PL2137655T3 - Zdefiniowane produkty glikoproteinowe i powiązane sposoby - Google Patents
Zdefiniowane produkty glikoproteinowe i powiązane sposobyInfo
- Publication number
- PL2137655T3 PL2137655T3 PL08754908T PL08754908T PL2137655T3 PL 2137655 T3 PL2137655 T3 PL 2137655T3 PL 08754908 T PL08754908 T PL 08754908T PL 08754908 T PL08754908 T PL 08754908T PL 2137655 T3 PL2137655 T3 PL 2137655T3
- Authority
- PL
- Poland
- Prior art keywords
- related methods
- glycoprotein products
- defined glycoprotein
- products
- methods
- Prior art date
Links
- 102000003886 Glycoproteins Human genes 0.000 title 1
- 108090000288 Glycoproteins Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B50/00—ICT programming tools or database systems specially adapted for bioinformatics
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Databases & Information Systems (AREA)
- Biophysics (AREA)
- Bioethics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Medical Informatics (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91210207P | 2007-04-16 | 2007-04-16 | |
| PCT/US2008/060354 WO2008128227A1 (en) | 2007-04-16 | 2008-04-15 | Defined glycoprotein products and related methods |
| EP08754908A EP2137655B1 (en) | 2007-04-16 | 2008-04-15 | Defined glycoprotein products and related methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2137655T3 true PL2137655T3 (pl) | 2012-12-31 |
Family
ID=39553226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL08754908T PL2137655T3 (pl) | 2007-04-16 | 2008-04-15 | Zdefiniowane produkty glikoproteinowe i powiązane sposoby |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20100113294A1 (pl) |
| EP (2) | EP2528002B1 (pl) |
| JP (1) | JP2010524467A (pl) |
| CN (1) | CN101681396A (pl) |
| AU (1) | AU2008240080A1 (pl) |
| BR (1) | BRPI0810471A2 (pl) |
| CA (1) | CA2682738A1 (pl) |
| ES (1) | ES2389618T3 (pl) |
| PL (1) | PL2137655T3 (pl) |
| PT (1) | PT2137655E (pl) |
| RU (1) | RU2009141965A (pl) |
| WO (1) | WO2008128227A1 (pl) |
Families Citing this family (87)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8911964B2 (en) | 2006-09-13 | 2014-12-16 | Abbvie Inc. | Fed-batch method of making human anti-TNF-alpha antibody |
| BRPI0716762A2 (pt) | 2006-09-13 | 2013-09-24 | Abbott Lab | melhorias da cultura celular |
| TWI610936B (zh) | 2008-10-20 | 2018-01-11 | 艾伯維有限公司 | 使用蛋白質a親和性層析進行抗體之分離及純化 |
| TW201028433A (en) | 2008-10-20 | 2010-08-01 | Abbott Lab | Viral inactivation during purification of antibodies |
| EP2325296A1 (en) * | 2009-11-20 | 2011-05-25 | LEK Pharmaceuticals d.d. | Production of glycoproteins with low N-glycolylneuraminic acid (Neu5Gc) content |
| CA2794709A1 (en) * | 2010-04-07 | 2011-10-13 | Momenta Pharmaceuticals, Inc. | Selection and use of host cells for production of glycoproteins |
| US9921210B2 (en) | 2010-04-07 | 2018-03-20 | Momenta Pharmaceuticals, Inc. | High mannose glycans |
| US9170249B2 (en) | 2011-03-12 | 2015-10-27 | Momenta Pharmaceuticals, Inc. | N-acetylhexosamine-containing N-glycans in glycoprotein products |
| EP2511293A1 (en) | 2011-04-13 | 2012-10-17 | LEK Pharmaceuticals d.d. | A method for controlling the main complex N-glycan structures and the acidic variants and variability in bioprocesses producing recombinant proteins |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| US8183227B1 (en) | 2011-07-07 | 2012-05-22 | Chemo S. A. France | Compositions, kits and methods for nutrition supplementation |
| US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
| WO2013114167A1 (en) * | 2012-01-30 | 2013-08-08 | Dr. Reddy's Laboratories Limited | Process of obtaining glycoform composition |
| EP2809773B1 (en) | 2012-01-30 | 2020-09-02 | Dr. Reddy's Laboratories Limited | Process of modulating man5 and/or afucosylation content of glycoprotein composition |
| US9505833B2 (en) | 2012-04-20 | 2016-11-29 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9334319B2 (en) | 2012-04-20 | 2016-05-10 | Abbvie Inc. | Low acidic species compositions |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| US20150158943A1 (en) * | 2012-06-01 | 2015-06-11 | Momenta Pharmaceuticals, Inc. | Methods related to adalimumab |
| WO2013181575A2 (en) * | 2012-06-01 | 2013-12-05 | Momenta Pharmaceuticals, Inc. | Methods related to denosumab |
| EP2856158A4 (en) * | 2012-06-01 | 2016-06-08 | Momenta Pharmaceuticals Inc | PROCEDURE RELATED TO RITUXIMAB |
| WO2013181577A2 (en) * | 2012-06-01 | 2013-12-05 | Momenta Pharmaceuticals, Inc. | Methods related to omalizumab |
| US20150210753A1 (en) | 2012-07-26 | 2015-07-30 | Momenta Pharmaceuticals, Inc. | Glycoproteins with anti-inflammatory properties |
| HK1211981A1 (en) | 2012-09-02 | 2016-06-03 | Abbvie Inc. | Methods to control protein heterogeneity |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| US8956830B2 (en) | 2013-03-14 | 2015-02-17 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| WO2014159579A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | MUTATED ANTI-TNFα ANTIBODIES AND METHODS OF THEIR USE |
| US9677105B2 (en) * | 2013-03-14 | 2017-06-13 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| US20140271622A1 (en) * | 2013-03-14 | 2014-09-18 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| WO2014151878A2 (en) | 2013-03-14 | 2014-09-25 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US10450361B2 (en) | 2013-03-15 | 2019-10-22 | Momenta Pharmaceuticals, Inc. | Methods related to CTLA4-Fc fusion proteins |
| WO2014179601A2 (en) | 2013-05-02 | 2014-11-06 | Momenta Pharmaceuticals, Inc. | Sialylated glycoproteins |
| ES2708759T3 (es) | 2013-05-13 | 2019-04-11 | Momenta Pharmaceuticals Inc | Procedimientos para el tratamiento de la neurodegeneración |
| WO2015051293A2 (en) | 2013-10-04 | 2015-04-09 | Abbvie, Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| WO2015057622A1 (en) | 2013-10-16 | 2015-04-23 | Momenta Pharmaceuticals, Inc. | Sialylated glycoproteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US8946395B1 (en) | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| KR20160088331A (ko) * | 2013-11-06 | 2016-07-25 | 엘앤드제이 바이오사이언스 인코포레이티드 | 연속적으로 조절되는 중공사 생물반응기 |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| WO2015115849A1 (ko) * | 2014-01-29 | 2015-08-06 | 주식회사 엘지생명과학 | 배양배지의 최적화를 통한 재조합 단백질의 갈락토오스화를 조절하는 방법 |
| SI3227454T1 (sl) | 2014-12-01 | 2020-06-30 | Amgen Inc. | Postopek za manipuliranje ravni vsebnosti glikana glikoproteina |
| CA3001761A1 (en) | 2015-10-26 | 2017-05-04 | Lonza Limited | A manufacturing facility for the production of biopharmaceuticals |
| WO2017117218A1 (en) | 2015-12-30 | 2017-07-06 | Momenta Pharmaceuticals, Inc. | Methods related to biologics |
| KR102593407B1 (ko) | 2016-03-02 | 2023-10-24 | 론자 리미티드 | 개선된 발효 공정 |
| CN118480433A (zh) * | 2016-03-10 | 2024-08-13 | 隆扎有限公司 | 可定制的设施 |
| US10689873B2 (en) | 2016-03-10 | 2020-06-23 | Lonza Ltd | Customizable facility |
| JP6942736B2 (ja) | 2016-06-03 | 2021-09-29 | ロンザ リミテッドLonza Limited | 使い捨てバイオリアクター |
| WO2017212071A1 (en) | 2016-06-10 | 2017-12-14 | Lonza Ltd | Method for stabilizing proteins |
| WO2017223269A1 (en) | 2016-06-24 | 2017-12-28 | Lonza Ltd. | Variable diameter bioreactors |
| EP3478821A1 (en) | 2016-08-02 | 2019-05-08 | Lonza Ltd | Customizable facility |
| US20200054972A1 (en) | 2016-11-17 | 2020-02-20 | Andrew Bryce | Filter assembly with filter lock design |
| EP3541490B1 (en) | 2016-11-17 | 2021-03-31 | Lonza Limited | Filter moving device |
| US10436338B2 (en) | 2016-12-09 | 2019-10-08 | Lonza Ltd | Rupture disks for bioreactors and methods of using same |
| EP3535047A1 (en) | 2016-12-09 | 2019-09-11 | Lonza Ltd | Method for the reduction of viral titer in pharmaceuticals |
| EP3555126A1 (en) | 2017-01-18 | 2019-10-23 | Lonza Ltd | Methods for evaluating monoclonality |
| US20190360980A1 (en) | 2017-02-03 | 2019-11-28 | Lonza Ltd | Methods of analyzing pluralities of cells and detecting protein sequence variants in biological product manufacturing |
| KR102499475B1 (ko) | 2017-02-10 | 2023-02-15 | 론자 리미티드 | 세포 배양 시스템 및 방법 |
| CN110494554A (zh) | 2017-02-17 | 2019-11-22 | 隆扎有限公司 | 用于生产生物产物变体的方法 |
| JP7467119B2 (ja) | 2017-02-17 | 2024-04-15 | ロンザ リミテッド | 発現困難タンパク質のための多部位ssi細胞 |
| JP7637470B2 (ja) | 2017-02-17 | 2025-02-28 | ロンザ リミテッド | アデノ随伴ウイルスを生産するための哺乳動物細胞 |
| US10244406B2 (en) | 2017-03-07 | 2019-03-26 | Lonza Ltd. | Wireless sensor information monitoring |
| IL270467B2 (en) | 2017-06-16 | 2025-05-01 | Lonza Ag | A universal self-control platform for a mammalian cell line for the preparation of biological materials |
| WO2019067966A1 (en) | 2017-09-29 | 2019-04-04 | Lonza Ltd. | INFUSION APPARATUS FOR USE IN BIOREACTOR SYSTEMS |
| IL273549B2 (en) | 2017-10-06 | 2023-10-01 | Lonza Ag | Automated control of cell culture using Raman spectroscopy |
| IL274776B2 (en) | 2017-11-20 | 2025-02-01 | Lonza Ag | Process and system for growing cell cultures while preventing lactate accumulation |
| CN108052801B (zh) * | 2017-11-30 | 2020-06-26 | 中国科学院计算技术研究所 | 一种基于正则表达式的n糖结构库构建方法与系统 |
| KR20200093602A (ko) | 2017-12-05 | 2020-08-05 | 론자 리미티드 | 트로폴론 분석 방법 |
| US12077786B2 (en) | 2018-02-02 | 2024-09-03 | Lonza Ltd | Methods of cell selection and modifying cell metabolism |
| KR20200135781A (ko) | 2018-03-26 | 2020-12-03 | 암젠 인크 | 세포 배양에서 생산된 항체의 총 비푸코실화 당형태 |
| US12071607B2 (en) | 2018-06-01 | 2024-08-27 | Lonza Ltd. | Midscale model for organic growth and phasing |
| CN112424339B (zh) | 2018-07-13 | 2025-03-28 | 隆萨有限公司 | 用于通过降低内源性蛋白质的水平来改善生物产物的生产的方法 |
| WO2020028616A1 (en) | 2018-08-02 | 2020-02-06 | Lonza Ltd | Methods for manufacturing recombinant protein comprising a disulfide bond |
| WO2020031115A1 (en) | 2018-08-09 | 2020-02-13 | Lonza Ltd. | Transfer station for api seed crystals |
| AR114548A1 (es) * | 2018-08-10 | 2020-09-16 | Genentech Inc | Estrategias de cultivo celular para modular la glicosilación de proteínas |
| WO2020041454A1 (en) | 2018-08-21 | 2020-02-27 | Lonza Ltd | A process for creating reference data for predicting concentrations of quality attributes |
| CN113227388A (zh) | 2018-10-01 | 2021-08-06 | 龙沙有限公司 | 具有可预测和稳定的转基因表达的ssi细胞及形成方法 |
| CN113438953A (zh) | 2018-10-11 | 2021-09-24 | 动量制药公司 | 采用高度唾液酸化IgG组合物的治疗 |
| CA3125443A1 (en) | 2018-12-31 | 2020-07-09 | Momenta Pharmaceuticals, Inc. | Methods of producing ustekinumab |
| SG11202106852QA (en) | 2019-02-11 | 2021-07-29 | Lonza Ag | Buffer formulation method and system |
| EP3931303A1 (en) | 2019-12-06 | 2022-01-05 | Regeneron Pharmaceuticals, Inc. | Anti-vegf protein compositions and methods for producing the same |
| US20220389363A1 (en) | 2020-01-10 | 2022-12-08 | Lonza Walkersville, Inc. | Filter Apparatus and Method for Purifying Biological Processes and Cell Populations |
| WO2021226444A2 (en) | 2020-05-08 | 2021-11-11 | Regeneron Pharmaceuticals, Inc. | Vegf traps and mini-traps and methods for treating ocular disorders and cancer |
| WO2022133105A1 (en) | 2020-12-18 | 2022-06-23 | Lonza Biologics Inc. | Sterile disconnect for bioprocess systems and method for using same |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4448884A (en) | 1982-03-03 | 1984-05-15 | Kms Fusion, Inc. | Glass-surface microcarrier for growth of cell cultures |
| US5135853A (en) | 1983-07-22 | 1992-08-04 | Rensselaer Polytechnic Institute | Three compartment bioreactor and method of use |
| US4764471A (en) | 1984-01-04 | 1988-08-16 | Nabisco Brands, Inc. | Continuous bioreactor and process |
| US5672502A (en) | 1985-06-28 | 1997-09-30 | Celltech Therapeutics Limited | Animal cell culture |
| US5231185A (en) | 1985-11-19 | 1993-07-27 | Cornell Research Foundation, Inc. | Monosaccharide analog-based glycosidase inhibitors |
| US5116742A (en) | 1986-12-03 | 1992-05-26 | University Patents, Inc. | RNA ribozyme restriction endoribonucleases and methods |
| US4987071A (en) | 1986-12-03 | 1991-01-22 | University Patents, Inc. | RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods |
| US6048729A (en) | 1987-05-01 | 2000-04-11 | Transkaryotic Therapies, Inc. | In vivo protein production and delivery system for gene therapy |
| JPH0667317B2 (ja) * | 1988-09-21 | 1994-08-31 | 財団法人野田産業科学研究所 | N−アセチルヘキソサミンデヒドロゲナーゼ、その製造法及び該酵素を用いるn−アセチルグルコサミン又はn−アセチルガラクトサミンの定量法及びその定量用キット |
| US5047335A (en) * | 1988-12-21 | 1991-09-10 | The Regents Of The University Of Calif. | Process for controlling intracellular glycosylation of proteins |
| DK167813B1 (da) * | 1989-12-07 | 1993-12-20 | Carlbiotech Ltd As | Pentapeptidderivat, farmaceutisk acceptable salte heraf, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende et saadant derivat |
| SK282950B6 (sk) | 1990-04-24 | 2003-01-09 | Biota Scientific Management Pty Ltd | Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze |
| ATE193551T1 (de) | 1991-03-18 | 2000-06-15 | Scripps Research Inst | Oligosaccharide als enzymsubstrate und - inhibitoren: verfahren und zusammensetzungen |
| US5641670A (en) | 1991-11-05 | 1997-06-24 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6270989B1 (en) | 1991-11-05 | 2001-08-07 | Transkaryotic Therapies, Inc. | Protein production and delivery |
| US5733761A (en) | 1991-11-05 | 1998-03-31 | Transkaryotic Therapies, Inc. | Protein production and protein delivery |
| US6063630A (en) | 1991-11-05 | 2000-05-16 | Transkaryotic Therapies, Inc. | Targeted introduction of DNA into primary or secondary cells and their use for gene therapy |
| JPH09503905A (ja) * | 1993-07-15 | 1997-04-22 | ネオゼ ファーマシューティカルス | 糖組成物の合成方法 |
| US5559103A (en) | 1993-07-21 | 1996-09-24 | Cytel Corporation | Bivalent sialyl X saccharides |
| TW479061B (en) | 1993-12-24 | 2002-03-11 | Mitsubishi Chem Corp | Sialic acid derivatives |
| US5567684A (en) | 1994-09-14 | 1996-10-22 | The Regents Of The University Of California | Synthetic ganglioside derivatives |
| US20030143204A1 (en) | 2001-07-27 | 2003-07-31 | Lewis David L. | Inhibition of RNA function by delivery of inhibitors to animal cells |
| WO1998041611A1 (en) | 1997-03-20 | 1998-09-24 | Regents Of The University Of Minnesota | Process for the continuous culture of cells |
| US5994511A (en) * | 1997-07-02 | 1999-11-30 | Genentech, Inc. | Anti-IgE antibodies and methods of improving polypeptides |
| WO1999057263A1 (en) | 1998-05-07 | 1999-11-11 | Transkaryotic Therapies, Inc. | Modifying the expression of the fsh beta gene by homologous recombination |
| NZ507451A (en) | 1998-05-07 | 2003-12-19 | Transkaryotic Therapies Inc | Genomic sequences upstream of the coding region of the g-csf gene for protein production and delivery and enhancement of g-csf transcription and translation trasfection and infection into mamalian cell |
| US6949372B2 (en) * | 1999-03-02 | 2005-09-27 | The Johns Hopkins University | Engineering intracellular sialylation pathways |
| DE60032349T2 (de) * | 1999-04-26 | 2007-07-12 | Genentech, Inc., South San Francisco | Zellenzuchtverfahren für glycoproteine |
| DE60009956T2 (de) | 1999-12-28 | 2005-04-28 | Iso Tis N.V. | Wachstumsfaktoren und l-glutamin enthaltendes zellkulturmedium |
| US7795002B2 (en) * | 2000-06-28 | 2010-09-14 | Glycofi, Inc. | Production of galactosylated glycoproteins in lower eukaryotes |
| AU2001271021A1 (en) * | 2000-07-05 | 2002-01-14 | Japan As Represented By Secretary Of Osaka University | Process for producing glycoprotein |
| US6946292B2 (en) * | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
| US6544788B2 (en) | 2001-02-15 | 2003-04-08 | Vijay Singh | Disposable perfusion bioreactor for cell culture |
| WO2002076578A1 (en) * | 2001-03-27 | 2002-10-03 | Smithkline Beecham Corporation | Control of glycoforms in igg |
| CA2459040A1 (en) * | 2001-09-14 | 2003-03-27 | Mimeon, Inc. | Methods of making glycolmolecules with enhanced activities and uses thereof |
| US20030157108A1 (en) * | 2001-10-25 | 2003-08-21 | Genentech, Inc. | Glycoprotein compositions |
| EP1572902B1 (en) | 2002-02-01 | 2014-06-11 | Life Technologies Corporation | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
| WO2003093430A2 (en) | 2002-05-03 | 2003-11-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for use in preparing sirnas |
| DE60328214D1 (de) | 2002-08-12 | 2009-08-13 | New England Biolabs Inc | Verfahren und zusammensetzungen in verbindung mit gen-silencing |
| EP1467299A3 (en) * | 2003-03-28 | 2005-02-09 | Solutia Inc. | Methods and structure for automated active pharmaceuticals development |
| EP1615945B1 (en) * | 2003-04-09 | 2011-09-28 | BioGeneriX AG | Glycopegylation methods and proteins/peptides produced by the methods |
| WO2005026720A1 (en) | 2003-09-04 | 2005-03-24 | Parivid Llc | Methods and apparatus for characterizing polymeric mixtures |
| US20060127950A1 (en) * | 2004-04-15 | 2006-06-15 | Massachusetts Institute Of Technology | Methods and products related to the improved analysis of carbohydrates |
| US8802820B2 (en) * | 2004-11-12 | 2014-08-12 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US20060252672A1 (en) * | 2005-04-05 | 2006-11-09 | Betenbaugh Michael J | Protein N-glycosylation of eukaryotic cells using dolichol-linked oligosaccharide synthesis pathway, other N-gylosylation-increasing methods, and engineered hosts expressing products with increased N-glycosylation |
| WO2006109781A1 (ja) * | 2005-04-11 | 2006-10-19 | Kyowa Hakko Kogyo Co., Ltd. | 糖タンパク質組成物の製造方法 |
| US8759005B2 (en) * | 2005-07-11 | 2014-06-24 | Glykos Finland Oy | Tissue carbohydrate compositions and analysis thereof |
| US20070017758A1 (en) * | 2005-07-20 | 2007-01-25 | Or Siu W | Magnetorheological damper and use thereof |
| US20090317834A1 (en) * | 2006-03-08 | 2009-12-24 | Jarmo Laine | Novel cellular glycan compositions |
| DE202006008733U1 (de) * | 2006-05-31 | 2007-10-11 | Dolmar Gmbh | Bremsbandhalterung |
| CA2655246A1 (en) * | 2006-06-09 | 2007-12-21 | University Of Maryland, Baltimore | Glycosylation engineered antibody therapy |
| BRPI0716762A2 (pt) * | 2006-09-13 | 2013-09-24 | Abbott Lab | melhorias da cultura celular |
| NZ576133A (en) * | 2006-10-27 | 2012-10-26 | Abbott Biotech Ltd | Crystalline anti-htnfalpha antibodies |
| GB0624092D0 (en) * | 2006-12-01 | 2007-01-10 | Seos Ltd | Image display apparatus |
| EP2097747A1 (en) * | 2006-12-22 | 2009-09-09 | Ares Trading S.A. | Analytical method for analyzing c-terminus truncation |
| CA2887752C (en) * | 2007-04-03 | 2020-03-24 | Vib Vzw | Glycosylation of molecules |
| AU2008243007A1 (en) * | 2007-04-16 | 2008-10-30 | Momenta Pharmaceuticals, Inc. | Characterization of N-glycans using exoglycosidases |
| TW201002346A (en) * | 2008-04-11 | 2010-01-16 | Galaxy Biotech Llc | Combination of HGF inhibitor and EGF inhibitor to treat cancer |
| WO2010036443A1 (en) * | 2008-09-26 | 2010-04-01 | Eureka Therapeutics, Inc. | Cell lines and proteins with variant glycosylation pattern |
| US11520643B2 (en) * | 2008-12-03 | 2022-12-06 | International Business Machines Corporation | Clipboard object sharing for instant messaging |
| JP4892051B2 (ja) * | 2009-11-30 | 2012-03-07 | 株式会社東芝 | 電子機器、及び機能設定データ設定方法 |
| US8524217B2 (en) * | 2010-05-11 | 2013-09-03 | Merck Sharp & Dohme Corp. | MCP1-Ig fusion variants |
| US8956830B2 (en) * | 2013-03-14 | 2015-02-17 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| US9677105B2 (en) * | 2013-03-14 | 2017-06-13 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
-
2008
- 2008-04-15 CA CA002682738A patent/CA2682738A1/en not_active Abandoned
- 2008-04-15 PL PL08754908T patent/PL2137655T3/pl unknown
- 2008-04-15 PT PT08754908T patent/PT2137655E/pt unknown
- 2008-04-15 US US12/596,171 patent/US20100113294A1/en not_active Abandoned
- 2008-04-15 AU AU2008240080A patent/AU2008240080A1/en not_active Abandoned
- 2008-04-15 RU RU2009141965/10A patent/RU2009141965A/ru unknown
- 2008-04-15 WO PCT/US2008/060354 patent/WO2008128227A1/en not_active Ceased
- 2008-04-15 BR BRPI0810471-9A2A patent/BRPI0810471A2/pt not_active IP Right Cessation
- 2008-04-15 JP JP2010504189A patent/JP2010524467A/ja active Pending
- 2008-04-15 CN CN200880016853A patent/CN101681396A/zh active Pending
- 2008-04-15 EP EP12158671.3A patent/EP2528002B1/en not_active Not-in-force
- 2008-04-15 EP EP08754908A patent/EP2137655B1/en not_active Not-in-force
- 2008-04-15 ES ES08754908T patent/ES2389618T3/es active Active
-
2015
- 2015-10-14 US US14/882,585 patent/US20160097074A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20100113294A1 (en) | 2010-05-06 |
| WO2008128227A1 (en) | 2008-10-23 |
| RU2009141965A (ru) | 2011-05-27 |
| CN101681396A (zh) | 2010-03-24 |
| US20160097074A1 (en) | 2016-04-07 |
| EP2137655A1 (en) | 2009-12-30 |
| EP2528002A2 (en) | 2012-11-28 |
| EP2137655B1 (en) | 2012-07-11 |
| BRPI0810471A2 (pt) | 2014-11-11 |
| PT2137655E (pt) | 2012-09-14 |
| EP2528002B1 (en) | 2015-11-04 |
| CA2682738A1 (en) | 2008-10-23 |
| JP2010524467A (ja) | 2010-07-22 |
| EP2528002A3 (en) | 2013-04-03 |
| AU2008240080A1 (en) | 2008-10-23 |
| ES2389618T3 (es) | 2012-10-29 |
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