PL2615089T3 - Związki pirazolochinolinowe - Google Patents
Związki pirazolochinolinoweInfo
- Publication number
- PL2615089T3 PL2615089T3 PL11823618.1T PL11823618T PL2615089T3 PL 2615089 T3 PL2615089 T3 PL 2615089T3 PL 11823618 T PL11823618 T PL 11823618T PL 2615089 T3 PL2615089 T3 PL 2615089T3
- Authority
- PL
- Poland
- Prior art keywords
- pyrazoloquinoline
- compounds
- pyrazoloquinoline compounds
- Prior art date
Links
- UXYHZIYEDDINQH-UHFFFAOYSA-N C1=CNC2=C3C=NN=C3C=CC2=C1 Chemical class C1=CNC2=C3C=NN=C3C=CC2=C1 UXYHZIYEDDINQH-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010200403 | 2010-09-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2615089T3 true PL2615089T3 (pl) | 2016-10-31 |
Family
ID=45810740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11823618.1T PL2615089T3 (pl) | 2010-09-07 | 2011-09-07 | Związki pirazolochinolinowe |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8822448B2 (pl) |
| EP (1) | EP2615089B1 (pl) |
| JP (1) | JP5888237B2 (pl) |
| KR (1) | KR101860583B1 (pl) |
| CN (1) | CN103097383B (pl) |
| BR (1) | BR112013005444B1 (pl) |
| CA (1) | CA2810696C (pl) |
| CY (1) | CY1117547T1 (pl) |
| DK (1) | DK2615089T3 (pl) |
| EA (1) | EA023493B1 (pl) |
| ES (1) | ES2583528T3 (pl) |
| HR (1) | HRP20160473T1 (pl) |
| HU (1) | HUE028038T2 (pl) |
| MX (1) | MX2013002584A (pl) |
| PL (1) | PL2615089T3 (pl) |
| RS (1) | RS54834B1 (pl) |
| SI (1) | SI2615089T1 (pl) |
| WO (1) | WO2012033144A1 (pl) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9169246B2 (en) * | 2011-09-26 | 2015-10-27 | Sanofi | Pyrazoloquinolinone derivatives, preparation thereof and therapeutic use thereof |
| JP6042060B2 (ja) * | 2011-09-26 | 2016-12-14 | サノフイ | ピラゾロキノリノン誘導体、その調製および治療上の使用 |
| SI2573073T1 (sl) * | 2011-09-26 | 2015-02-27 | Sanofi | Pirazolokinolinonski derivati, njihova priprava in njihova terapevtska uporaba |
| EP2769980B1 (en) * | 2011-10-07 | 2016-02-03 | Eisai R&D Management Co., Ltd. | Pyrazoloquinoline derivative as pde9 inhibitors |
| CN102786525B (zh) | 2012-08-08 | 2014-12-17 | 中山大学 | N-取代吡唑并[3,4-d]嘧啶酮类化合物、其制备方法及其应用 |
| KR101997955B1 (ko) * | 2013-04-05 | 2019-07-08 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 피라졸로퀴놀린 유도체의 염, 및 이의 결정 |
| US9550776B2 (en) * | 2013-04-05 | 2017-01-24 | Eisai R&D Management Co., Ltd. | Pyridinylpyrazoloquinoline compounds |
| WO2016054491A1 (en) | 2014-10-03 | 2016-04-07 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| AR102849A1 (es) * | 2015-03-09 | 2017-03-29 | Astellas Pharma Inc | Compuesto de piridina bicíclica |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| AU2018276565A1 (en) | 2017-06-01 | 2019-11-07 | Eisai R&D Management Co., Ltd. | Dementia therapeutic agent combining pyrazoloquinoline derivative and donepezil |
| JP7177772B2 (ja) | 2017-06-01 | 2022-11-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピラゾロキノリン誘導体とメマンチンの併用による認知症治療剤 |
| CN116585316A (zh) | 2017-06-01 | 2023-08-15 | 卫材R&D管理有限公司 | 包含pde9抑制剂的药物组合物 |
| ES2961554T3 (es) | 2017-06-01 | 2024-03-12 | Eisai R&D Man Co Ltd | Agente terapéutico para enfermedad con cuerpos de Lewy que contiene derivado de pirazoloquinolina |
| MX2024001155A (es) * | 2021-07-30 | 2024-07-01 | Confo Therapeutics N V | Compuestos para el tratamiento del dolor, en particular el dolor neuropatico, y/u otras enfermedades o trastornos que se asocian con at2r y/o se?alizacion mediada por at2r. |
| IL312114A (en) | 2021-10-14 | 2024-06-01 | Incyte Corp | Quinoline compounds as Kras inhibitors |
| US20250214980A1 (en) | 2022-03-14 | 2025-07-03 | Slap Pharmaceuticals Llc | Multicyclic compounds |
| WO2025036472A1 (en) * | 2023-08-16 | 2025-02-20 | Pharmaengine, Inc. | Spirocyclic mta-cooperative prmts inhibitor |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5192768A (en) | 1990-09-14 | 1993-03-09 | Kyowa Hakko Kogyo Co., Ltd. | Pyrazoloquinoline derivatives |
| JPH05132484A (ja) * | 1991-04-26 | 1993-05-28 | Otsuka Pharmaceut Factory Inc | ピラゾロキノリン及びピラゾロナフチリジン誘導体 |
| JP2005508978A (ja) | 2001-11-02 | 2005-04-07 | ファイザー・プロダクツ・インク | Ｐｄｅ９阻害薬によるインスリン抵抗性症候群及び２型糖尿病の治療 |
| HN2002000317A (es) | 2001-11-02 | 2003-05-21 | Pfizer | Inhibidores de pde9 para tratamiento de trastornos cardiovasculares |
| DE10238723A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
| KR101026819B1 (ko) | 2003-01-09 | 2011-04-04 | 아스테라스 세이야쿠 가부시키가이샤 | 피롤로피리다진 유도체 |
| WO2005028474A2 (en) | 2003-05-29 | 2005-03-31 | Millennium Pharmaceuticals, Inc. | Pyrazoloquinoline derivatives as chk-1 inhibitors |
| JP2006045118A (ja) | 2004-08-04 | 2006-02-16 | Mochida Pharmaceut Co Ltd | 新規ピラゾロキノロン誘導体 |
| CA2612176C (en) | 2005-06-14 | 2015-02-17 | Aska Pharmaceutical Co., Ltd. | Dihydrothieno[2,3-d]pyramidine-6-carboxylic acid derivatives as pde9 inhibitors |
| US7671069B2 (en) | 2006-03-30 | 2010-03-02 | Chemocentryx, Inc. | Tricyclic, heteroaromatic compounds modulating CXCR4 and/ or CXCR7 |
| KR101419075B1 (ko) | 2006-08-08 | 2014-07-11 | 아스카 세이야쿠 가부시키가이샤 | 퀴나졸린 유도체 |
| AU2007332439A1 (en) | 2006-12-13 | 2008-06-19 | Aska Pharmaceutical Co., Ltd. | Therapeutic agent for urinary tract disease |
| CA2671980C (en) | 2006-12-13 | 2015-05-05 | Aska Pharmaceutical Co., Ltd. | Quinoxaline derivatives |
| DK2152712T3 (da) | 2007-05-11 | 2012-03-26 | Pfizer | Aminoheterocykliske fobindelser |
| EP2217602B1 (en) | 2007-11-30 | 2018-08-29 | Boehringer Ingelheim International GmbH | 1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one derivatives and their use as pde9a modulators for the treatment of cns disorders |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| PE20110383A1 (es) | 2008-09-08 | 2011-07-15 | Boehringer Ingelheim Int | Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a) |
| US9259564B2 (en) | 2009-01-22 | 2016-02-16 | Avent, Inc. | Enteral feeding assembly with lock assembly |
| TWI404721B (zh) | 2009-01-26 | 2013-08-11 | Pfizer | 胺基－雜環化合物 |
-
2011
- 2011-09-07 EP EP11823618.1A patent/EP2615089B1/en active Active
- 2011-09-07 SI SI201130826A patent/SI2615089T1/sl unknown
- 2011-09-07 ES ES11823618.1T patent/ES2583528T3/es active Active
- 2011-09-07 WO PCT/JP2011/070410 patent/WO2012033144A1/ja not_active Ceased
- 2011-09-07 CA CA2810696A patent/CA2810696C/en active Active
- 2011-09-07 DK DK11823618.1T patent/DK2615089T3/en active
- 2011-09-07 EA EA201390353A patent/EA023493B1/ru not_active IP Right Cessation
- 2011-09-07 RS RS20160364A patent/RS54834B1/sr unknown
- 2011-09-07 JP JP2012533012A patent/JP5888237B2/ja not_active Expired - Fee Related
- 2011-09-07 HU HUE11823618A patent/HUE028038T2/en unknown
- 2011-09-07 HR HRP20160473TT patent/HRP20160473T1/hr unknown
- 2011-09-07 CN CN201180043183.XA patent/CN103097383B/zh not_active Expired - Fee Related
- 2011-09-07 BR BR112013005444-1A patent/BR112013005444B1/pt not_active IP Right Cessation
- 2011-09-07 PL PL11823618.1T patent/PL2615089T3/pl unknown
- 2011-09-07 MX MX2013002584A patent/MX2013002584A/es active IP Right Grant
- 2011-09-07 KR KR1020137005776A patent/KR101860583B1/ko not_active Expired - Fee Related
-
2013
- 2013-03-07 US US13/788,907 patent/US8822448B2/en active Active
-
2016
- 2016-05-24 CY CY20161100451T patent/CY1117547T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK2615089T3 (en) | 2016-06-06 |
| JP5888237B2 (ja) | 2016-03-16 |
| MX2013002584A (es) | 2013-04-29 |
| SI2615089T1 (sl) | 2016-08-31 |
| RS54834B1 (sr) | 2016-10-31 |
| KR20130106358A (ko) | 2013-09-27 |
| ES2583528T3 (es) | 2016-09-21 |
| CY1117547T1 (el) | 2017-04-26 |
| WO2012033144A1 (ja) | 2012-03-15 |
| CA2810696A1 (en) | 2012-03-15 |
| US8822448B2 (en) | 2014-09-02 |
| CN103097383B (zh) | 2015-09-16 |
| HUE028038T2 (en) | 2016-11-28 |
| BR112013005444A2 (pt) | 2017-09-19 |
| EP2615089A4 (en) | 2014-01-01 |
| CA2810696C (en) | 2018-09-18 |
| JPWO2012033144A1 (ja) | 2014-01-20 |
| EA201390353A1 (ru) | 2013-08-30 |
| HRP20160473T1 (hr) | 2016-07-29 |
| BR112013005444B1 (pt) | 2019-07-09 |
| EP2615089B1 (en) | 2016-04-27 |
| EA023493B1 (ru) | 2016-06-30 |
| CN103097383A (zh) | 2013-05-08 |
| KR101860583B1 (ko) | 2018-05-23 |
| US20130225553A1 (en) | 2013-08-29 |
| EP2615089A1 (en) | 2013-07-17 |
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