PL2609075T3 - Sposób wytwarzania związków pośrednich do produkcji inhibitorów NEP - Google Patents
Sposób wytwarzania związków pośrednich do produkcji inhibitorów NEPInfo
- Publication number
- PL2609075T3 PL2609075T3 PL11758421.9T PL11758421T PL2609075T3 PL 2609075 T3 PL2609075 T3 PL 2609075T3 PL 11758421 T PL11758421 T PL 11758421T PL 2609075 T3 PL2609075 T3 PL 2609075T3
- Authority
- PL
- Poland
- Prior art keywords
- intermediates
- manufacture
- preparation
- nep inhibitors
- nep
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Materials Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010076245 | 2010-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2609075T3 true PL2609075T3 (pl) | 2016-09-30 |
Family
ID=44658722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11758421.9T PL2609075T3 (pl) | 2010-08-23 | 2011-08-22 | Sposób wytwarzania związków pośrednich do produkcji inhibitorów NEP |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8835668B2 (pl) |
| EP (1) | EP2609075B1 (pl) |
| JP (1) | JP5705984B2 (pl) |
| KR (1) | KR101476937B1 (pl) |
| AU (1) | AU2011295170B2 (pl) |
| BR (1) | BR112013004164A2 (pl) |
| CA (1) | CA2806780A1 (pl) |
| ES (1) | ES2576179T3 (pl) |
| MX (1) | MX2013002150A (pl) |
| PL (1) | PL2609075T3 (pl) |
| PT (1) | PT2609075E (pl) |
| RU (1) | RU2588572C2 (pl) |
| SI (1) | SI2609075T1 (pl) |
| WO (1) | WO2012025501A1 (pl) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20091364A1 (es) * | 2008-01-17 | 2009-10-13 | Novartis Ag | Proceso para la preparacion de inhibidores de nep |
| PL3218351T3 (pl) | 2014-11-14 | 2019-12-31 | Zentiva K.S. | Sposób wytwarzania, wyodrębniania i oczyszczania farmaceutycznie dopuszczalnych postaci AHU-377 |
| TW201632493A (zh) | 2015-02-13 | 2016-09-16 | 諾華公司 | 新穎方法 |
| WO2016135751A1 (en) | 2015-02-25 | 2016-09-01 | Mylan Laboratories Limited | Novel process for the preparation of sacubitril and its intermediates |
| WO2017051326A1 (en) | 2015-09-23 | 2017-03-30 | Novartis Ag | New processes and intermediates useful in synthesis of nep inhibitors |
| US10377697B2 (en) | 2015-12-10 | 2019-08-13 | Novartis Ag | Process and intermediates |
| EP3386945A1 (en) | 2015-12-11 | 2018-10-17 | Zentiva, K.S. | Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method |
| CN109415308B (zh) | 2016-07-05 | 2022-09-06 | 诺华股份有限公司 | 用于早期沙卡布曲中间体的新方法 |
| JP6945619B2 (ja) | 2016-08-17 | 2021-10-06 | ノバルティス アーゲー | Ｎｅｐ阻害剤合成のための新規な方法および中間体 |
| EP3558930B1 (en) | 2016-12-23 | 2021-05-26 | Novartis AG | New process for early sacubitril intermediates |
| CN106946742A (zh) * | 2017-03-28 | 2017-07-14 | 常州沃腾化工科技有限公司 | 一种三苯基氧磷含量低的沙库必曲中间体的制备方法 |
| CN109503404A (zh) * | 2018-12-28 | 2019-03-22 | 凯瑞斯德生化(苏州)有限公司 | 一种lcz-696关键中间体的制备方法 |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5015793B2 (pl) | 1972-06-07 | 1975-06-07 | ||
| JPS53103412A (en) * | 1977-02-18 | 1978-09-08 | Kuraray Co Ltd | Preparation of farnesyl acetic acid or its ester |
| US4219683A (en) * | 1978-09-25 | 1980-08-26 | Phillips Petroleum Company | Isomerization of unsaturated alcohols |
| FR2597100A1 (fr) | 1986-01-21 | 1987-10-16 | Nippon Shinyaku Co Ltd | Derives du pyroglutamide |
| DE3713127A1 (de) * | 1987-04-16 | 1988-11-03 | Consortium Elektrochem Ind | Verfahren zur herstellung von tiglinaldehyd |
| JPH07103101B2 (ja) | 1989-07-24 | 1995-11-08 | キッセイ薬品工業株式会社 | ピログルタミン酸誘導体 |
| DE122010000024I1 (de) | 1990-02-19 | 2010-07-08 | Novartis Ag | Acylverbindungen |
| US5273990A (en) | 1992-09-03 | 1993-12-28 | Ciba-Geigy Corporation | Phosphono substituted tetrazole derivatives |
| US5250522A (en) | 1992-10-09 | 1993-10-05 | Ciba-Geigy Corporation | Phosphono/biaryl substituted amino acid derivatives |
| FR2688503B1 (fr) | 1992-03-16 | 1994-05-06 | Synthelabo | Procede de preparation de derives de 2-(tetrazol-5-yl)-[1,1'-biphenyle]. |
| EP0550313A1 (fr) | 1991-12-30 | 1993-07-07 | Synthelabo | Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse |
| US5217996A (en) | 1992-01-22 | 1993-06-08 | Ciba-Geigy Corporation | Biaryl substituted 4-amino-butyric acid amides |
| US5412102A (en) | 1994-05-27 | 1995-05-02 | Syntex (U.S.A.) Inc. | Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) biphenyl-4-ylmethyl]-1H-indole-3-carboxylic acid |
| US5550119A (en) | 1995-03-02 | 1996-08-27 | Ciba-Geigy Corporation | Phosphono substituted tetrazole derivatives as ECE inhibitors |
| BR9707588A (pt) | 1996-02-19 | 1999-07-27 | Japan Tobacco Inc | Agente terapeutico para diabetes |
| TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
| DK0916656T3 (da) | 1997-11-14 | 2004-01-05 | Schering Ag | Fremgangsmåde til fremstilling af pyrrolidinoderivater |
| WO2000017162A1 (en) | 1998-09-21 | 2000-03-30 | Takeda Chemical Industries, Ltd. | Novel thiol derivatives, process for producing the same and utilization thereof |
| YU68102A (sh) * | 2000-03-16 | 2006-01-16 | F. Hoffmann-La Roche Ag. | Derivati karboksilne kiseline kao ip antagonisti |
| PT1467728E (pt) | 2002-01-17 | 2007-11-14 | Novartis Ag | Composições farmacêuticas compreendendo valsartan e inibidores da nep |
| WO2003082837A1 (en) | 2002-03-29 | 2003-10-09 | Senju Pharmaceutical Co., Ltd. | Hydroxymorpholinone derivative and medicinal use thereof |
| GB0402262D0 (en) | 2004-02-02 | 2004-03-10 | Novartis Ag | Process for the manufacture of organic compounds |
| US7618981B2 (en) | 2004-05-06 | 2009-11-17 | Cytokinetics, Inc. | Imidazopyridinyl-benzamide anti-cancer agents |
| RU2006143155A (ru) | 2004-05-07 | 2008-06-20 | Умикоре Аг Энд Ко. Кг (De) | Ферроценильные лиганды для гомогенных энантиоселективных катализаторов гидрирования |
| GB0418046D0 (en) | 2004-08-12 | 2004-09-15 | Prosidion Ltd | Eantioselective process |
| MY146830A (en) | 2005-02-11 | 2012-09-28 | Novartis Ag | Combination of organic compounds |
| EP1903027A1 (en) * | 2006-09-13 | 2008-03-26 | Novartis AG | Process for preparing biaryl substituted 4-amino-butyric acid or derivatives thereof and their use in the production of NEP inhibitors |
| RU2530900C2 (ru) | 2007-01-12 | 2014-10-20 | Новартис Аг | Способ получения 5-бифенил-4-амино-2-метилпентановой кислоты |
| EP2532673A3 (en) | 2007-05-10 | 2014-01-08 | R & D Biopharmaceuticals Gmbh | Tubulysine derivatives |
| PE20091364A1 (es) | 2008-01-17 | 2009-10-13 | Novartis Ag | Proceso para la preparacion de inhibidores de nep |
| SI2526088T1 (sl) | 2010-01-22 | 2015-12-31 | Novartis Ag | Intermediati nevtralnih endopeptidaznih inhibitorjev in metoda za njihovo pripravo |
| ES2608780T3 (es) | 2010-08-23 | 2017-04-17 | Novartis Ag | Nuevo proceso para la preparación de intermediarios útiles para la elaboración de inhibidores de NEP |
-
2011
- 2011-08-22 BR BR112013004164A patent/BR112013004164A2/pt not_active IP Right Cessation
- 2011-08-22 US US13/818,507 patent/US8835668B2/en active Active
- 2011-08-22 CA CA2806780A patent/CA2806780A1/en not_active Abandoned
- 2011-08-22 KR KR1020137007279A patent/KR101476937B1/ko not_active Expired - Fee Related
- 2011-08-22 SI SI201130827A patent/SI2609075T1/sl unknown
- 2011-08-22 JP JP2013525279A patent/JP5705984B2/ja active Active
- 2011-08-22 WO PCT/EP2011/064410 patent/WO2012025501A1/en not_active Ceased
- 2011-08-22 PT PT117584219T patent/PT2609075E/pt unknown
- 2011-08-22 EP EP11758421.9A patent/EP2609075B1/en active Active
- 2011-08-22 PL PL11758421.9T patent/PL2609075T3/pl unknown
- 2011-08-22 AU AU2011295170A patent/AU2011295170B2/en not_active Ceased
- 2011-08-22 RU RU2013112946/04A patent/RU2588572C2/ru not_active IP Right Cessation
- 2011-08-22 MX MX2013002150A patent/MX2013002150A/es active IP Right Grant
- 2011-08-22 ES ES11758421.9T patent/ES2576179T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2013112946A (ru) | 2014-09-27 |
| AU2011295170B2 (en) | 2014-12-18 |
| EP2609075A1 (en) | 2013-07-03 |
| KR20130061735A (ko) | 2013-06-11 |
| ES2576179T3 (es) | 2016-07-06 |
| CA2806780A1 (en) | 2012-03-01 |
| EP2609075B1 (en) | 2016-03-16 |
| PT2609075E (pt) | 2016-06-03 |
| AU2011295170A1 (en) | 2013-03-21 |
| JP2013539462A (ja) | 2013-10-24 |
| KR101476937B1 (ko) | 2014-12-24 |
| MX2013002150A (es) | 2013-04-03 |
| US8835668B2 (en) | 2014-09-16 |
| RU2588572C2 (ru) | 2016-07-10 |
| SI2609075T1 (sl) | 2016-06-30 |
| WO2012025501A1 (en) | 2012-03-01 |
| US20130158285A1 (en) | 2013-06-20 |
| JP5705984B2 (ja) | 2015-04-22 |
| BR112013004164A2 (pt) | 2016-05-10 |
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