DK2428574T3 - Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser - Google Patents
Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelserInfo
- Publication number
- DK2428574T3 DK2428574T3 DK11189703.9T DK11189703T DK2428574T3 DK 2428574 T3 DK2428574 T3 DK 2428574T3 DK 11189703 T DK11189703 T DK 11189703T DK 2428574 T3 DK2428574 T3 DK 2428574T3
- Authority
- DK
- Denmark
- Prior art keywords
- oxidoreductases
- keto compounds
- stereoselective reduction
- stereoselective
- reduction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0126105A AT502395B1 (de) | 2005-07-27 | 2005-07-27 | Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen |
| EP06776315A EP1907556A1 (de) | 2005-07-27 | 2006-07-20 | Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2428574T3 true DK2428574T3 (da) | 2014-10-27 |
Family
ID=37216025
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11189701.3T DK2426209T3 (da) | 2005-07-27 | 2006-07-20 | Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser |
| DK11189703.9T DK2428574T3 (da) | 2005-07-27 | 2006-07-20 | Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser |
| DK11189708T DK2428576T3 (da) | 2005-07-27 | 2006-07-20 | Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11189701.3T DK2426209T3 (da) | 2005-07-27 | 2006-07-20 | Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11189708T DK2428576T3 (da) | 2005-07-27 | 2006-07-20 | Oxidoreduktaser til stereoselektiv reduktion af ketoforbindelser |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20090311762A1 (da) |
| EP (5) | EP2428574B1 (da) |
| JP (1) | JP2009502148A (da) |
| KR (2) | KR101354546B1 (da) |
| CN (1) | CN101273137A (da) |
| AT (1) | AT502395B1 (da) |
| AU (1) | AU2006274252B2 (da) |
| CA (5) | CA2869218C (da) |
| DK (3) | DK2426209T3 (da) |
| ES (3) | ES2524167T3 (da) |
| HU (1) | HUE024985T2 (da) |
| PL (3) | PL2428574T3 (da) |
| PT (3) | PT2426209E (da) |
| SI (3) | SI2426209T1 (da) |
| WO (1) | WO2007012428A1 (da) |
| ZA (1) | ZA200800732B (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT501928B1 (de) | 2004-10-27 | 2010-09-15 | Iep Gmbh | Verfahren zur herstellung von chiralen alkoholen |
| CN101528917B (zh) | 2006-10-02 | 2015-07-29 | 科德克希思公司 | 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法 |
| KR101502634B1 (ko) | 2007-02-08 | 2015-03-16 | 코덱시스, 인코포레이티드 | 케토 환원 효소 및 이의 용도 |
| JP2010536385A (ja) | 2007-08-24 | 2010-12-02 | コデクシス， インコーポレイテッド | （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド |
| KR101586503B1 (ko) | 2007-09-13 | 2016-01-18 | 코덱시스, 인코포레이티드 | 아세토페논의 환원을 위한 케토리덕타제 폴리펩티드 |
| TWI601825B (zh) * | 2007-09-27 | 2017-10-11 | Ｉｅｐ有限公司 | 對映異構選擇性酶催化還原中間產物之方法 |
| KR20100061571A (ko) | 2007-09-28 | 2010-06-07 | 코덱시스, 인코포레이티드 | 케토리덕타제 폴리펩티드 및 이의 용도 |
| US7883879B2 (en) | 2007-10-01 | 2011-02-08 | Codexis, Inc. | Ketoreductase polypeptides for the production of azetidinone |
| US8426178B2 (en) | 2008-08-27 | 2013-04-23 | Codexis, Inc. | Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| WO2010025287A2 (en) | 2008-08-27 | 2010-03-04 | Codexis, Inc. | Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine |
| CN102186972B (zh) | 2008-08-29 | 2014-08-20 | 科德克希思公司 | 用于立体选择性生产(4s)-3-[(5s)-5-(4-氟苯基)-5-羟基戊酰基]-4-苯基-1，3-噁唑烷-2-酮的酮还原酶多肽 |
| EP2226386A1 (de) | 2009-03-05 | 2010-09-08 | IEP GmbH | Verfahren zur stereoselektiven enzymatischen Reduktion von Ketoverbindungen |
| AU2009348523B2 (en) | 2009-06-22 | 2015-02-26 | Sk Biopharmaceuticals Co., Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
| SG178456A1 (en) | 2009-08-19 | 2012-04-27 | Codexis Inc | Ketoreductase polypeptides for the preparation of phenylephrine |
| US8404461B2 (en) | 2009-10-15 | 2013-03-26 | SK Biopharmaceutical Co. Ltd. | Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester |
| JP2013511498A (ja) * | 2009-11-24 | 2013-04-04 | ビーエーエスエフ ソシエタス・ヨーロピア | 水性生体変換混合物からのアルカノールの単離方法 |
| HUE026367T2 (en) | 2010-05-04 | 2016-06-28 | Codexis Inc | Biocatalysts of ezetimibe synthesis |
| ES2619338T3 (es) | 2012-06-18 | 2017-06-26 | Olon S.P.A. | Procedimiento para la producción de 3-piperidinoles quirales sustituidos en posición 1 empleando oxidorreductasas |
| WO2014086702A2 (de) * | 2012-12-03 | 2014-06-12 | Basf Se | Enzymatische reduktion von hydroxymethylfurfuralen |
| DE102013104418B4 (de) | 2013-04-30 | 2018-09-27 | Cambrex Iep Gmbh | Biokatalytisches Verfahren für die Herstellung von (R)-3-Chinuclidinol |
| SG10201901713RA (en) * | 2014-08-25 | 2019-03-28 | Hli Cellular Therapeutics Llc | Extracellular matrix compositions |
| CN108441433B (zh) * | 2018-03-31 | 2021-08-20 | 湖南科技大学 | 胶红酵母nq1及在制备手性醇中的应用 |
| CN108753851B (zh) * | 2018-05-28 | 2022-05-20 | 中国科学院成都生物研究所 | 羰基还原酶生物催化生产手性1,2-二醇类化合物 |
| JP7375052B2 (ja) * | 2019-06-13 | 2023-11-07 | アシムケム ラボラトリーズ （ティエンジン） カンパニー リミテッド | ケトレダクターゼ突然変異体及びキラルアルコールの生産方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH03127998A (ja) | 1989-10-13 | 1991-05-31 | Taunzu:Kk | 尿素の定量法 |
| DE4014573C1 (da) | 1990-05-07 | 1991-10-10 | Forschungszentrum Juelich Gmbh, 5170 Juelich, De | |
| US5200355A (en) | 1990-12-10 | 1993-04-06 | Samsung Electronics Co., Ltd. | Method for manufacturing a mask read only memory device |
| US5385833A (en) | 1992-02-26 | 1995-01-31 | The Scripps Research Institute | Pseudomonas sp. ATCC No. 49794 alcohol dehydrogenase |
| DE59306681D1 (de) * | 1992-03-13 | 1997-07-10 | Forschungszentrum Juelich Gmbh | Neue ketoester-reduktase, deren herstellung und verwendung für enzymatische redoxreaktionen |
| JP3574682B2 (ja) * | 1993-09-24 | 2004-10-06 | ダイセル化学工業株式会社 | 新規な酵素、該酵素を製造する方法、該酵素をコードするｄｎａ、該ｄｎａを含む形質転換体、該酵素による光学活性アルコール等の製造方法 |
| US5523233A (en) * | 1995-05-03 | 1996-06-04 | Merck & Co., Inc. | Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters |
| DE19610984A1 (de) | 1996-03-21 | 1997-09-25 | Boehringer Mannheim Gmbh | Alkohol-Dehydrogenase und deren Verwendung zur enzymatischen Herstellung chiraler Hydroxyverbindungen |
| AU5704100A (en) * | 1999-07-21 | 2001-02-05 | Kaneka Corporation | Process for producing optically active pyridineethanol derivatives |
| TWI275645B (en) * | 2000-02-16 | 2007-03-11 | Daicel Chemical Industries Ltd. | (R)-2-octanol dehydrogenases, methods for producing the enzymes, DNA encoding the enzymes, and methods for producing alcohols using the enzymes |
| DE10037101A1 (de) * | 2000-07-27 | 2002-02-07 | Degussa | Rekombinant hergestellte Enzyme mit verbesserter NAD(H)-Akzeptanz |
| DE10119274A1 (de) * | 2001-04-20 | 2002-10-31 | Juelich Enzyme Products Gmbh | Enzymatisches Verfahren zur enantioselektiven Reduktion von Ketoverbindungen |
| AU2003214111A1 (en) * | 2002-03-18 | 2003-09-29 | Ciba Specialty Chemicals Holding Inc. | Alcohol dehydrogenases with high solvent and temperature stability |
| DE10218689A1 (de) * | 2002-04-26 | 2003-11-20 | Degussa | ADH aus Rhodococcus erythropolis |
| DE10300335B4 (de) * | 2003-01-09 | 2008-06-26 | Iep Gmbh | Oxidoreduktase |
| US20050037946A1 (en) * | 2003-01-13 | 2005-02-17 | Millennium Pharmaceuticals, Inc. | Methods and compositions for treating cardiovascular disease using 1722, 10280, 59917, 85553, 10653, 9235, 21668, 17794, 2210, 6169, 10102, 21061, 17662, 1468, 12282, 6350, 9035, 1820, 23652, 7301, 8925, 8701, 3533, 9462, 9123, 12788, 17729, 65552, 1261, 21476, 33770, 9380, 2569654, 33556, 53656, 44143, 32612, 10671, 261, 44570, 41922, 2552, 2417, 19319, 43969, 8921, 8993, 955, 32345, 966, 1920, 17318, 1510, 14180, 26005, 554, 16408, 42028, 112091, 13886, 13942, 1673, 54946 or 2419 |
| DE10327454A1 (de) * | 2003-06-18 | 2005-01-20 | Juelich Enzyme Products Gmbh | Oxidoreduktase aus Pichia capsulata |
| JP2007502111A (ja) * | 2003-08-11 | 2007-02-08 | コデクシス， インコーポレイテッド | ４−置換３−ヒドロキシ酪酸誘導体およびビシナルなシアノ，ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス |
| JP2007502124A (ja) * | 2003-08-11 | 2007-02-08 | コデクシス， インコーポレイテッド | 改良ケトレダクターゼポリペプチドおよび関連ポリヌクレオチド |
| JP2005095022A (ja) * | 2003-09-22 | 2005-04-14 | Daicel Chem Ind Ltd | 光学活性アルコールの製造方法 |
| EP1731618A1 (en) | 2005-06-07 | 2006-12-13 | Prodotti Chimici E Alimentari Spa | Process for the selective oxydation of colic acid |
| AT503486B1 (de) * | 2006-04-11 | 2008-05-15 | Iep Gmbh | Verfahren zur enantioselektiven reduktion von steroiden |
-
2005
- 2005-07-27 AT AT0126105A patent/AT502395B1/de not_active IP Right Cessation
-
2006
- 2006-07-20 PT PT111897013T patent/PT2426209E/pt unknown
- 2006-07-20 ZA ZA200800732A patent/ZA200800732B/xx unknown
- 2006-07-20 CA CA2869218A patent/CA2869218C/en active Active
- 2006-07-20 CA CA2821720A patent/CA2821720C/en active Active
- 2006-07-20 US US11/996,968 patent/US20090311762A1/en not_active Abandoned
- 2006-07-20 DK DK11189701.3T patent/DK2426209T3/da active
- 2006-07-20 CA CA2821717A patent/CA2821717C/en active Active
- 2006-07-20 SI SI200631878T patent/SI2426209T1/sl unknown
- 2006-07-20 EP EP11189703.9A patent/EP2428574B1/de not_active Not-in-force
- 2006-07-20 HU HUE11189708A patent/HUE024985T2/hu unknown
- 2006-07-20 AU AU2006274252A patent/AU2006274252B2/en not_active Ceased
- 2006-07-20 CA CA2625834A patent/CA2625834C/en active Active
- 2006-07-20 JP JP2008523190A patent/JP2009502148A/ja active Pending
- 2006-07-20 PL PL11189703T patent/PL2428574T3/pl unknown
- 2006-07-20 CA CA2821719A patent/CA2821719C/en active Active
- 2006-07-20 ES ES11189703.9T patent/ES2524167T3/es active Active
- 2006-07-20 CN CNA2006800356804A patent/CN101273137A/zh active Pending
- 2006-07-20 DK DK11189703.9T patent/DK2428574T3/da active
- 2006-07-20 PT PT111897088T patent/PT2428576E/pt unknown
- 2006-07-20 WO PCT/EP2006/007150 patent/WO2007012428A1/de active Application Filing
- 2006-07-20 EP EP11189707A patent/EP2428575A1/de not_active Withdrawn
- 2006-07-20 SI SI200631899T patent/SI2428576T1/sl unknown
- 2006-07-20 PL PL11189708T patent/PL2428576T3/pl unknown
- 2006-07-20 DK DK11189708T patent/DK2428576T3/da active
- 2006-07-20 PT PT111897039T patent/PT2428574E/pt unknown
- 2006-07-20 SI SI200631849T patent/SI2428574T1/sl unknown
- 2006-07-20 EP EP11189701.3A patent/EP2426209B1/de not_active Not-in-force
- 2006-07-20 PL PL11189701T patent/PL2426209T3/pl unknown
- 2006-07-20 EP EP11189708.8A patent/EP2428576B1/de active Active
- 2006-07-20 EP EP06776315A patent/EP1907556A1/de not_active Withdrawn
- 2006-07-20 ES ES11189701.3T patent/ES2525549T3/es active Active
- 2006-07-20 ES ES11189708.8T patent/ES2534657T3/es active Active
- 2006-07-20 KR KR1020137022212A patent/KR101354546B1/ko active IP Right Grant
-
2008
- 2008-02-26 KR KR1020087004580A patent/KR101341392B1/ko active IP Right Grant
-
2011
- 2011-10-25 US US13/280,876 patent/US9040265B2/en not_active Expired - Fee Related
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