PL1991690T3 - Sposób wytwarzania sialilowanych oligosacharydów - Google Patents

Sposób wytwarzania sialilowanych oligosacharydów

Info

Publication number
PL1991690T3
PL1991690T3 PL07726672T PL07726672T PL1991690T3 PL 1991690 T3 PL1991690 T3 PL 1991690T3 PL 07726672 T PL07726672 T PL 07726672T PL 07726672 T PL07726672 T PL 07726672T PL 1991690 T3 PL1991690 T3 PL 1991690T3
Authority
PL
Poland
Prior art keywords
sialylated oligosaccharides
producing sialylated
producing
oligosaccharides
sialylated
Prior art date
Application number
PL07726672T
Other languages
English (en)
Inventor
Eric Samain
Original Assignee
Centre Nat Rech Scient
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient
Publication of PL1991690T3 publication Critical patent/PL1991690T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL07726672T 2006-03-09 2007-03-07 Sposób wytwarzania sialilowanych oligosacharydów PL1991690T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US78035006P 2006-03-09 2006-03-09
EP07726672.4A EP1991690B1 (en) 2006-03-09 2007-03-07 Method of producing sialylated oligosaccharides
PCT/EP2007/052114 WO2007101862A1 (en) 2006-03-09 2007-03-07 Method of producing sialylated oligosaccharides

Publications (1)

Publication Number Publication Date
PL1991690T3 true PL1991690T3 (pl) 2014-07-31

Family

ID=38197625

Family Applications (1)

Application Number Title Priority Date Filing Date
PL07726672T PL1991690T3 (pl) 2006-03-09 2007-03-07 Sposób wytwarzania sialilowanych oligosacharydów

Country Status (13)

Country Link
US (1) US8507227B2 (pl)
EP (1) EP1991690B1 (pl)
CN (1) CN101415834B (pl)
AU (1) AU2007222375B2 (pl)
CA (1) CA2645141C (pl)
DK (1) DK1991690T3 (pl)
ES (1) ES2456292T3 (pl)
MY (1) MY148510A (pl)
PL (1) PL1991690T3 (pl)
PT (1) PT1991690E (pl)
RU (1) RU2473695C2 (pl)
SI (1) SI1991690T1 (pl)
WO (1) WO2007101862A1 (pl)

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7820422B2 (en) 2005-06-16 2010-10-26 Centre National De La Recherche Scientifique (Cnrs) Efficient production of oligosaccharides using metabolically engineered microorganisms
US20070202578A1 (en) * 2005-08-26 2007-08-30 Centre National De La Recherche Scientifique (Cnrs) Production of globosides oligosaccharides using metabolically engineered microorganisms
EP2379708B1 (en) 2008-12-19 2016-04-27 Jennewein Biotechnologie GmbH Synthesis of fucosylated compounds
SG186836A1 (en) * 2010-07-12 2013-02-28 Univ Gent Metabolically engineered organisms for the production of added value bio-products
CN108823254A (zh) * 2010-11-03 2018-11-16 柯碧恩生物技术公司 具有降低倾点的微生物油、从其中产生的介电流体、以及相关方法
WO2013019625A2 (en) 2011-07-29 2013-02-07 The University Of Wyoming Methods of using a bacterial glcnac-6-p 2'-epimerase to promote sialylation of glycoconjugates
US9816107B2 (en) 2011-07-29 2017-11-14 The University Of Wyoming Transgenic insect cells comprising a bacterial GlcNAc-6-P 2′-epimerase
US9816122B2 (en) 2012-09-25 2017-11-14 Glycom A/S Glycoconjugate synthesis
WO2014135167A1 (en) * 2013-03-08 2014-09-12 Glycom A/S Purification of oligosaccaharides by reversible derivatization
ES2930286T3 (es) * 2013-03-14 2022-12-09 Glycosyn LLC Microorganismos y métodos para producir oligosacáridos sialilados y que contienen N-acetilglucosamina
EP2999358B1 (en) 2013-05-22 2021-07-07 Glycom A/S Synthetic mixture of oligosaccharides for the treating a microbiota of a mammal
CN104342469B (zh) * 2013-08-01 2017-06-30 东北师范大学 一种生物转化制备单唾液酸四己糖神经节苷脂的方法
EP3041947A4 (en) * 2013-09-06 2017-07-26 Glycom A/S Fermentative production of oligosaccharides
CN103602627B (zh) * 2013-11-25 2015-03-18 武汉中科光谷绿色生物技术有限公司 一种产n-乙酰神经氨酸大肠杆菌工程菌及其构建方法和应用
EP4477741A3 (en) * 2014-06-27 2025-03-05 Glycom A/S Oligosaccharide production
US11926858B2 (en) 2014-06-27 2024-03-12 Glycom A/S Oligosaccharide production
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
WO2016063262A1 (en) 2014-10-24 2016-04-28 Glycom A/S MIXTURES OF HMOs
PL3212198T3 (pl) 2014-10-29 2021-08-23 Glycom A/S Syntetyczna kompozycja i sposób promowania gojenia się błony śluzowej
EP3212197A4 (en) 2014-10-29 2018-07-11 Glycom A/S Synthetic composition and method for treating irritable bowel syndrome
US11040050B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
US11040049B2 (en) 2014-10-29 2021-06-22 Glycom A/S Composition comprising HMSs/HMOs and use thereof
SG11201701585VA (en) * 2014-11-14 2017-05-30 Univ Gent Mutant microorganisms resistant to lactose killing
US10835544B2 (en) 2014-12-08 2020-11-17 Glycom A/S Synthetic composition for regulating satiety
US10881674B2 (en) 2014-12-08 2021-01-05 Glycom A/S Synthetic composition for treating metabolic disorders
US10987368B2 (en) 2014-12-08 2021-04-27 Glycom A/S Synthetic composition for preventing or treating CVD
CN107106584A (zh) 2014-12-08 2017-08-29 格礼卡姆股份公司 用于治疗代谢障碍的合成组合物
PL3277287T3 (pl) 2015-03-31 2024-04-22 Glycom A/S Mieszaniny oligosacharydów mleka ludzkiego zawierające 3'-O-sialilolaktozę
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
ES2870973T3 (es) 2015-06-09 2021-10-28 Glycom As Mezclas ternarias de 6'-SL, LNnT y LST c
EP3141610A1 (en) 2015-09-12 2017-03-15 Jennewein Biotechnologie GmbH Production of human milk oligosaccharides in microbial hosts with engineered import / export
US10751354B2 (en) 2015-09-14 2020-08-25 Glycom A/S Synthetic composition for microbiota modulation
EP3368047B1 (en) 2015-10-28 2023-04-26 Glycom A/S Synthetic composition and method for modulating emotion and mood disorders
US10835545B2 (en) 2015-10-28 2020-11-17 Glycom A/S Synthetic composition and method for modulating brain function and behaviour
CN108348536B (zh) 2015-11-17 2021-09-24 格礼卡姆股份公司 治疗抗生素相关性并发症的合成组合物
CA3006400A1 (en) 2015-11-30 2017-06-08 Limmatech Biologics Ag Methods of producing glycosylated proteins
EP3389668A4 (en) 2015-12-15 2019-08-21 Glycom A/S MIXTURE OF HMOS
US10829508B2 (en) 2015-12-18 2020-11-10 Glycom A/S Fermentative production of oligosaccharides
US10857168B2 (en) 2016-02-24 2020-12-08 Glycom A/S Synthetic composition for microbiota modulation
DE202017007249U1 (de) 2016-03-07 2020-04-23 Glycom A/S Abtrennung von Oligosacchariden aus der Fermentationsbrühe
WO2017190755A1 (en) 2016-05-05 2017-11-09 Glycom A/S Composition comprising hmos for use in the treatment of mast cell mediated visceral hypersensitivity and/or pain
DK3452050T3 (da) 2016-05-05 2023-02-20 Glycom As Composition comprising hmos for the treatment of noninfectious diarrhoea
EP3458073B1 (en) 2016-05-19 2023-10-25 Glycom A/S Use of human milk oligosaccharides for treating migraine in patients with inflammatory bowel syndrome
EP3474861A4 (en) 2016-06-24 2020-04-15 Glycom A/S COMPOUNDS COMPRISING HMOS FOR THE PREVENTION AND / OR TREATMENT OF VIRAL AND / OR BACTERIAL INFECTIONS.
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11535878B2 (en) 2016-12-27 2022-12-27 Inbiose N.V. In vivo synthesis of sialylated compounds
US11278558B2 (en) 2017-03-01 2022-03-22 Glycom A/S Synthetic composition for microbiota modulation
EP3634429A4 (en) 2017-05-09 2020-11-04 Glycom A/S SYNTHETIC COMPOSITION FOR MICROBIOTE MODULATION
US11541068B2 (en) 2017-05-24 2023-01-03 Glycom A/S HMO compositions and methods for reducing autism spectrum disorder symptoms
WO2018215960A1 (en) 2017-05-24 2018-11-29 Glycom A/S Synthetic composition comprising one or more human milk oligosaccharides (hmos)
US11214588B2 (en) 2017-06-30 2022-01-04 Glycom A/S Synthesis of oligosaccharides
CN110914284B (zh) 2017-07-12 2025-01-07 格礼卡姆股份公司 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物
SG11202000640RA (en) 2017-07-26 2020-02-27 Jennewein Biotechnologie Gmbh Sialyltransferases and their use in producing sialylated oligosaccharides
EP3672600A4 (en) 2017-08-21 2021-05-19 Glycom A/S SYNTHETIC COMPOSITION TO REDUCE ALLERGY SYMPTOMS
EP3456836A1 (en) 2017-09-13 2019-03-20 Glycom A/S Separation of sialylated oligosaccharides from fermentation broth
WO2019071021A2 (en) 2017-10-04 2019-04-11 The Regents Of The University Of California IMMUNOMODULATORY OLIGOSACCHARIDES
CA3081496A1 (en) 2017-11-02 2019-05-09 Glycom A/S Mixture of hmos for reducing or preventing fatigue
CN111698994A (zh) 2017-11-30 2020-09-22 格礼卡姆股份公司 治疗小麦敏感性的hmo混合物
CN111556755A (zh) 2017-12-05 2020-08-18 格礼卡姆股份公司 用于治疗偏头痛的人乳寡糖
AU2018386217A1 (en) * 2017-12-15 2020-07-02 Glycosyn LLC Sialyltransferases and uses thereof
US11304966B2 (en) 2017-12-22 2022-04-19 Glycom A/S Composition comprising HMOs for preventing or reducing nociception
GB2573539A (en) 2018-05-09 2019-11-13 Mjn Us Holdings Llc Wellbeing supplement for postpartum maternal nutrition
ES2933995T3 (es) 2018-05-28 2023-02-15 Chr Hansen Hmo Gmbh Producción fermentativa de sacáridos sialilados
BR112020022892A2 (pt) 2018-05-31 2021-02-23 Glycom A/S mistura de hmos para tratamento de doenças autoi-munes
SG11202011734QA (en) 2018-06-01 2020-12-30 Jennewein Biotechnologie Gmbh A simple method for the purification of a sialyllactose
BR112021010116A2 (pt) * 2018-12-04 2021-08-31 Glycom A/S Síntese do oligossacarídeo fucosilado lnfp-v
CN113194960A (zh) 2018-12-19 2021-07-30 格礼卡姆股份公司 用于治疗使用低fodmap饮食的人的组合物和方法
CN109852651B (zh) 2018-12-27 2022-03-15 大连大学 一种重组大肠杆菌质周腔内生产唾液酸修饰n-糖基化重组蛋白方法
CN110195043A (zh) * 2019-05-15 2019-09-03 武汉格莱利生物科技有限公司 一种高水溶性的cgta酶及其制备方法和应用
EP3789495A1 (en) * 2019-09-03 2021-03-10 Jennewein Biotechnologie GmbH Production of sialylated oligosaccharides in bacillus cells
WO2021081670A1 (en) * 2019-11-01 2021-05-06 The University Of British Columbia Compositions and methods for sialylated mucin-type o-glycosylation of therapeutic proteins
WO2021094133A2 (en) 2019-11-13 2021-05-20 Basf Se Enzymatic hydrolysis of 2',3-difucosyllactose
JP7833397B2 (ja) 2019-11-29 2026-03-19 グリコム・アクティーゼルスカブ 妊婦の細菌叢を改善するためのｈｍｏの混合物
CA3178327A1 (en) * 2019-12-18 2021-06-24 Inbiose N.V. Production of sialylated oligosaccharide in host cells
EP4077702A4 (en) * 2019-12-19 2023-11-01 Glycom A/S SEPARATION OF SIALYLATED OLIGOSACCHARIDES FROM A FERMENTATION BROTH
EP3848471A1 (en) * 2020-01-10 2021-07-14 Chr. Hansen HMO GmbH Sequential fermentative production of oligosaccharides
CN115151651A (zh) 2020-02-24 2022-10-04 碳码股份公司 目的糖基化鞘氨醇碱或其类似物的合成
WO2021170621A1 (en) 2020-02-24 2021-09-02 Carbocode S.A. Synthesis of c-glycosides of interest
US20230098432A1 (en) * 2020-02-24 2023-03-30 Carbocode S.A. Synthesis of glycosyl fluorides
CN111500660A (zh) * 2020-04-23 2020-08-07 武汉糖智药业有限公司 一种单唾液酸四己糖神经节苷脂的合成方法
EP3954769A1 (en) * 2020-08-10 2022-02-16 Inbiose N.V. Production of oligosaccharide mixtures by a cell
EP3954778B1 (en) 2020-08-10 2023-10-04 Inbiose N.V. Production of a mixture of neutral non-fucosylated oligosaccharides by a cell
FR3110176B1 (fr) 2020-05-12 2022-05-13 Institut Nat Des Sciences Appliquees De Toulouse Souche et procédé de production d’oligosaccharides
US20250188504A1 (en) 2020-08-10 2025-06-12 Inbiose N.V. Production of a mixture of mammalian milk oligosaccharides by a cell
US20240024343A1 (en) 2020-12-04 2024-01-25 Glycom A/S Human milk oligosaccharides for use in supporting maturation or improvement of sleeping patterns
EP4263565A4 (en) * 2020-12-18 2025-04-16 Glycom A/S SEPARATION OF CHARGED OLIGOSACCHARIDES
BR112023014557A2 (pt) 2021-01-22 2023-10-17 Glycom As Nova proteína (fred) da superfamília de facilitadores principais (mfs) na produção de hmos sialiado
US20240307431A1 (en) * 2021-01-29 2024-09-19 Centre National De La Recherche Scientifique (Cnrs) Novel sialosides and their use in therapy
DK181061B1 (en) 2021-03-12 2022-10-31 Glycom As Purification of sialooligosaccharides
KR20230170961A (ko) * 2021-04-16 2023-12-19 인바이오스 엔.브이. 시알릴화 이당 및/또는 올리고당의 세포 생산
AU2022258873A1 (en) 2021-04-16 2023-11-30 Inbiose N.V. Fermentative production
WO2022223430A1 (en) 2021-04-19 2022-10-27 Dsm Ip Assets B.V. A composition of enzymes and human milk oligosaccharides
KR20240010471A (ko) 2021-05-20 2024-01-23 시에이치알. 한센 에이/에스 올리고사카라이드의 연속 발효 생산
BE1029435B1 (nl) 2021-06-15 2023-07-31 Dsm Ip Assets Bv Scheiding van moedermelkoligosachariden uit een fermentatiebouillon
WO2022263425A1 (en) 2021-06-15 2022-12-22 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
BE1029434B1 (nl) 2021-06-15 2023-07-31 Dsm Ip Assets Bv Scheiding van moedermelkoligosachariden uit een fermentatiebouillon
WO2022263426A1 (en) 2021-06-15 2022-12-22 Dsm Ip Assets B.V. Separation of human milk oligosaccharides from a fermentation broth
WO2023097604A1 (zh) * 2021-12-02 2023-06-08 岩唐生物科技(杭州)有限责任公司 分离的多肽及其应用
DK181683B1 (en) 2022-03-02 2024-09-20 Dsm Ip Assets Bv Cells exprssing new sialyltransferases for in vivo synthesis of lst-a, methods using same and constructs encoding said sialyltransferases
US20260028634A1 (en) 2022-03-02 2026-01-29 Dsm Ip Assets B.V. New sialyltransferases for in vivo synthesis of 3'sl and 6'sl
DK181319B1 (en) 2022-03-02 2023-08-10 Dsm Ip Assets Bv Genetically engineered cells and methods comprising use of a sialyltransferase for in vivo synthesis of 3’sl
CN114965543B (zh) * 2022-06-13 2023-10-20 青岛科技大学 壳寡糖nmr波谱的归属及脱乙酰度相关指标的测定方法
DK182283B1 (en) 2022-06-20 2026-02-10 Dsm Ip Assets Bv Methods and cell comprising new sialyltransferases for in vivo synthesis of lst-c and use of the same
DK202200588A1 (en) 2022-06-20 2024-02-23 Dsm Ip Assets Bv Mixture of fucosylated HMOs
CN115094103A (zh) * 2022-07-22 2022-09-23 南宁东恒华道生物科技有限责任公司 以蔗糖、淀粉或糖原为原料组合酶法生产半乳糖的新工艺
CN115820594B (zh) * 2022-12-27 2026-04-21 中国科学院海洋研究所 一种病毒来源的几丁质合成酶的表达纯化方法及其用途
CN117778345A (zh) * 2024-01-14 2024-03-29 北京睿脉医药科技有限公司 可固化和重复利用的幽门螺杆菌岩藻糖基转移酶突变体
CN119876092B (zh) * 2024-12-30 2025-10-31 嘉必优生物技术（武汉）股份有限公司 一种尿苷5′-二磷酸-n-乙酰氨基葡萄糖2差向异构酶的突变体及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2125092C1 (ru) * 1991-10-15 1999-01-20 Дзе Скриппс Рисерч Инститьют Способ получения фукозилированного углевода, способ получения фукозилированной сиалилированной углеводной молекулы, реакционная система in vitro
US6194178B1 (en) * 1998-09-03 2001-02-27 Synsorb Biotech Inc. Method for the production of sialylated oligosaccharides
FR2796082B1 (fr) 1999-07-07 2003-06-27 Centre Nat Rech Scient Procede de production d'oligosaccharides
US7329514B2 (en) * 2002-02-28 2008-02-12 Kyowa Hakko Kogyo Co., Ltd. Process for producing n-acetylneuraminic acid
EP1730293A2 (en) 2004-03-17 2006-12-13 Glycofi, Inc. Method of engineering a cytidine monophosphate-sialic acid synthetic pathway in fungi and yeast
WO2006034225A2 (en) 2004-09-17 2006-03-30 Neose Technologies, Inc. Production of oligosaccharides by microorganisms

Also Published As

Publication number Publication date
CA2645141C (en) 2018-07-10
MY148510A (en) 2013-04-30
SI1991690T1 (sl) 2014-06-30
RU2473695C2 (ru) 2013-01-27
CN101415834B (zh) 2014-09-24
ES2456292T3 (es) 2014-04-21
EP1991690B1 (en) 2014-01-15
CN101415834A (zh) 2009-04-22
RU2008139968A (ru) 2010-04-20
US20110014661A1 (en) 2011-01-20
DK1991690T3 (da) 2014-04-14
WO2007101862A1 (en) 2007-09-13
CA2645141A1 (en) 2007-09-13
EP1991690A1 (en) 2008-11-19
AU2007222375B2 (en) 2012-12-20
AU2007222375A1 (en) 2007-09-13
US8507227B2 (en) 2013-08-13
PT1991690E (pt) 2014-04-22

Similar Documents

Publication Publication Date Title
PL1991690T3 (pl) Sposób wytwarzania sialilowanych oligosacharydów
PL1903019T3 (pl) Sposób wytwarzania izoolefin
AP2914A (en) Method for producing 4-oxoquinoline compound
GB2449991B (en) Non-bolt joint structure and method for producing non-bolt joint structure
PT2234712T (pt) Processo para a produção de microcápsulas
EP2233548A4 (en) PROCESS FOR PRODUCING FERROCOKE
EP1995254A4 (en) PROCESS FOR PRODUCING PEPTIDE
GB0605360D0 (en) Method of manufacture
EP2141178A4 (en) PROCESS FOR PRODUCING ANTITHROMBIN COMPOSITION
HUE036191T2 (hu) Eljárás többrétegû anyag elõállítására
EP1972615A4 (en) CYCLOALCANECARBOXAMIDE DERIVATIVE AND METHOD FOR PRODUCING THE SAME
IL192702A0 (en) Process for producing 5-alkoxy-4-hydroxymethylpyrazole compound
EP2040561A4 (en) PREBIOTIC CHOCOLATE AND PROCESS FOR PRODUCING THE SAME
ZA200807547B (en) Method for producing 4-oxoquinoline compound
EP2197859A4 (en) PROCESS FOR PRODUCING BENZOXAZINONE-BASED COMPOUND
ZA200806840B (en) Improved process for producing nitroisourea derivatives
TWI319390B (en) Process of producing o-methyl-n-nitroisourea
IL198589A0 (en) Method for producing 2-alkyl-3-aminothiophene derivative
PL2097046T3 (pl) Sposób wytwarzania implantu
ZA200905055B (en) Method for the production of benzofuran-2-carboxamides
ZA200904567B (en) Process for producing 2-isopropenyl-5-methyl-4-hexene-1-yl-3-methyl-2-butenoate
EP2206777A4 (en) PROCESS FOR PRODUCING AMINOPEPTIDASE
ZA200809008B (en) 2-alkenyl-3-aminothipene derivative and process for producing thereof
EP2042479A4 (en) PROCESS FOR THE PREPARATION OF FLUORAMINE
ZA200902530B (en) Method for producing pradofloxacin