric conjugates |
| SE504074C2 (sv) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| CN100335503C (zh) | 1998-04-28 | 2007-09-05 | 应用研究系统Ars股份公司 | 多元醇干扰素β偶联物 |
| US6759216B1 (en) | 1998-11-06 | 2004-07-06 | Emory University | Glycosylated, low antigenicity low immunogenicity factor VIII |
| AU775529B2 (en) | 1998-11-10 | 2004-08-05 | Stichting Sanquin Bloedvoorziening | A factor VIII-polypeptide with factor VIII:C-activity |
| ES2411007T3 (es) * | 2001-10-10 | 2013-07-04 | Novo Nordisk A/S | Remodelación y glicoconjugación de péptidos |
| JP4758608B2 (ja) * | 2001-11-07 | 2011-08-31 | ネクター セラピューティックス | 分枝ポリマーおよびそれらの結合体 |
| US20040249134A1 (en) * | 2001-11-30 | 2004-12-09 | Lollar John S. | Factor viii c2 domain variants |
| AU2003227687B2 (en) | 2002-04-29 | 2009-10-15 | Stichting Sanquin Bloedvoorziening | Antagonists of factor VIII interaction with low-density lipoprotein receptor-related protein |
| US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| US20100056428A1 (en) | 2006-09-01 | 2010-03-04 | Novo Nordisk Health Care Ag | Modified proteins |
| WO2008151258A2 (en) * | 2007-06-04 | 2008-12-11 | Neose Technologies, Inc. | O-linked glycosylation using n-acetylglucosaminyl transferases |
| RU2573587C2 (ru) | 2008-02-27 | 2016-01-20 | Ново Нордиск А/С | Конъюгированные молекулы фактора viii |
| EP2742949A1 (en) | 2009-11-13 | 2014-06-18 | Puget Sound Blood Center | Factor VIII B cell epitope variants having reduced immunogenicity |
-
2011
- 2011-09-14 CN CN2011800549583A patent/CN103209992A/zh active Pending
- 2011-09-14 EP EP18195448.8A patent/EP3466968A1/en not_active Withdrawn
- 2011-09-14 CN CN201510070728.6A patent/CN104788557A/zh active Pending
- 2011-09-14 JP JP2013528649A patent/JP6042335B2/ja not_active Expired - Fee Related
- 2011-09-14 AU AU2011303916A patent/AU2011303916A1/en not_active Abandoned
- 2011-09-14 PL PL11769805T patent/PL2616486T3/pl unknown
- 2011-09-14 US US13/822,942 patent/US9321827B2/en not_active Expired - Fee Related
- 2011-09-14 WO PCT/EP2011/065913 patent/WO2012035050A2/en not_active Ceased
- 2011-09-14 EP EP11769805.0A patent/EP2616486B1/en not_active Not-in-force
-
2015
- 2015-09-23 US US14/862,934 patent/US20160002314A1/en not_active Abandoned
-
2016
- 2016-07-07 JP JP2016134866A patent/JP6336522B2/ja not_active Expired - Fee Related
- 2016-11-18 US US15/355,475 patent/US10047142B2/en active Active
-
2018
- 2018-07-06 US US16/028,603 patent/US10906960B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP2616486B1 (en) | 2019-01-02 |
| EP2616486A2 (en) | 2013-07-24 |
| CN104788557A (zh) | 2015-07-22 |
| JP2016180002A (ja) | 2016-10-13 |
| US20170066813A1 (en) | 2017-03-09 |
| CN103209992A (zh) | 2013-07-17 |
| WO2012035050A3 (en) | 2012-06-14 |
| AU2011303916A1 (en) | 2013-03-21 |
| US20160002314A1 (en) | 2016-01-07 |
| US10906960B2 (en) | 2021-02-02 |
| US10047142B2 (en) | 2018-08-14 |
| US20180327479A1 (en) | 2018-11-15 |
| EP3466968A1 (en) | 2019-04-10 |
| US9321827B2 (en) | 2016-04-26 |
| PL2616486T3 (pl) | 2019-05-31 |
| WO2012035050A2 (en) | 2012-03-22 |
| US20140057848A1 (en) | 2014-02-27 |
| JP2013541521A (ja) | 2013-11-14 |
| JP6336522B2 (ja) | 2018-06-06 |
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