PL2426209T3 - Oksydoreduktazy do stereoselektywnej redukcji związków ketonowych - Google Patents
Oksydoreduktazy do stereoselektywnej redukcji związków ketonowychInfo
- Publication number
- PL2426209T3 PL2426209T3 PL11189701T PL11189701T PL2426209T3 PL 2426209 T3 PL2426209 T3 PL 2426209T3 PL 11189701 T PL11189701 T PL 11189701T PL 11189701 T PL11189701 T PL 11189701T PL 2426209 T3 PL2426209 T3 PL 2426209T3
- Authority
- PL
- Poland
- Prior art keywords
- oxidoreductases
- stereo
- selective reduction
- keto compounds
- keto
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0126105A AT502395B1 (de) | 2005-07-27 | 2005-07-27 | Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen |
| EP06776315A EP1907556A1 (de) | 2005-07-27 | 2006-07-20 | Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen |
| EP11189701.3A EP2426209B1 (de) | 2005-07-27 | 2006-07-20 | Oxidoreduktasen zur stereoselektiven Reduktion von Ketoverbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2426209T3 true PL2426209T3 (pl) | 2015-04-30 |
Family
ID=37216025
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11189708T PL2428576T3 (pl) | 2005-07-27 | 2006-07-20 | Oksydoreduktazy do stereoselektywnej redukcji związków ketonowych |
| PL11189703T PL2428574T3 (pl) | 2005-07-27 | 2006-07-20 | Oksydoreduktazy do selektywnej redukcji związków ketonowych |
| PL11189701T PL2426209T3 (pl) | 2005-07-27 | 2006-07-20 | Oksydoreduktazy do stereoselektywnej redukcji związków ketonowych |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11189708T PL2428576T3 (pl) | 2005-07-27 | 2006-07-20 | Oksydoreduktazy do stereoselektywnej redukcji związków ketonowych |
| PL11189703T PL2428574T3 (pl) | 2005-07-27 | 2006-07-20 | Oksydoreduktazy do selektywnej redukcji związków ketonowych |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20090311762A1 (pl) |
| EP (5) | EP2428574B1 (pl) |
| JP (1) | JP2009502148A (pl) |
| KR (2) | KR101354546B1 (pl) |
| CN (1) | CN101273137A (pl) |
| AT (1) | AT502395B1 (pl) |
| AU (1) | AU2006274252B2 (pl) |
| CA (5) | CA2821720C (pl) |
| DK (3) | DK2428574T3 (pl) |
| ES (3) | ES2524167T3 (pl) |
| HU (1) | HUE024985T2 (pl) |
| PL (3) | PL2428576T3 (pl) |
| PT (3) | PT2426209E (pl) |
| SI (3) | SI2428574T1 (pl) |
| WO (1) | WO2007012428A1 (pl) |
| ZA (1) | ZA200800732B (pl) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT501928B1 (de) | 2004-10-27 | 2010-09-15 | Iep Gmbh | Verfahren zur herstellung von chiralen alkoholen |
| EP2066788B1 (en) | 2006-10-02 | 2014-07-23 | Codexis, Inc. | Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor |
| ATE518946T1 (de) * | 2007-02-08 | 2011-08-15 | Codexis Inc | Ketoreduktasen und anwendungen davon |
| WO2009029554A2 (en) | 2007-08-24 | 2009-03-05 | Codexis, Inc. | Improved ketoreductase polypeptides for the stereoselective production of (r)-3-hydroxythiolane |
| CN101855342B (zh) | 2007-09-13 | 2013-07-10 | 科德克希思公司 | 用于还原苯乙酮的酮还原酶多肽 |
| TWI601825B (zh) * | 2007-09-27 | 2017-10-11 | Ｉｅｐ有限公司 | 對映異構選擇性酶催化還原中間產物之方法 |
| JP2010539948A (ja) | 2007-09-28 | 2010-12-24 | コデクシス， インコーポレイテッド | ケトレダクターゼポリペプチドおよびその使用 |
| JP5646328B2 (ja) | 2007-10-01 | 2014-12-24 | コデクシス， インコーポレイテッド | アゼチジノンの生産のためのケトレダクターゼポリペプチド |
| WO2010025287A2 (en) * | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| HUE026181T2 (en) * | 2008-08-27 | 2016-05-30 | Codexis Inc | Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine |
| SI2329014T1 (sl) | 2008-08-29 | 2015-01-30 | Codexis, Inc. | Polipeptidi ketoreduktaze za stereoselektivno produkcijo (4s)-3(5s)-5(4-fluorofenil)-5-hidroksipentanoil)-4-fenil-1,3-oksazolidin -2-ona |
| EP2226386A1 (de) * | 2009-03-05 | 2010-09-08 | IEP GmbH | Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen |
| WO2010150946A1 (en) | 2009-06-22 | 2010-12-29 | Sk Holdings Co., Ltd. | Method for preparation of carbamic acid (r)-1-aryl-2-tetrazolyl-ethyl ester |
| SG10201405022PA (en) | 2009-08-19 | 2014-10-30 | Codexis Inc | Ketoreductase polypeptides for the preparation of phenylephrine |
| US8404461B2 (en) | 2009-10-15 | 2013-03-26 | SK Biopharmaceutical Co. Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
| US20120285816A1 (en) * | 2009-11-24 | 2012-11-15 | Basf Se | Method for isolating an alkanol from an aqueous biotransformation mixture |
| EP2566497B1 (en) | 2010-05-04 | 2015-07-29 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
| CA2874055A1 (en) | 2012-06-18 | 2013-12-27 | Laboratorio Chimico Internazionale S.P.A. | Enzymatic reduction |
| WO2014086702A2 (de) * | 2012-12-03 | 2014-06-12 | Basf Se | Enzymatische reduktion von hydroxymethylfurfuralen |
| DE102013104418B4 (de) | 2013-04-30 | 2018-09-27 | Cambrex Iep Gmbh | Biokatalytisches Verfahren für die Herstellung von (R)-3-Chinuclidinol |
| CA2958211C (en) * | 2014-08-25 | 2023-09-26 | Hli Cellular Therapeutics, Llc | Extracellular matrix compositions |
| CN108441433B (zh) * | 2018-03-31 | 2021-08-20 | 湖南科技大学 | 胶红酵母nq1及在制备手性醇中的应用 |
| CN108753851B (zh) * | 2018-05-28 | 2022-05-20 | 中国科学院成都生物研究所 | 羰基还原酶生物催化生产手性1,2-二醇类化合物 |
| EP3985109A4 (en) * | 2019-06-13 | 2023-02-08 | Asymchem Laboratories (Tianjin) Co., Ltd | KETOREDUCTASE MUTANT AND PROCESS FOR THE PRODUCTION OF CHIRAL ALCOHOLS |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03127998A (ja) | 1989-10-13 | 1991-05-31 | Taunzu:Kk | 尿素の定量法 |
| DE4014573C1 (pl) | 1990-05-07 | 1991-10-10 | Forschungszentrum Juelich Gmbh, 5170 Juelich, De | |
| US5200355A (en) | 1990-12-10 | 1993-04-06 | Samsung Electronics Co., Ltd. | Method for manufacturing a mask read only memory device |
| US5385833A (en) | 1992-02-26 | 1995-01-31 | The Scripps Research Institute | Pseudomonas sp. ATCC No. 49794 alcohol dehydrogenase |
| CA2117482C (en) | 1992-03-13 | 2005-02-15 | Maria-Regina Kula | New ketonic ester reductases, its preparation and use for enzymatic redox reactions |
| JP3574682B2 (ja) * | 1993-09-24 | 2004-10-06 | ダイセル化学工業株式会社 | 新規な酵素、該酵素を製造する方法、該酵素をコードするｄｎａ、該ｄｎａを含む形質転換体、該酵素による光学活性アルコール等の製造方法 |
| US5523233A (en) * | 1995-05-03 | 1996-06-04 | Merck & Co., Inc. | Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters |
| DE19610984A1 (de) | 1996-03-21 | 1997-09-25 | Boehringer Mannheim Gmbh | Alkohol-Dehydrogenase und deren Verwendung zur enzymatischen Herstellung chiraler Hydroxyverbindungen |
| WO2001005996A1 (fr) * | 1999-07-21 | 2001-01-25 | Kaneka Corporation | Procede d'obtention de derives optiquement actifs du pyridineethanol |
| TWI275645B (en) * | 2000-02-16 | 2007-03-11 | Daicel Chemical Industries Ltd. | (R)-2-octanol dehydrogenases, methods for producing the enzymes, DNA encoding the enzymes, and methods for producing alcohols using the enzymes |
| DE10037101A1 (de) * | 2000-07-27 | 2002-02-07 | Degussa | Rekombinant hergestellte Enzyme mit verbesserter NAD(H)-Akzeptanz |
| DE10119274A1 (de) * | 2001-04-20 | 2002-10-31 | Juelich Enzyme Products Gmbh | Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen |
| JP2005520517A (ja) * | 2002-03-18 | 2005-07-14 | チバ スペシャルティ ケミカルズ ホールディング インコーポレーテッド | 高い溶媒および温度安定性を有するアルコールデヒドロゲナーゼ |
| DE10218689A1 (de) * | 2002-04-26 | 2003-11-20 | Degussa | ADH aus Rhodococcus erythropolis |
| DE10300335B4 (de) * | 2003-01-09 | 2008-06-26 | Iep Gmbh | Oxidoreduktase |
| US20050037946A1 (en) * | 2003-01-13 | 2005-02-17 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cardiovascular disease using 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 or 2419 |
| DE10327454A1 (de) | 2003-06-18 | 2005-01-20 | Juelich Enzyme Products Gmbh | Oxidoreduktase aus Pichia capsulata |
| JP2007502111A (ja) * | 2003-08-11 | 2007-02-08 | コデクシス， インコーポレイテッド | ４−置換３−ヒドロキシ酪酸誘導体およびビシナルなシアノ，ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス |
| US7629157B2 (en) * | 2003-08-11 | 2009-12-08 | Codexis, Inc. | Ketoreductase polypeptides and related polynucleotides |
| JP2005095022A (ja) * | 2003-09-22 | 2005-04-14 | Daicel Chem Ind Ltd | 光学活性アルコールの製造方法 |
| EP1731618A1 (en) | 2005-06-07 | 2006-12-13 | Prodotti Chimici E Alimentari Spa | Process for the selective oxydation of colic acid |
| AT503486B1 (de) * | 2006-04-11 | 2008-05-15 | Iep Gmbh | Verfahren zur enantioselektiven reduktion von steroiden |
-
2005
- 2005-07-27 AT AT0126105A patent/AT502395B1/de not_active IP Right Cessation
-
2006
- 2006-07-20 EP EP11189703.9A patent/EP2428574B1/de not_active Not-in-force
- 2006-07-20 EP EP06776315A patent/EP1907556A1/de not_active Withdrawn
- 2006-07-20 DK DK11189703.9T patent/DK2428574T3/da active
- 2006-07-20 US US11/996,968 patent/US20090311762A1/en not_active Abandoned
- 2006-07-20 PL PL11189708T patent/PL2428576T3/pl unknown
- 2006-07-20 HU HUE11189708A patent/HUE024985T2/hu unknown
- 2006-07-20 EP EP11189701.3A patent/EP2426209B1/de not_active Not-in-force
- 2006-07-20 WO PCT/EP2006/007150 patent/WO2007012428A1/de active Application Filing
- 2006-07-20 EP EP11189708.8A patent/EP2428576B1/de active Active
- 2006-07-20 CA CA2821720A patent/CA2821720C/en active Active
- 2006-07-20 ES ES11189703.9T patent/ES2524167T3/es active Active
- 2006-07-20 PT PT111897013T patent/PT2426209E/pt unknown
- 2006-07-20 PT PT111897088T patent/PT2428576E/pt unknown
- 2006-07-20 PT PT111897039T patent/PT2428574E/pt unknown
- 2006-07-20 PL PL11189703T patent/PL2428574T3/pl unknown
- 2006-07-20 DK DK11189701.3T patent/DK2426209T3/da active
- 2006-07-20 ES ES11189708.8T patent/ES2534657T3/es active Active
- 2006-07-20 SI SI200631849T patent/SI2428574T1/sl unknown
- 2006-07-20 JP JP2008523190A patent/JP2009502148A/ja active Pending
- 2006-07-20 DK DK11189708T patent/DK2428576T3/en active
- 2006-07-20 CA CA2821717A patent/CA2821717C/en active Active
- 2006-07-20 PL PL11189701T patent/PL2426209T3/pl unknown
- 2006-07-20 AU AU2006274252A patent/AU2006274252B2/en not_active Ceased
- 2006-07-20 SI SI200631899T patent/SI2428576T1/sl unknown
- 2006-07-20 ES ES11189701.3T patent/ES2525549T3/es active Active
- 2006-07-20 SI SI200631878T patent/SI2426209T1/sl unknown
- 2006-07-20 CA CA2869218A patent/CA2869218C/en active Active
- 2006-07-20 CN CNA2006800356804A patent/CN101273137A/zh active Pending
- 2006-07-20 KR KR1020137022212A patent/KR101354546B1/ko active IP Right Grant
- 2006-07-20 CA CA2821719A patent/CA2821719C/en active Active
- 2006-07-20 CA CA2625834A patent/CA2625834C/en active Active
- 2006-07-20 EP EP11189707A patent/EP2428575A1/de not_active Withdrawn
- 2006-07-20 ZA ZA200800732A patent/ZA200800732B/xx unknown
-
2008
- 2008-02-26 KR KR1020087004580A patent/KR101341392B1/ko active IP Right Grant
-
2011
- 2011-10-25 US US13/280,876 patent/US9040265B2/en not_active Expired - Fee Related
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