PL1968592T3 - Preparaty zawierające związki pokrewne jorumycyny, renieramycyny, safracyny lub saframycyny oraz dwucukier do leczenia chorób proliferacyjnych - Google Patents
Preparaty zawierające związki pokrewne jorumycyny, renieramycyny, safracyny lub saframycyny oraz dwucukier do leczenia chorób proliferacyjnychInfo
- Publication number
- PL1968592T3 PL1968592T3 PL06795019T PL06795019T PL1968592T3 PL 1968592 T3 PL1968592 T3 PL 1968592T3 PL 06795019 T PL06795019 T PL 06795019T PL 06795019 T PL06795019 T PL 06795019T PL 1968592 T3 PL1968592 T3 PL 1968592T3
- Authority
- PL
- Poland
- Prior art keywords
- formulations
- jorumycin
- renieramycin
- safracin
- saframycin
- Prior art date
Links
- 238000009472 formulation Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 4
- 229930190585 Saframycin Natural products 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000002062 proliferating effect Effects 0.000 title abstract 2
- 150000002016 disaccharides Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 229930183496 Safracin Natural products 0.000 abstract 1
- QCUVHQFXYHRYHX-PIHYCAAOSA-N chembl539920 Chemical compound C([C@H](N1C)[C@@H]2O)C(C(C(C)=C(OC)C3=O)=O)=C3[C@@H]1[C@H](C1)N2[C@@H](COC(C)=O)C2=C1C(=O)C(C)=C(OC)C2=O QCUVHQFXYHRYHX-PIHYCAAOSA-N 0.000 abstract 1
- QCUVHQFXYHRYHX-UHFFFAOYSA-N jorumycin Natural products OC1C(N2C)CC(C(C(C)=C(OC)C3=O)=O)=C3C2C(C2)N1C(COC(C)=O)C1=C2C(=O)C(C)=C(OC)C1=O QCUVHQFXYHRYHX-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229930188681 renieramycin Natural products 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dermatology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0522082.7A GB0522082D0 (en) | 2005-10-31 | 2005-10-31 | Formulations |
| PCT/GB2006/050362 WO2007052076A2 (en) | 2005-10-31 | 2006-10-30 | Formulations comprising jorumycin-, reni eramycin-, safracin- or saframycin-related compounds for treating proliferative diseases |
| EP06795019A EP1968592B1 (en) | 2005-10-31 | 2006-10-30 | Formulations comprising jorumycin-, renieramycin-, safracin- or saframycin-related compounds and a disaccharide for treating proliferative diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL1968592T3 true PL1968592T3 (pl) | 2012-08-31 |
Family
ID=35515969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL06795019T PL1968592T3 (pl) | 2005-10-31 | 2006-10-30 | Preparaty zawierające związki pokrewne jorumycyny, renieramycyny, safracyny lub saframycyny oraz dwucukier do leczenia chorób proliferacyjnych |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9192568B2 (pl) |
| EP (1) | EP1968592B1 (pl) |
| JP (1) | JP5197373B2 (pl) |
| KR (1) | KR101434230B1 (pl) |
| CN (1) | CN101300011B (pl) |
| AT (1) | ATE549023T1 (pl) |
| AU (1) | AU2006310260C1 (pl) |
| CA (1) | CA2625096C (pl) |
| DK (1) | DK1968592T3 (pl) |
| ES (1) | ES2383967T3 (pl) |
| GB (1) | GB0522082D0 (pl) |
| HR (1) | HRP20120478T1 (pl) |
| IL (1) | IL190774A (pl) |
| NO (1) | NO341057B1 (pl) |
| NZ (1) | NZ567291A (pl) |
| PL (1) | PL1968592T3 (pl) |
| PT (1) | PT1968592E (pl) |
| RS (1) | RS52312B (pl) |
| RU (1) | RU2429845C2 (pl) |
| SI (1) | SI1968592T1 (pl) |
| UA (1) | UA97629C2 (pl) |
| WO (1) | WO2007052076A2 (pl) |
| ZA (1) | ZA200803420B (pl) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0117402D0 (en) * | 2001-07-17 | 2001-09-05 | Pharma Mar Sa | New antitumoral derivatives of et-743 |
| GB0708691D0 (en) * | 2007-05-04 | 2007-06-13 | Pharma Mar Sa | Anticancer treatments a |
| NZ589270A (en) * | 2008-05-16 | 2011-12-22 | Pharma Mar Sa | Multiple myeloma treatments |
| RU2010151602A (ru) * | 2008-05-16 | 2012-06-27 | Фарма Мар, С.А. (Es) | Комбинированная терапия с помощью рм00104 и другого противоопухолевого средства |
| WO2011048210A1 (en) | 2009-10-22 | 2011-04-28 | Pharma Mar, S.A. | PDGFR-α AS RESPONSE MARKER FOR PM00104 TREATMENT |
| HRP20221355T1 (hr) * | 2011-04-28 | 2022-12-23 | Oncopeptides Ab | Liofilizirani pripravak citotoksičnih dipeptida |
| PL2928463T3 (pl) | 2012-10-26 | 2020-06-01 | Oncopeptides Ab | Liofilizowane preparaty flufenamidu melfalanu |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
| WO2019018539A1 (en) | 2017-07-19 | 2019-01-24 | California Institute Of Technology | PROCESSES FOR PREPARING COMPOUNDS CONTAINING BIS-TETRAHYDROISOQUINOLINE |
| EP4303221A4 (en) * | 2021-03-03 | 2025-02-26 | The University of Tokyo | NOVEL TETRAHYDROISOQUINOLINE ALKALOID COMPOUND WITH A MACROCYCLE |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5089273A (en) | 1986-06-09 | 1992-02-18 | Board Of Trustees Of The University Of Illinois | Ecteinascidins 729, 743, 745, 759A, 759B and 770 |
| US5256663A (en) | 1986-06-09 | 1993-10-26 | The Board Of Trustees Of The University Of Illinois | Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith |
| US5149804A (en) | 1990-11-30 | 1992-09-22 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins 736 and 722 |
| DE3635711A1 (de) | 1986-10-21 | 1988-04-28 | Knoll Ag | 5-nitrobenzo(de)isochinolin-1,3-dione, ihre herstellung und verwendung |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5336669A (en) | 1991-12-10 | 1994-08-09 | Erbamont, Inc. | Cyclophosphamide monohydrate and lactose |
| FR2697752B1 (fr) | 1992-11-10 | 1995-04-14 | Rhone Poulenc Rorer Sa | Compositions antitumorales contenant des dérivés du taxane. |
| US5478932A (en) | 1993-12-02 | 1995-12-26 | The Board Of Trustees Of The University Of Illinois | Ecteinascidins |
| US20040059112A1 (en) | 1994-02-18 | 2004-03-25 | Rinehart Kenneth L. | Ecteinascidins |
| GB9508195D0 (en) | 1995-04-20 | 1995-06-07 | Univ British Columbia | Novel biologically active compounds and compositions,their use and derivation |
| DE19605212A1 (de) * | 1996-02-13 | 1997-08-14 | Basf Ag | Phosphordotiertes Silberkatalysator-Festbett |
| US5721362A (en) | 1996-09-18 | 1998-02-24 | President And Fellows Of Harvard College | Process for producing ecteinascidin compounds |
| US5985876A (en) | 1997-04-15 | 1999-11-16 | Univ Illinois | Nucleophile substituted ecteinascidins and N-oxide ecteinascidins |
| WO1998052598A1 (en) | 1997-05-21 | 1998-11-26 | Genentech, Inc. | Novel administration of thrombopoietin |
| KR100603219B1 (ko) | 1998-04-06 | 2006-07-20 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 반합성 엑테이나시딘 |
| AU759281B2 (en) | 1998-05-11 | 2003-04-10 | Pharma Mar S.A. | Metabolites of ecteinascidin 743 |
| JP2000081438A (ja) | 1998-06-25 | 2000-03-21 | Sekisui Chem Co Ltd | 被験者の癌化学療法による免疫機能低下の測定方法 |
| US6124292A (en) | 1998-09-30 | 2000-09-26 | President And Fellows Of Harvard College | Synthetic analogs of ecteinascidin-743 |
| MY164077A (en) | 1999-05-13 | 2017-11-30 | Pharma Mar Sa | Compositions and uses of et743 for treating cancer |
| AR035842A1 (es) * | 1999-05-14 | 2004-07-21 | Pharma Mar Sa | Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo |
| JP5219323B2 (ja) | 2000-04-12 | 2013-06-26 | ファルマ・マール・ソシエダード・アノニマ | 抗腫瘍性エクチナサイジン誘導体 |
| MXPA02011319A (es) | 2000-05-15 | 2003-06-06 | Pharma Mar Sa | Analogos antitumorales de ecteinascidina 743. |
| US7420051B2 (en) | 2000-05-15 | 2008-09-02 | Pharma Mar, S.A. | Synthetic process for the manufacture of an ecteinaschidin compound |
| CA2418320A1 (en) | 2000-08-11 | 2002-02-21 | City Of Hope | The anti-neoplastic agent et-743 inhibits trans activation by sxr |
| BR0114912A (pt) * | 2000-10-31 | 2003-10-14 | Pharma Mar Sa | Kahalalide f |
| EP1339713A2 (en) * | 2000-11-03 | 2003-09-03 | President And Fellows Of Harvard College | Saframycins, analogues and uses thereof |
| WO2002036135A2 (en) | 2000-11-06 | 2002-05-10 | Pharma Mar, S.A. | Compositions for antitumour treatment containing ecteinascidin 743 |
| CZ20032022A3 (cs) | 2001-01-25 | 2004-04-14 | Bristol-Myers Squibb Company | Parenterální prostředek obsahující epothilonová analoga |
| WO2002064843A1 (en) * | 2001-02-09 | 2002-08-22 | The Regents Of The University Of California | Ecteinascidin family compounds: compositions and methods |
| YU69903A (sh) | 2001-03-06 | 2006-08-17 | Bristol-Myers Squibb Company | Postupak i dozni oblik za lečenje tumora primenom tegafura, uracila, folne kiseline, paklitaksela i karboplatina |
| WO2002078678A2 (en) | 2001-03-30 | 2002-10-10 | Shire Biochem Inc. | Methods of treating cancer using cyplastin combined with a dioxolane nucleoside such as troxacitabine |
| GB0121285D0 (en) | 2001-09-03 | 2001-10-24 | Cancer Res Ventures Ltd | Anti-cancer combinations |
| BR0213424A (pt) | 2001-10-19 | 2004-12-14 | Pharma Mar Sa | Uso aperfeiçoado de composto antitumoral na terapia contra câncer |
| US20040019027A1 (en) | 2002-04-12 | 2004-01-29 | Barry Forman | Method of treating cerebrotendinous xanthomatosis |
| GB0218813D0 (en) | 2002-08-13 | 2002-09-18 | Pharma Mar Sa | DNA sequences from an endosymbiont and their uses |
| GB0229793D0 (en) | 2002-12-20 | 2003-01-29 | Pharma Mar Sa | The gene cluster involved in safracin biosynthesis and its uses for genetic engineering |
| GB0312407D0 (en) | 2003-05-29 | 2003-07-02 | Pharma Mar Sau | Treatment |
| US7251892B2 (en) * | 2003-07-09 | 2007-08-07 | Temper Corporation | Bearing assembly spacer adjustable system and method for adjusting a spacer |
| GB0324201D0 (en) | 2003-10-15 | 2003-11-19 | Pharma Mar Sau | Improved antitumoral combinations |
| EP1689404B9 (en) | 2003-11-13 | 2009-04-22 | Pharma Mar, S.A.U. | Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer |
| EP1691809A1 (en) | 2003-11-14 | 2006-08-23 | Pharma Mar, S.A. | Combination therapy comprising the use of et-743 and paclitaxel for treating cancer |
| GB0326486D0 (en) | 2003-11-14 | 2003-12-17 | Pharma Mar Sau | Combination treatment |
| WO2005118584A2 (en) | 2004-05-26 | 2005-12-15 | Axys Pharmaceuticals, Inc. | Saframycin analogs as therapeutic agents in the treatment of cancer |
| NZ552607A (en) | 2004-07-09 | 2009-07-31 | Pharma Mar Sa | Prognostic molecular markers |
| CN101068596A (zh) | 2004-09-29 | 2007-11-07 | 法马马私人股份有限公司 | 艾可特耐思地作抗炎药 |
| US20090117176A1 (en) | 2004-10-26 | 2009-05-07 | Pharma Mar, S.A. Sociedad Unipersonal | Anticancer Treatments |
| NZ554761A (en) * | 2004-10-29 | 2010-01-29 | Pharma Mar Sa | Formulations comprising ecteinascidin and a disaccharide |
| WO2006066183A2 (en) * | 2004-12-16 | 2006-06-22 | Axys Pharmaceuticals, Inc. | Novel saframycin analogs as therapeutic agents |
| EP1962843B1 (en) | 2005-11-25 | 2011-02-23 | Pharma Mar S.A., Sociedad Unipersonal | Use of parp-1 inhibitors |
| WO2007134203A2 (en) | 2006-05-12 | 2007-11-22 | Pharma Mar, S.A. | Anticancer treatments with a combination of docetaxel and ecteinascidin |
-
2005
- 2005-10-31 GB GBGB0522082.7A patent/GB0522082D0/en not_active Ceased
-
2006
- 2006-10-30 HR HRP20120478TT patent/HRP20120478T1/hr unknown
- 2006-10-30 CN CN2006800404704A patent/CN101300011B/zh not_active Expired - Fee Related
- 2006-10-30 DK DK06795019.6T patent/DK1968592T3/da active
- 2006-10-30 CA CA2625096A patent/CA2625096C/en not_active Expired - Fee Related
- 2006-10-30 US US12/091,540 patent/US9192568B2/en not_active Expired - Fee Related
- 2006-10-30 AU AU2006310260A patent/AU2006310260C1/en not_active Ceased
- 2006-10-30 ES ES06795019T patent/ES2383967T3/es active Active
- 2006-10-30 WO PCT/GB2006/050362 patent/WO2007052076A2/en not_active Ceased
- 2006-10-30 NZ NZ567291A patent/NZ567291A/en not_active IP Right Cessation
- 2006-10-30 SI SI200631346T patent/SI1968592T1/sl unknown
- 2006-10-30 PT PT06795019T patent/PT1968592E/pt unknown
- 2006-10-30 UA UAA200807478A patent/UA97629C2/ru unknown
- 2006-10-30 RU RU2008121716/15A patent/RU2429845C2/ru not_active IP Right Cessation
- 2006-10-30 AT AT06795019T patent/ATE549023T1/de active
- 2006-10-30 JP JP2008537207A patent/JP5197373B2/ja not_active Expired - Fee Related
- 2006-10-30 KR KR1020087010283A patent/KR101434230B1/ko not_active Expired - Fee Related
- 2006-10-30 RS RS20120235A patent/RS52312B/sr unknown
- 2006-10-30 PL PL06795019T patent/PL1968592T3/pl unknown
- 2006-10-30 EP EP06795019A patent/EP1968592B1/en active Active
-
2008
- 2008-04-10 IL IL190774A patent/IL190774A/en not_active IP Right Cessation
- 2008-04-17 ZA ZA200803420A patent/ZA200803420B/xx unknown
- 2008-05-30 NO NO20082425A patent/NO341057B1/no not_active IP Right Cessation
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