PL1981858T4 - 3,5-di(arylo albo heteroarylo) izoksazole oraz 1,2,4-oksadiazole jako agoniści receptora S1P1, środki immunosupresyjne i przeciwzapalne - Google Patents

3,5-di(arylo albo heteroarylo) izoksazole oraz 1,2,4-oksadiazole jako agoniści receptora S1P1, środki immunosupresyjne i przeciwzapalne

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Publication number
PL1981858T4
PL1981858T4 PL07703028T PL07703028T PL1981858T4 PL 1981858 T4 PL1981858 T4 PL 1981858T4 PL 07703028 T PL07703028 T PL 07703028T PL 07703028 T PL07703028 T PL 07703028T PL 1981858 T4 PL1981858 T4 PL 1981858T4
Authority
PL
Poland
Prior art keywords
immunosuppresssive
isoxazoles
oxadiazoles
heteroaryl
aryl
Prior art date
Application number
PL07703028T
Other languages
English (en)
Other versions
PL1981858T3 (pl
Inventor
Rainer Albert
Frédéric Zecri
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of PL1981858T3 publication Critical patent/PL1981858T3/pl
Publication of PL1981858T4 publication Critical patent/PL1981858T4/pl

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
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    • C07D271/00Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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PL07703028T 2006-01-27 2007-01-25 3,5-di(arylo albo heteroarylo) izoksazole oraz 1,2,4-oksadiazole jako agoniści receptora S1P1, środki immunosupresyjne i przeciwzapalne PL1981858T4 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0601744.6A GB0601744D0 (en) 2006-01-27 2006-01-27 Organic compounds
EP07703028A EP1981858B1 (en) 2006-01-27 2007-01-25 3,5-di(aryl or heteroaryl)isoxazoles and 1,2,4-oxadiazoles as s1p1 receptor agonists, immunosuppresssive and anti-inflammatory agents
PCT/EP2007/000638 WO2007085451A2 (en) 2006-01-27 2007-01-25 3,5-di (aryl or heteroaryl) isoxazoles and 1, 2, 4-oxadiazoles as s1p1 receptor agonists, immunosuppresssive and anti -inflammatory agents

Publications (2)

Publication Number Publication Date
PL1981858T3 PL1981858T3 (pl) 2010-12-31
PL1981858T4 true PL1981858T4 (pl) 2010-12-31

Family

ID=36061049

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Application Number Title Priority Date Filing Date
PL07703028T PL1981858T4 (pl) 2006-01-27 2007-01-25 3,5-di(arylo albo heteroarylo) izoksazole oraz 1,2,4-oksadiazole jako agoniści receptora S1P1, środki immunosupresyjne i przeciwzapalne

Country Status (16)

Country Link
US (1) US7799812B2 (pl)
EP (2) EP2233473A1 (pl)
JP (1) JP2009524611A (pl)
KR (1) KR20080091161A (pl)
CN (1) CN101374821A (pl)
AT (1) ATE471313T1 (pl)
AU (1) AU2007209533A1 (pl)
BR (1) BRPI0707285A2 (pl)
CA (1) CA2637081A1 (pl)
DE (1) DE602007007186D1 (pl)
ES (1) ES2347015T3 (pl)
GB (1) GB0601744D0 (pl)
PL (1) PL1981858T4 (pl)
PT (1) PT1981858E (pl)
RU (1) RU2008134534A (pl)
WO (1) WO2007085451A2 (pl)

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BRPI0820868A2 (pt) 2007-12-10 2019-09-24 Actelion Pharmaceuticals Ltd composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado
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