PH31395A - Bis-naphthalimides for the treatment of cancer. - Google Patents

Bis-naphthalimides for the treatment of cancer.

Info

Publication number
PH31395A
PH31395A PH48763A PH48763A PH31395A PH 31395 A PH31395 A PH 31395A PH 48763 A PH48763 A PH 48763A PH 48763 A PH48763 A PH 48763A PH 31395 A PH31395 A PH 31395A
Authority
PH
Philippines
Prior art keywords
cancer
treatment
naphthalimides
bis
formula
Prior art date
Application number
PH48763A
Other languages
English (en)
Inventor
Keilhauer Gerhard
Romerdahl Cynthia
Brana Miguel Fernand Xiao-Dong
Bousquet Peter
Berlanga Jose Maria Castillano
Moset Marina Moran
Vega De Maria Jesus Perez
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of PH31395A publication Critical patent/PH31395A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/14—Aza-phenalenes, e.g. 1,8-naphthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PH48763A 1993-08-18 1994-08-08 Bis-naphthalimides for the treatment of cancer. PH31395A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10894993A 1993-08-18 1993-08-18

Publications (1)

Publication Number Publication Date
PH31395A true PH31395A (en) 1998-10-29

Family

ID=22324990

Family Applications (1)

Application Number Title Priority Date Filing Date
PH48763A PH31395A (en) 1993-08-18 1994-08-08 Bis-naphthalimides for the treatment of cancer.

Country Status (28)

Country Link
US (3) US5616589A (no)
EP (1) EP0714387B1 (no)
JP (1) JPH09501662A (no)
KR (1) KR960703863A (no)
CN (1) CN1039414C (no)
AT (1) ATE166647T1 (no)
AU (1) AU677696B2 (no)
BR (2) BR9407257A (no)
CA (1) CA2169059A1 (no)
CZ (1) CZ34296A3 (no)
DE (1) DE69410614T2 (no)
DK (1) DK0714387T3 (no)
ES (1) ES2116612T3 (no)
FI (1) FI960658A (no)
HR (1) HRP940458B1 (no)
HU (1) HU219232B (no)
IL (1) IL110460A (no)
NO (1) NO305554B1 (no)
NZ (1) NZ271374A (no)
PH (1) PH31395A (no)
PL (1) PL313078A1 (no)
RU (1) RU2138484C1 (no)
SG (1) SG64906A1 (no)
SI (1) SI9420053A (no)
TW (1) TW408112B (no)
UA (1) UA42733C2 (no)
WO (1) WO1995005365A1 (no)
ZA (1) ZA946196B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5703089A (en) * 1994-04-28 1997-12-30 Knoll Aktiengesellschaft Dihydrodibenzisoquinolinediones
EP0930883B1 (en) * 1996-10-21 2006-01-11 Allelix Biopharmaceuticals Inc. Neurotrophin antagonists for the treatment of epilepsy, alzheimer's disease and pain
US6531454B1 (en) 1999-03-16 2003-03-11 The Regents Of The University Of California Glycosylated polyamines and methods of use therefor
AU3883600A (en) 1999-03-16 2000-10-04 Regents Of The University Of California, The Glycosylated polyamines
US6468990B1 (en) 1999-05-17 2002-10-22 Queen's University At Kingston Method of inhibiting binding of nerve growth factor to p75 NTR receptor
US6492380B1 (en) 1999-05-17 2002-12-10 Queen's University At Kingston Method of inhibiting neurotrophin-receptor binding
EP1265898B1 (en) 2000-03-07 2003-09-24 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES 1,8-NAPHTHALIMIDE IMIDAZO 4,5,1- i de /i ]ACRIDONES WITH ANTI-TUMOR ACTIVITY
EP1689441A1 (en) * 2003-11-05 2006-08-16 PhotoBioMed Corporation Bonding tissues and cross-linking proteins with naphthalimide compounds
WO2005105753A2 (en) * 2004-05-05 2005-11-10 Unibioscreen S.A. Naphthalimide derivatives, methods for their production and pharmaceutical compositions therefrom
US20070134243A1 (en) * 2004-12-01 2007-06-14 Gazzard Lewis J Antibody drug conjugates and methods
US7947839B2 (en) 2004-12-01 2011-05-24 Genentech, Inc. Heterocyclic-substituted bis-1,8 naphthalimide compounds, antibody drug conjugates, and methods of use
WO2006060533A2 (en) 2004-12-01 2006-06-08 Genentech, Inc. Conjugates of 1, 8-bis-naphthalimides with an antibody
EP1931637A4 (en) 2005-09-15 2009-09-16 Painceptor Pharma Corp METHODS FOR MODULATING NEUROTROPHIN-INDUCED ACTIVITY
WO2009089537A2 (en) 2008-01-11 2009-07-16 Northwestern University Anti-cancer compounds

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3535496A1 (de) * 1985-10-04 1987-04-16 Bayer Ag Verfahren zur fluoreszenzloeschung und neue kationische naphthalin-peri-dicarbonsaeureimid-derivate
DE3707651A1 (de) * 1987-03-10 1988-09-22 Knoll Ag Bis-naphthalimide, ihre herstellung und verwendung
US5086052A (en) * 1987-07-17 1992-02-04 Abbott Laboratories Substituted 1,4,5,6-tetrahydro-2H-pyridazin-3-one and -3-thione compounds having lipoxygenase inhibitory activity
US5086059A (en) * 1990-06-07 1992-02-04 Du Pont Merck Pharmaceutical Company Bis-naphthalimides as anticancer agents
US5206249A (en) * 1991-03-27 1993-04-27 Du Pont Merck Pharmaceutical Company Bis-naphthalimides containing amino-acid derived linkers as anticancer agents
CA2125142A1 (en) * 1991-12-11 1993-06-24 Jung-Hui Sun Highly water soluble bis-naphthalimides useful as anticancer agents
DE4232739A1 (de) * 1992-09-30 1994-03-31 Knoll Ag Neue asymmetrisch substituierte bis-Naphthalimide

Also Published As

Publication number Publication date
JPH09501662A (ja) 1997-02-18
AU677696B2 (en) 1997-05-01
AU7498494A (en) 1995-03-14
FI960658A0 (fi) 1996-02-14
US5789418A (en) 1998-08-04
BR9407257A (pt) 1996-09-24
WO1995005365A1 (en) 1995-02-23
TW408112B (en) 2000-10-11
EP0714387A1 (en) 1996-06-05
NO305554B1 (no) 1999-06-21
UA42733C2 (uk) 2001-11-15
RU2138484C1 (ru) 1999-09-27
HRP940458B1 (en) 2000-02-29
DK0714387T3 (da) 1998-10-12
CA2169059A1 (en) 1995-02-23
ES2116612T3 (es) 1998-07-16
EP0714387B1 (en) 1998-05-27
IL110460A0 (en) 1994-10-21
DE69410614D1 (de) 1998-07-02
DE69410614T2 (de) 1998-09-24
ATE166647T1 (de) 1998-06-15
BR1100143A (pt) 2000-03-14
NZ271374A (en) 1997-05-26
NO960632D0 (no) 1996-02-16
US5616589A (en) 1997-04-01
HU219232B (en) 2001-03-28
HU9600360D0 (en) 1996-04-29
PL313078A1 (en) 1996-05-27
CN1039414C (zh) 1998-08-05
SG64906A1 (en) 1999-05-25
US5981753A (en) 1999-11-09
SI9420053A (en) 1996-08-31
FI960658A (fi) 1996-02-14
HRP940458A2 (en) 1997-06-30
IL110460A (en) 2001-01-11
CN1132506A (zh) 1996-10-02
CZ34296A3 (en) 1996-08-14
KR960703863A (ko) 1996-08-31
HUT73529A (en) 1996-08-28
NO960632L (no) 1996-02-16
ZA946196B (en) 1996-02-19

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