PL2569314T3 - Skondensowane bicykliczne inhibitory kinazy - Google Patents
Skondensowane bicykliczne inhibitory kinazyInfo
- Publication number
- PL2569314T3 PL2569314T3 PL11721678T PL11721678T PL2569314T3 PL 2569314 T3 PL2569314 T3 PL 2569314T3 PL 11721678 T PL11721678 T PL 11721678T PL 11721678 T PL11721678 T PL 11721678T PL 2569314 T3 PL2569314 T3 PL 2569314T3
- Authority
- PL
- Poland
- Prior art keywords
- kinase inhibitors
- fused bicyclic
- bicyclic kinase
- fused
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33473410P | 2010-05-14 | 2010-05-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2569314T3 true PL2569314T3 (pl) | 2017-02-28 |
Family
ID=44211949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11721678T PL2569314T3 (pl) | 2010-05-14 | 2011-05-16 | Skondensowane bicykliczne inhibitory kinazy |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8445510B2 (pl) |
| EP (1) | EP2569314B1 (pl) |
| JP (1) | JP5820472B2 (pl) |
| KR (1) | KR20130118213A (pl) |
| CN (1) | CN102971316A (pl) |
| AR (1) | AR081039A1 (pl) |
| AU (1) | AU2011252784A1 (pl) |
| BR (1) | BR112012028674A2 (pl) |
| CA (1) | CA2790847A1 (pl) |
| EA (1) | EA201291246A1 (pl) |
| ES (1) | ES2604481T3 (pl) |
| MX (1) | MX2012013206A (pl) |
| PL (1) | PL2569314T3 (pl) |
| PT (1) | PT2569314T (pl) |
| SG (1) | SG184822A1 (pl) |
| TW (1) | TW201141863A (pl) |
| WO (1) | WO2011143645A1 (pl) |
| ZA (1) | ZA201208489B (pl) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012509342A (ja) * | 2008-11-20 | 2012-04-19 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換ピロロ［２，３−ｂ］−ピリジンおよび−ピラジン |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
| MX2013001313A (es) * | 2010-08-05 | 2013-06-13 | Amgen Inc | Compuestos de bencimidazol y azabencimidazol que inhiben la cinasa del linfoma anaplasico. |
| EP2710003A1 (en) * | 2011-05-16 | 2014-03-26 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
| WO2013152252A1 (en) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Combination anti-cancer therapy |
| SG11201408816QA (en) * | 2012-07-03 | 2015-03-30 | Aurigene Discovery Tech Ltd | 3-(PYRAZOLYL)-1H-PYRROLO[2,3-b]PYRIDINE DERIVATIVES AS KINASE INHIBITORS |
| CN103613591B (zh) * | 2012-09-29 | 2016-04-13 | 上海科州药物研发有限公司 | 作为cMet抑制剂的化合物及其制备方法和用途 |
| EP2945938B1 (en) * | 2013-01-18 | 2018-03-07 | F. Hoffmann-La Roche AG | 3-substituted pyrazoles and use as dlk inhibitors |
| US20140303121A1 (en) | 2013-03-15 | 2014-10-09 | Plexxikon Inc. | Heterocyclic compounds and uses thereof |
| KR102244719B1 (ko) * | 2013-03-15 | 2021-04-26 | 플렉시콘 인코퍼레이티드 | 헤테로시클릭 화합물 및 그의 용도 |
| CN104513253A (zh) | 2013-10-01 | 2015-04-15 | 南京波尔泰药业科技有限公司 | 用于治疗增殖性疾病的大环化合物 |
| CN104628555B (zh) * | 2015-01-05 | 2016-11-30 | 烟台蓓丰医药科技有限公司 | 一种药物中间体4-(4-氯苯基)环己基-1-甲酸的合成方法 |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CN111194318B (zh) | 2017-10-13 | 2023-06-09 | Opna生物公司 | 用于调节激酶的化合物固体形式 |
| ES2962605T3 (es) | 2018-02-26 | 2024-03-20 | Gilead Sciences Inc | Compuestos de pirrolizina sustituidos como inhibidores de la replicación del VHB |
| US20230339937A1 (en) | 2020-06-19 | 2023-10-26 | Sato Pharmaceutical Co., Ltd. | Condensed ring compounds that inhibit h-pgds |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4360531A (en) | 1981-04-09 | 1982-11-23 | The Upjohn Company | Substituted cycloalkanes |
| US6235769B1 (en) | 1997-07-03 | 2001-05-22 | Sugen, Inc. | Methods of preventing and treating neurological disorders with compounds that modulate the function of the C-RET receptor protein tyrosine kinase |
| IL159506A0 (en) | 2001-06-23 | 2004-06-01 | Aventis Pharma Inc | Pyrrolopyrimidines as protein kinase inhibitors |
| TW200301251A (en) | 2001-12-20 | 2003-07-01 | Wyeth Corp | Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands |
| KR20040111445A (ko) | 2002-03-28 | 2004-12-31 | 에자이 가부시키가이샤 | 신경퇴행성 질환 치료용 ｃ─Ｊｕｎ Ｎ─말단 키나아제억제제로서의 ７─아자인돌 |
| AU2003297727A1 (en) | 2002-12-10 | 2004-06-30 | Wyeth | Substituted 3-alkyl and 3-arylalkyl 1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1) |
| EP2476667B1 (en) | 2003-02-26 | 2014-07-16 | Sugen, Inc. | Aminoheteroaryl compounds as protein kinase inhibitors |
| CA2530589A1 (en) | 2003-07-02 | 2005-01-20 | Sugen Inc. | Arylmethyl triazolo and imidazopyrazines as c-met inhibitors |
| US7122548B2 (en) | 2003-07-02 | 2006-10-17 | Sugen, Inc. | Triazolotriazine compounds and uses thereof |
| US20070066641A1 (en) | 2003-12-19 | 2007-03-22 | Prabha Ibrahim | Compounds and methods for development of RET modulators |
| SI1696920T1 (sl) | 2003-12-19 | 2015-02-27 | Plexxikon Inc. | Spojine in postopki za razvoj modulatorjev ret |
| US20050182060A1 (en) | 2004-02-13 | 2005-08-18 | Kelly Michael G. | 2-Substituted and 4-substituted aryl nitrone compounds |
| AU2005269387A1 (en) | 2004-07-27 | 2006-02-09 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| US7626021B2 (en) | 2004-07-27 | 2009-12-01 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
| US7709645B2 (en) | 2004-07-27 | 2010-05-04 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| US7361764B2 (en) | 2004-07-27 | 2008-04-22 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
| RS51601B (en) | 2004-08-26 | 2011-08-31 | Pfizer Inc. | PYRAZOLS SUBSTITUTED BY AMINOHETEROARYL UNITS AS PROTEIN KINASE INHIBITORS |
| EP1786777A1 (en) | 2004-08-26 | 2007-05-23 | Pfizer, Inc. | Aminoheteroaryl compounds as protein tyrosine kinase inhibitors |
| PL1786785T3 (pl) | 2004-08-26 | 2010-08-31 | Pfizer | Enancjomerycznie czyste związki aminoheteroarylowe jako kinazy białkowe |
| CA2608733A1 (en) | 2005-05-17 | 2007-02-01 | Plexxikon, Inc. | Pyrrol (2,3-b) pyridine derivatives protein kinase inhibitors |
| CA2610588A1 (en) | 2005-06-10 | 2006-12-21 | Boehringer Ingelheim International Gmbh | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof |
| EP3088400A1 (en) | 2005-06-22 | 2016-11-02 | Plexxikon Inc. | Pyrrolo[2,3-b]pyridine derivatives as protein kinase inhibitors |
| WO2007064797A2 (en) | 2005-11-30 | 2007-06-07 | Vertex Pharmaceuticals Incorporated | Inhibitors of c-met and uses thereof |
| RU2008120141A (ru) | 2005-11-30 | 2010-01-10 | Ф. Хоффманн-Ля Рош Аг (Ch) | 3-амино-2-арилпропилазаиндолы и их применения |
| ES2402419T3 (es) | 2005-12-05 | 2013-05-03 | Pfizer Products Inc. | Polimorfos de un inhibidor de C-MET/HGFR |
| WO2007067537A1 (en) | 2005-12-07 | 2007-06-14 | Osi Pharmaceuticals, Inc. | Pyrrolopyridine kinase inhibiting compounds |
| US8030305B2 (en) | 2005-12-21 | 2011-10-04 | Janssen Pharmaceutica N.V. | Triazolopyridazines as kinase modulators |
| NL2000613C2 (nl) | 2006-05-11 | 2007-11-20 | Pfizer Prod Inc | Triazoolpyrazinederivaten. |
| WO2007138472A2 (en) | 2006-05-30 | 2007-12-06 | Pfizer Products Inc. | Triazolopyridazine derivatives |
| PE20080403A1 (es) | 2006-07-14 | 2008-04-25 | Amgen Inc | Derivados heterociclicos fusionados y metodos de uso |
| WO2008019968A1 (en) | 2006-08-16 | 2008-02-21 | F. Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
| DE102006043443A1 (de) | 2006-09-15 | 2008-03-27 | Bayer Healthcare Ag | Neue aza-bicyclische Verbindungen und ihre Verwendung |
| US8639558B2 (en) | 2006-09-25 | 2014-01-28 | International Business Machines Corporation | Providing markdown item pricing and promotion calendar |
| US7960569B2 (en) | 2006-10-17 | 2011-06-14 | Bristol-Myers Squibb Company | Indole antagonists of P2Y1 receptor useful in the treatment of thrombotic conditions |
| JP5378222B2 (ja) | 2006-10-23 | 2013-12-25 | エスジーエックス ファーマシューティカルズ、インコーポレイテッド | タンパク質キナーゼ調節物質としての二環式トリアゾール |
| ES2393132T3 (es) | 2006-10-23 | 2012-12-18 | Sgx Pharmaceuticals, Inc. | Moduoladores de proteína quinasa de triazolopiridazina |
| GB0621607D0 (en) | 2006-10-31 | 2006-12-06 | Chroma Therapeutics Ltd | Inhibitors of c-Met |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| PE20081581A1 (es) | 2006-12-21 | 2008-11-12 | Plexxikon Inc | COMPUESTOS PIRROLO[2,3-b]PIRIDINAS COMO MODULADORES DE QUINASA |
| US7872018B2 (en) | 2006-12-21 | 2011-01-18 | Plexxikon, Inc. | Compounds and methods for kinase modulation, and indications therefor |
| EP2120578B1 (en) | 2007-01-19 | 2014-11-19 | Xcovery, INC. | Kinase inhibitor compounds |
| CL2008001540A1 (es) | 2007-05-29 | 2009-05-22 | Sgx Pharmaceuticals Inc | Compuestos derivados de pirrolopiridinas y pirazolopiridinas; composicion farmaceutica; y uso en el tratamiento del cancer. |
| JP5411160B2 (ja) | 2007-12-21 | 2014-02-12 | エフ．ホフマン−ラ ロシュ アーゲー | 複素環式抗ウイルス性化合物 |
| EP2231282A1 (en) | 2008-01-22 | 2010-09-29 | Merck Patent GmbH | Protein kinase inhibitors and use thereof |
| EP2288383A1 (en) | 2008-05-14 | 2011-03-02 | Amgen, Inc | Combinations vegf(r) inhibitors and hepatocyte growth factor (c-met) inhibitors for the treatment of cancer |
| MX2011003363A (es) | 2008-10-01 | 2011-04-27 | Ludwig Inst Cancer Res | Metodos para el tratamiento de cancer. |
| JP2012509342A (ja) * | 2008-11-20 | 2012-04-19 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換ピロロ［２，３−ｂ］−ピリジンおよび−ピラジン |
| RU2011141123A (ru) | 2009-03-11 | 2013-04-20 | Плексксикон, Инк. | ПРОИЗВОДНЫЕ ПИРРОЛО[2,3-b]ПИРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ RAF-КИНАЗ |
| JP2013526570A (ja) * | 2010-05-14 | 2013-06-24 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 縮合二環式キナーゼ阻害剤 |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
-
2011
- 2011-05-12 AR ARP110101643A patent/AR081039A1/es not_active Application Discontinuation
- 2011-05-13 TW TW100116943A patent/TW201141863A/zh unknown
- 2011-05-16 AU AU2011252784A patent/AU2011252784A1/en not_active Abandoned
- 2011-05-16 PL PL11721678T patent/PL2569314T3/pl unknown
- 2011-05-16 CN CN2011800236682A patent/CN102971316A/zh active Pending
- 2011-05-16 KR KR1020127032736A patent/KR20130118213A/ko not_active Application Discontinuation
- 2011-05-16 EA EA201291246A patent/EA201291246A1/ru unknown
- 2011-05-16 US US13/108,024 patent/US8445510B2/en active Active
- 2011-05-16 WO PCT/US2011/036572 patent/WO2011143645A1/en active Application Filing
- 2011-05-16 PT PT117216788T patent/PT2569314T/pt unknown
- 2011-05-16 JP JP2013511247A patent/JP5820472B2/ja active Active
- 2011-05-16 BR BR112012028674A patent/BR112012028674A2/pt not_active IP Right Cessation
- 2011-05-16 EP EP11721678.8A patent/EP2569314B1/en active Active
- 2011-05-16 MX MX2012013206A patent/MX2012013206A/es active IP Right Grant
- 2011-05-16 SG SG2012075495A patent/SG184822A1/en unknown
- 2011-05-16 ES ES11721678.8T patent/ES2604481T3/es active Active
- 2011-05-16 CA CA2790847A patent/CA2790847A1/en not_active Abandoned
-
2012
- 2012-11-12 ZA ZA2012/08489A patent/ZA201208489B/en unknown
-
2013
- 2013-04-30 US US13/873,353 patent/US20130253197A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EA201291246A1 (ru) | 2013-04-30 |
| TW201141863A (en) | 2011-12-01 |
| MX2012013206A (es) | 2012-12-17 |
| US20130253197A1 (en) | 2013-09-26 |
| US20110281888A1 (en) | 2011-11-17 |
| US8445510B2 (en) | 2013-05-21 |
| EP2569314B1 (en) | 2016-09-07 |
| PT2569314T (pt) | 2016-10-25 |
| JP5820472B2 (ja) | 2015-11-24 |
| JP2013526569A (ja) | 2013-06-24 |
| AR081039A1 (es) | 2012-05-30 |
| SG184822A1 (en) | 2012-12-28 |
| CA2790847A1 (en) | 2011-11-17 |
| ES2604481T3 (es) | 2017-03-07 |
| BR112012028674A2 (pt) | 2016-08-16 |
| ZA201208489B (en) | 2013-09-25 |
| CN102971316A (zh) | 2013-03-13 |
| AU2011252784A1 (en) | 2012-09-13 |
| KR20130118213A (ko) | 2013-10-29 |
| WO2011143645A1 (en) | 2011-11-17 |
| EP2569314A1 (en) | 2013-03-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL247405A0 (en) | Apoptosis signal-regulating kinase inhibitors | |
| ZA201208489B (en) | Fused bicyclic kinase inhibitors | |
| HK1200828A1 (en) | Kinase inhibitors | |
| HK1200451A1 (zh) | 蛋白激酶抑制劑 | |
| HUE048834T2 (hu) | Kináz inhibitorok | |
| EP2552208A4 (en) | IMIDAZOLYL-IMIDAZOLES AS KINASE INHIBITORS | |
| EP2694517A4 (en) | PROTEIN KINASE INHIBITORS | |
| EP2552214A4 (en) | PYRAZOLYL-PYRIMIDINES AS KINASE INHIBITORS | |
| EP2552211A4 (en) | INDAZOLYL-PYRIMIDINE AS KINASEHEMMER | |
| GB201009731D0 (en) | Kinase inhibitors | |
| HK1213252A1 (zh) | 雙環二氫吡啶酮激酶抑制劑 | |
| IL228311A0 (en) | Protein kinase inhibitors | |
| IL229028A0 (en) | Kinase inhibitors | |
| HK1199873A1 (en) | Kinase inhibitors | |
| HK1213181A1 (zh) | 雙環氧雜內酰胺激酶抑制劑 | |
| PL2646448T3 (pl) | Makrocykliczne inhibitory kinazy | |
| EP2642856A4 (en) | INTEGRIN-RELATED KINASE INHIBITORS |