PL1981858T3 - 3,5-di(arylo albo heteroarylo) izoksazole oraz 1,2,4-oksadiazole jako agoniści receptora S1P1, środki immunosupresyjne i przeciwzapalne - Google Patents
3,5-di(arylo albo heteroarylo) izoksazole oraz 1,2,4-oksadiazole jako agoniści receptora S1P1, środki immunosupresyjne i przeciwzapalneInfo
- Publication number
- PL1981858T3 PL1981858T3 PL07703028T PL07703028T PL1981858T3 PL 1981858 T3 PL1981858 T3 PL 1981858T3 PL 07703028 T PL07703028 T PL 07703028T PL 07703028 T PL07703028 T PL 07703028T PL 1981858 T3 PL1981858 T3 PL 1981858T3
- Authority
- PL
- Poland
- Prior art keywords
- immunosuppresssive
- isoxazoles
- oxadiazoles
- heteroaryl
- aryl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Hematology (AREA)
- Virology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0601744.6A GB0601744D0 (en) | 2006-01-27 | 2006-01-27 | Organic compounds |
PCT/EP2007/000638 WO2007085451A2 (en) | 2006-01-27 | 2007-01-25 | 3,5-di (aryl or heteroaryl) isoxazoles and 1, 2, 4-oxadiazoles as s1p1 receptor agonists, immunosuppresssive and anti -inflammatory agents |
EP07703028A EP1981858B1 (en) | 2006-01-27 | 2007-01-25 | 3,5-di(aryl or heteroaryl)isoxazoles and 1,2,4-oxadiazoles as s1p1 receptor agonists, immunosuppresssive and anti-inflammatory agents |
Publications (2)
Publication Number | Publication Date |
---|---|
PL1981858T4 PL1981858T4 (pl) | 2010-12-31 |
PL1981858T3 true PL1981858T3 (pl) | 2010-12-31 |
Family
ID=36061049
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL07703028T PL1981858T3 (pl) | 2006-01-27 | 2007-01-25 | 3,5-di(arylo albo heteroarylo) izoksazole oraz 1,2,4-oksadiazole jako agoniści receptora S1P1, środki immunosupresyjne i przeciwzapalne |
Country Status (16)
Country | Link |
---|---|
US (1) | US7799812B2 (pl) |
EP (2) | EP2233473A1 (pl) |
JP (1) | JP2009524611A (pl) |
KR (1) | KR20080091161A (pl) |
CN (1) | CN101374821A (pl) |
AT (1) | ATE471313T1 (pl) |
AU (1) | AU2007209533A1 (pl) |
BR (1) | BRPI0707285A2 (pl) |
CA (1) | CA2637081A1 (pl) |
DE (1) | DE602007007186D1 (pl) |
ES (1) | ES2347015T3 (pl) |
GB (1) | GB0601744D0 (pl) |
PL (1) | PL1981858T3 (pl) |
PT (1) | PT1981858E (pl) |
RU (1) | RU2008134534A (pl) |
WO (1) | WO2007085451A2 (pl) |
Families Citing this family (57)
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WO2004010949A2 (en) | 2002-07-30 | 2004-02-05 | University Of Virginia Patent Foundation | Compounds active in spinigosine 1-phosphate signaling |
WO2005041899A2 (en) | 2003-11-03 | 2005-05-12 | University Of Virginia Patent Foundation | Orally available sphingosine 1-phosphate receptor agonists and antagonists |
WO2006010379A1 (en) | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
CA2596990A1 (en) | 2005-02-14 | 2006-08-24 | University Of Virginia Patent Foundation | Sphingosine 1-phosphate agonists comprising cycloalkanes and 5 -membered heterocycles substituted by amino and phenyl groups |
SI1863787T1 (sl) | 2005-03-23 | 2011-10-28 | Actelion Pharmaceuticals Ltd | Hidrogenirani benzo(c)tiofenski derivati kot imunomodulatorji |
WO2006131336A1 (en) * | 2005-06-08 | 2006-12-14 | Novartis Ag | POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS |
AR057894A1 (es) | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
TWI404706B (zh) | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
ATE447568T1 (de) | 2006-01-24 | 2009-11-15 | Actelion Pharmaceuticals Ltd | Neue pyrinderivate |
RU2008134702A (ru) | 2006-01-27 | 2010-03-10 | Юниверсити Оф Вирждиния Пэтент Фаундейшн (Us) | Способ лечения невропатической боли |
EP1987013A1 (en) | 2006-02-09 | 2008-11-05 | University Of Virginia Patent Foundation | Bicyclic sphingosine 1-phosphate analogs |
ES2400533T3 (es) | 2006-09-07 | 2013-04-10 | Actelion Pharmaceuticals Ltd. | Derivados de piridin 4-ilo como agentes inmunomoduladores |
TWI408139B (zh) | 2006-09-07 | 2013-09-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
SI2069335T1 (sl) | 2006-09-08 | 2013-04-30 | Actelion Pharmaceuticals Ltd. | Derivati piridin-3-ila kot imunomodulacijska sredstva |
RU2442780C2 (ru) | 2006-09-21 | 2012-02-20 | Актелион Фармасьютиклз Лтд | Фенильные производные и их применение в качестве иммуномодуляторов |
EP2099741A2 (en) | 2006-11-21 | 2009-09-16 | University Of Virginia Patent Foundation | Hydrindane analogs having sphingosine 1-phosphate receptor agonist activity |
NZ576893A (en) | 2006-11-21 | 2012-01-12 | Univ Virginia Patent Found | Tetralin analogs having sphingosine 1-phosphate agonist activity |
CA2669124A1 (en) | 2006-11-21 | 2008-05-29 | University Of Virginia Patent Foundation | Benzocycloheptyl analogs having sphingosine 1-phosphate receptor activity |
MX2009006304A (es) | 2006-12-15 | 2009-06-23 | Abbott Lab | Nuevos compuestos de oxadiazol. |
JO2701B1 (en) | 2006-12-21 | 2013-03-03 | جلاكسو جروب ليميتد | Vehicles |
NZ580454A (en) | 2007-03-16 | 2011-05-27 | Actelion Pharmaceuticals Ltd | Amino- pyridine derivatives as s1p1 /edg1 receptor agonists |
KR20090130062A (ko) * | 2007-04-19 | 2009-12-17 | 글락소 그룹 리미티드 | 스핑고신 1―포스페이트 (s1p) 효능제로서 사용하기 위한 옥사디아졸 치환된 인다졸 유도체 |
RU2492168C2 (ru) | 2007-08-17 | 2013-09-10 | Актелион Фармасьютиклз Лтд | Производные пиридина в качестве модуляторов s1p1/edg1 рецептора |
WO2009053481A1 (en) * | 2007-10-25 | 2009-04-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Compositions and methods for modulating nk and t cell trafficking |
KR20100092473A (ko) * | 2007-11-01 | 2010-08-20 | 액테리온 파마슈티칼 리미티드 | 신규한 피리미딘 유도체 |
BRPI0820868A2 (pt) | 2007-12-10 | 2019-09-24 | Actelion Pharmaceuticals Ltd | composto de tiofeno fórmula(i), composição farmacêutica contendo o mesmo e uso deste para a prevenção ou tratamento de doenças ou disturbíos associados a um sistema imune ativado |
US9045442B2 (en) | 2007-12-21 | 2015-06-02 | University Of Notre Dame Du Lac | Antibacterial compounds and methods of using same |
EP2262799B1 (en) * | 2008-03-06 | 2012-07-04 | Actelion Pharmaceuticals Ltd. | Pyridine compounds |
EP2262800A1 (en) * | 2008-03-06 | 2010-12-22 | Actelion Pharmaceuticals Ltd. | Novel pyrimidine-pyridine derivatives |
MX2010009645A (es) | 2008-03-07 | 2010-09-28 | Actelion Pharmaceuticals Ltd | Derivados novedosos de aminometil benceno. |
WO2010011316A1 (en) | 2008-07-23 | 2010-01-28 | Arena Pharmaceuticals, Inc. | SUBSTITUTED 1,2,3,4- TETRAHYDROCYCLOPENTA[b]INDOL-3-YL) ACETIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISORDERS |
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EP2210890A1 (en) * | 2009-01-19 | 2010-07-28 | Almirall, S.A. | Oxadiazole derivatives as S1P1 receptor agonists |
JP2012515788A (ja) | 2009-01-23 | 2012-07-12 | ブリストル−マイヤーズ スクイブ カンパニー | 自己免疫疾患および炎症性疾患の処置における、s1pアゴニストとしての置換オキサジアゾール誘導体 |
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CN108558740B (zh) | 2010-01-27 | 2021-10-19 | 艾尼纳制药公司 | S1p1受体调节剂及其盐的制备方法 |
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US8273776B2 (en) * | 2010-04-16 | 2012-09-25 | Allergan, Inc | Biphenyl oxadiazole derivatives as sphingosine-1-phosphate receptors modulators |
EP2560969B1 (en) * | 2010-04-23 | 2015-08-12 | Bristol-Myers Squibb Company | 4-(5-isoxazolyl or 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelic acid amides as sphingosin-1-phosphate 1 receptor agonists |
TW201206429A (en) * | 2010-07-08 | 2012-02-16 | Merck Serono Sa | Substituted oxadiazole derivatives |
EP2595969B1 (en) | 2010-07-20 | 2015-04-22 | Bristol-Myers Squibb Company | Substituted 3-phenyl-1,2,4-oxadiazole compounds |
US9187437B2 (en) | 2010-09-24 | 2015-11-17 | Bristol-Myers Squibb Company | Substituted oxadiazole compounds |
ES2544086T3 (es) | 2011-01-19 | 2015-08-27 | Actelion Pharmaceuticals Ltd. | Derivados de 2-metoxi-piridin-4-ilo |
EP2570404A1 (en) * | 2011-09-16 | 2013-03-20 | Syngenta Participations AG. | Plant growth regulating compounds |
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US10662164B2 (en) | 2014-09-25 | 2020-05-26 | University Of Notre Dame Du Lac | Non-beta lactam antibiotics |
WO2016112075A1 (en) | 2015-01-06 | 2016-07-14 | Arena Pharmaceuticals, Inc. | Methods of treating conditions related to the s1p1 receptor |
BR112017024785B1 (pt) | 2015-05-20 | 2022-05-17 | Idorsia Pharmaceuticals Ltd | Forma cristalina do composto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4] oxadiazol-3- il]-2-etil-6-metilfenoxi}-propano-1,2-diol, composição farmacêutica, e, uso |
BR112017027656B1 (pt) | 2015-06-22 | 2023-12-05 | Arena Pharmaceuticals, Inc. | Hábito cristalino de placa livre de sal de l-arginina de ácido (r)-2-(7-(4- ciclopentil-3-(trifluorometil)benzilóxi)- 1,2,3,4-tetra-hidrociclo-penta[b]indol-3- il)acético, composição farmacêutica que o compreende, seus usos e método de preparação do mesmo |
WO2018049404A1 (en) | 2016-09-12 | 2018-03-15 | University Of Notre Dame Du Lac | Compounds for the treatment of clostridium difficile infection |
AU2018222747A1 (en) | 2017-02-16 | 2019-09-05 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of inflammatory bowel disease with extra-intestinal manifestations |
AU2018220521A1 (en) | 2017-02-16 | 2019-09-05 | Arena Pharmaceuticals, Inc. | Compounds and methods for treatment of primary biliary cholangitis |
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WO2000015213A1 (fr) | 1998-09-11 | 2000-03-23 | Shionogi & Co., Ltd. | Agent de prevention ou de traitement de l'insuffisance cardiaque congestive |
DE19904389A1 (de) * | 1999-02-04 | 2000-08-10 | Bayer Ag | Verwendung von substituierten Isoxazolcarbonsäuren und Derivate und neue Stoffe |
BR0110211A (pt) | 2000-04-21 | 2003-06-03 | Shionogi & Co | Derivados de oxadiazol tendo efeitos anticâncer |
WO2001083464A1 (fr) * | 2000-04-21 | 2001-11-08 | Shionogi & Co., Ltd. | Derives d'oxadiazole efficaces en matiere de traitement ou de prevention d'etats pathologiques glomerulaire |
NZ525656A (en) | 2000-11-07 | 2004-12-24 | Novartis Ag | Indolylmaleimide derivatives as protein kinase C inhibitors |
WO2003000249A1 (fr) * | 2001-06-26 | 2003-01-03 | Takeda Chemical Industries, Ltd. | Regulateur de la fonction du recepteur relatif aux retinoides |
WO2003035610A1 (fr) * | 2001-10-26 | 2003-05-01 | Shionogi & Co., Ltd. | Derive de sulfonamide a effet inhibiteur sur les mmp |
US20050227994A1 (en) * | 2002-03-27 | 2005-10-13 | Shionogi & Co., Ltd. | Decomposition inhibitor for extracellular matrix of cartilage |
TWI324064B (en) | 2002-04-03 | 2010-05-01 | Novartis Ag | Indolylmaleimide derivatives |
KR20050084224A (ko) | 2002-12-09 | 2005-08-26 | 더 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 야누스 티로신 키나제 3을 선택적으로 저해하는 방법 |
EP1625123A4 (en) * | 2003-05-15 | 2007-08-29 | Merck & Co Inc | 3- (2-AMINO-1-AZACYCLYL) -5-ARYL-1,2,4-OXADIAZOLE AS S1P RECEPTOR AGONISTS |
MXPA05012460A (es) * | 2003-05-19 | 2006-05-25 | Irm Llc | Compuestos y composiciones inmunosupresoras. |
US7825146B2 (en) * | 2003-07-30 | 2010-11-02 | Shionogi & Co., Ltd. | Sulfonamide derivative having isoxazole ring |
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CN1894225A (zh) | 2003-12-17 | 2007-01-10 | 默克公司 | 作为鞘氨醇1-磷酸(内皮分化基因)受体激动剂的(3,4-二取代)丙酸酯 |
EP1704145B1 (en) | 2004-01-12 | 2012-06-13 | YM BioSciences Australia Pty Ltd | Selective kinase inhibitors |
TW200538433A (en) * | 2004-02-24 | 2005-12-01 | Irm Llc | Immunosuppressant compounds and compositiions |
WO2006131336A1 (en) * | 2005-06-08 | 2006-12-14 | Novartis Ag | POLYCYCLIC OXADIAZOLES OR I SOXAZOLES AND THEIR USE AS SlP RECEPTOR LIGANDS |
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2006
- 2006-01-27 GB GBGB0601744.6A patent/GB0601744D0/en not_active Ceased
-
2007
- 2007-01-25 DE DE602007007186T patent/DE602007007186D1/de active Active
- 2007-01-25 KR KR1020087018321A patent/KR20080091161A/ko not_active Application Discontinuation
- 2007-01-25 US US12/162,413 patent/US7799812B2/en not_active Expired - Fee Related
- 2007-01-25 PL PL07703028T patent/PL1981858T3/pl unknown
- 2007-01-25 JP JP2008551722A patent/JP2009524611A/ja active Pending
- 2007-01-25 ES ES07703028T patent/ES2347015T3/es active Active
- 2007-01-25 RU RU2008134534/04A patent/RU2008134534A/ru not_active Application Discontinuation
- 2007-01-25 EP EP10005624A patent/EP2233473A1/en not_active Withdrawn
- 2007-01-25 CA CA002637081A patent/CA2637081A1/en not_active Abandoned
- 2007-01-25 AU AU2007209533A patent/AU2007209533A1/en not_active Abandoned
- 2007-01-25 CN CNA2007800036158A patent/CN101374821A/zh active Pending
- 2007-01-25 BR BRPI0707285-6A patent/BRPI0707285A2/pt not_active IP Right Cessation
- 2007-01-25 PT PT07703028T patent/PT1981858E/pt unknown
- 2007-01-25 EP EP07703028A patent/EP1981858B1/en not_active Not-in-force
- 2007-01-25 AT AT07703028T patent/ATE471313T1/de active
- 2007-01-25 WO PCT/EP2007/000638 patent/WO2007085451A2/en active Application Filing
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KR20080091161A (ko) | 2008-10-09 |
CA2637081A1 (en) | 2007-08-02 |
BRPI0707285A2 (pt) | 2011-04-26 |
WO2007085451A2 (en) | 2007-08-02 |
DE602007007186D1 (de) | 2010-07-29 |
US7799812B2 (en) | 2010-09-21 |
EP1981858B1 (en) | 2010-06-16 |
GB0601744D0 (en) | 2006-03-08 |
WO2007085451A3 (en) | 2007-12-21 |
CN101374821A (zh) | 2009-02-25 |
PL1981858T4 (pl) | 2010-12-31 |
EP1981858A2 (en) | 2008-10-22 |
JP2009524611A (ja) | 2009-07-02 |
ES2347015T3 (es) | 2010-10-22 |
PT1981858E (pt) | 2010-09-07 |
RU2008134534A (ru) | 2010-03-10 |
EP2233473A1 (en) | 2010-09-29 |
US20090137636A1 (en) | 2009-05-28 |
AU2007209533A1 (en) | 2007-08-02 |
ATE471313T1 (de) | 2010-07-15 |
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